Two-photon NAD(P)H-FLIM reveals unperturbed energy metabolism of Ascaris suum larvae, in contrast to host macrophages upon artemisinin derivatives exposure by Zaneta D. Musimbi, Arkadi Kundik, Jürgen Krücken, Anja E. Hauser, Sebastian Rausch, Peter H. Seeberger, Raluca Niesner, Ruth Leben, Susanne Hartmann

“…Overall, two-photon NAD(P)H-FLIM proved to be a powerful tool for studying specific metabolic pathways in Ascaris larvae and host macrophages, offering valuable insights into the metabolic mechanisms of drug action on both parasite and host.…”
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Liver transcriptomics-metabolomics integration reveals biological pathways associated with fetal programming in beef cattle by Guilherme Henrique Gebim Polizel, Simara Larissa Fanalli, Wellison J. S. Diniz, Aline Silva Mello Cesar, Nara Regina Brandão Cônsolo, Heidge Fukumasu, Angela Cánovas, Arícia Christofaro Fernandes, Barbara Carolina Teixeira Prati, Édison Furlan, Gabriela do Vale Pombo, Miguel Henrique de Almeida Santana

“…This study highlights the significant impact of prenatal nutrition on the liver tissue of Nelore bulls, shedding light on critical metabolic pathways and hub components related to energy and protein metabolism, as well as immune system and epigenetics.…”
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Structural elucidation of mulberry leaf oligosaccharide and its selective promotion of gut microbiota to alleviate type 2 diabetes mellitus by Tenggen Hu, Yuanshan Yu, Jijun Wu, Yujuan Xu, Gengsheng Xiao, Kejing An, Erna Li, Sentai Liao, Yuxiao Zou

“…Meanwhile, MLO 2-1 was effectively metabolized by fecal bacteria to produce lactate and short chain fatty acids, especially acetate and butyrate. The specific metabolic pathways of MLO 2-1 by gut microbiota were further illuminated. …”
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Unveiling the mechanism of micro-and-nano plastic phytotoxicity on terrestrial plants: A comprehensive review of omics approaches by Asad Jamil, Ambreen Ahmad, Muhammad Moeen-ud-din, Yihao Zhang, Yuxuan Zhao, Xiaochen Chen, Xiaoyu Cui, Yindong Tong, Xianhua Liu

“…This literature review synthesizes current findings regarding MNPs-induced phytotoxicity, emphasizing alterations in gene expression, protein synthesis, metabolic pathways, and physiological disruptions as revealed through omics analyses. …”
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Untargeted metabolomic analysis uncovers metabolic variability of four Bifidobacterial strains for probiotic development by Kailong Liu, Kailong Liu, Kailong Liu, Kailong Liu, Guoqiang Yao, Guoqiang Yao, Guoqiang Yao, Guoqiang Yao, Zhan Yang, Zhan Yang, Zhan Yang, Zhan Yang, Tian Huang, Tian Huang, Tian Huang, Tian Huang, Lai-Yu Kwok, Lai-Yu Kwok, Lai-Yu Kwok, Lai-Yu Kwok, Heping Zhang, Heping Zhang, Heping Zhang, Heping Zhang

“…Targeted analyses of specific metabolites further revealed strain-specific metabolic pathways. This study systematically elucidates the metabolic profile differences among the four investigated Bifidobacterium strains at the untargeted metabolomic level, providing valuable insights into their metabolic characteristics and potential applications in probiotic development.…”
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Microbial methanogenesis fueled by freshwater infiltration and oil biodegradation in the Siljan impact structure, Sweden by Femke van Dam, Riikka Kietäväinen, George Westmeijer, Manuel Reinhardt, Shuhei Ono, Mark Dopson, Marcelo Ketzer, Jennifer C. McIntosh, Henrik Drake

“…Previous studies report signs of ancient microbial methanogenesis in the Devonian Siljan meteorite impact structure in Sweden, but the proportion of microbial methane, metabolic pathways, and potential modern activity remain elusive. …”
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Using DIMet for Differential Analysis of Labeled Metabolomics Data: A Step-by-step Guide Showcasing the Glioblastoma Metabolism by Johanna Galvis, Joris Guyon, Thomas Daubon, Macha Nikolski

“…By incorporating isotopes, such as 13C, into substrates, researchers can trace reaction rates across specific metabolic pathways. Integrating metabolomics data with gene expression profiles further enriches the analysis, as we demonstrated in our prior study on glioblastoma metabolic symbiosis. …”
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Histological, physiological and transcriptomic analysis in hepatopancreas of Procambarus clarkii under heat stress by Yongfeng Zou, Panhui Cao, Zhiming Bao, Yu Xu, Zhiqiang Xu, Hui Guo

“…In summary, heat stress induced oxidative damage, disrupted metabolic pathways, impacted protein processing, and compromised immune defense mechanisms, ultimately resulting in decreased survival rates of P. clarkii. …”
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Transcriptome analysis reveals regulatory mechanism of methyl jasmonate-induced monoterpenoid biosynthesis in Mentha arvensis L. by Tingting Huang, Wenjin Men, Ariuntungalag Myanganbayar, Undarmaa Davaasambuu

“…KEGG enrichment analysis revealed that “Monoterpenoid biosynthesis” was among the most significantly enriched metabolic pathways. Key genes involved in jasmonic acid (JA) signaling (JAZs and MYCs) and monoterpenoid biosynthesis (GPPSs, LSs, L3Hs, and IPRs) were significantly up-regulated. …”
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Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways. by Abel Tesfai, Niall MacCallum, Nicholas S Kirkby, Hime Gashaw, Nicola Gray, Elizabeth Want, Gregory J Quinlan, Sharon Mumby, James M Leiper, Mark Paul-Clark, Blerina Ahmetaj-Shala, Jane A Mitchell

“…A top down approach was also taken to examine the most changed metabolic pathways by Ingenuity Pathway Analysis. The iNOS supporting capacity of plasma was determined using a mouse macrophage cell-based bioassay.…”
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Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state by Yao Li, Hui Xin, Zhexun Lian, Wei Zhang

“…Enrichment analysis revealed alterations in sugar metabolism pathways, such as the Warburg effect and glycolysis, indicating their involvement in postmenopausal hypertension. …”
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Human microbiome, applied to clinical practice by V. T. Ivashkin, K. V. Ivashkin

“…The main features of human microbiome include: great variety at the level of genus and at the level of species, varying modes of diversification within samples, variability of microbiome of separate individuals is much less in comparison to interindividual variability, metabolic pathways remain unchanged until the patient is healthy, the lack of pathogenic bacteria in healthy microbiomes serves as microbiota alteration evidence in the state of disease. …”
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Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma by Zhengyan Li, Wei Chen, Shu Yao, Zuxiang Peng, Hongming Liu, Yongliang Tang, Yi Feng

“…These subtypes had different biological states, cell-cell communications, and metabolic pathways. Mitophagy levels were elevated in tumor samples. …”
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Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food. by Laura Dearden, Isadora C Furigo, Lucas C Pantaleão, L W P Wong, Denise S Fernandez-Twinn, Juliana de Almeida-Faria, Katherine A Kentistou, Maria V Carreira, Guillaume Bidault, Antonio Vidal-Puig, Ken K Ong, John R B Perry, Jose Donato, Susan E Ozanne

“…We demonstrate that targets of miR-505-5p are enriched in fatty acid metabolism pathways and overexpression of miR-505-5p decreased neuronal fatty acid metabolism in vitro. miR-505-5p targets are associated with increased BMI in human genetic studies. …”
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Human papillomavirus, vaginal microbiota and metagenomics: the interplay between development and progression of cervical cancer by Paul Leon-Gomez, Vanessa I. Romero, Vanessa I. Romero

“…Alterations in microbial composition, function, and metabolic pathways may contribute to this process. Despite the potential of metagenomics to explore these interactions, studies on the vaginal microbiota’s role in cervical cancer are limited. …”
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Fucose as a nutrient ligand for Dikarya and a building block of early diverging lineages by Małgorzata Orłowska, Drishtee Barua, Sebastian Piłsyk, Anna Muszewska

“…Massive gene loss has shaped the evolutionary history of these metabolic pathways, leading to a repeated reduction of these pathways in most yeast-forming lineages. …”
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Role of inflammatory aging in the development of age-related macular degeneration by A.S. Khalatyan, Yu. Yusef

“…The development of AMD involves various pro-inflammatory stimuli, cells, mediators, and metabolic pathways. The pathogenesis of AMD begins with the thickening of Bruch's membrane caused by the accumulation of lipids and proteins, resulting in the formation of subretinal deposits called drusen. …”
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De novo transcriptome assembly and discovery of drought-responsive genes in white spruce (Picea glauca). by Zoé Ribeyre, Claire Depardieu, Julien Prunier, Gervais Pelletier, Geneviève J Parent, John Mackay, Arnaud Droit, Jean Bousquet, Philippe Nolet, Christian Messier

“…In this study, we examined the transcriptome of white spruce (Picea glauca (Moench) Voss) to identify key genes and metabolic pathways involved in the species' response to water stress. …”
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The role of the pAbp gene encoding the cytoplasmic poly(A)-binding protein in spermatogenesis of Drosophila melanogaster by E. U. Bolobolova, E. M. Baricheva, N. V. Dorogova

“…Cytoplasmic PABPs participate in the metabolic pathways of the mRNA: translation initiation and termination, cytoplasmic polyadenylation/deadenylation, mRNA stability, mRNA degradation. …”
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Comparative miRNAome combined with transcriptome and degradome analysis reveals a novel miRNA-mRNA regulatory network associated with starch metabolism affecting pre-harvest sprout... by Longqing Sun, Ting Zhao, Dandan Qin, Jing Dong, Daorong Zhang, Xifeng Ren

“…Combined with degradome data, the miRNA-mRNA networks analysis was performed after genome-wide screening of target genes, and then KEGG enrichment highlighted that the starch and sucrose metabolism pathway related to PHS was specifically enriched in an especial target-gene dataset derived from R12R18-HE miRNAs. …”
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