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121
Effects of Salmonella Typhimurium infection on intestinal flora and intestinal tissue arachidonic acid metabolism in Wenchang chickens
Published 2025-01-01“…Typhimurium activates the ARA cyclooxygenase metabolic pathway, which in turn mediates the development of intestinal inflammation in Wenchang chickens. …”
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122
Systematic qualitative proteome-wide analysis of lysine malonylation profiling in Platycodon grandiflorus
Published 2025-01-01“…Motif analysis showed the enrichment of Alanine (A), Cysteine (C), Glycine (G), and Valine (V) amino acids surrounding malonylated lysine residues. Metabolic pathway and protein-protein interaction network analyses suggested these modifications are mainly involved in plant photosynthesis. …”
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123
Denitrification research based on green electron supply and cell metabolism regulation
Published 2024-02-01“…Then, the microbial metabolic pathway of denitrification using methane, propane, and other short-chain alkanes as carbon sources is described, the performance of kitchen waste and other organic wastes as carbon source is introduced, and the formation mechanism and utilization characteristics of microbial carbon sources are also analyzed. …”
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124
Differentially expressed whey proteins of donkey and bovine colostrum revealed with a label-free proteomics approach
Published 2023-07-01“…Gene Ontology analysis revealed that these DEWPs were mainly related to cellular components, such as extracellular exosome, plasma membrane, and mitochondrion; biological processes, such as oxidation-reduction process, cell-cell adhesion, and small guanosine triphosphate (GTP) ase-mediated signal transduction; and molecular functions, such as GTP binding, GTPase activity, and soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor activity. Metabolic pathway analysis suggested that the majority of the DEWPs were associated with soluble NSF factor attachment protein receptor interactions in vesicular transport, fatty acid biosynthesis, and estrogen signaling pathways. …”
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125
Effects of <i>Lactiplantibacillus plantarum</i> and Fermentation Time on the Quality, Bacterial Community, and Functional Prediction of Silage from <i>Lotus corniculatus</i> L. in...
Published 2024-12-01“…LP promoted the growth of beneficial bacteria and inhibited harmful bacteria, with LP becoming the predominant genus and species after 45 days of fermentation. The metabolic pathway analysis revealed that the addition of LP enhanced carbohydrate metabolism and improved the replication and repair, translation, transcription, and membrane transport functions of the bacterial community. …”
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126
Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i>
Published 2025-01-01“…However, this essential metabolic pathway is highly susceptible to oxidative stress, which can lead to lipid peroxidation, a damaging process induced by reactive oxygen species. …”
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127
Effects of Cooking Treatment on the Changes of Polyphenol and Antioxidant Activity in Sorghum Rice and Its Exploration on the Flavor Enhancement Based on the Multi-omics Technique
Published 2025-02-01“…L-tyrosine, L-isoleucine, and guaiacol in SRC might be related to its flavor formation. KEGG metabolic pathway analysis showed that the up-regulated compound serotonin in SRC might be related to its aroma-enhancing effect. …”
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128
WRKY Transcription Factors Modulate the Flavonoid Pathway of <i>Rhododendron chrysanthum</i> Pall. Under UV-B Stress
Published 2025-01-01“…WRKY transcription factors can influence the expression of key enzyme genes in the flavonoid metabolic pathway, thereby affecting metabolite production. …”
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129
Principles of Medical Biochemistry /
Published 2017Table of Contents: “…Introduction to biomolecules -- Introduction to protein structure -- Oxygen-binding proteins : hemoglobin and myoglobin -- Enzymatic reactions -- Coenzymes -- DNA, RNA, and protein synthesis -- The human genome -- Protein targeting and proteostasis -- Introduction to genetic diseases -- Viruses -- DNA technology -- Biological membranes -- The cytoskeleton -- The extracellular matrix -- Extracellular messengers -- Intracellular messengers -- Plasma proteins -- Defense mechanisms -- Cellular growth control and cancer -- Digestive enzymes -- Introduction to metabolic pathways -- Glycolysis, tricarboxylic acid cycle, and oxidative phosphorylation -- Oxygen deficiency and oxygen toxicity -- Carbohydrate metabolism -- The metabolism of fatty acids and triglycerides -- The metabolism of membrane lipids -- Lipid transport -- Amino acid metabolism -- Metabolism of iron and heme -- The metabolism of purines and pyrimidines -- Micronutrients -- Integration of metabolism.…”
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130
Genomic Analysis of a New Estrogen-Degrading Bacterial Strain, Acinetobacter sp. DSSKY-A-001
Published 2019-01-01“…Three kinds of estrogen metabolism intermediates were detected by high-performance liquid chromatography and mass spectrometry, and the estrogen metabolic pathway and possible estrogen-degrading enzymes were predicted. …”
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131
A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment
Published 2024-11-01“…Here, the authors have reviewed the recent advancements in genetic engineering, metabolic pathway manipulation, and synthetic biology to improve the production and yield of these SMs. …”
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132
Metabonomic-Transcriptome Integration Analysis on Osteoarthritis and Rheumatoid Arthritis
Published 2020-01-01“…Then, the principal component analysis (PCA) and linear models were used to reveal DEG-metabolite relations. Finally, metabolic pathway enrichment analysis was performed to investigate the differences between the molecular mechanisms of OA and RA. …”
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133
Protopanaxadiol manipulates gut microbiota to promote bone marrow hematopoiesis and enhance immunity in cyclophosphamide‐induced immunosuppression mice
Published 2023-04-01“…KEGG topology analysis showed that the PPD‐M treatment significantly enriched the sphingolipid metabolic pathway with ceramide as a main metabolite. Our findings reveal that PPD enhances immunity by manipulating gut microbiota and has the potential to be used as an immunomodulator in cancer chemotherapy.…”
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134
RETRACTED ARTICLE: Single-cell omics and machine learning integration to develop a polyamine metabolism-based risk score model in breast cancer patients
Published 2024-10-01“…Abstract Background Breast cancer remains the leading malignant neoplasm among women globally, posing significant challenges in terms of treatment and prognostic evaluation. The metabolic pathway of polyamines is crucial in breast cancer progression, with a strong association to the increased capabilities of tumor cells for proliferation, invasion, and metastasis. …”
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135
Saprotrophic Wood Decay Ability and Plant Cell Wall Degrading Enzyme System of the White Rot Fungus <i>Crucibulum laeve</i>: Secretome, Metabolome and Genome Investigations
Published 2024-12-01“…Multiple copies of the family AA1_1, AA3_2, AA7 and LPMOs CAZyme genes, as well as eight genes encoding proteins of the YvrE superfamily (COG3386), which includes sugar lactone lactonases, were predicted in the <i>C. laeve</i> genome. According to metabolic pathway analysis, the litter saprotroph <i>C. laeve</i> can catabolize D-gluconic and D-galacturonic acids, and possibly other aldonic acids, which seems to confer certain ecological advantages.…”
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136
Associations of urinary caffeine metabolites with sex hormones: comparison of three statistical models
Published 2025-01-01“…In the BKMR model, despite no significant difference in the overall association between caffeine metabolites and the sex hormones (E2, TT, SHBG), there was nonetheless a declining trend in the male population E2 group, in the male and female population SHBG groups also observed a downward trend.ConclusionWhen considering the results of these three models, the whole-body burden of caffeine metabolites, especially the caffeine metabolites in the PC2 metabolic pathway was significantly negatively associated with E2 in males. …”
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137
Integrated transcriptomics and metabolomics analyses provide new insights into cassava in response to nitrogen deficiency
Published 2025-01-01“…Transcriptomic and metabolomic analyses further demonstrated notable alterations in genes and metabolites linked to carbon and nitrogen metabolism, flavonoid biosynthesis, and the purine metabolic pathway. Additionally, several transcription factors associated with cassava flavonoid biosynthesis under nitrogen-deficient conditions were identified. …”
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138
Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages
Published 2023-11-01“…Amino acid metabolism, energy metabolism and purine metabolism were disordered in LPS-treated group, and metabolic pathway analysis indicated that the double-targeting PC nanoparticles reversed some of LPS impacts. …”
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139
Metabolomic characterisation of the glioblastoma invasive margin reveals a region-specific signature
Published 2025-01-01“…Bioinformatic interpretation of the GBM metabolome has highlighted the invasive region to be biologically distinct compared to tumour core and revealed putative drug-targetable metabolic pathways associated with purine and pyrimidine metabolism.…”
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140
Persistent functional and taxonomic groups dominate an 8,000-year sedimentary sequence from Lake Cadagno, Switzerland
Published 2025-02-01“…As the conservation of these metabolic pathways through changes in microbial community compositions helps preserve the metabolic pathway connectivity required for nutrient cycling, we hypothesize that the persistence of these functional groups helps enable the Lake Cadagno sedimentary communities persist amidst changing environmental conditions.…”
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