Evaluation of taste quality of Keemun congou black tea during ripening and the effect of this quality on antioxidant capacity and in vitro inhibition of α-amylase and α-glucosidase... by Wenjing Huang, Zhibin Ye, Yida Wu, Tianzi Yu, Wei Zhao, Zihao Qi, Yanqun Jiang, Qiuyan Liu, Guofu Lu, Jingming Ning

“…In this study, taste was quantitatively evaluated by using sensory and biomimetic electrodes and by employing metabolomic techniques. The results revealed that the content of polyphenols was greatly affected by ripening, catechins and flavonoids reduced by 63.5 % and 9.2 %, respectively, and theaflavins increased by 14.6 %, thereby attenuating the bitterness and astringency of the tea infusion while enhancing its sweetness and mellowness. …”
Get full text

Apiospora arundinis, a panoply of carbohydrate-active enzymes and secondary metabolites by Trine Sørensen, Celine Petersen, Asmus T. Muurmann, Johan V. Christiansen, Mathias L. Brundtø, Christina K. Overgaard, Anders T. Boysen, Rasmus D. Wollenberg, Thomas O. Larsen, Jens L. Sørensen, Kåre L. Nielsen, Teis E. Sondergaard

“…Through transcriptomic analysis, we observed differential gene expression in response to varying growth media, with several genes related to carbohydrate metabolism showing significant upregulation when the fungus was cultivated on a hay-based medium. Finally, our metabolomic analysis unveiled a fungus capable of producing a diverse array of metabolites.…”
Get full text

Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice by Chen Wang, Junying Bai, Botao Wang, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Huayi Suo, Wei Chen, Qixiao Zhai

“…Oral stachyose could restore DSS-induced disturbance in intestinal bacteria. Besides, the metabolome result of serum samples showed that stachyose treatment significantly altered serum metabolites against inflammatory responses in colitis mice. …”
Get full text

The clove (Syzygium aromaticum) genome provides insights into the eugenol biosynthesis pathway by Sonia Ouadi, Nicolas Sierro, Simon Goepfert, Lucien Bovet, Gaetan Glauser, Armelle Vallat, Manuel C. Peitsch, Felix Kessler, Nikolai V. Ivanov

“…On the basis of our transcriptomic and metabolomic findings, we propose a hypothetical scenario in which eugenol acetate plays a key role in high eugenol accumulation in clove leaves and buds. …”
Get full text

A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications by Francesca Conserva, Loreto Gesualdo, Massimo Papale

“…We performed a systematic analysis of the most relevant studies investigating genetic susceptibility and specific transcriptomic, epigenetic, proteomic, and metabolomic patterns in order to summarize the most significant traits associated with the disease onset and progression. …”
Get full text

<i>METTL3</i> and <i>FTO</i> Regulate Heat Stress Response in Hu Sheep Through Lipid Metabolism via m6A Modification by Bowen Chen, Chao Yuan, Tingting Guo, Jianbin Liu, Zengkui Lu

“…In an established hepatocyte lipid deposition heat stress model, the expression levels of <i>METTL3</i> and <i>FTO</i> were significantly upregulated (<i>p</i> < 0.05), indicating that <i>METTL3</i> and <i>FTO</i> play important roles in the process of lipid deposition heat stress in hepatocytes. Transcriptome and metabolome analyses showed that lipid deposition heat stress had significant effects on the linoleic acid, linolenic acid, glycerophospholipid, and arachidonic acid metabolic pathways in hepatocytes. …”
Get full text

Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice by Jing Geng, Xiaoliang Zhang, Yanjie Guo, He Wen, Dong Guo, Qi Liang, Siying Pu, Ying Wang, Mingchuan Liu, Zhelong Li, Wei Hu, Xue Yang, Pan Chang, Lang Hu, Yan Li

“…However, physical exercise exacerbated HFCD-induced cardiac damage. Further metabolomic analysis results showed that physical exercise induced circulating lipid redistribution, leading to excessive cardiac lipid uptake and lipotoxicity. …”
Get full text

Optimization of a Sonotrode Extraction Method and New Insight of Phenolic Composition of <i>Fucus vesiculosus</i> by Lidia Gil-Martínez, Alejandro Santos-Mejías, José Manuel De la Torre-Ramírez, Alberto Baños, Vito Verardo, Ana M. Gómez-Caravaca

“…HPLC-ESI-QTOF-MS analysis tentatively identified 25 phenolic compounds, including sulfated phenolic acids, phlorotannins, flavonoids, and halophenols, with some reported for the first time in <i>F. vesiculosus</i>, underscoring the complexity of this alga’s metabolome. The antioxidant activity of the optimized extract was evaluated through FRAP (143.7 µmol TE/g), DPPH (EC₅₀ 105.6 µg/mL), and TEAC (189.1 µmol Trolox/g) assays. …”
Get full text

Leptin decreases Th17/Treg ratio to facilitate neuroblastoma via inhibiting long-chain fatty acid catabolism in tumor cells by Meng Li, Di Li, Hai-Yun Wang, Weixin Zhang, Zhenjian Zhuo, Huiqin Guo, Jiabin Liu, Yue Zhuo, Jue Tang, Jing He, Lei Miao

“…The exploration of therapeutic targets in neuroblastoma (NB), which needs more attempts, can benefit patients with high-risk NB. Based on metabolomic and transcriptomic data in mediastinal NB tissues, we found that the content of long-chain acylcarnitine (LCAC) was increased and positively associated with leptin expression in advanced NB. …”
Get full text

Metabolite Profiling and Association Analysis of Leaf Tipburn in Heat-Tolerant Bunching Onion Varieties by Tetsuya Nakajima, Reina Yamamoto, Kanako Matsuse, Masato Fuji, Koei Fujii, Sho Hirata, Mostafa Abdelrahman, Muneo Sato, Masami Yokota Hirai, Masayoshi Shigyo

“…The results revealed that <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>β</mi></semantics></math></inline-formula>-carotene accumulation peaked with May sowing and July harvest, while the highest accumulation of other pigment compounds was observed with May sowing and September harvest. Additionally, metabolome analysis related to leaf tipburn rates identified several organosulfur compounds, with gamma-glutamyl-propenyl cysteine sulfoxide emerging as one of the key compounds. …”
Get full text

Volatile Organic Metabolites as Potential Biomarkers for Genitourinary Cancers: Review of the Applications and Detection Methods by Kiana L. Holbrook, Wen-Yee Lee

“…Finding new and cost-effective diagnostic methods is of clinical need. Metabolomic-based approaches, notably volatile organic compound (VOC) analysis, have shown promise in detecting cancer. …”
Get full text

Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms by Pengcheng Zhang, Zixian Zhou, Jiaqi Yao, Yuhong Jiang, Hang Lei, Zhijun Xie, Juan Li, Xianlin Zhao, Lv Zhu, Meihua Wan, Ling Liu, Wenfu Tang

“…RNA sequencing and metabolomic analyses revealed that the pathways affected by DDVP exposure in hepatocytes include ABC transporters and amino acid biosynthesis processes. …”
Get full text

Biomarkers as Key Contributors in Treating Malignant Melanoma Metastases by Camila Ferreira de Souza, Alice Santana Morais, Miriam Galvonas Jasiulionis

“…Fortunately, there are now evidences sustaining the importance of genetic, epigenetic, and metabolomic alterations as biomarkers for classification, staging, and better management of melanoma patients. …”
Get full text

A quantitative prediction method utilizing whole omics data for biosensing by Takahiko Koizumi, Kenta Suzuki, Inoue Mizuki, Kie Kumaishi, Yasunori Ichihashi

“…Application of OmicSense to single-cell transcriptome, metabolome, and microbiome datasets confirmed high prediction performance (r > 0.8), suggesting applicability to diverse scientific fields. …”
Get full text

Microbial phenolic metabolites 3-(3′,4′-dihydroxyphenyl)propanoic acid and 3′,4′-dihydroxyphenylacetic acid prevent obesity in mice fed with high-fat diet by Wanbing Chen, Ruonan Liu, Xiaoling Zhu, Qun Lu, Hong Yang, Rui Liu

“…Surprisingly, the 16S rRNA sequencing and UHPLC-Q-TOF/MS demonstrated that DHPA and DHAA only slightly disturbed the intestinal microbiome, but significantly altered the urine metabolome of HFD mice mainly by regulating pentose and glucuronate interconversion, tyrosine metabolism, pentose phosphate and tricarboxylic acid (TCA) cycle as indicated by metabolic pathway analysis based on Kyoto Encyclopedia of Genes and Genomes (KEGG) database. …”
Get full text

Effects of in situ experimental warming on metabolic expression in a soft sediment bivalve by Orlando Lam-Gordillo, Emily J. Douglas, Sarah F. Hailes, Vonda Cummings, Andrew M. Lohrer

“…Our findings provide new evidence of the metabolomic response of these important bivalve to heat stress, which could be used for resource managers when implementing strategies to mitigate the impacts of climate change on valuable marine resources.…”
Get full text

Untargeted Metabolite Profiling of Specialty Rice Grains Using Gas Chromatography Mass Spectrometry by Rohit Kambale, M. Raveendran, J. Ramalingam

“…Initial studies on sensory analysis using potassium hydroxide (1.7% KOH) identified the presence of a distinct aroma of the traditional rice cultivar Chakhao Amubi in comparison with other aromatic rice varieties were conducted. The metabolomic profiling of aromatic rice grains Chakhao Amubi, Pusa Basmati 1, and nonaromatic rice, Improved White Ponni was attempted to use gas chromatography-mass spectrometry (GC-MS). …”
Get full text

Multi-omic spatial effects on high-resolution AI-derived retinal thickness by V. E. Jackson, Y. Wu, R. Bonelli, J. P. Owen, L. W. Scott, S. Farashi, Y. Kihara, M. L. Gantner, C. Egan, K. M. Williams, B. R. E. Ansell, A. Tufail, A. Y. Lee, M. Bahlo

“…Analysis of common genomic variants, metabolomic, blood and immune biomarkers, disease PheCodes and genetic scores across a fine-scale macular thickness grid, reveals multiple novel genetic loci including four on the X chromosome; retinal thinning associated with many systemic disorders including multiple sclerosis; and multiple associations to correlated metabolites that cluster spatially in the retina. …”
Get full text

Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management by Eleonora Spinozzi, Marta Ferrati, Cecilia Baldassarri, Paolo Rossi, Guido Favia, Giorgio Cameli, Giovanni Benelli, Angelo Canale, Livia De Fazi, Roman Pavela, Luana Quassinti, Cristiano Giordani, Fabrizio Araniti, Loredana Cappellacci, Riccardo Petrelli, Filippo Maggi

“…A GC–MS-driven untargeted metabolomic analysis revealed 32 affected metabolic pathways in treated larvae. …”
Get full text

Characterization of Anthocyanins Including Acetylated Glycosides from Highbush Blueberry (<i>Vaccinium corymbosum</i> L.) Cultivated in Korea Based on UPLC-DAD-QToF/MS and UPLC-Qtr... by Ju Hyung Kim, Ryeong Ha Kwon, So Ah Kim, Hyemin Na, Jeong-Yong Cho, Heon-Woong Kim

“…These comprehensive anthocyanin profiles of Korean blueberries will serve as fundamental data for breeding superior cultivars, evaluating and developing related products as well as clinical and metabolomic research.…”
Get full text