Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB by Christian Engelmann, Ronny Haenold

“…Recent research on transgenic mice with impaired or hyperactivated NF-κB gave important insights into plasticity-related target gene expression that is regulated by NF-κB. …”
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Developmental Defects in Trisomy 21 and Mouse Models by Jean Maurice Delabar, Revital Aflalo-Rattenbac, Nicole Créau

“…Embryos can be studied freely in mice, making murine models particularly useful for the characterization of developmental abnormalities. …”
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Calcineurin, Synaptic Plasticity, and Memory by Carl Weitlauf, Danny Winder

“…A current experimental strategy is to generate genetically altered mice with mutations in genes thought to be involved in LTP and assess the effects of these mutations both on LTP and animal behavior[1,2]. …”
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Long-term live-cell imaging of GFAP+ astroglia and laminin+ vessels in organotypic mouse brain slices using microcontact printing by Christian Humpel

“…Organotypic brain slices are three-dimensional, 150-μm-thick sections derived from postnatal day 10 mice that can be cultured for several weeks in vitro. …”
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Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia by Haotian Ma, Zhifeng Yan, Runxia Gu, Yingxi Xu, Shaowei Qiu, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Min Wang, Jianxiang Wang

“…By monitoring body weight and survival of tumor-bearing mice, Loop33 × 123 and Loop123 × 33 CAR-T cells were further assessed for their efficacy in vivo. …”
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Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions by Yuanyuan Liu, Zerong Zhang, Xiaoyan Li, Qinghong Hu, Zhangyu Jiang, Jia Lv, Jiayi Xue, Dongyu Wang, Jianxiong Cao, Lingyu Li, Xiaowen Ou, Lijun Zhu, Zhongqiu Liu, Tao Su

“…Using dextran sulfate sodium (DSS)-induced UC model, we found that the anti-UC efficacy of wogonin was diminished in Bcrp-/--Mrp2-/- mice compared to wild-type (WT) mice. In these knockout mice, the content of wogonin was increased in the plasma but decreased in the colon tissues, suggesting that deficiencies in BCRP and MRP2 hinder the efflux of wogonin, resulting in elevated content in the plasma. …”
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Hepatitis D virus infection triggers CXCL9-11 upregulation in hepatocytes and liver infiltration of CXCR3+ CD4 T cells by Jan-Hendrik Bockmann, Lena Allweiss, Annika Volmari, David da Fonseca Araújo, Matin Kohsar, Anastasia Hyrina, Janine Kah, Zhijuan Song, Josolyn Chan, Katja Giersch, Tassilo Volz, Marc Lütgehetmann, Jeffrey J. Wallin, Dmitry Manuilov, Meghan M. Holdorf, Simon P. Fletcher, Ansgar W. Lohse, Antonio Bertoletti, Julian Schulze zur Wiesch, Maura Dandri

“…Lastly, adoptive transfer of human T cells in humanised mice led to recruitment of non-HBV/HDV-specific CD4+ T cells only in the setting of HBV/HDV coinfection, but not in HBV-mono-infected mice. …”
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αAsarone alleviates neuronal injury by facilitating autophagy via miR-499-5p/PDCD4/ATG5 signaling pathway in ischemia stroke by Yonghuan Yan, Linfang Wu, Lu Wang, Dandan Wang, Mengting Huang, Jinyong Peng, Jinyong Peng, Yingying Huang, Yingying Huang, Yingying Huang

“…In vivo experiments further confirmed that αAsarone improved mice MCAO as evidenced by the amelioration of the neurological deficits and facilitated neuronal autophagy. …”
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Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair by Penghui Wang, Zaifeng Chen, Ping Li, Abdullah Al Mamun, Shaoxia Ning, Jinjing Zhang, Chonghui Tang, Tianmiao Sun, Jian Xiao, Xiaojie Wei, Fenzan Wu

“…Crucially, our findings reveal that QLipTC@HDM induces M2 phenotype transformation in glial cells and in mice with SCI, thereby mitigating inflammation. This intervention additionally preserves the integrity of the blood-spinal cord barrier, optimizes the spinal cord microenvironment, reduces glial scarring, promotes axonal regeneration, and enhances motor function recovery in SCI mice. …”
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Identification of Potential Diagnostic Biomarkers of Carotid Atherosclerosis in Obese Populations by Wu X, Pan J, Pan X, Kang J, Ren J, Huang Y, Gong L, Li Y

“…Finally, high-fat diet-fed C57BL/6J ApoE−/− mice were used for in vivo validation.Results: MMP9, PLA2G7, and SPP1 as regulators of the immune infiltration microenvironment in OB patients with CAS, and stratified CAS samples into subtypes with differences in metabolic pathways based on OB classification. …”
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Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway by Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin, Qibing Xie

“…SBR significantly alleviated arthritis in CIA mice through macrophage repolarization and inhibition of inflammation. …”
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β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques by Taisuke Okano, Kengo Sato, Remina Shirai, Tomomi Seki, Koichiro Shibata, Tomoyuki Yamashita, Ayaka Koide, Hitomi Tezuka, Yusaku Mori, Tsutomu Hirano, Takuya Watanabe

“…Chronic β-endorphin infusion into Apoe−/− mice significantly aggravated the development of aortic atherosclerotic lesions, with an increase in vascular inflammation and the intraplaque macrophage/smooth muscle cell ratio, an index of plaque instability. …”
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms by Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity

“…Though our data point to the potential clinical utility of FNDC5/irisin-targeted agents in the treatment of chemotherapy-induced cardiotoxicity, we also found significant down regulation in FNDC5 expression in the hearts of aged mice that attenuated the cardioprotective impacts of FNDC5 overexpression following doxorubicin exposure. …”
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Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy by Yu Feng, Keziah S. Diego, Zhe Dong, Zoé Christenson Wick, Lucia Page-Harley, Veronica Page-Harley, Julia Schnipper, Sophia I. Lamsifer, Zachary T. Pennington, Lauren M. Vetere, Paul A. Philipsberg, Ivan Soler, Albert Jurkowski, Christin J. Rosado, Nadia N. Khan, Denise J. Cai, Tristan Shuman

“…To investigate how hippocampal-entorhinal dysfunction contributes to progressive memory deficits in epilepsy, we performed simultaneous in vivo electrophysiology in the hippocampus (HPC) and medial entorhinal cortex (MEC) of control and epileptic mice 3 or 8 weeks after pilocarpine-induced status epilepticus (Pilo-SE). …”
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Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo by Melissa de Carvalho Santuchi, Miriane Fernandes Dutra, Juliana Priscila Vago, Kátia Maciel Lima, Izabela Galvão, Fernando Pedro de Souza-Neto, Mario Morais e Silva, Aline Cristina Oliveira, Flávia Carvalho Bittencourt de Oliveira, Ricardo Gonçalves, Mauro Martins Teixeira, Lirlândia Pires Sousa, Robson Augusto Souza dos Santos, Rafaela Fernandes da Silva

“…Therapeutic administration of these peptides in LPS-induced inflammation in mice decreased the number of neutrophils and M1 (F4/80lowGr1+CD11bmed) macrophage frequency without affecting the other investigated macrophage subsets. …”
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Mesenchymal stem cell-derived extracellular vesicles enriched with miR-124 exhibit anti-inflammatory effects in collagen-induced arthritis by Guo Zhonghua, He Mengyuan, Shi Dongliang, Zhang Zhongbo, Wang Lisha, Ren Bowen, Wang Yunfei, Wang Junjie, Yang Shaoxiang, Yu Hongchao

“…Arthritis was induced in mice by collagen injection, followed by intravenous administration of miR-124 EVs, miR-control, or vehicle. …”
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Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios by Hu Liu, Peiqi Li, Tan Zhou, Ziqi Yu, Weigao Zhang, Yunfeng Zhu, Jiayi Xu, Xiaoxiao Wu, Jing Li, Chi Zhang, Lei Chen, Dan Weng

“…AML12 hepatocytes exposed to leachates from three different PP plastic containers exhibited significant disruptions in the homeostasis of lipid and glucose metabolism, evidenced by increased intracellular lipid content and altered gene expression related to lipogenesis, lipid uptake, lipolysis, and fatty acid β-oxidation. C57BL/6J mice were fed with the mouse diet that had been heated in two distinct types of PP plastic food containers for 8 weeks and these mice exhibited accelerated body weight gain, altered fasting blood glucose levels, and changes in serum lipid profiles. …”
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Ferula communis leaf extract: antioxidant capacity, UHPLC–MS/MS analysis, and in vivo and in silico toxicity investigations by Imad Ed-Dahmani, Mohamed El Fadili, Ghizlane Nouioura, Fahd Kandsi, Yassine El Atki, Hatem A. Abuelizz, Raffaele Conte, Fatima Zahra Lafdil, Abdeslam Taleb, Abdelfattah Abdellaoui, Mustapha Taleb

“…The toxicity study revealed that the mice’s behavior, body weight, and organ weights (liver and kidneys) were unaffected by Ferula communis leaf extract administration compared to controls. …”
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Polyethylene microplastic exposure adversely affects oocyte quality in human and mouse by Qiaoling Wang, Fengli Chi, Yingdong Liu, Qiurong Chang, Siyu Chen, Pengcheng Kong, Wanli Yang, Wenqiang Liu, Xiaoming Teng, Yan Zhao, Yi Guo

“…Differential metabolites in follicular fluid were analyzed via untargeted metabolomics. Female mice were exposed to polyethylene (PE) to validate human findings. …”
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iRGD-Targeted Biosynthetic Nanobubbles for Ultrasound Molecular Imaging of Osteosarcoma by Liu T, Liang X, Liu W, Yang S, Cui T, Yan F, Li Z

“…Biocompatibility analysis showed no significant cytotoxicity of iRGD-sGVs to mice.Conclusion: Our study provides a new strategy for early diagnosis of osteosarcoma. …”
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