Amino acid stable carbon isotopes in nail keratin illuminate breastfeeding and weaning practices of mother – infant dyads by Hana Salahuddin, Andrea L. Waters-Rist, Fred J. Longstaffe

“…We propose that glycine’s ‘conditionally essential’ metabolic pathway during infancy allows it to reflect maternal glycine δ 13C, indicating breastmilk consumption. …”
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Uncovering the Heterogeneity of Signaling Pathways in Skin Cutaneous Melanoma: Insights into Prognostic Values and Immune Interactions by Liu Y, Li C, Deng W

“…Unfavorably elevated metabolic pathways strongly correlated with Wnt/beta-catenin signaling. …”
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PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways by Yves Lecarpentier, Victor Claes, Jean-Louis Hébert

“…Moreover, PPARs are directly or indirectly involved in cellular oscillatory processes such as the Wnt-b-catenin pathway, circadian rhythms of arterial blood pressure and cardiac frequency and glycolysis metabolic pathway. Dysfunction of clock genes and PPARγ may lead to hyperphagia, obesity, metabolic syndrome, myocardial infarction and sudden cardiac death, In pathological conditions, regulatory processes of the cardiovascular system may bifurcate towards new states, such as those encountered in hypertension, type 2 diabetes, and heart failure. …”
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Nitric oxide modulates interleukin-2-induced proliferation in CTLL-2 cells by J. Padrón, L. Glaría, O. Martinez, M. Torres, E. Lopez, R. Delgado, L. Caveda, A. Rojas

“…The role of the L-arginine–nitric oxide metabolic pathway was explored for interleukin-2-induced proliferation in the cytotoxic T lymphocyte clone CTLL-2. …”
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Artificial intelligence driven innovations in biochemistry: A review of emerging research frontiers by Mohammed Abdul Lateef Junaid

“…This review explores current and potential AI applications in biochemistry, with a focus on data analysis, molecular modeling, enzyme engineering, and metabolic pathway studies. Key AI techniques—such as machine learning algorithms, natural language processing, and AI-based molecular modeling—are discussed. …”
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Diagnosis of Methyl Malonicaciduria from 2013 to 2018 by Alina Concepción Álvarez, Ivette Camayd Viera, Norma Elena de León Ojeda, Alina García García, Laritza Martínez Rey, Daniel Quintana Hernández

“…The excretion of this metabolite may or may not be accompanied by elevated homocysteine levels depending on the affected metabolic pathway. <br /><strong>Objective:</strong> to describe the implementation of a laboratory methodology that combines methylmalonic acid and homocysteine in the differential diagnosis and monitoring of methylmalonic aciduria in the period from 2013 to 2018. …”
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Elucidating the Mechanisms of Acquired Palbociclib Resistance via Comprehensive Metabolomics Profiling by Lulu Yang, Yajun Yue, Zhendong Wang, You Jiang, Zhichao Xue, Yongzhuo Zhang

“…MetaboAnalyst 6.0 metabolic pathway analysis showed that arginine synthesis, β-alanine metabolism, and purine metabolism were disrupted. …”
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Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis by Qianlei Wang, James Asenso, Ning Xiao, Jinzhang Gao, Feng Xiao, Jiajie Kuai, Wei Wei, Chun Wang

“…Rapid energy supply depends on the anaerobic glucose metabolic pathway in both RA animal models and clinical patients. …”
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Biodesulfurization enhancement via targeted re-insertion of the flavin reductase dszD in the genome of the model strain Rhodococcus qingshengii IGTS8 by Olga Martzoukou, Fotios Klenias, Eleni Kopsini, Dimitris G. Hatzinikolaou

“…The model desulfurizing strain Rhodococcus qingshengii IGTS8 is responsible for the removal of sulfur through the 4S metabolic pathway, operating through a plasmid-borne dszABC operon, as well as the chromosomal gene for the flavin reductase, dszD. …”
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Effect of Salicylic Acid on Triterpenoid Biosynthesis and Reactive Oxygen Species Content in Ganoderma applanatum Mycelium by GUO Peijie, WANG Zhanbin, XIA Yongqiao, WANG Xingpei

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathway and heatmap analyses found that the up-regulated metabolite farnesol to be an important precursor in the triterpenoid biosynthesis pathway and its production was significantly correlated with ROS. …”
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Primary metabolomics and transcriptomic techniques were used to explore the regulatory mechanisms that may influence the flavor characteristics of fresh Corylus heterophylla × Cory... by Minmin Lu, Tiantian Xie, Yaru Wang, Jieyan Yang, Yan Bai, Shuang Gao, Xiaofan Wu, Xiuqing Yang

“…CS and OGDH were deemed as the genes involved in the citric acid cycle, which was a central metabolic pathway that generated energy through the oxidation of carbohydrates, fats and proteins in hazelnuts. …”
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Chronic prostatitis/chronic pelvic pain syndrome induces metabolomic changes in expressed prostatic secretions and plasma by Fang-Xing Zhang, Xi Chen, De-Cao Niu, Lang Cheng, Cai-Sheng Huang, Ming Liao, Yu Xue, Xiao-Lei Shi, Zeng-Nan Mo

“…Pathway analysis revealed dysregulation of amino acid metabolism, lipid metabolism, and the citrate cycle in EPS. The tryptophan metabolic pathway was found to be the most significantly altered pathway associated with distinct CP/CPPS phenotypes. …”
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Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease by O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, D. A. Kovalevsky

“…Violations in the activity of FADS1 and FADS2 and their genes are accompanied by dysregulation of the metabolic pathway involved in the biosynthesis of fatty acids. …”
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Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats by Sebastian Marciniak, Artur Wnorowski, Katarzyna Smolińska, Beata Walczyna, Waldemar Turski, Tomasz Kocki, Piotr Paluszkiewicz, Jolanta Parada-Turska

“…Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. …”
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Fibrolytic efficiency of the large intestine microbiota may benefit running speed in French trotters: A pilot study by Maximilien Vasseur, Romuald Lepers, Nicolas Langevin, Samy Julliand, Pauline Grimm

“…In contrast, the metabolic pathway of starch degradation appeared negatively associated with MRS (r = −0.55; p = 0.06). …”
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Alteration of Mevalonate Pathway in Proliferated Vascular Smooth Muscle from Diabetic Mice: Possible Role in High-Glucose-Induced Atherogenic Process by Guo-Ping Chen, Xiao-Qin Zhang, Tao Wu, Liang Li, Jie Han, Chang-Qing Du

“…Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. …”
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Metabolic engineering of Priestia megaterium for 2’-fucosyllactose production by Bu-Soo Park, Jihee Yoon, Jun-Min Lee, Sang-Hyeok Cho, Yoojeong Choi, Byung-Kwan Cho, Min-Kyu Oh

“…Conclusions The GRAS strain P. megaterium ATCC 14581 was successfully engineered to overproduce 2’-FL, a valuable human milk oligosaccharide, through a series of genetic modifications and metabolic pathway optimizations. This work underscores the feasibility of using GRAS strains for the production of oligosaccharides, paving the way for safer and more efficient methods in biotechnological applications. …”
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Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics by Xiaomin Xu, Donghua Yu, Yu Wang, Xin Jiang, Fang Lu, Shumin Liu

“…Through related metabolic pathway analysis, the most affected metabolic pathways were found to be Sphingolipid metabolism, Glycerophospholipid metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Pantothenate and CoA, Citrate cycle (TCA cycle), and Arachidonic acid metabolism.ConclusionResveratrol can regulate the biosynthetic pathways of arachidonic acid, phenylalanine, tyrosine, and tryptophan, pantothenic acid and CoA biosynthesis pathways, TCA cycle, and other metabolic pathways, thereby regulating the NF-κB, MAPK, and JAK/STAT3 signaling pathways, and inhibiting the acute inflammatory response during GA attacks, showing characteristics of multi-pathway and multi-target action.…”
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Integrated Network Pharmacology and Gut Microbiota Study on the Mechanism of Huangqin Decoction in Treatment Diabetic Enteritis by Xiaomin Xu, Cheng Fang, Fang Lu, Shumin Liu

“…Using picurst2 for functional prediction and metabolic pathway statistics, seven metabolic pathways were obtained consistent with gut microbiota sequencing, and the NOD-like receptor signaling pathway may be its potential molecular mechanism. …”
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Metabonomics and physiology revealed the critical function of 5-Phosphoribosylamine and antioxidant enzymes in enhancing aged oat seed germination by Yi Hua, Linling Dong, Shengnan Sun, Kexin Wang, Yilin Zou, Yongqi Gao, Ting Gong, Guofu Hu, Ligang Qin

“…In addition, metabolic profiling highlighted the significance of 5-phosphoribosylamine in the purine metabolic pathway. Particularly in the SuT, the upregulation of 5-phosphoribosylamine facilitated the synthesis of (R)-Allantoin, consequently augmenting antioxidant enzyme activity.…”
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