CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway. by Shuaini Yang, Jinxi Yu, Xue Dong, Jiajia Zeng, Lu Tan, Hong Zhang, Ruoyuan Sun, Yuqing Tuo, Jing Yang, Chunxiao Wan, Hong Bai

“…Furthermore, these mice show higher levels of IL-17 along with an enhanced Th17-type immune response, characterized by increased Th17-promoting cytokines TGFB, transcription factors stat3 and RORγt, and il-21, suggesting a compensatory mechanism that drives neutrophil infiltration to exacerbate lung inflammation. …”
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The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment by Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping He

“…Further studies showed that the intragastric administration of 40 mg/kg/day MGF for 6 weeks significantly improved spatial learning ability and long-term memory in C57/BL6 mice with FA-induced cognitive impairment by reducing Tau hyperphosphorylation and the expression of GRP78, GSK-3β, and CaMKII in the brains. …”
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Augmenter of Liver Regeneration Crotonylation Assists in Mitochondria-ER Contact to Alleviate Hepatic SteatosisSummary by Xiao-lin Wang, Jia-hao He, Ping Xie, Yuan Wu, Ling-yue Dong, Wei An

“…Methods: Steatotic liver samples from human and Western diet (WD)-fed mice were employed for detecting Kcr levels. Mitochondrial function and mitochondria-ER interaction (MAM) relevant to ALR-Kcr modification was evaluated for hepatocyte lipid metabolism both in in vivo and in vitro experiments. …”
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Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites by Zeng Zhang, Yajing Fang, Yangli He, Mohamed A. Farag, Min Zeng, Yukai Sun, Siqi Peng, Shuaiming Jiang, Xian Zhang, Kaining Chen, Meng Xu, Zhe Han, Jiachao Zhang

“…Probio-M8 significantly improved muscle function in aged mice and enhanced physical performance in sarcopenia patients. …”
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pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity by Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Thais Graziela Donegá França, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Bianca Balbino, Camila Marques, Maura Rosane Valerio Ikoma, Ana Paula Masson, Célio Lopes Silva, Alexandrina Sartori

“…Vaccinated mice presented significant lower clinical scores and lost less body weight. …”
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Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction by Karin G. F. Gerritsen, Jan Willem Leeuwis, Maarten P. Koeners, Stephan J. L. Bakker, Willem van Oeveren, Jan Aten, Lise Tarnow, Peter Rossing, Jack F. M. Wetzels, Jaap A. Joles, Robbert Jan Kok, Roel Goldschmeding, Tri Q. Nguyen

“…In diabetic mice, uCTGF was increased and fractional excretion (FE) of recombinant CTGF was substantially elevated indicating reduced tubular reabsorption. …”
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Renal and Hematological Effects of CLCF-1, a B-Cell-Stimulating Cytokine of the IL-6 Family by Virginia J. Savin, Mukut Sharma, Jianping Zhou, David Gennochi, Timothy Fields, Ram Sharma, Ellen T. McCarthy, Tarak Srivastava, Jos Domen, Aurélie Tormo, Jean-François Gauchat

“…CLCF-1 increased urine albumin/creatinine ratio in mice and increased B-cell expression of IgG in mouse spleen. …”
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Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9 by Cancan Zhou, Zhengyuan Feng, Weikun Qian, Zeen Zhu, Ruiqi Cao, Qiqi Wang, Wunai Zhang, Rujuan Liu, Shuai Wu, Jie Hao, Zheng Wang, Qingyong Ma, Zheng Wu, Xuqi Li

“…In LSL-Kras G12D/+ ;Trp53 fl/+ ;Pdx1-Cre (KPC) mice, we confirmed the tumor-promoting role of SREBP1 in pancreatic cancer progression. …”
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T cell receptors specific for an imatinib-induced mutation in BCR-ABL for adoptive T cell therapy by Meng-Tung Hsu, Gerald Willimsky, Gerald Willimsky, Gerald Willimsky, Leo Hansmann, Leo Hansmann, Leo Hansmann, Leo Hansmann, Thomas Blankenstein

“…By immunizing transgenic mice that express a diverse human T cell receptor (TCR) repertoire restricted to HLA-A2, we detected CD8+ T cell responses against the ABL-E255V, but not the ABL-T315I peptide. …”
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Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury by A. P. J. Vlaar, M. T. Kuipers, J. J. Hofstra, E. K. Wolthuis, C. W. Wieland, J. J. T. H. Roelofs, L. Boon, M. J. Schultz, R. Lutter, N. P. Juffermans

“…We determined whether onset of TRALI is dependent on the titer of MHC-I antibodies infused in a combined model of ventilator-induced lung injury and antibody-induced TRALl. Methods. BALB/c mice were ventilated for five hours with low (7.5 ml/kg) or high (15 ml/kg) tidal volume. …”
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Liver GlucokinaseA456V Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase by Anna Vidal-Alabró, Alícia G. Gómez-Valadés, Andrés Méndez-Lucas, Jordi Llorens, Ramon Bartrons, Jordi Bermúdez, Jose C. Perales

“…GKA456V was overexpressed in the liver of streptozotocin diabetic mice. Metabolite profiling in serum and liver extracts, together with changes in key components of glucose and lipid homeostasis, were analyzed and compared to GK wild-type transfected livers. …”
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Imaging the large‐scale and cellular response to focal traumatic brain injury in mouse neocortex by Yelena Bibineyshvili, Thomas J. Vajtay, Shiva Salsabilian, Nicholas Fliss, Aastha Suvarnakar, Jennifer Fang, Shavonne Teng, Janet Alder, Laleh Najafizadeh, David J. Margolis

“…Our results in unanaesthetized mice describe novel spatial and temporal neural adaptations that occur at cortical sites remote to a focal brain injury.…”
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Luteolin Regulates the Differentiation of Regulatory T Cells and Activates IL-10-Dependent Macrophage Polarization against Acute Lung Injury by Ke Xie, Yu-sen Chai, Shi-hui Lin, Fang Xu, Chuan-jiang Wang

“…The levels of Treg-related cytokines in serum and bronchoalveolar lavage fluid (BALF) of mice were detected. The protein levels of NF-κB p65 in lung tissues were measured. …”
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Cannabidiol Ameliorates Doxorubicin-Induced Myocardial Injury via Activating Hippo Pathway by Dong T, Li J, Liang X, Wang W, Chen M, Yang G, Wu D

“…After YAP depletion, the role of the Hippo pathway in CBD function was investigated. C57BL/6 mice were treated with DOX to establish an in vivo model, and CBD and verteporfin (VP) were used to treat the mice. …”
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Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D by Yang Qin, Li Liu, Yanwen Zhang, Xiaowei Chen, Jiani Zhang, Sunwang Ling, Jianguang Wang, Xinyu Yang

“…Experiments in collagen-induced arthritis (CIA) mice, the classical animal model of RA, show that IGF2BP1 R176K point mutation (Igf2bp1 R167K/R167K) mice exert reduced inflammatory response, clinical scores, and joint destruction. …”
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Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy by Qianqian Yan, Zihao Zhao, Dongwei Liu, Jia Li, Shaokang Pan, Jiayu Duan, Zhangsuo Liu

“…Finally, the relevant findings were validated using histology and immunohistochemistry analysis of IBD mice. Immune infiltration analysis showed no significant differences between IBD and IgAN samples in most immune cells. …”
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Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease by Maria Victoria Legorreta-Haquet, Rocio Flores-Fernández, Francisco Blanco-Favela, Ezequiel M Fuentes-Pananá, Luis Chávez-Sánchez, Rafael Hernández-González, Emiliano Tesoro-Cruz, Lourdes Arriaga-Pizano, Adriana Karina Chávez-Rueda

“…We observed that the PRL-receptor is expressed in early bone-marrow B-cell; the expression in lupus-prone mice, which had the highest level of expression in pro-B cells and immature cells, differed from that in wild-type mice. …”
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Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation by Lixia Wang, Binshan Zha, Qiying Shen, Hongyun Zou, Cheng Cheng, Huimei Wu, Rongyu Liu

“…Then, some of the mice received MCC950 (10 mg/kg; i.p.) or 3% sevoflurane. …”
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High-Performance Liquid Chromatography Assay for Moxifloxacin in Brain Tissue and Plasma: Validation in a Pharmacokinetic Study in a Murine Model of Cerebral Listeriosis by Renaud Respaud, Solene Grayo, Eric Singlas, Sophie Dubouch, Alban Le Monnier, Marie-Catherine Lott

“…Moxifloxacin pharmacokinetics are modeled in an infected model compared to control mice.…”
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Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated... by Takekatsu Saito, Naotoshi Sugimoto, Kunio Ohta, Tohru Shimizu, Kaori Ohtani, Yuko Nakayama, Taichi Nakamura, Yashiaki Hitomi, Hiroyuki Nakamura, Shoichi Koizumi, Akihiro Yachie

“…L. casei cell wall extract (LCWE) develops arteritis in mice through Toll-like receptor-2 signaling. The purpose of this study was to investigate whether intracellular cAMP affects LCWE-induced pathological signaling. …”
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