Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival by Seahyoung Lee, Eunhyun Choi, Min-Ji Cha, Ki-Chul Hwang

“…Nevertheless, only a handful of empirical data regarding miRNA-dependent regulation of pyroptosis is currently available. …”
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Handgrip-Ring Structure Sensing Probe Assisted Multiple Signal Amplification Strategy for Sensitive and Label-Free Single-Stranded Nucleic Acid Analysis by Ying Ren, Yu He, Ping Li

“…By utilizing this innovative design, the current biosensor demonstrates a remarkable ability to detect miRNA with a limit as low as 376 aM and single-stranded DNA sequences with a limit as low as 45.3 aM. …”
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microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome by Qian Ge, Sonia Brichard, Xu Yi, QiFu Li

“…This review will focus on the implication of miRNAs in white AT inflammation in obesity, and will also highlight the potential of miRNAs as targets for therapeutic intervention in MS as well as the challenges lying in miRNA-targeting therapeutics.…”
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The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics by Preethi Krishnan, Sambasivarao Damaraju

“…The second aim of this review therefore is to highlight some of the challenges that hinder application of miRNA and piRNA as in guiding treatment decisions.…”
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The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection by Matthias Hamdorf, Satoru Kawakita, Matthew Everly

“…In this review, we discuss whether circulating miRNA can serve as an early noninvasive diagnostic biomarker and an expression fingerprint of allograft rejection and transplant failure. …”
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miR-155: An Important Role in Inflammation Response by Jingyan Hu, Songli Huang, Xiaoli Liu, Yuan Zhang, Shengli Wei, Xiuhua Hu

“…MicroRNAs (miRNAs) are a class of small, mature, noncoding RNA that lead to posttranscriptional gene silencing to regulate gene expression. miRNAs are instrumental in biological processes such as cell development, cell differentiation, cell proliferation, and cell apoptosis. The miRNA-mediated gene silencing is an important part of the regulation of gene expression in many kinds of diseases. miR-155, one of the best-characterized miRNAs, has been found to be closely related to physiological and pathological processes. …”
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Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs by Wei Li, Wei Li, Wei Li, Peiyue Luo, Peiyue Luo, Peiyue Luo, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Lifeng Gan, Lifeng Gan, Lifeng Gan, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Liying Zheng, Biao Qian, Biao Qian

“…Research has demonstrated that DNA methylation not only directly influences the expression of miRNA genes but also indirectly affects the maturation and functionality of miRNAs by modulating the methylation status of miRNA promoter regions. …”
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MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…Additionally, the differential expression of miRNAs between DSS-Exo and Exo was explored and validation of key miRNA. Results DSS-Exo significantly upregulated E-cadherin, downregulated VEGFA, α-SMA, CTGF and Fibronectin expression in HMrSV5 cells compared to untreated Exo. …”
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MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction by Teng Ma, Yueqiu Chen, Yihuan Chen, Qingyou Meng, Jiacheng Sun, Lianbo Shao, Yunsheng Yu, Haoyue Huang, Yanqiu Hu, Ziying Yang, Junjie Yang, Zhenya Shen

“…Exosomes loaded with miR-132, as a vehicle for miRNA transfer, significantly increased tube formation of endothelial cells. …”
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An Alternative to the Human Hemoglobin Test in the Investigation of Bloodstains Treated with Active Oxygen: The Human Glycophorin A Test by Ana Castelló, Francesc Francés, Fernando Verdú

“…The need to determine the nature of the evidence is reflected in the latest bibliography, where the possibility of employing mRNA and miRNA markers for this purpose is proposed. While these new proposals are being investigated, the kits for determining human hemoglobin currently provide a simple solution for resolving this issue. …”
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MicroRNAs as Prognostic Biomarkers for Atrial Fibrillation Recurrence After Catheter Ablation: Current Evidence and Future Directions by Emmanouil P. Vardas, Evangelos Oikonomou, Panos E. Vardas, Dimitris Tousoulis

“…We examined studies investigating the association between miRNA expression and post-ablation AF recurrence. …”
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Modulation of miRNAs in Pulmonary Hypertension by Sudhiranjan Gupta, Li Li

“…They are a class of small, noncoding RNAs that contributes crucial roles typically through binding of the 3′-untranslated region of mRNA. A single miRNA may influence several signaling pathways associated with cardiac remodeling by targeting multiple genes. …”
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Networks of pre-diagnostic circulating RNA in testicular germ cell tumour by Joshua Burton, Trine B. Rounge, Trine B. Haugen, Marcin W. Wojewodzic

“…In this study, we performed Weighted Gene Co-expression Network Analysis (WGCNA) on mRNA and miRNA data from these samples. Central genes (hub genes) enriched functional pathways, and regulatory feature prediction were identified for all TGCT subtypes together and according to histology. …”
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Development of RNA interference-based therapy for rare genetic diseases by Milya Urfa Ahmad, Syarifah Dewi

“…RNAi employs small RNA molecules, such as small interfering RNA (siRNA) and microRNA (miRNA), to bind specific mRNA molecules and prevent their translation into proteins. …”
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MicroRNAs as Haematopoiesis Regulators by Ram Babu Undi, Ravinder Kandi, Ravi Kumar Gutti

“…In this review we have focused on discussing the role of miRNA in haematopoiesis.…”
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M6A Modification and Transcription Analysis of LncRNA in Cerebral Ischemia/Reperfusion Injury by Jierong Mo, Zhiquan Li, Zhengfei Yang, Zuhua Huang, Pengpeng Guo, Jianfeng Gao, Haiqiong xiao, Ping Ye, Haini Qin, Tianen Zhou, Jun Jiang

“…Moreover, positive regulation of angiogenesis, protein domain–specific binding, autophagy pathway, PPAR signaling pathway, and MAPK signaling pathway were co-enriched between LncRNAs with different expression levels and different methylation levels. Finally, a LncRNA-miRNA-mRNA network was constructed. Therefore, this study explored the potential key LncRNAs and regulatory mechanisms of CIRI.…”
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CircRNA FAT1 Regulates Osteoblastic Differentiation of Periodontal Ligament Stem Cells via miR-4781-3p/SMAD5 Pathway by Yu Ye, Yue Ke, Liu Liu, Tong Xiao, Jinhua Yu

“…The osteogenic differentiation of PDLSCs was benefited from circFAT1, which serves as a miRNA sponge for miR-4781-3p targeting SMAD5. Both knockdown of circFAT1 and overexpression of miR-4781-3p suppressed the osteogenic differentiation of PDLSCs. …”
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Regulation of Long Noncoding RNAs Responsive to Phytoplasma Infection in Paulownia tomentosa by Guoqiang Fan, Yabing Cao, Zhe Wang

“…These lncRNAs showed low conservation among plant species and some of them were miRNA precursors. Further analysis revealed that the 112 identified lncRNAs were related to phytoplasma infection. …”
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Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture by Xi Sun, Qi Guo, Wenhua Wei, Stephen Robertson, Ying Yuan, Xianghang Luo

“…Appropriate chemical modifications and delivery vectors, which improve the biological performance and potency of microRNA-based drugs, hold the key to translating miRNA technologies into clinical practice. Thus, this review summarizes the current attempts and existing deficiencies of chemical modifications and delivery systems applied in microRNA-based therapies for osteoporosis and osteoporotic fractures to inform further explorations.…”
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Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics by John Burke, Ravindra Kolhe, Monte Hunter, Carlos Isales, Mark Hamrick, Sadanand Fulzele

“…Exosomal products can include miRNA, other genetic products, proteins, and various factors. …”
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