The bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis by Matteo Massara, Michelle Ballabio, Bastien Dolfi, Golnaz Morad, Vladimir Wischnewski, Eleni Lamprou, Joao Lourenco, Stéphanie Claudinot, Hector Gallart-Ayala, Rui Santalla Méndez, Annamaria Kauzlaric, Nadine Fournier, Ashish V. Damania, Matthew C. Wong, Julijana Ivanisevic, Nadim J. Ajami, Jennifer A. Wargo, Johanna A. Joyce

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Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep by Yinhan Li, Xinhui Zou, Ying Ma, Jiaqi Cheng, Xiangmin Yu, Wenya Shao, Fuli Zheng, Zhenkun Guo, Guangxia Yu, Siying Wu, Huangyuan Li, Hong Hu

“…Moreover, animal studies demonstrated that exposure to blue light during sleep (BLS) induced depression-like behaviors in the animals. Metabolomics and colorimetric analyses revealed elevated levels of lactic acid in the cerebrospinal fluid and lateral habenula (LHb) of rats with depression-like behaviors induced by BLS. …”
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Observational study protocol: the faecal microbiome in the acute stage of new-onset paediatric type 1 diabetes in an Irish cohort by Eugene Dempsey, Catherine Stanton, Paul Ross, Colin Patrick Hawkes, Aonghus Lavelle, Carol-Anne O’Shea, Elaine Catherine Kennedy, Fiona Catherine Ross

“…This study aims to describe the evolution of the microbiome and metabolome during the first year of clinical T1D, or stage 3 T1D diagnosis, and investigate whether there are differences in the microbiome and metabolome of children who present with and without diabetic ketoacidosis. …”
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Spireoside Controls Blast Disease by Disrupting Membrane Integrity of Magnaporthe oryzae by Xu Liting, He Kaiwei, Guo Chunyu, Quan Cantao, Ma Yahuan, Zhang Wei, Ren Lifen, Wang Long, Song Li, Ouyang Qing, Yin Junjie, Zhu Xiaobo, Tang Yongyan, He Min, Chen Xuewei, Li Weitao

“…Following metabolomic analysis, we identified nine flavonoids that were differentially accumulated and are considered potential candidates for disease control. …”
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Association of ultra-processed food-related metabolites with selected biochemical markers in the UK Biobank by Anthony Kityo, Byeonggeun Choi, Jung-Eun Lee, Chulho Kim, Sang-Ah Lee

“…This metabolomic profile should be explored as a potential mediators of UPF-disease associations, and as an objective marker of UPF intake.…”
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A Pilot Proteomic Analysis of Huntington’s Disease by Functional Capacity by Andrew McGarry, Ruin Moaddel

“…<b>Background:</b> The molecular biology of Huntington’s Disease (HD) has grown substantially, with pathological considerations extending to genetic modifiers, epigenetic changes, transcriptomics, the proteome, and the metabolome. The metabolome and proteome are especially intriguing in that they most directly reflect the functional state of the cellular environment, which may involve some combination of pathology as well as compensation. …”
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The gut–kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity by Cong Han, Ran-ran Gao, Le Zhou, Wei Li

“…The gut microbiota, renal transcriptome, and urine metabolome were separately detected to construct a gut–transcriptome–metabolome coexpression network. …”
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Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites by Zeng Zhang, Yajing Fang, Yangli He, Mohamed A. Farag, Min Zeng, Yukai Sun, Siqi Peng, Shuaiming Jiang, Xian Zhang, Kaining Chen, Meng Xu, Zhe Han, Jiachao Zhang

“…We analyzed 43 subjects, including gut microbiome, fecal metabolome, and serum metabolome, using a multi-omics approach to assess whether Probio-M8 can improve sarcopenia by modulating gut microbial metabolites. …”
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Metabolic Analysis of the Mode of Action and Mode of Resistance for Novobiocin in Staphylococcus aureus by Weile Xie, Dan Luo, Zhe Wang

“…Through adaptive laboratory evolution, key resistance mutations (in gyrB, potB, and fpgS) in S. aureus were identified after repeated exposure to novobiocin. Further metabolomic analysis revealed the function of the major mutation (in gyrB) in relation to the potential mechanism through which S. aureus responds to novobiocin. …”
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Fecal microbiota transplantation modulates jejunal host-microbiota interface in weanling piglets by Shankumar Mooyottu, Muhammed Shafeekh Muyyarikkandy, Farnaz Yousefi, Ganwu Li, Orhan Sahin, Eric Burrough, Joy Scaria, Brett Sponseller, Alejandro Ramirez

“…Prior FMT treatment in the context of ETEC infection indicated a potential protective role, as evidenced by a significant shift in microbial diversity and metabolomic compositions and decreased diarrhea severity even though no effect on pathogen shedding was evident. …”
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Selenium improves the flavor-promoting substances of summer tea (Camellia sinensis) by altering the expression of flavonoid and amino acids metabolic genes by Ruiming Zhang, Huishan Tang, Xinlong Hu, Yuqiong Chen, Dejiang Ni, Mingle Wang

“…This study examines the alteration of trace elements, the metabolome, and the transcriptome in tea plants subjected to Se treatment. …”
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Supplementation with Branched-Chain Amino Acids Induces Unexpected Deleterious Effects on Astrocyte Survival and Intracellular Metabolism with or without Hyperammonemia: A Prelimin... by Ting Wang, Kazuyuki Suzuki, Toshimi Chiba, Keisuke Kakisaka, Yasuhiro Takikawa

“…Subsequently, we used metabolomic analysis to investigate intracellular metabolite levels in astrocytes with and without BCAA treatment. …”
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Integrated multi-omics analysis reveals the underlying molecular mechanism for the neurotoxicity of triclosan in zebrafish by Shasha Zhao, Yuhang Ling, Baohua Zhang, Danting Wang, Limei Sun

“…Transcriptomics indicated that immune- and metabolism-related gene expression patterns were severely disturbed by TCS. Metabolomic analysis revealed 82 distinct metabolites in adult zebrafish exposed to TCS. …”
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Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (<i>Pelodiscus sinensis... by Liqin Ji, Qing Shi, Chen Chen, Xiaoli Liu, Junxian Zhu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Wei Li

“…Herein, plasma biochemical, hepatic morphological, apoptotic, transcriptomic, and metabolomic detection methods were performed to investigate the response of <i>P. sinensis</i> to acute cold stress. …”
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Are Chemicals a Useful Tool for Glass Eel Traceability? by Pedro Reis, Mafalda Fernandes, Luís Pereira, Carlos Antunes

“…These unique chemical fingerprints were assessed using Chemical Integrating Approaches (CIA) based on multi-element (macro, trace and ultra-trace metals), global metabolome and stable isotope analyses. Thus, CIA are intended to be an effective chemical “weapon” to (i) fingerprint wild glass eels; (ii) fingerprint captive glass eels; (iii) authenticate and trace glass eels; and (iv) combat the illegal trade in juvenile European eels. …”
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Reshaping lipid metabolism with long-term alternate day feeding in type 2 diabetes mice by Eleni Beli, Yuanqing Yan, Leni Moldovan, Todd A. Lydic, Preethi Krishman, Sarah A. Tersey, Yaqian Duan, Tatiana E. Salazar, James M. Dominguez, Dung V. Nguyen, Abigail Cox, Sergio Li Calzi, Craig Beam, Raghavendra G. Mirmira, Carmella Evans-Molina, Julia V. Busik, Maria B. Grant

“…We demonstrated using lipidomic, microbiome, metabolomic and liver transcriptomic studies that chronic IF improved carbohydrate utilization and glucose homeostasis without weight loss and reduced white adipose tissue inflammation and significantly impacted lipid metabolism in the liver. …”
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Identification of defensive antimicrobial compounds from environmental Serratia marcescens SNB-CN88 strain associated with macro-holobiont (termite nest) using a molecular network... by Nguyen, Dung, Levasseur, Marceau, Segret, Juliette, Sorres, Jonathan, Hebra, Téo, Touboul, David, Eparvier, Véronique

“…An integrated approach combining reversed-phase high-performance liquid chromatography and high-resolution tandem mass spectrometry with the use of molecular networks was applied to annotate novel chemical structures with potential antimicrobial activities. This metabolomic approach coupled with biological screening of environmental strains allowed the identification of 22 compounds, including 11 glucosamine derivatives and 10 cyclopeptides, from a bacterial strain of Serratia marcescens. …”
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Osteoarthritic Synovial Fluid Modulates Cell Phenotype and Metabolic Behavior In Vitro by Eduardo Branco de Sousa, Gilson Costa dos Santos Junior, Ramon Pinheiro Aguiar, Rafaela da Costa Sartore, Ana Carolina Leal de Oliveira, Fabio Ceneviva Lacerda Almeida, Vivaldo Moura Neto, Diego Pinheiro Aguiar

“…Our goal was to characterize the inflammatory and metabolomic profile of the synovial fluid from osteoarthritic patients and to identify its modulatory effect on synovial fluid cells. …”
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The Genetics of Racing Performance in Arabian Horses by K. Ropka-Molik, M. Stefaniuk-Szmukier, A. D. Musiał, B. D. Velie

“…To date, the modern approaches such as transcriptome, miRNAome, and metabolome analyses have been used to investigate the genetic background of racing performance as well as endurance capacity in Arabians. …”
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Identification of Secondary Metabolites in Flammulina velutipes by UPLC-Q-Exactive-Orbitrap MS by Ying Ding, Sitan Chen, Honglin Wang, Shanlei Li, Changyang Ma, Jinmei Wang, Lili Cui

“…The metabolites were identified by comparing the retention time, accurate molecular weight, and MS2 data with standard databases of mzVault and mzCloud (compound: 17,000+) and BGI high-resolution accurate mass plant metabolome database (plant metabolite: 2500+). Finally, 26 secondary metabolites were preliminarily identified, including flavonoids, phenylpropanoids, organic acids, and steroids.…”
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