Metabolics-Based Study on the Therapeutic Mechanism Behind the Effect of Shenhuang Plaster Applied to the Shenque Acupoint on Gastrointestinal Motility in POI Mice by Yanan Shi, Chenglei Wu, Ting Liu, Rongyun Wang, Bin Ding, Qiuhua Sun

“…SHP could effectively regulate the concentration of intestinal flora and serum metabolites and the metabolic pathway related to amino acids in vivo and, ultimately, achieve a therapeutic purpose in POI. …”
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Variation of microbiological and small molecule metabolite profiles of Nuodeng ham during ripening by high-throughput sequencing and GC-TOF-MS by Cong Li, Yingling Zou, Guozhou Liao, Zijiang Yang, Dahai Gu, Yuehong Pu, Changrong Ge, Guiying Wang

“…Totally, 252 kinds of small molecular metabolites were identified from Nuodeng ham in different processing years, and 12 different metabolites were screened through multivariate statistical analysis. Further metabolic pathway analysis showed that 23 metabolic pathways were related to ham fermentation, of which 8 metabolic pathways had significant effects on ham fermentation (Impact > 0.01, P < 0.05). …”
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Mitigation of PFOA/PFOS toxicity in zebrafish (Danio rerio) by oxidative stress modulation and gut microbial metabolism through the use of aquatic probiotic Lactobacillus rhamnosus by Chun Wang, Guanyi Li, Sibao Chen, Ruixuan Li, Mengyan Wang, Xia Wang, Ning Ding, Yingxue Sun

“…Notably, through the analysis of metabolic pathway differences, it was observed that the PFOA-exposure group exhibited a higher proportion of Rhodococcus in the PWY-7315 pathway, whereas L. rhamnosus mitigated this trend. …”
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Transcriptome-Wide Identification of miRNAs and Their Targets During Riboflavin-Promoted Dormancy Release in <i>Lilium</i> ‘Siberia’ by Xiaoping Xu, Chenglong Yang, Yiping Zheng, Wenjie Guo, Zhongxiong Lai, Shaozhong Fang

“…<i>LoPurple acid phosphatase17</i> (<i>LoPAP17</i>), a pivotal gene of the riboflavin metabolism pathway, was subsequently cloned. LoPAP17 was most closely related to the orthologous genes of <i>Acorus calamus</i>, <i>Asparagus officinalis</i>, and <i>Musa acuminata</i>. …”
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The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis by Javier Conde, Isabel Fernández‐Pisonero, L. Francisco Lorenzo‐Martín, Rocío García‐Gómez, Berta Casar, Piero Crespo, Xosé R. Bustelo

“…Furthermore, in vivo tumorigenesis experiments indicated that the two most upstream steps of this metabolic pathway [3‐hydroxy‐3‐methylglutaryl‐coenzyme A synthase 1 (HMGCS1) and 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR)] are important for primary tumorigenesis, angiogenesis, and cell survival in breast cancer cells. …”
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Stage-specific function of sphingolipid synthases in African trypanosomes by Norton Heise, Carolina M. Koeller, Mohamed Sharif, James D. Bangs

“…These results are consistent with this metabolic pathway being a valid target for chemotherapeutic intervention.…”
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THE BIOSYNTHESIS REGULATION OF POTATO STEROIDAL GLYCOALKALOIDS by K. A. Ivanova, S. V. Gerasimova, E. K. Khlestkina

“…The advent of approaches for manipulation with the regulation of metabolic pathways provides an opportunity to overcome the undesirable direct relationship between the potato resistance to pests and the toxicity of its tubers. …”
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Metabolomics Reveals Distinct Metabolites between Lonicera japonica and Lonicera macranthoides Based on GC-MS by Rui-ying Liu, Jing Deng, Xiu-Lian Lin, Ya-mei Li, Yan Lin, Bo-hou Xia, Li-mei Lin

“…The results showed that LJ and LM were obviously classified into two groups. 10 metabolites were obtained as biomarkers on account of their p values, pcorr values, and differing variable importance in projection (VIP) values. Metabolic pathway analysis showed that the galactose metabolism and starch and sucrose metabolism gathered as potential pathways caused these extraordinary differences of primary metabolites between LJ and LM. …”
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Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections by Maura Rojas-Pirela, Diego Andrade-Alviárez, Verónica Rojas, Miguel Marcos, Daniel Salete-Granado, Marirene Chacón-Arnaude, María Á. Pérez-Nieto, Ulrike Kemmerling, Juan Luis Concepción, Paul A. M. Michels, Wilfredo Quiñones

“…Glycolysis, present in most organisms, is evolutionarily one of the oldest metabolic pathways. It has great relevance at a physiological level because it is responsible for generating ATP in the cell through the conversion of glucose into pyruvate and reducing nicotinamide adenine dinucleotide (NADH) (that may be fed into the electron chain in the mitochondria to produce additional ATP by oxidative phosphorylation), as well as for producing intermediates that can serve as substrates for other metabolic processes. …”
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Optimizing Cucumber (<i>Cucumis sativus</i> L.) Fruit Metabolomics Under Elevated CO₂ and High-Temperature Stress in the Greenhouse by Xian Du, Yang Song, Lu Pan, Shimao Cui

“…These modifications were linked to the galactose metabolic pathway and the zeatin and arginine biosynthetic pathways. …”
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Integrative analysis of ferroptosis in the hypoxic microenvironment of gastric cancer unveils the immune landscape and personalized therapeutic strategies by Xiao Xu, Liangling Fa, Xiaoxiao Sun, Fangfang Yang, Yongrui Liu, Jifu Song, Yongli Zhao, Jigang Dong, Jigang Dong

“…BackgroundFerroptosis is a cell death mode caused by excessive accumulation of lipid peroxides caused by disturbance of intracellular metabolic pathway, which is closely related to iron and cholesterol metabolism homeostasis. …”
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Insight into influence of degradation metabolism of Firmicutes on the microstructure of anthracite coal by Yuewu Wang, Bingjun Liu, Sheng Xue, Yang Yang, Jian Chen, Jingbei Zhang, Chunshan Zheng, Tianyao Zhou

“…The results showed that the maximum methane migration during the period of biodegradation reached 0.640 mL/g coal, and the cumulative migration of the whole cycle was as high as 1.318 mL/g coal. 16S rRNA high-throughput sequencing results indicated that the bacterial community structure had undergone significant succession after the biodegradation experiments, and that the Firmicutes represented by Bacillus(82.41% of the total) occupied the dominant niche. Metabolic pathway analysis based on Kyoto Encyclopedia of Genes and Genomes (KEGG) database showed that the degradation of aromatic compounds by microorganisms appeared to be significantly enhanced by the addition of nitrogen sources. …”
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High-level production of free fatty acids from lignocellulose hydrolysate by co-utilizing glucose and xylose in yeast by Xin Ni, Jingjing Li, Wei Yu, Fan Bai, Zongbao K. Zhao, Jiaoqi Gao, Fan Yang, Yongjin J. Zhou

“…The non-oxidative branch of the pentose phosphate pathway, and the adaptive expression levels of xylose metabolic pathway genes XYL1, XYL2 and XYL3, were systematically optimized. …”
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Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024 by Congxu Zhu, Jingjing Yang, Lumei Liu, Bonan Li, Tiansong Sun, Wen Sheng, Qinghu He

“…Currently, leading research in this area encompasses the application of nanotechnology to PCa glycolysis, the roles of long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) in this metabolic pathway, and the interactions between glycolysis and other biological processes in PCa. …”
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Differences in Metabolites of Different Varieties from Xinjiang Large-fruit Sea Buckthorn as Analyzed by Non-targeted Metabolomics by Rong HAN, Yan MA, Shengjie LI, Xintao MENG, Mingqiang XU, Ting ZHANG, Yan PAN

“…A total of 160 differential metabolites were screened between 'Mixed Fruit' and 'Xiangyang' and a total of 126 differential metabolites were screened between 'Mixed Fruit' and 'Zhuangyuan Yellow'. The metabolic pathway enrichment analysis showed that the differential metabolites of different large-fruit sea buckthorns were mainly enriched in the pathways of unsaturated fatty acid biosynthesis, fatty acid biosynthesis, tryptophan metabolism, and flavonoid and flavonol biosynthesis. …”
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Exploring therapeutic mechanisms of Chuan Huang Fang-II in the treatment of acute kidney injury on chronic kidney disease patients from the perspective of lipidomics by Ling Chen, Qian Wang, Tonglu Li, Lejia Li, Chen Wang, Bing Xu, Xuezhong Gong

“…According to the KEGG database, the possible metabolic pathways involved triglyceride metabolic pathway and fat digestion and absorption metabolic pathways.Conclusion CHF-II effectively alleviated kidney injury and improved TCM syndrome scores in patients with A on C. …”
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Unraveling nitrogen metabolism, cold and stress adaptation in polar Bosea sp. PAMC26642 through comparative genome analysis by Anamika Khanal, Anamika Khanal, So-Ra Han, So-Ra Han, So-Ra Han, Jun Hyuck Lee, Tae-Jin Oh, Tae-Jin Oh, Tae-Jin Oh, Tae-Jin Oh

“…PAMC26642, assimilatory nitrogen metabolic pathway and its associated enzymes such as nitrate reductase, NAD(P)H-nitrite reductase, ferredoxin-nitrite reductase, glutamine synthetase, glutamine synthase, and glutamate dehydrogenase were identified. …”
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Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Wom... by Marica Franzago, Federica Fraticelli, Antonio Nicolucci, Claudio Celentano, Marco Liberati, Liborio Stuppia, Ester Vitacolonna

“…Studies have demonstrated a significant correlation between several genes involved in the metabolic pathway of insulin and environmental factors. …”
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Acidity, sugar, and alcohol contents during the fermentation of Osmanthus-flavored sweet rice wine and microbial community dynamics by Ping Tian, Jiaqiong Wan, Tuo Yin, Li Liu, Hongbing Ren, Hanbing Cai, Xiaozhen Liu, Hanyao Zhang

“…Diversity analysis revealed that the dominant species at the beginning of natural fermentation was A. johnsonii, and R. delemar became the dominant species as natural fermentation progressed. Metabolic pathway analysis revealed that energy production and conversion, carbohydrate transport, amino acid transport, and metabolic pathways were the most active metabolic pathways in the fermenter. …”
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Elucidating the metabolic mechanisms and active constituents of ZuoGui Wan in combatting postmenopausal osteoporosis: A metabolomics and network pharmacology approach by Yanchen Feng, KaiKai Shi, Dingming Li, Shunzhi Yang, Xue Dang, Jinyao Li, Yan Chen, Jianping Yao, Yunke Zhang, Lu Sun, Feixiang Liu

“…Additionally, network pharmacology and molecular docking analyses further dissected the active ingredients of ZGW, constructing a ''Compound-Targets-Metabolic pathway-Metabolites'' network against PMOP. Conclusion: this study comprehensively revealed the metabolic mechanism and active ingredients of ZGW against PMOP for the first time, providing a new perspective on the study of the mechanism of ZGW against PMOP.…”
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