Transcriptomic landscape of Hras12V oncogene-induced hepatocarcinogenesis with gender disparity by Huaiyuan Di, Zhuona Rong, Nan Mao, Huiling Li, Jun Chen, Renwu Liu, Aiguo Wang

“…A transcriptomic database was established via RNA-Seq of HCC (T) and the adjacent precancerous liver tissue (P) of Hras12V transgenic mice (Ras-Tg, HCC model) and the normal liver tissue of wild-type mice (W) of both sexes. …”
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Membrane Bound CRT Fragment Accelerates Tumor Growth of Melanoma B16 Cell In Vivo through Promoting M2 Polarization via TLR4 by Hong-Min Wang, Zhe Zhou, Jie Miao, Bo Zhu, Xiao-Qiu Dai, Qiao Zhong, Fang-Yuan Gong, Xiao-Ming Gao

“…We found that B16-tmCRT/39-272 cells subcutaneously inoculated into C57BL/6 mice exhibited stronger tumorigenicity than the B16-EGFP control cells. …”
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Potential Nociceptive Regulatory Effect of Probiotic Lactobacillus rhamnosus PB01 (DSM 14870) on Mechanical Sensitivity in Diet-Induced Obesity Model by Fereshteh Dardmeh, Hans Ingolf Nielsen, Hiva Alipour, Benedict Kjærgaard, Erik Brandsborg, Parisa Gazerani

“…The present study examined the effect of a single daily oral dose (1 × 109 CFU) of probiotics (Lactobacillus rhamnosus PB01, DSM14870) supplement on mechanical pain thresholds in behaving diet-induced obese (DIO) mice and their normal weight (NW) controls. The mice (N=24, 6-week-old male) were randomly divided into four groups on either standard or high fat diet with and without probiotic supplementation. …”
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Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene by Mst. Hasina Akter, Md. Abdur Razzaque, Liu Yang, Toshio Fumoto, Kiyoto Motojima, Tomohiro Yamaguchi, Fumiko Hirose, Takashi Osumi

“…GSPA expression was induced by a peroxisome proliferator, Wy14,643, in the liver of wild-type mice, but not PPARα-null mice. GSPA and AOX share the promoter and two peroxisome proliferator-response elements. …”
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Inactivation of Zika Virus with Hydroxypropyl-Beta-Cyclodextrin by Cory R. Hewitt, Nicholas J. Wixon, Arthur Gallegos, You Zhou, Victor C. Huber, M. Scott Killian

“…The BCD-treated ZIKV was evaluated for infectivity using immunofluorescence and quantitative RT-PCR (qRT-PCR) assays, for immunoreactivity in Western blots, structural integrity by electron microscopy, and immunogenicity in mice. <b>Results</b>: Here, we show that 200 mM BCD-treated ZIKV is non-infectious in cell culture, remains immunoreactive with an Env-specific antibody, retains its virion shape and size, and elicits the production of immunogen-specific antibodies in immunized mice. …”
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Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine by Yanfei Ma, Yifan Zhong, Wenjie Tang, Teresa G. Valencak, Jingliang Liu, Zhaoxi Deng, Jiangdi Mao, Daren Liu, Shanshan Wang, Yuhao Wang, Haifeng Wang

“…Here, we show that the supplementation of Lactobacillus reuteri ZJ617 ameliorates symptoms of MetS in mice induced by the high-fat diet. L. reuteri ZJ617 modulates host metabolism by interacting with the microbiome, resulting in the production of spermidine synthesized by the microbiota. …”
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Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro by Ting Li, Ting Fang, Linxin Xu, Xiangyang Liu, Xiaoyu Li, Mei Xue, Xiaochen Yu, Bei Sun, Liming Chen

“…Empagliflozin is a sodium-glucose cotransporter-2 inhibitor that effectively lowers blood glucose, but its effect on MAFLD and associated mechanisms are not fully understood.Methods: Eight-week-old db/db mice, an in vivo model, were administered empagliflozin or saline intragastrically. …”
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A Novel Cortex Phellodendri Chinensis–Based Carbon Dots Platform for Remarkable Analgesia for Clinical Pain Management by Huimin Peng, Xingxing Zeng, Songbai Li, Xin Wang

“…Furthermore, the prepared CCDs were studied for their in vivo analgesic effect in mice by performing tail‐immersion, hot plate and acetic acid writhing tests. …”
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Baricitinib represses the myocardial fibrosis via blocking JAK/STAT and TGF-β1 pathways in vivo and in vitro by Renlei Feng, Hongli Liu, Yunqing Chen

“…Results Baricitinib not only attenuated myocardial cell widening, inflammatory infiltration, fibrous tissue, and heart index, but also reduced collagen volume fraction, the expressions of Col1, Col3, α-SMA, Fn, MMP9, and TIMP1 in ISO-induced myocardial fibrosis mice. Meanwhile, baricitinib decreased the expressions of p-STAT3 and TGF-βRII in these mice. …”
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The Beneficial Effect of IL-12 and IL-18 Transduced Dendritic Cells Stimulated with Tumor Antigens on Generation of an Antitumor Response in a Mouse Colon Carcinoma Model by Jagoda Mierzejewska, Katarzyna Węgierek-Ciura, Joanna Rossowska, Agnieszka Szczygieł, Natalia Anger-Góra, Bożena Szermer-Olearnik, Magdalena Geneja, Elżbieta Pajtasz-Piasecka

“…On the 15th day, DCs genetically modified for production of IL-12 and/or IL-18 were administered peritumorally to C57BL/6 female mice with established MC38 tumors. Lymphoid organs and tumor tissue were collected from mice on the 3rd, 5th, and 7th days after a single administration of DCs for further analysis. …”
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HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF-κβ Pathway by Hao Wu, Legao Chen, Kaiping Lu, Yi Liu, Weiqin Lu, Jinsong Jiang, Chao Weng

“…Increased HMGB2 level was observed in Ang-II-treated VSMCs and Ang-II-induced mice model. HMGB2 depletion accelerated viability and impeded apoptosis in Ang-II-irritatived VSMCs. …”
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Feasibility of Ex Vivo Ligandomics by Prabuddha Waduge, Remya Ammassam Veettil, Bojun Zhang, Chengchi Huang, Hong Tian, Wei Li

“…We developed ligandomics for the in vivo profiling of vascular ligands in mice, discovering secretogranin III (Scg3) as a novel angiogenic factor that selectively binds to retinal vessels of diabetic but not healthy mice. …”
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Network Pharmacology Analysis and Experimental Validation to Explore the Anti-inflammatory Mechanism of Asiatic Acid on Alcoholic Steatohepatitis by Tao Jiang, Jinhong Xu, Yang Lu, Xiaojin Chen, Yongxia Li

“…This study provides multiple lines of evidence that asiatic acid may alleviate alcoholic hepatitis in mice by modulating the NF-κB pathway.…”
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Bone Marrow-Derived Cells Contribute to the Maintenance of Thymic Stroma including TECs by Shami Chakrabarti, Mohammed Hoque, Nawshin Zara Jamil, Varan J. Singh, Daniel Pollacksmith, Neelab Meer, Mark T. Pezzano

“…We identified a new population of progenitor cells, present in both the thymus and bone marrow (BM) of mice, that coexpress the hematopoietic marker CD45 and the definitive thymic epithelial marker EpCAM and maintain the capacity to form functional thymic tissue. …”
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Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions by Ju-Hye Yang, Jae-Myung Yoo, Won-Kyung Cho, Jin Yeul Ma

“…We have demonstrated that ESR decreased AD symptoms in mice and inhibits degranulation of IgE/Ag-activated mast cells. …”
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Trypanosoma cruzi Infection in Genetically Selected Mouse Lines: Genetic Linkage with Quantitative Trait Locus Controlling Antibody Response by Francisca Vorraro, Wafa H. K. Cabrera, Orlando G. Ribeiro, José Ricardo Jensen, Marcelo De Franco, Olga M. Ibañez, Nancy Starobinas

“…We also analyzed the involvement of previously mapped Ab and T. cruzi response QTL with the survival of Selection III mice to T. cruzi infections in a segregating backcross [F1(HIII×LIII) ×LIII] population. …”
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Pituranthos chloranthus Oil as an Antioxidant-Based Adjuvant Therapy against Cisplatin-Induced Nephrotoxicity by Aida Lahmar, Zaineb Dhaouefi, Rihab Khlifi, Fairouz Sioud, Leila Chekir- Ghedira

“…Mice were pretreated by intraperitoneal administration of PC (5 and 10 mg/Kg b.w) for one week. …”
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Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease by G. D’Arcangelo, D. Grossi, M. Racaniello, A. Cardinale, A. Zaratti, S. Rufini, A. Cutarelli, V. Tancredi, D. Merlo, C. Frank

“…Here, we studied synaptic plasticity phenomena and evaluated ERKs activation in the hippocampus of BALB/c NPC1−/− mice, a well described animal model of the disease. …”
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Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex by Malgorzata Jasinska, Ewa Siucinska, Ewa Jasek, Jan A. Litwin, Elzbieta Pyza, Malgorzata Kossut

“…In the barrel cortex of conditioned, pseudoconditioned, and untreated mice, we analyzed the number and morphological features of dendritic spines at various maturation and stability levels: sER-free spines, spines containing smooth endoplasmic reticulum (sER), and spines containing spine apparatus. …”
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Human SLC26A1 Gene Variants: A Pilot Study by Paul A. Dawson, Pearl Sim, David W. Mudge, David Cowley

“…The solute linked carrier (SLC) 26A1 gene has previously been linked to kidney stones in mice. SLC26A1 encodes the sulfate anion transporter 1 (SAT1) protein, and its loss in mice leads to hyperoxaluria and calcium oxalate renal stones. …”
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