Effects of Apatinib on the “Stemness” of Non-Small-Cell Lung Cancer Cells In Vivo and Its Related Mechanisms by Bin Yang, Yan Wang, Zhuoying Chen, Yi-Ming Feng, Liang-Liang Shi

“…A xenograft model of lung cancer cells A549 was established in nude mice and randomized into a control group (n = 4) and an Apatinib group (n = 4). …”
Get full text

LncRNA MDRL Mitigates Atherosclerosis through miR-361/SQSTM1/NLRP3 Signaling by Ling You, Yanjie Zheng, Jing Yang, Qian Hou, Lianxia Wang, Yan Zhang, Chunxia Zhao, Ruiqin Xie

“…In vivo experiments, we applied LDLR knockout (LDLR-/-) mice fed the high-fat diet to investigate the effects of MDRL on atherosclerosis. …”
Get full text

Culture and Characterization of Microglia from the Adult Murine Retina by Gayathri Devarajan, Mei Chen, Elizabeth Muckersie, Heping Xu

“…We have developed a simple method for isolating and culturing retinal microglia from adult mice.…”
Get full text

The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation by Huikang Tao, Pei Xie, Yuhang Cao, Liqi Shu, Liping Li, Junchen Chen, Guangfeng Tian, Yingliang Zhuang, Qiang Shu, Xuekun Li

“…DNA demethylation displayed dynamic features during postnatal neuronal development and the differentiation of aNSCs of mice, which could contribute to appropriate gene expression.…”
Get full text

Maternal Sevoflurane Exposure Causes Abnormal Development of Fetal Prefrontal Cortex and Induces Cognitive Dysfunction in Offspring by Ruixue Song, Xiaomin Ling, Mengyuan Peng, Zhanggang Xue, Jing Cang, Fang Fang

“…Brain tissues of fetal mice were subjected to immunofluorescence staining to assess differentiation, proliferation, and cell cycle dynamics of the fetal PFC. …”
Get full text

Subtype-specific role for Jagged1 in promoting or inhibiting breast tumor formation by Wen-Cheng Chung, Wei Wang, Lavanya Challagundla, Charles D. Moore, Sean E. Egan, Keli Xu

“…In contrast, deletion of Jagged1 in alveolar cells of pregnant mice had no effect on alveolar and lactogenic differentiation or post-lactational involution. …”
Get full text

Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway. by Yushuang Xing, Di Jia, Xinping Zhu, Jialu Yang, Zhipeng Gao, Nana Meng, Haohao Xu, Mengxiao Wang, Shijun Chang, Mingqian Zhao, Shanbo Zhang, Zichen Mu, Qiang Tang, Weiming Zhao

“…Animal studies demonstrated that inotodiol possessed the ability to suppress tumor growth in nude mice models, at the same time, there was no significant impact on the body weight and organs of the mice. …”
Get full text

Resin-Modified Glass Ionomer Nanocomposite: Subcutaneous Connective Tissue Response and Polymerization Shrinkage Resistance by Edélcio Garcia-Júnior, Beatriz Kelly Barros Lopes, Fabricio Kitazono de Carvalho, Raquel Assed Bezerra da Silva, Fernanda de Carvalho Panzeri Pires de Souza, Alberto Consolaro, Lea Assed Bezerra da Silva, Paulo Nelson-Filho

“…Objective: To evaluate the in vitro polymerization shrinkage resistance and in vivo tissue response of the resin-modified glass ionomer cement (RMGIC) Ketac N100 after implantation in the subcutaneous connective tissue of isogenic mice. Material and Methods: A total of 90 isogenic BALB/c mice were randomly distributed into nine groups, with each group receiving an implant of one of the following materials: ChemFil, Ketac N100, Compoglass, and Filtek Z350, as well as empty tubes serving as controls. …”
Get full text

Functional Role of SIL1 in Neurodevelopment and Learning by Shilian Xu, Jia Zhu, Kai Mi, Yan Shen, Xiaomin Zhang

“…Finally, the spatial learning of young mice was assessed by the Barnes maze task. Results. …”
Get full text

Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects by Xiao-yan Zhou, Rong Gao, Jian Hu, Da-peng Gao, Yan-ling Liao, Jian-jun Yang

“…Here, we showed that repeated low-dose LPS injection-induced immune memory protected mice from sepsis-induced cognitive and affective impairments, which were accompanied by significantly decreased brain proinflammatory cytokines and immune response. …”
Get full text

Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism by L. Di Cesare Mannelli, G. D'Agostino, A. Pacini, R. Russo, M. Zanardelli, C. Ghelardini, A. Calignano

“…Aimed to evaluate the antineuropathic properties of PEA, a damage of the sciatic nerve was induced in mice by chronic constriction injury (CCI) and a subcutaneous daily treatment with 30 mg kg−1 PEA was performed. …”
Get full text

The Anticonvulsant Enaminone E139 Attenuates Paclitaxel-Induced Neuropathic Pain in Rodents by Dhandapani Thangamani, Ivan Ogheneochuko Edafiogho, Willias Masocha

“…Administration of E139 (10–40 mg/kg) produced antinociceptive activity against thermal nociception in naïve mice. Treatment with E139, amitriptyline, or gabapentin reduced paclitaxel-induced thermal hyperalgesia. …”
Get full text

Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis by Udari Eshani Perera, Louise Organ, Simon G. Royce, Chrishan S. Samuel, Habtamu B. Derseh, Sasika N. V. Dewage, Emmanuel Koumoundouros, Andrew Stent, Kenneth J. Snibson

“…Lung samples were taken for the histopathological assessment 28 days in sheep and 21 days in mice after the first bleomycin administration. We observed tertiary lymphoid aggregates, in the fibrotic lung parenchyma of sheep, but not in mouse lung tissues exposed to bleomycin. …”
Get full text

Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis by Shicheng Jiao, Lijun Deng, Mu Niu, Jie Yang

“… This study aimed to evaluate the therapeutic efficacy of camellia oil on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice, as well as its effect on the expression of skin-barrier-related proteins. …”
Get full text

Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria by Arjun Sengupta, Angika Basant, Soumita Ghosh, Shobhona Sharma, Haripalsingh M. Sonawat

“…1H NMR-based metabonomics was used to investigate the multimodal response of mice to malarial parasite infection by P. berghei ANKA. …”
Get full text

Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling by Yu Zhang, Shengjie Fan, Na Hu, Ming Gu, Chunxiao Chu, Yiming Li, Xiong Lu, Cheng Huang

“…Using diet-induced obese (DIO) C57BL/6 mice, we identified that rhein blocked high-fat diet-induced obesity, decreased fat mass and the size of white and brown adipocytes, and lowered serum cholesterol, LDL cholesterol, and fasting blood glucose levels in the mice. …”
Get full text

Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway by Jiameng Ding, null WenjuanYang, Yuhui Jiang, Jie Ji, Jie Zhang, Liwei Wu, Jiao Feng, Yuanyuan Zheng, Yan Li, Ziqi Cheng, Qiang Yu, Jianye Wu, Jingjing Li, Kan Chen, Chuanyong Guo

“…Mice were subjected to I/R, and cordycepin was intragastrically administered for seven consecutive days before surgery. …”
Get full text

Study on mechanism of increased allergenicity induced by Ara h 3 from roasted peanut using bone marrow-derived dendritic cells by MinJia Wang, Shuo Wang, Xiaodong Sun, ZhiRui Deng, Bing Niu, Qin Chen

“…Allergenicity of roasted peanut emulsion to mice, differences in uptakes between Ara h 3 purified from raw peanuts (named as Ara h 3-Raw) and that purified from roasted peanuts (named as Ara h 3-Roasted) by bone marrow-derived dendritic cells (BMDCs) and the implication of cell surface receptors involving in uptake, and changes in glycosylation and structure of Ara h 3 after roasting were analyzed in this study. …”
Get full text

A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats by Menuka M. Pallebage-Gamarallage, Virginie Lam, Ryusuke Takechi, Susan Galloway, John C. L. Mamo

“…This study investigated in wild-type mice if a PUFA diet enriched in docosahexanoic acid (DHA) restored blood-brain barrier integrity and attenuated parenchymal apo B abundance induced by chronic ingestion of SFA. …”
Get full text

Decoding SFRP2 progenitors in sustaining tooth growth at single-cell resolution by Tianyuan Zhao, Qing Zhong, Zewen Sun, Xiaoyi Yu, Tianmeng Sun, Zhengwen An

“…This distinct subset, evolutionarily conserved between humans and mice, provides valuable insights into translational approaches for dental tissue regeneration and repair. …”
Get full text