Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications by Liang Huang, Yu Xie, Shusuan Jiang, Kan Liu, Zhihao Ming, Hong Shan

“…Through transcriptomic and single-cell RNA sequencing analyses, we explored metabolic pathway enrichment, immune infiltration patterns, and differential gene expression in prostate cancer samples. …”
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Exploring the causal role of plasma metabolites and metabolite ratios in prostate cancer: a two-sample Mendelian randomization study by Changzhou Feng, Haining Li, Chu Zhang, Ying Zhou, Huanhuan Zhang, Ping Zheng, Shaolin Zhao, Lei Wang, Jin Yang

“…Steiger’s directionality test (P < 0.001) and reverse MR confirmed the proposed causal direction. Furthermore, metabolic pathway analysis revealed a significant association between the “Glutathione Metabolism” pathway and PCa development.ConclusionThis study provides novel insights into the potential causal effects of plasma metabolites and metabolite ratios on PCa. …”
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Untargeted metabolomics analysis of glycerophospholipid metabolism in very low birth weight infants administered multiple oil lipid emulsions by Xiaoyan Zeng, Tao Yu, Luping Xia, Zhiqiang Ruan

“…Subsequently, enrichment and topological analyses were conducted with MetaboAnalyst software to identify key metabolic pathways. Finally, receiver operating characteristic (ROC) analysis was performed on metabolites associated with the identified key metabolic pathways. …”
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Exploring the effects of Tianma Gouteng granules on L-NAME-induced hypertensive rats based on 16S rDNA gene sequencing and metabolomics by Li Cheng, Zhenyang Huang, Jiawei He, Xinyi Zhang, Jiangxue Di, Hanmei Jiang, Yi Liu

“…TG treatment of hypertension was found to be associated with vitamin B6 metabolic pathway and lipid metabolic pathway. Conclusions: TG can treat hypertension by affecting differential strains and differential metabolites, providing a scientific basis for guiding the rational use of TG.…”
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Effects of combined inoculation of arbuscular mycorrhizal fungi and plant growth-promoting rhizosphere bacteria on seedling growth and rhizosphere microecology by Wanli Zeng, Dan Xiang, Xuemei Li, Qian Gao, Yudong Chen, Kunmiao Wang, Yingying Qian, Luoping Wang, Jing Li, Qili Mi, Haitao Huang, Li Xu, Mingfang Zhao, Yingzhen Zhang, Haiying Xiang

“…Furthermore, the A_SG29 treatment yielded the highest diversity indexes and largest percentages of significantly enriched bacterial taxa, and significantly promoted the colonization of AMF in tobacco roots and Pseudomonas in rhizosphere soil. Differential metabolic-pathway predictions using PICRUSt2 showed that the A_SG29 treatment significantly increased the metabolic pathway richness of tobacco rhizosphere microorganisms, and significantly up-regulated some metabolic pathways that may benefit plant growth. …”
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Bone-spicule pattern in retinitis pigmentosa by Krzysztof Eder, Rafał Leszczyński, Ewa Mrukwa-Kominek, Paulina Langosz, Sebastian Sirek

“…The occurrence of the disease is not due to damage in a single metabolic pathway. Rather, it is a multifactorial pathophysiological process involving the failure of various cellular regulatory mechanisms and the presence of histopathological changes. …”
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The Association between Polymorphisms of Vitamin D Metabolic-Related Genes and Vitamin D3 Supplementation in Type 2 Diabetic Patients by Zhiyong Hu, ShaSha Tao, Huaqing Liu, Guotao Pan, Bingyan Li, Zengli Zhang

“…To investigate the effect of single nucleotide polymorphisms (SNPs) of the key genes in vitamin D metabolic pathway on the serum 25(OH)D level after long-term vitamin D3 supplementation and provide a theoretical basis for rational vitamin D3 supplementation in diabetic patients with different genetic backgrounds. …”
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The biological functions of sphingolipids in plant pathogenic fungi. by Xue-Ming Zhu, Lin Li, Jian-Dong Bao, Jiao-Yu Wang, Asen Daskalov, Xiao-Hong Liu, Maurizio Del Poeta, Fu-Cheng Lin

“…However, our knowledge on the metabolism and function of the sphingolipid metabolic pathway of pathogenic fungi affecting plants is still very limited. …”
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Research Progress in Natural Sources, Biosynthesis and Metabolism Regulation of Rutin in Plant-Derived Food Materials by ZHOU Ting, WANG Haige, ZHANG Jixing, BAO Yingcai, YU Yongli, CHANG Jie

“…Rutin, a flavanol glycoside derived from quercetin, is classified as a secondary metabolite from the phenylpropane metabolic pathway in higher plants. It possesses various pharmacological and physiological activities, including antioxidant, anti-aging, anti-inflammatory, anti-diabetic, and anti-cancer properties. …”
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Analysis of glutamate-dependent mechanism and optimization of fermentation conditions for poly-gamma-glutamic acid production by Bacillus subtilis SCP017-03. by Caiyun Wu, Yutao Gou, Shuai Jing, Wei Li, Fanglan Ge, Jiao Li, Yao Ren

“…The introduction of glutamate substantially altered gene expression within the central metabolic pathway of cellular carbon. Most genes in the pentose phosphate pathway (PPP), tricarboxylic acid (TCA) cycle, and energy-consuming phase of the glycolysis pathway (EMP) were down-regulated, whereas those in the energy-producing phase of glycolysis and those responsible for γ-PGA synthesis were up-regulated. …”
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Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP by Jarmon G. Lees, David K. Gardner, Alexandra J. Harvey

“…The significance of altered nutrient availability, particularly oxygen, and metabolic pathway activity has been highlighted by extensive studies of their impact on preimplantation embryo development, physiology, and viability. …”
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Effect of Microbial Community Succession on Tyrosine Metabolism during Soybean Paste Fermentation by JIN Manqin, LUO Dan, WANG Gangtu, LI Yixin, PEI Wei, XUE Wentong

“…To find an effective method for eliminating white spots on the surface of soybean paste and enhancing its quality, this study analyzed the relationship between microbial community succession and physicochemical properties and the tyrosine metabolic pathway throughout the entire production cycle of soybean paste. …”
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Peningkatan akumulasi tiamin pada kultur Escherichia coli melalui peningkatan oksigenasi dan penghilangan rpoS by Nuraliah Rusman, Prayoga Suryadarma, Nisa Rachmania Mubarik

“…Thiamine diphosphate is one of the coenzymes that are commonly found in the metabolic pathways of microbial cells. Increasing the thiamine formation pathway as a precursor in the thiamine metabolic pathway is a strategy in this study. …”
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Asymmetric Dimethyl Arginine as a Biomarker of Atherosclerosis in Rheumatoid Arthritis by Manuela Di Franco, Bruno Lucchino, Fabrizio Conti, Guido Valesini, Francesca Romana Spinelli

“…Asymmetric dimethylarginine is gaining attention for its implication in the pathogenesis of endothelial dysfunction and as biomarkers of subclinical atherosclerosis. Moreover, the metabolic pathway of methylarginines offers possible targets for therapeutic interventions to decrease the cardiovascular risk. …”
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Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines by Gabriela García-Cerón, Alba Fernanda Solano-González, Iván Hazael Bello-Cortés, Ileana Andrea Bonilla-Brunner, Daniela Araiza-Olivera, Manuel Gutiérrez-Aguilar, Yazmin Ramiro-Cortés, Marcos Francisco Rosetti, Roeb García-Arrazola

“…MS is the key enzyme in the metabolic pathway that has been proposed elsewhere to be related to redox/methylation related disorders.…”
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Analysis of the spatial distribution of metabolites in Aloe vera leaves by mass spectrometry imaging and UHPLC-UHRMS by Sumi Krupa, Tomasz Ruman, Wiktoria Szuberla, Joanna Nizioł

“…Analysis of the results of mass spectrometry imaging provided information about the potential changes in metabolic pathway expression in different regions of the leaf.…”
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Comparative metabolomics reveals eggshell translucency formation using LC-MS Analysis by Ying Ma, Zhonghua Ning

“…The results showed that we identified two essential metabolic pathways through differential metabolite pathway analysis, which were glycine, serine, and threonine metabolism related to amino acids metabolism and the PPAR metabolic pathway related to lipid metabolism. …”
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The impact of glycolysis on ischemic stroke: from molecular mechanisms to clinical applications by Yingquan Liu, Peijia Hu, Hongliang Cheng, Fangyuan Xu, Yu Ye

“…Glycolysis, a central metabolic pathway, plays a critical role in bridging the gap between metabolic dysfunction and neurological impairment. …”
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The comparative gene expression concern to the seed pigmentation in maize ( L.) by Kyu Jin Sa, Ik-Young Choi, Ju Kyong Lee

“…Additionally, 37 genes were detected in the metabolic pathway concern to the seed pigmentation by BINs analysis using MAPMAN software. …”
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The emerging role of 12/15-lipoxygenase in ischemic stroke by Xuening Wang, Qiuji Shao, Yuan Gao

“…The arachidonic acid metabolic pathway is a classic inflammatory pathway. 12/15-lipoxygenase (LOX), a member of the lipoxygenase family that metabolizes arachidonic acid, has been implicated in the pathogenesis of numerous central nervous system (CNS) diseases. …”
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