Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model by Cheuk-Kwan Sun, Yen-Yi Zhen, Hung-I Lu, Pei-Hsun Sung, Li-Teh Chang, Tzu-Hsien Tsai, Jiunn-Jye Sheu, Yung-Lung Chen, Sarah Chua, Hsueh-Wen Chang, Yi-Ling Chen, Fan-Yen Lee, Hon-Kan Yip

“…We tested the hypothesis that Lipofectamine siRNA delivery to deplete transient receptor potential cation channel (TRPC) 1 protein expression can suppress hypoxia-induced pulmonary arterial hypertension (PAH) in mice. Adult male C57BL/6 mice were equally divided into group 1 (normal controls), group 2 (hypoxia), and group 3 (hypoxia + siRNA TRPC1). …”
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Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide by Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J

“…The in vivo targeting effect as well as antitumor efficacy were determined in HCT116 tumor-bearing mice. Finally, the acute toxicity of Rg3-Lip-OXA/CaO2 was investigated in ICR mice to explore its safety.Results: The XRD and XPS analyses confirmed the successful synthesis of CaO2 nanoparticles. …”
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Reliability of radiomics features as imaging biomarkers for evaluating brain aging: A study based on myelin protein and diffusion tensor imaging by Yuting Yan, Mengmeng Hu, Xiaodong He, Yuyun Xu, Xiaojun Sun, Jiaxuan Peng, Fanfan Zhao, Yuan Shao

“…Ten middle-aged and ten old-aged mice were assigned to the testing set to further validate the reproducibility of the features. …”
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Structural Features and Transcriptional Activity of Chicken PPARs (α, β, and γ) by Ichiro Takada, Mime Kobayashi

“…Chickens have three PPAR gene subtypes (α, β, and γ) that function differently from those present in humans and mice. The chicken PPAR-gamma (cPPARγ) gene is shorter than that in humans and lacks a γ2 isoform. …”
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DYRK1A (Dual-Specificity Tyrosine-Phosphorylated and -Regulated Kinase 1A): A Gene with Dosage Effect During Development and Neurogenesis by M. Dierssen, M. Martínez de Lagrán

“…In Drosophila, disruption of the homolog minibrain gene results in flies with reduced neuroblast proliferation, decreased numbers of central brain neurons, and learning/memory deficits. Knockout DYRK1A mice are embryonic lethal, and heterozygotes show decreased viability and region-specific reductions in brain size. …”
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Aging Adults and Seasonal Influenza: Does the Vitamin D Status (H)Arm the Body? by Pierre Olivier Lang, Dimitrios Samaras

“…Evidence that VitD affects clearance of selected pathogens is supported by epidemiological and clinical data, while its coadministration with influenza vaccine in mice enhanced both mucosal and systemic antibody responses. …”
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Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse by Meirui Li, Salem Alowami, Miranda Schell, Clive Davis, Asghar Naqvi

“…We report a case of secondary PAP in a 47-year-old man, whose risk factors include occupational exposure to inhaled toxins, especially aluminum dust, the use of anabolic steroids, and alcohol abuse, which in mice leads to alveolar macrophage dysfunction through a zinc-dependent mechanism that inhibits granulocyte macrophage-colony stimulating factor (GM-CSF) receptor signalling. …”
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Annexin A5–Functionalized Nanoparticle for Multimodal Imaging of Cell Death by Rui Zhang, Miao Huang, Min Zhou, Xiaoxia Wen, Qian Huang, Chun Li

“…In contrast, there was relatively low signal in the corresponding tissues of control mice. Moreover, the radioactive signal from 111 In-labeled annexin A5–CCPM colocalized with its fluorescence signal, and both signals were confined to regions of dying cells. 111 In-labeled annexin A5–CCPM allows visualization of cell death by both nuclear and optical techniques at the whole-body level as well as at the microscopic level. …”
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Cellular Origins of Regenerating Nodules and Malignancy in the FAH Model of Liver Injury after Bone Marrow Cell Transplantation by Pei-Rong Wang, Yi Li

“…The hepatic malignancy was of host origin in these mice. There was higher expression of extracellular matrix proteins and more inflammatory cells in liver tumor nodules than in regenerating normal liver nodules. …”
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A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies. by Melanie Rissmann, Danny Noack, Thomas M Spliethof, Vincent P Vaes, Rianne Stam, Peter van Run, Jordan J Clark, Georges M G M Verjans, Bart L Haagmans, Florian Krammer, Marion P G Koopmans, Judith M A van den Brand, Barry Rockx

“…A proof-of-concept preclinical study showed treatment of these mice with a virus neutralizing antibody could block Andes orthohantavirus infection and dissemination. …”
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Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis by Stefania Bruno, Maria Beatriz Herrera Sanchez, Chiara Pasquino, Marta Tapparo, Massimo Cedrino, Ciro Tetta, Giovanni Camussi

“…Injection of HLSCs into immunodeficient mice fed with a methionine-choline-deficient diet to induce nonalcoholic steatohepatitis ameliorates liver function and morphology. …”
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GABAergic neurons in the ventral tegmental area represent and regulate force vectors by Qiaochu Jiang, Konstantin I. Bakhurin, Ryan N. Hughes, Bryan Lu, Shaolin Ruan, Henry H. Yin

“…In this study, by using in vivo electrophysiology and continuous quantification of force exertion in head-fixed mice, we identify distinct populations of VTA GABA neurons that exhibit precise force tuning independently of learning, reward prediction, and outcome valence. …”
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Ensuring the Stability of the Genome: DNA Damage Checkpoints by Christine Latif, Susan H. Harvey, Susan J. O'Connell

“…Checkpoint signalling in model systems including mice, Xenopus laevis, Drosophila melanogaster, and the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe have been useful in elucidating these pathways in mammalian cells. …”
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Construction of Nanomaterials and the Role of Rutin in the Treatment of Cerebral Hemorrhage by Xin Li, Zhenzhong Gao

“…The experimental results showed that the RSD of samples at room temperature, freeze-thaw cycles, and long-term stability of the mice were less than 5.0%, and the stability of mouse brain tissue homogenate samples completely meets the requirements of troxerutin, rutin, and troxerutin aglycone.…”
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Endocrine Actions of Osteocalcin by Aurora Patti, Luigi Gennari, Daniela Merlotti, Francesco Dotta, Ranuccio Nuti

“…Recent provocative data from experimental observations in mice showed that the circulating undercarboxylated fraction of osteocalcin increases insulin secretion and sensitivity, lowers blood glucose, and decreases visceral fat in both genders, while it enhances testosterone production by the testes in males. …”
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Dissolving microneedle patch loaded with adipokines-enriched adipose extract relieves atopic dermatitis in mouse via modulating immune disorders, microbiota imbalance, and skin bar... by Jingyan Guan, Kaiqi Chen, Feng Lu, Yunfan He

“…The morphological characteristics, mechanical properties, penetration ability, as well as biocompatibility and degradation efficiency of ACF-MN were evaluated, and its efficacy on ovalbumin-induced AD mice was also investigated. ACF-MN exhibited excellent penetration ability, biocompatibility, degradation efficiency, and satisfying efficacy on murine AD similar with fresh-made ACF. …”
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The Union between Structural and Practical Identifiability Makes Strength in Reducing Oncological Model Complexity: A Case Study by Maria Pia Saccomani, Karl Thomaseth

“…A complex model to study “in vivo” antitumor activity of interleukin-21 on tumor eradication in different cancers in mice is illustrated.…”
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In Vivo Exposure of Deltamethrin Dysregulates the NFAT Signalling Pathway and Induces Lung Damage by Prakriti Sharma, R. S. Sethi

“…The lung samples were extracted from the Swiss albino mice following the treatment of low (2.5 mg/kg) and high (5 mg/kg) doses of deltamethrin. …”
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Evidence for a general cognitive structure in pigeons (Columba livia) by Mary Flaim, Aaron P. Blaisdell

“…While some neurobiological correlates of g have been identified in humans, causal experiments are only feasible in animals. When mice and some avian species are assessed with cognitive test batteries, performance positively correlates, and the first component extracted has similar properties to g. …”
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Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury by Lili Quan, Akiko Uyeda, Ichiro Manabe, Rieko Muramatsu

“…Inhibition of Hnrnpu in astrocytes impairs the formation of astrocytic glial scar, motor function recovery, and neuronal regeneration after spinal cord injury (SCI) in mice. In human astrocytes, HNRNPU knockdown downregulates the genes related to the astrocyte functions in scar formation and neuronal regeneration. …”
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