ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer by Pingping Su, Xiaodan Mao, Jincheng Ma, Lixiang Huang, Lirui Yu, Shuting Tang, Mingzhi Zhuang, Zhonglei Lu, Kelvin Stefan Osafo, Yuan Ren, Xinrui Wang, Xite Lin, Leyi Huang, Xiaoli Huang, Elena Ioana Braicu, Jalid Sehouli, Pengming Sun

“…The results of these experiments were further confirmed in endometrial cancer (EC)-derived organoids and nude mice. In addition, the expression of ERRα-related pyroptosis genes was analyzed using The Cancer Genome Atlas and Gene Expression Omnibus database. …”
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Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology wit... by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…A comprehensive analysis of the multi-level bioinformatic analysis, including protein-protein interactions (PPI) and functional pathways of the targets, was conducted, followed by verification through immunohistochemistry (IHC) to clarify SHSY’s pharmacological basis and action mechanisms in treating GD.ResultsAfter 8 weeks of treatment, SHSY significantly reduced serum T4 and TRAb levels in GD mice and enhanced the morphology of thyroid tissues. …”
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Prophylactic phage administration provides a time window for delayed treatment of vancomycin-resistant Enterococcus faecalis in a murine bacteremia model by Wei-Xiao Wang, Jiao-Yang Yu, Xiu-Zhen Chen, Xiu-Zhen Chen, Shi-Yong Fu, Hui Li, Peng-Cheng Yi, Yun-Yao Ren, Shuang-Lin Gu, Jing-Han Gao, Jing Fan, Yan-Mei Sun, Jie Feng, Shi-Wei Wang, Wei Chen, Wei Chen

“…In a mouse bacteremia model, phage treatment alone rescued 60% of infected mice, while combining phage with levofloxacin increased survival to 80%. …”
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Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells by Bum-Ho Bin, Juyeon Seo, Sung Tae Kim

“…A precise, comprehensive understanding of the structures and transport mechanisms of ZIP and ZnT in combination with mice experiments would provide promising drug targets as well as a basis for identifying other transporters with therapeutic potential.…”
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Microdissection and Single-Cell Suspension of Neocortical Layers From Ferret Brain for Single-Cell Assays by Lucia Del-Valle-Anton, Salma Amin, Víctor Borrell

“…It also facilitates the study of laboratory animal models that recapitulate human cortical development better than mice, like ferrets.…”
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Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils by Ming Yuan, Ha Zhu, Junfang Xu, Yuanyuan Zheng, Xuetao Cao, Qiuyan Liu

“…Here, we detected that chemokine CXCL1 was dramatically elevated in serum from 3LL tumor-bearing mice. In vitro, 3LL cells constitutively expressed and secreted higher level of CXCL1. …”
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Alpiniae oxyphyllae Fructus ameliorates renal lipid accumulation in diabetic kidney disease via activating PPARα by Zi-Jie Yan, Lin Zhang, Xin-Yao Han, Yu Kang, Shu-Man Liu, Tian-Peng Ma, Man Xiao, Yi-Qiang Xie

“…AOF lowered blood glucose, improved dyslipidemia, and attenuated renal injury in DKD mice. AOF-containing serum accentuated high glucose-induced decrease in cell viability and ameliorated lipid accumulation. …”
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Effect of Hepatitis E Virus on the Male Reproductive System: A Review of Current Evidence by Ahmed A. Kotb, Mohamed A. El-Mokhtar, Ibrahim M. Sayed

“…Studies of HEV infection in animal models such as pigs, gerbils, and mice showed that HEV infection caused distortion on the testes, damage of the blood–testis barrier, and induction of inflammatory responses leading to abnormalities in the sperm. …”
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Inhibition of Murine Pulmonary Microvascular Endothelial Cell Apoptosis Promotes Recovery of Barrier Function under Septic Conditions by Lefeng Wang, Sanjay Mehta, Michael Brock, Sean E. Gill

“…Our recent work identified a strong correlation between PMVEC apoptosis and microvascular leak in septic mice in vivo, but the specific role of apoptosis in septic PMVEC barrier dysfunction remains unclear. …”
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BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex by Emily Petrus, Hey-Kyoung Lee

“…Here we demonstrate that mice lacking the major neuronal β-secretase, BACE1, exhibit a similar phenotype: stronger basal excitatory synaptic transmission and failure to adapt to changes in visual experience. …”
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An ingestible bioimpedance sensing device for wireless monitoring of epithelial barriers by Brian M. Holt, Justin M. Stine, Luke A. Beardslee, Hammed Ayansola, Younggeon Jin, Pankaj J. Pasricha, Reza Ghodssi

“…Through an animal study, we demonstrate how the device exhibits altered impedance response to tight junction dilation induced on mice colonic tissue through calcium-chelator exposure. …”
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Herpes Simplex Virus-2 Glycoprotein Interaction with HVEM Influences Virus-Specific Recall Cellular Responses at the Mucosa by Sarah J. Kopp, Christopher S. Storti, William J. Muller

“…We investigated whether the gD-HVEM interaction during priming changes lymphocyte recall responses in the murine intravaginal model. Mice were primed with attenuated HSV-2 expressing wild-type gD or mutant gD unable to engage HVEM and challenged 32 days later with virulent HSV-2 expressing wild-type gD. …”
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Effects and Mechanisms of Silibinin on Influenza A/H1N1 Pathogenesis in a Mouse Model by Mohsen Keshavarz, Mohsen Ghorbani, Forough Shamsizadeh, Haideh Namdari, Vahid Salimi, Farhad Rezaei

“…The present study aimed to determine the inflammatory and anti-inflammatory cytokine secretion patterns in mice before and after silibinin treatment. For this, bronchoalveolar lavage (BAL) fluids were collected from the thoracic cavity 5 days after the intervention, and viral quantification was performed using TaqMan Real-time PCR. …”
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Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes by Daniel Espes, Mats Martinell, Per-Ola Carlsson

“…Betatrophin has recently been described as a key hormone to stimulate beta-cell mass expansion in response to insulin resistance and obesity in mice. The finding has generated an interest in the development of antidiabetic drugs with betatrophin as the active component. …”
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Lipoprotein Nanoplatform for Targeted Delivery of Diagnostic and Therapeutic Agents by Jerry D. Glickson, Sissel Lund-Katz, Rong Zhou, Hoon Choi, I-Wei Chen, Hui Li, Ian Corbin, Anatoliy V. Popov, Weiguo Cao, Liping Song, Chenze Qi, Diane Marotta, David S. Nelson, Juan Chen, Britton Chance, Gang Zheng

“…Surface loading was used for delivery of gadolinium-bis-stearylamide contrast agents for in vivo MRI detection in tumor-bearing mice. Chlorin and phthalocyanine near-infrared photodynamic therapy agents (≤ 400/LDL) have been attached by core loading. …”
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Improvement of the Survival of Human Autologous Fat Transplantation by Adipose-Derived Stem-Cells-Assisted Lipotransfer Combined with bFGF by Aimei Jiang, Ming Li, Wenjing Duan, Yilong Dong, Yanmei Wang

“…In the present study, human fat tissues were mixed with ASCs, ASCs plus 100 U bFGF, or medium as the control and then injected subcutaneously into immunologically compromised nude mice for 12 weeks. Our findings demonstrated that mixture with the ASCs significantly increased the weight and volume of the fat grafts compared to control grafts, and histological analysis revealed that both ASCs and ASCs plus bFGF grafts consisted predominantly of adipose tissue and had significantly less fibrosis but greater microvascular density compared with control and also grafts mixed with ASCs had a high expression of angiogenic factors. …”
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Chemokine (C-X-C) Ligand 12 Facilitates Trafficking of Donor Spermatogonial Stem Cells by Zhiyv Niu, Shaun M. Goodyear, Mary R. Avarbock, Ralph L. Brinster

“…Inhibition of CXCR4 signaling using a small molecule inhibitor (AMD3100) during the critical window of homing also significantly lowered the efficiency of donor-derived SSCs to establish spermatogenic colonies in recipient mice; however, the self-renewal of SSCs was not affected by exposure to AMD3100. …”
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Untethering the Nuclear Envelope and Cytoskeleton: Biologically Distinct Dystonias Arising from a Common Cellular Dysfunction by Nadia A. Atai, Scott D. Ryan, Rashmi Kothary, Xandra O. Breakefield, Flávia C. Nery

“…Mutation/deletion of the gene (Dst) encoding dystonin in mice results in a dystonic movement disorder termed dystonia musculorum, which resembles aspects of dystonia in humans. …”
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Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia by Ji-Eun Park, Hye-Bin Lee, Yu Ra Lee, Guijae Yoo, Hee-Kyoung Son, Sang Yoon Choi, Miri Park, Ho-Young Park

“…This study evaluated the prebiotic and anti-MASLD effects of parsnip root water-soluble extract (PRE) in a mouse model. Mice fed a high-fat diet with 50 or 100 mg/kg PRE for eight weeks showed reduced fat accumulation, improved serum metabolic profiles, and decreased liver injury markers. …”
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A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration by Gábor Eros, Petra Hartmann, Szilvia Berkó, Eszter Csizmazia, Erzsébet Csányi, Anita Sztojkov-Ivanov, István Németh, Piroska Szabó-Révész, István Zupkó, Lajos Kemény

“…The experiments were performed on SKH-1 hairless mice. A skin fold in the dorsal region was fixed with two fenestrated titanium plates. …”
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