Disulfidptosis-related gene signatures as prognostic biomarkers and predictors of immunotherapy response in HNSCC by Haotian Qin, Haotian Qin, Juan Xu, Yaohang Yue, Yaohang Yue, Meiling Chen, Zheng Zhang, Panpan Xu, Yan Zheng, Hui Zeng, Jian Weng, Jian Weng, Jun Yang, Fei Yu

“…Currently, the biological mechanisms of disulfidptosis-related genes (DRGs) in head and neck squamous cell carcinoma (HNSCC) remain unclear.MethodsThe study includes sections on methodologies, data sources, clinical data collection, subtype establishment, identification and analysis of differentially expressed genes, genetic variation, and the construction and validation of a DRG prognostic model. …”
Get full text

Different exercise interventions on quality of sleep in breast cancer survivors—a network meta-analysis of randomized controlled trials by Qi Song, Qi Song, You-kang Zhu, You-kang Zhu, Hai Liu, Hai Liu, Xiao Liu, Xiao Liu, Zhang-dong Jiang, Yu-jia Wang, Yu-jia Wang, Li-yun Xue, Li-yun Xue, Shao-ying Yang, Shao-ying Yang, Xi-fang Liu

“…The primary outcomes included Yoga, Pilates, Qigong, Tai Chi, Walking, Dance, Resistance training, Football, Virtual reality therapy, Activity change exercise, Software-guided exercises. The methodological quality of the included studies was assessed using the Cochrane Bias risk Assessment tool, and network meta-analysis was performed using Stata15 software. …”
Get full text

Systematic review of multidrug-resistant Klebsiella pneumoniae in the Arabian Peninsula: molecular epidemiology and resistance patterns by Enaam K. Idrees, Enaam K. Idrees, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Manal M. Alkhulaifi, Majed F. Alghoribi, Majed F. Alghoribi, Majed F. Alghoribi

“…Implementing standardized methodologies and fostering molecular and genome-based AMR surveillance programs at both national and regional levels within the GHC are essential for effectively combating the spread of MDR K. pneumoniae and improving public health outcomes in the region.…”
Get full text

Life cycle assessment and life cycle cost of tofu production and its extended recycling scenario by S. Hartini, A.N. Fatliana, N.U. Handayani, P.A. Wicaksono, B.S. Ramadan, T. Matsumoto

“…The impact of waste recycling on the eco-efficiency of small and medium-sized enterprises in Sugihmanik Village, Grobogan Regency, Indonesia is also examined.METHODS: To achieve this goal, this study employed life cycle assessment and life cycle cost methodologies to evaluate eco-efficiency. Data were collected through interviews and direct observations. …”
Get full text

High-throughput methylation sequencing reveals novel biomarkers for the early detection of renal cell carcinoma by Wenhao Guo, Weiwu Chen, Jie Zhang, Mingzhe Li, Hongyuan Huang, Qian Wang, Xiaoyi Fei, Jian Huang, Tongning Zheng, Haobo Fan, Yunfei Wang, Hongcang Gu, Guoqing Ding, Yicheng Chen

“…Comparative analysis and Least Absolute Shrinkage and Selection Operator (LASSO) regression methods were employed to identify RCC methylation signatures.Subsequently, methylation markers-based diagnostic and prognostic models for RCC were independently trained and validated using random forest and Cox regression methodologies, respectively. Results Comparative analysis revealed 864 differentially methylated CpG islands (DMCGIs), 96.3% of which were hypermethylated. …”
Get full text

Global comparison of the economic costs of coronary heart disease: a systematic review and meta-analysis by Lan Gao, Susan Brumby, Crystal Man Ying Lee, George Mnatzaganian, Suzanne Robinson, Helen Brown, Rachel Huxley, Anna Peeters, Dan Xu, James Boyd, Sean Randall, Adrienne O’Neil, Sangita Shakya, Sarah Gauci, Anita Shrestha, James Lucas

“…We conducted a systematic review with meta-analysis to examine the costs of CHD treatment by region and CHD subtypes, examine whether there are cost difference by sex, and examine costing methodologies.Design We conducted a systematic review and meta-analysis of non-randomised studies.Data sources We searched Medline, Embase, CINAHL, EconLit and Google Scholar from 1 January 2000 to February 2023.Eligibility criteria for selecting studies We included observational studies reporting economic costs of CHD treatment and outcomes for adults that were published in English.Data extraction and synthesis Data extraction and quality assessment were independently undertaken by two reviewers. …”
Get full text

'Which treatment do you believe you received?' A randomised blinding feasibility trial of spinal manual therapy by Javier Muñoz Laguna, Astrid Kurmann, Léonie Hofstetter, Emanuela Nyantakyi, Julia Braun, Lauren Clack, Heejung Bang, Mazda Farshad, Nadine E. Foster, Milo A. Puhan, Cesar A. Hincapié, the SALuBRITY Blinding Clinician Group

“…Blinding of outcome assessors seemed adequate. Further methodological work on blinding of SMT is needed. Trial registration number NCT05778396.…”
Get full text

Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…Particularly, Matrigel™ coating induced spheroid growth under certain coating thickness and cell seeding density but did not improve NCM metabolic activity. Current methodologies in NCM isolation, culture, and research applications were summarized. …”
Get full text

Tibial stem extension versus standard configuration in primary cemented total knee arthroplasty: systematic review and meta-analysis by Arash Heidari, Mohammad H. Ebrahimzadeh, Mahla Daliri, Ali Moradi, Mahdieh Sahebi, Masoumeh Sadeghi

“…The retrieved studies were assessed for methodological quality using Cochrane Collaborations tool for assessing the risk of bias in randomized trials (ROB) and Cochrane Risk of Bias in Non-Randomized Studies—of Interventions (ROBINS-I) tools. …”
Get full text

The infiltration risk prediction models by logistic regression for ground-glass pulmonary nodules: a systematic review and meta-analysis by Mengqian Li, Mengqian Li, Xiaomei Zhang, Yuxin Lai, Yunlong Sun, Tianshu Yang, Xinlei Tan

“…The overall risk of bias in the methodological quality evaluation of the included studies was small, and the AUC value of the model was 0.736–0.977.ConclusionThe included model has a good predictive performance for the invasion of ground-glass nodules. …”
Get full text

Alexitimia como predictor directo y mediado por la depresión en la violencia de pareja / Response to Special Educational Needs and Teaching Efforts in Elementary School by José Moral de la Rubia, Sandra Ramos-Basurto

“…The areas in which teachers indicated they need training were related to curricular modifications and specific methodologies for SEN. This research is useful for teacher training and Educational Psychology. …”
Get full text

Effects of open-skill exercise on executive functions in children and adolescents: a systematic review and meta-analysis by Shunding Hu, Peng Shi, Ziyun Zhang, Xiaosu Feng, Kai Zhang, Kai Zhang, Kai Zhang, Teng Jin

“…Two researchers independently screened the articles and extracted data, and used the bias risk assessment tool recommended by the Cochrane Collaboration Network and the Methodological Index for Non- Randomized Studies (MINORS) scale to assess included randomized controlled trials (RCTs) and quasi-experimental designs (QEDs). …”
Get full text

Designing an Innovative Human Resources Model Based on Perceived Organizational Support Case Study of Qazvin's Government organizations by Hossein Rasouli, Morteza Mousakhani, Mahdi Alvani, parham azimi

“…Methods This research employs a comprehensive mixed exploratory approach, amalgamating qualitative and quantitative methodologies, which is applied in intent and descriptive-survey in its implementation method. …”
Get full text

Telehomecare Monitoring for Patients Receiving Anticancer Oral Therapy: Protocol for a Mixed Methods Evaluability Study by Dominique Tremblay, Thomas Joly-Mischlich, Annick Dufour, Marie-Claude Battista, Djamal Berbiche, José Côté, Marco Décelles, Catherine Forget, Brigitte Guérin, Manon Larivière, Frédéric Lemay, Manon Lemonde, Éric Maillet, Nathalie Moreau, Michel Pavic, Sara Soldera, Catherine Wilhelmy

“…The concurrent approach allows results at multiple stages of this study to be integrated iteratively. The methodological choice aims to provide real-world data that are rigorous, rapidly usable in practice, and transferable to other settings. …”
Get full text

The importance of interlanguage in language teaching: an analysis of its development in l2 learners by Saverio Barone

“…The concept of interlanguage represented an important theoretical innovation in applied linguistics and has had significant implications for the development of teaching methodologies in the context of language learning. Interlanguage is defined as a dynamic linguistic system that evolves during the process of acquiring a second language. …”
Get full text

Risk prediction models for feeding intolerance in patients with enteral nutrition: a systematic review and meta-analysis by Huijiao Chen, Jin Han, Jing Li, Jianhua Xiong, Dong Wang, Mingming Han, Yuehao Shen, Wenli Lu

“…These endeavors should incorporate more extensive and diverse sample sizes, adhere to stringent methodological designs, and undergo rigorous multicenter external validation to ensure robustness and generalizability.Systematic review registrationIdentifier CRD42024585099, https://www.crd.york.ac.uk/prospero/display_record.php?…”
Get full text

Research Status and Direction of Chronic Obstructive Pulmonary Disease Complicated with Coronary Heart Disease: A Bibliometric Analysis from 2005 to 2024 by Bian H, Zhu S, Xing W, Qi L, Xue J, Peng X, Jin Z, Zhao H

“…Through keyword clustering analysis, we categorized all keywords into three distinct groups: management strategies for COPD and CHD; diseases associated with both conditions; and epidemiological characteristics concerning their burden—current hotspots include multimorbidity factors such as hypertension and obesity alongside outcomes like diagnosis during COVID-19 pandemic implications within societal contexts are highlighted here too.Conclusion: Presently focused research on COPD coupled with CHD primarily revolves around five key areas: pathogenesis exploration, early diagnostic techniques, COVID-19 infection, dynamics intervention, methodologies, and treatment protocol development efforts. …”
Get full text

A Systematic Review of Research on Guided Access Cavity Preparation Endodontic Treatment: Dentin Preservation Perspectives by Muryani A, Aripin D, Dharsono HDA, Rajion ZA, Wicaksono S

“…In the context of dentin preservation, this paper provides a thorough scoping review of a variety of methodologies for evaluating the accuracy of guided access cavity preparation.Materials and Methods: Article searches were conducted using Tthe keywords ”Guide Access Cavity Preparation” AND “Static Guide OR 3D Printing Template” AND ”Dynamic Guide through digital databases including PubMed, Scopus, Cochrane Library, Science Direct, and Google Scholar. …”
Get full text

Modalities for the treatment of primary open-angle glaucoma by Zh.G. Oganezova, S.V. Simonova

“… Simonova — Head of the organizational and methodological department of ophthalmology of the Moscow Healthcare Department, ORCID iD 0000-0002-1271-1630.…”
Get full text

Effectiveness of Virtual Reality Training in Improving Outcomes for Dialysis Patients: Systematic Review and Meta-Analysis by Xin Kang, Yiping Zhang, Chaonan Sun, Jiaxin Zhang, Zhe Che, Jinhui Zang, Rongzhi Zhang

“…Two reviewers independently extracted data and assessed methodological quality using Cochrane’s risk of bias criteria, ensuring data synthesis reliability. …”
Get full text