Small Extracellular Vesicles from Inflamed Adipose Derived Stromal Cells Enhance the NF-κB-Dependent Inflammatory/Catabolic Environment of Osteoarthritis by Carola Cavallo, Giulia Merli, Nicoletta Zini, Stefania D’Adamo, Luca Cattini, Michele Guescini, Brunella Grigolo, Alessandro Di Martino, Spartaco Santi, Rosa Maria Borzì, Giuseppe Filardo

“…This is important in the clinical perspective where many OA patients are also affected by the metabolic syndrome (MetS). ADSC from MetS OA patients are dysfunctional and “inflammatory” primed within the adipose tissue. …”
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The Relationship Between Body Composition, Physical Activity, Self-Esteem, and Body Image in Female and Male Adolescents by Ligia Rusu, Denisa Piele, Eva Ilie, Gheorghe Ionescu, Mihnea Ion Marin, Mihai Robert Rusu, Mirela Lucia Calina

“…Conclusions: The degree of obesity and therefore the risk of developing cardiovascular disease and metabolic syndrome were higher in males than in females. …”
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Novel Organic Mineral Complex Prevents High-Fat Diet-Induced Changes in the Gut and Liver of Male Sprague-Dawley Rats by M. S. Crawford, A. E. Mohr, K. L. Sweazea

“…Diet-induced obesity and metabolic syndrome are associated with the onset of gastrointestinal diseases, such as hepatic steatosis and gut inflammation. …”
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Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western China by Yi-Zhong Yan, Ru-Lin Ma, Jing-Yu Zhang, Jia He, Jiao-Long Ma, Hong-Rui Pang, La-Ti Mu, Yu-Song Ding, Heng Guo, Mei Zhang, Jia-Ming Liu, Dong-Sheng Rui, Kui Wang, Shu-Xia Guo

“…We could consider reducing the occurrence of abnormal glucose and lipid metabolism by controlling IR and aiming to reduce the prevalence of metabolic syndrome and related diseases.…”
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Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion by V. V. Tsukanov, M. F. Osipenko, E. V. Beloborodova, M. A. Livzan, I. B. Khlynov, S. A. Alekseenko, Yu. P. Sivolap, J. L. Tonkikh, A. V. Vasyutin

“…In the treatment of NAFLD, diet and lifestyle modification, weight loss, the use of insulin sensitizers, vitamin E, statins (in the presence of hyperlipidemia) and drugs with metabolic activity are effective.Currently, a point of view is being actively expressed about the synergism of the action of alcohol and the metabolic syndrome on the development of fibrosis, cirrhosis, and hepatocellular carcinoma. …”
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Mouse Models of Nonalcoholic Steatohepatitis: Head-to-Head Comparison of Dietary Models and Impact on Inflammation and Animal Welfare by Andreas Kroh, Vanina Ivanova, Hannah Drescher, Julia Andruszkow, Thomas Longerich, Jochen Nolting, Roman Eickhoff, D. Heise, Karl P. Rheinwalt, Ulf P. Neumann, Florian T. Ulmer

“…The WD represents a model of advanced-stage NASH, and the HFD60 is a strong model of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome. However, the CAFD should not be considered a NASH model.…”
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Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort by J. Korduner, P. M. Nilsson, O. Melander, M. J. Gerl, G. Engström, E. Bachus, M. Magnusson, F. Ottosson

“…The group differences in metabolite profiles were to a large extent explained by factors included in the metabolic syndrome. Conclusion. Compared to MUO individuals, corresponding MHO individuals present with a more favorable lipid metabolic profile, accompanied by a downregulation of potentially harmful proteomic biomarkers. …”
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Effects of Immediate or Delayed Estradiol on Behavior in Old Menopausal Macaques on Obesogenic Diet by Kristine Coleman, Nicola D. Robertson, Adriane Maier, Cynthia L. Bethea

“…Macaques have served as effective models of human disease, including pathological processes associated with obesity and the metabolic syndrome. This study approached several questions: (1) does a western-style diet (WSD) contribute to sedentary behavior or is sedentary behavior a consequence of obesity and (2) does estradiol (E) hormone therapy offset WSD or ameliorate sedentary behavior? …”
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Differences in metabolic characteristics between Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUO) in weight reduction therapy by Shiori Kawai, Hajime Yamakage, Kazuhiko Kotani, Mitsuhiko Noda, Noriko Satoh-Asahara, Koshi Hashimoto

“…Cohort data from the Japan Obesity and Metabolic Syndrome (JOMS) study were analyzed. Subjects were divided into the MHO (n = 25) and MUO (n = 120) groups. …”
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Time Course of the Development of Nonalcoholic Fatty Liver Disease in the Otsuka Long-Evans Tokushima Fatty Rat by Yi-Sun Song, Cheng-Hu Fang, Byung-Im So, Jun-Young Park, Yonggu Lee, Jeong Hun Shin, Dae Won Jun, Hyuck Kim, Kyung-Soo Kim

“…Nonalcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic syndrome. In this study, we investigated histological and biochemical changes in NAFLD and the gene expression involving de novo lipogenesis in Otsuka Long-Evans Tokushima fatty (OLETF) rats. …”
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A narrative review about cognitive impairment in Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD): Another matter to face through a holistic approach by Marica Meroni, Miriam Longo, Erika Paolini, Paola Dongiovanni

“…It is well established that MASLD represents the hepatic manifestation of the metabolic syndrome whose definition includes the presence of obesity, type 2 diabetes (T2D), dyslipidemia, hypertension and hypercoagulability. …”
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From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease by Mi Zhou, Jianyu Lv, Xinli Chen, Yujie Shi, Guanqun Chao, Shuo Zhang

“…Its prevalence is intricately linked to obesity, insulin resistance, and other components of the metabolic syndrome. As our comprehension of MASLD deepens, it has become evident that this condition extends beyond the liver, embodying a complex, multi-systemic disease with hepatic manifestations that mirror the broader metabolic landscape. …”
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The Effects of Extra Virgin Olive Oil on Alanine Aminotransferase, Aspartate Aminotransferase, and Ultrasonographic Indices of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease... by Farzad Shidfar, Samaneh Sadat Bahrololumi, Saeid Doaei, Assieh Mohammadzadeh, Maryam Gholamalizadeh, Ali Mohammadimanesh

“…Studies have shown that there is a strong relation between the increase in the aminotransferase levels and fat accumulation in the liver with cardiovascular complications, independent of all aspects of the metabolic syndrome. This study aimed to examine the effect of virgin olive oil on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the severity of steatosis in the NAFLD patients undergoing a weight-loss diet. …”
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The Intracellular Growth of M. tuberculosis Is More Associated with High Glucose Levels Than with Impaired Responses of Monocytes from T2D Patients by Martha Torres, María Teresa Herrera, Guadalupe Fabián-San-Miguel, Yolanda Gonzalez

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Non-alcoholic fatty liver disease: comparative assessment of diagnostic and treatment approaches in the Russian Federation and People’s Republic of China by M. Ch. Semenistaya, Fan Jian-Gao, O. B. Velichenko, Ye. A. Kuznetsova, Ch. S. Pavlov

“…Pharmacotherapy is recommended in the case of nonalcoholic steatohepatitis (NASH) progression (bridging fibrosis ³ F2 and cirrhosis), as well as the earlier stages of NASH with two and more fibrosis progression risk factors (age over 50 years, diabetes mellitus, metabolic syndrome, alanine transaminase elevation). Bicyclol is a drug developed in Materia Medica institute of Academy of medical sciences of China. …”
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Predicting high sensitivity C-reactive protein levels and their associations in a large population using decision tree and linear regression by Somayeh Ghiasi Hafezi, Toktam Sahranavard, Alireza Kooshki, Marzieh Hosseini, Amin Mansoori, Elham Amir Fakhrian, Helia Rezaeifard, Mark Ghamsary, Habibollah Esmaily, Majid Ghayour-Mobarhan

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Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver Disease by Kadir Ozturk, Omer Kurt, Tolga Dogan, Alptug Ozen, Hakan Demirci, Fatih Yesildal, Murat Kantarcioglu, Turker Turker, Ahmet Kerem Guler, Yıldırım Karslioglu, Battal Altun, Ahmet Uygun, Sait Bagci

“…Elevated plasma PTX3 levels are associated with the presence of fibrosis in patients with NAFLD, independently of metabolic syndrome components. This study demonstrated that for the first time there is a close association between elevated PTX3 levels and increased arterial stiffness in patients with NAFLD.…”
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The BET inhibitor JQ1 targets fat metabolism and counteracts obesity by Claudia Fornelli, Alessia Sofia Cento, Lorenzo Nevi, Raffaella Mastrocola, Gustavo Ferreira Alves, Giuseppina Caretti, Massimo Collino, Fabio Penna

“…Objectives: Starting from those observations, the aim of this study was to investigate the ability of JQ1 to reduce adiposity in a chronic diet-induced obesity (DIO) mouse model mimicking the human metabolic syndrome. Methods: Male C57BL/6J mice were divided in subgroups, either fed a standard diet or a high fat diet for 22 or 12 weeks, treated over the last 14 days with JQ1 or with vehicle. …”
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Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus by Nailú Angélica Sinicato, Mariana Postal, Fernando Augusto Peres, Karina de Oliveira Peliçari, Roberto Marini, Allan de Oliveira dos Santos, Celso Dario Ramos, Simone Appenzeller

“…In systemic lupus erythematosus (SLE), atherosclerosis is attributed to traditional and lupus related risk factors, including metabolic syndrome (MetS), obesity, and inflammation. Objective. …”
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Self-Reported Disability in Adults with Severe Obesity by I. Kyrou, G. Osei-Assibey, N. Williams, R. Thomas, L. Halder, S. Taheri, P. Saravanan, S. Kumar

“…It also correlated to type 2 diabetes, metabolic syndrome, and clinical depression, but not to gender. …”
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