Feeding disruptions lead to a significant increase in disease modules in adult mice by Xiaoqin Mou, Pengxing Nie, Renrui Chen, Yang Cheng, Guang-Zhong Wang

“…Here, we investigate this hypothesis using transcriptomic data from a large cohort of adult mice subjected to feeding disruptions. Our computational analysis indicates that altered feeding schedules significantly increase disease-related modules in adult mouse livers, well before aging and disease onset. …”
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Paradoxical Glucose-Sensitizing yet Proinflammatory Effects of Acute ASP Administration in Mice by Alexandre Fisette, Pegah Poursharifi, Katerina Oikonomopoulou, Mercedes N. Munkonda, Marc Lapointe, Katherine Cianflone

“…We hypothesized that ASP would specifically exert proinflammatory effects. C57Bl/6 wild-type mice were put on a high-fat-high-sucrose diet for 12 weeks. …”
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Reprogramming of Mice Primary Hepatocytes into Insulin-Producing Cells by Transfection with Multicistronic Vectors by Haizhao Luo, Rongping Chen, Rui Yang, Yan Liu, Youping Chen, Yi Shu, Hong Chen

“…Furthermore, when transplanted into streptozotocin-induced diabetic mice, the cells markedly ameliorated glucose tolerance. …”
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Toxoplasma Reduces Complications of Parkinson’s Disease: An Experimental Study in BALB/c Mice by Mohammad Nohtani, Qasem Asgari, Fattaneh Mikaeili, Vahid Reza Ostovan, Mehdi Mirzaeipour, Mohammad Saleh Bahreini, Sajad Rashidi

“…Findings of the rotarod test showed the highest and lowest average of running duration belonged to the uninfected mice and PD mice, respectively. Remarkably, the running duration of infected mice with PD was higher than PD mice. …”
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Divergence in photoreceptor cell death and neuroinflammation in transvitreal and transscleral subretinal delivery in mice by Daniel E. Maidana, Sara Pastor Puente, Catherine Wang, Shivam Chandra, Lucia Gonzalez-Buendia, Eleftherios Paschalis Ilios, Andrius Kazlauskas, Demetrios G. Vavvas

“…Subretinal injection in CX3CR1 + /GFP CCR2 + /RFP mice revealed early inflammatory responses, with TS injections inducing higher infiltration of CD11b + CCR2 + cells compared to TV. …”
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Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota by Yiqiang Xie, Man Xiao, Yali Ni, Shangfei Jiang, Guizhu Feng, Shenggang Sang, Guankui Du

“…We performed an 8-week administration protocol on T2DM (C57BL/6J db-/db-) mice and fecal samples were collected. Comparisons of fecal bacterial communities were performed between db-/db- mice and normal mice (DB/DB) and between the db-/db mice treated and untreated with AOE using next-generation sequencing technology. …”
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Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice by Zhuo Chen, Xiang Qian, Shasha Chen, Xiaoxuan Fu, Guanjun Ma, Aiqin Zhang

“…Using the murine lung cancer model by subcutaneously inoculating Lewis lung cancer model, 50 mice were divided into five groups: normal, model, CDDP, CDDP+Akk, and CDDP+antibiotics. …”
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Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice by Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner

“…Adenovirus-mediated Ch25h overexpression in mice improved glucose tolerance and insulin sensitivity and lowered HOMA-IR. …”
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Electroacupuncture Alleviates Neuropathic Pain and Negative Emotion in Mice by Regulating Gut Microbiota by Feng C, Pan H, Zhang Y, Ye Z, Zhou Y, Zou H, Wang K

“…To investigate the impact of gut microbiota on CCI mice, we employed a variety of methods, including various behavioral tests and 16S ribosomal DNA (rDNA) sequencing.Results: The results indicated that EA significantly ameliorated mechanical allodynia and emotional dysfunction induced by CCI in mice. …”
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Isolation of Pleurotus florida derived acetylcholinesterase inhibitor for the treatment of cognitive dysfunction in mice by Kudrat Randhawa, Varinder Singh, Sanimardeep Kaur, Ravinder Kaur, Suresh Kumar, Richa Shri

“…It improved STZ induced dementia and neurodegeneration in mice by reducing brain acetylcholinesterase action and oxidative stress. …”
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Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration by Gao Han, Gong Xuewu, Zhang Meng, Wang Yuejing, Wang Yuchun, Zhang Keshuang, Yao Hongbo

“…Abstract Objectives This study focuses on the preventive and therapeutic effects of Dihydroartemisinin (DHA) on Alzheimer’s disease (AD) model mice and the effects of DHA and donepezil on amyloid β-protein deposition and autophagy in nerve cells. …”
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Potential radiosensitive germline biomarkers in the testes of wild mice after the Fukushima accident by Syun Tokita, Ryo Nakayama, Yohei Fujishima, Valerie Swee Ting Goh, Donovan Anderson, Ippei Uemura, Hikari Ikema, Jin Shibata, Yoh Kinoshita, Yoshinaka Shimizu, Hisashi Shinoda, Jun Goto, Maria Grazia Palmerini, Abdulla Mohamed Hatha, Takashi Satoh, Akifumi Nakata, Manabu Fukumoto, Tomisato Miura, Hideaki Yamashiro

“…We investigated potential germline‐specific radiosensitive biomarkers in the testes of large Japanese field mice (Apodemus speciosus) exposed to low‐dose‐rate (LDR) radiation after the Fukushima accident. …”
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Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice by Hajime Terao, Kazuhito Asano, Ken-ichi Kanai, Yoshiyuki Kyo, So Watanabe, Tadashi Hisamitsu, Harumi Suzaki

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Plac8 regulates the fibrogenic ability of cardiac fibroblasts in mice with myocardial infarction by Ting Fu, Jianping Gong, Lei Xu, Ningning Ji

“…In addition, primary CFs of the neonatal mice were isolated, cultured and treated with hypoxia for in vitro cell model construction. …”
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Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice by Sadako Nakamura, Naoyuki Kondo, Yoshitake Yamaguchi, Michiru Hashiguchi, Kenichi Tanabe, Chihiro Ushiroda, Miho Kawahashi-Tokuhisa, Katsuyuki Yui, Mana Miyakoda, Tsuneyuki Oku

“…Here, we raised senescence accelerated mice prone 8 (SAMP8) on the AIN93 diet (CONT), with sucrose being substituted for 5% of fructooligosaccharide (FOS) or 5% of glucomannan (GM), 15 mice per group. …”
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Effects of Topical Emu Oil on Burn Wounds in the Skin of Balb/c Mice by Mohammad Afshar, Reza Ghaderi, Mahmoud Zardast, Parvin Delshad

“…The goal of this study was to determine the effect of topical Emu oil on the healing of burn wounds and hair follicle restoration in superficial II-degree burns in the skin of Balb/c mice. Thirty-two male Balb/c mice with burns on the back of the neck were divided into two groups: The Emu oil group received topical Emu oil twice daily, whereas the control was left untreated. …”
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Maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant mice by Fernanda Luz De la Cruz Borthiry, Jimena Soledad Beltrame, Julieta Aylen Schander, Aime Florencia Silva, Fernanda Parborell, Ana María Franchi, María Laura Ribeiro

“…Previously, we demonstrated that maternal environmental enrichment promotes pregnancy success in BALB/c mice. As progesterone regulates gestation, we decided to study the effect of maternal environmental enrichment on ovarian physiology during early gestation.MethodsFor this, six-week-old female mice were housed in enriched or control cages for six weeks and then mated with control fertile males. …”
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Early-life gut mycobiome core species modulate metabolic health in mice by Mackenzie W. Gutierrez, Erik van Tilburg Bernardes, Ellen Ren, Kristen N. Kalbfleisch, Madeline Day, Ewandson Luiz Lameu, Thaís Glatthardt, Emily M. Mercer, Sunita Sharma, Hong Zhang, Ali Al-Azawy, Faye Chleilat, Simon A. Hirota, Raylene A. Reimer, Marie-Claire Arrieta

“…R. mucilaginosa and M. restricta increased adiposity in mice fed SD, while only R. mucilaginosa exacerbated metabolic disease. …”
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Effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in healthy mice by Wenxian Dang, Rong Li, Jinyue Yang, Changhu Xue, Qingrong Huang, Yuming Wang, Tiantian Zhang

“…The effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in BALB/c mice were investigated after gavage and tail intravenous injection. …”
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A Self-Emulsifying Nanococktail of Pomegranate and Cannabidiol Reduces Cognitive Decline in Mice by Shoseyov O, Palatnik A, Dadon-Freiberg M, Dagan O, Shaltiel Karyo R

“…The best-performing extract in the in-vitro assays was nano-formulated via self-emulsifying system with PSO and administered to aged mice and mice with MK-801-induced cognitive decline, which were then subjected to a Morris water maze test and Y-maze test, respectively.Results: Aged mice chronically fed Nano-PSO:CBD performed with a 22– 31% shorter escape latency (p ≤ 0.05), 23% shorter distance swam and increased average speed as compared to aged control mice. …”
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