Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice by Brecht Attema, Montserrat A. de la Rosa Rodriguez, Evert M. van Schothorst, Sander Grefte, Guido JEJ. Hooiveld, Sander Kersten

“…Depending on the nutritional status, metabolomic analysis showed modest alterations in plasma, liver, and hepatic mitochondrial levels of various metabolites related to amino acid metabolism, TCA cycle, and fatty acid metabolism. …”
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Cooperation Between <i>Rhodococcus qinshengii</i> and <i>Rhodococcus erythropolis</i> for Carbendazim Degradation by Roosivelt Solano-Rodríguez, Fortunata Santoyo-Tepole, Mario Figueroa, Voleta Larios-Serrato, Nora Ruiz-Ordaz, Abigail Pérez-Valdespino, Everardo Curiel-Quesada

“…The alternative gene for the first catabolic step (<i>mhe</i>I) was detected by PCR in strain RC9 but not in RC1. Metabolomic analysis by HPLC and LC-MS showed that both strains have the ability to metabolize carbendazim. …”
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Atg5 deficiency in basophils improves metabolism in lupus mice by regulating gut microbiota dysbiosis by Jiaxuan Chen, Quanren Pan, Lu Lu, Xiaorong Huang, Shuting Wang, Xiaoxian Liu, Jiaqi Lun, Xiaowei Xu, Hongyong Su, Fengbiao Guo, Lawei Yang, Liuyong You, Haiyan Xiao, Wenying Luo, Hua-feng Liu, Qingjun Pan

“…Metagenomic and targeted metabolomic sequencing results indicated considerable reduction in the levels of plasma autoantibodies and inflammatory cytokines in the Atg5 −/− basophil transfer group compared with that in the control group. …”
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Multimedia: multimodal mediation analysis of microbiome data by Hanying Jiang, Xinran Miao, Margaret W. Thairu, Mara Beebe, Dan W. Grupe, Richard J. Davidson, Jo Handelsman, Kris Sankaran

“…The first re-analyzes a study of the microbiome and metabolome of Inflammatory Bowel Disease patients, uncovering potential mechanistic interactions between the microbiome and disease-associated metabolites, not found in the original study. …”
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Multi-omics elucidates the kidney damage caused by aquatic Cu via the gut-kidney axis in ducks by Mingcai Duan, Jinyu Liu, Zhaoxia Cai, Li Chen, Yong Tian, Wenwu Xu, Tao Zeng, Tiantian Gu, Lizhi Lu

“…GO and KEGG enrichment analyses were most involved in Interleukin-1 Receptor Activity, Taurine and hypotaurine metabolism, Nitrogen metabolism, and Proximal tubule bicarbonate reclamation. Metabolomic analysis revealed that 28 metabolites are present in both kidney tissue and cecal contents. …”
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High-speed centrifugation reduces immune rejection by removing bone marrow elements from fresh osteochondral allografts by Yongsheng Ma, Wenming Yang, Qitai Lin, Meiming Li, Zehao Li, Yugang Xing, Lei Wei, Wangping Duan, Xiaochun Wei

“…Finally, the residues in the centrifuge tubes were analysed using ELISA, haematoxylin and eosin (HE) staining, and metabolomic analysis. Results: Centrifugal speeds of 12000 rpm for 1 min were sufficient to reduce BMEs by over 90 %. …”
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Half-Elemental Diet Shifts the Human Intestinal Bacterial Compositions and Metabolites: A Pilot Study with Healthy Individuals by Jun Miyoshi, Daisuke Saito, Mio Nakamura, Miki Miura, Tatsuya Mitsui, Toru Kudo, Shinnosuke Murakami, Minoru Matsuura, Tadakazu Hisamatsu

“…We performed 16S rRNA gene amplicon sequencing and metabolomic analysis to examine the bacterial compositions and intestinal metabolites. …”
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Xiaohua Funing decoction ameliorates non-alcoholic fatty liver disease by modulating the gut microbiota and bile acids by Jindong Zhao, Jindong Zhao, Yan Li

“…Furthermore, metagenomic sequencing and BA metabolomic analyses were performed.ResultsCompared to the Con group, the Mod group presented significant differences in body and liver weights; serum total cholesterol (TC) and triglyceride (TG) levels; and liver TG, TC, and bile salt hydrolase levels (p &lt; 0.05 or p &lt; 0.01). …”
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Lower respiratory tract microbiome dysbiosis impairs clinical responses to immune checkpoint blockade in advanced non‐small‐cell lung cancer by Yong Zhang, Xiang‐Xiang Chen, Ruo Chen, Ling Li, Qing Ju, Dan Qiu, Yuan Wang, Peng‐Yu Jing, Ning Chang, Min Wang, Jian Zhang, Zhi‐Nan Chen, Ke Wang

“…Methods During this study, 26 bronchoalveolar lavage fluids (BALF) from advanced NSCLC participants who received immune checkpoint inhibitor monotherapy were performed 16S rRNA sequencing and untargeted metabolome sequencing to identify differentially abundant microbes and metabolic characteristics. …”
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Childhood body size, adulthood adiposity, underlying mechanisms, and risk of incident hypertension: a prospective cohort study of 180,527 participants by Shujing Ma, Xue Liu, Ruilang Lin, Ye Yao, Min Zhao, Yongfu Yu, Costan G. Magnussen, Bo Xi

“…In this study, we aimed to investigate the potential biochemical and metabolomic mechanisms underlying the association between adiposity and incident hypertension. …”
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Application of the DEB-TKTD model with multi-omics data: Prediction of life history traits of Chinese mitten crab (Eriocheir sinensis) under different salinities by Hanzun Zhang, Shipeng Dong, Hongwei Shan, Chao Yang, Fang Wang

“…Subsequently, tissues including the eyestalk, posterior gill, hepatopancreas, and ovary were sampled from crabs in both the freshwater control group and the 18 ‰ salinity treatment group for transcriptional and metabolomic analysis. The omics data were used to ascertain the physiological mode of action (pMoA) affected by salinity in the crabs. …”
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Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women by Kayla R. Getz, Myung Sik Jeon, Lili Liu, Lei Liu, Haixiang Zhang, Chongliang Luo, Jingqin Luo, Adetunji T. Toriola

“…Louis, MO, and provided a fasting blood sample. Our comprehensive metabolomic and lipidomic profiling yielded complete data for 828 metabolites and 857 lipid species after imputation. …”
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The prebiotic potential of dietary onion extracts: shaping gut microbial structures and promoting beneficial metabolites by Yebeen Yoo, Seongok Kim, WonJune Lee, Jinwoo Kim, Bokyung Son, Kwang Jun Lee, Hakdong Shin

“…This study explores the impact of onion extracts on gut microbiome using an in vitro fecal incubation model and metabolome analysis. Fecal samples were collected from 19 healthy donors and incubated in the presence or absence of onion extracts for 24 h. …”
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Magnesium ions regulate the Warburg effect to promote the differentiation of enteric neural crest cells into neurons by Qiongqian Xu, Xixi He, Yaru Mou, Dong Sun, Xintao Zhang, Jichang Han, Xiaoyang Liu, Xingjian Liu, Xue Ren, Dongming Wang, Jian Wang, Chuncan Ma, Qiangye Zhang, Aiwu Li

“…Materials and methods We used polymerase chain reaction, western blot, immunofluorescence, and multielectrode array techniques to assess magnesium ions' impact on ENCCs differentiation. Non-targeted metabolomic sequencing, cellular acidification rate, oxygen consumption, and western blot analyzed sugar metabolism changes. …”
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A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart by Bart Jacobs, Inge Derese, Sarah Derde, Sarah Vander Perre, Lies Pauwels, Greet Van den Berghe, Jan Gunst, Lies Langouche

“…Cardiac tissue was collected for assessment of inflammatory and metabolic markers through gene expression, metabolomic analysis and histological assessment. Results In prolonged sepsis, cardiac expression of IL-1β and IL-6 and macrophage infiltration remained upregulated (p ≤ 0.05). …”
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The impact of different gastrointestinal reconstruction techniques on gut microbiota after gastric cancer surgery by Yu Yang, Yu Yang, Hang-Yu Zhou, Guo-Min Zhou, Guo-Min Zhou, Jin Chen, Rui Ming, Dong Zhang, Huai-Wu Jiang, Huai-Wu Jiang

“…Future studies should expand the sample size and conduct metabolomic analyses to further validate these preliminary findings.…”
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Dynamic conditioning of porcine kidney grafts with extracellular vesicles derived from urine progenitor cells: A proof‐of‐concept study by Perrine Burdeyron, Sébastien Giraud, Maryne Lepoittevin, Nina Jordan, Sonia Brishoual, Maïté Jacquard, Virginie Ameteau, Nadège Boildieu, Estelle Lemarie, Jonathan Daniel, Frédéric Martins, Nicolas Mélis, Marine Coué, Raphaël Thuillier, Henri Leuvenink, Luc Pellerin, Thierry Hauet, Clara Steichen

“…Regarding perfusate analysis, metabolomic analyses and cytokine quantification showed an immunomodulation signature in G3 compared with G1 and highlighted potential metabolic targets. …”
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