Uncovering molecular mechanisms of soybean response to 12C6+ heavy ion irradiation through integrated transcriptomic and metabolomic profiling by Honglei Ren, Bixian Zhang, Chunlei Zhang, Xiulin Liu, Xueyang Wang, Fengyi Zhang, Kezhen Zhao, Rongqiang Yuan, Ahmed M. Abdelghany, Sobhi F. Lamlom

“…Specifically, we observed significant up-regulation of 24 DEGs, notable down-regulation of 8 DEMs, and significant activation of 15 metabolic pathways, all of which contributed to the observed phenotypic changes. …”
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Comprehensive analysis of histophysiology, transcriptomics and metabolomics in goslings exposed to gossypol acetate: unraveling hepatotoxic mechanisms by Jun Yu, Jun Yu, Haiming Yang, Jian Wang, Zixin Huang, Shi Chen, Hongchang Zhao, Jun Wang, Zhiyue Wang

“…These findings highlight the vulnerability of mitochondria and critical metabolic pathways, providing insights into the molecular mechanisms of GA toxicity and guiding future studies on mitigating GA-induced liver damage in goslings.…”
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Analysis of thyroid function and structure and serum metabolomics in pregnant rats exposed to airborne contaminants: Combined perchlorate, thiocyanate, and nitrate exposure by Chenchen Wang, Xiaohui Xu, Jiangling Yuan, Ran An, Aierken Taxitiemuer, Yan Zhang, Tao Luo, Jing Zhou, Chang Wang, Ling Zhang, Shunhua Wu

“…Thyroid epithelial cells demonstrated diffuse proliferation and lamination with increased atomisation concentrations, and thyroid cells tended to undergo apoptosis in the group with high thyroid epithelial cell concentration. Eight and 18 metabolic pathways were significantly affected in the GD15 and GD19 groups（GD15: The demise occurring 15 days into gestation,GD19: The demise occurring 15 days into gestation.）, respectively, post-exposure. …”
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Association between airway microbiota and systemic inflammation markers in non-small cell lung cancer patients by DanHui Huang, QianNan Ren, LingYan Xie, YueHua Chen, Cui Li, XiaoFang Su, LiShan Lin, LaiYu Liu, Haijin Zhao, Tingyue Luo, JianHua Wu, Shaoxi Cai, Hangming Dong

“…Function analysis identified propionate metabolism pathway was significantly enriched in CRP_low and PLR_low groups. …”
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Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism by Lin Li, Senjie Zhong, Jiahao Ye, Siyuan Hu, Xiajun Xiong, Guangyu Chen, Zhixi Hu

“…According to metabolomics and 16S rRNA sequencing, by reestablishing homeostasis in the gut microbiota, SMI affects vital metabolic pathways, such as energy metabolism, amino acid metabolism, and bile acid metabolism. …”
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Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage by Shan Tian, Ruixue Li, Jiao Li, Jinhui Zou

“…The metabolic effects of cancer cells exposed to PS-NPs were significantly inhibited by the activation of the fatty acid metabolism pathway by fenofibrate. PS-NPs exposure disturbed lipid metabolism and induced DNA damage via the activation of PI3K/AKT/mTOR to promote CAC progression. …”
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Bioinformatics screening and clinical validation of CircRNA and related miRNA in male osteoporosis by Jiayi Li, Sijia Guo, Qingyun Sun, Ning An, Jisheng Lin, Qi Fei

“…The shared mRNAs were significantly enriched in the metabolic pathways, RNA transport, Ubiquitin mediated proteolysis and Amyotrophic lateral sclerosis. …”
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Identification and functional analysis of energy metabolism and pyroptosis-related genes in diabetic nephropathy by Shan He, Jian Ye, Yu Wang, Lu yang Xie, Si Yi Liu, Qin kai Chen

“…Results: Thirteen EMAPRDEGs were identified, with GO and KEGG analyses indicating their involvement in energy metabolism pathways. GSEA revealed significant enrichment of these genes in biological pathways associated with diabetic nephropathy. …”
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Variations in rumen microbiota and host genome impacted feed efficiency in goat breeds by Alaa Emara Rabee, Ibrahim Abou-souliman, Ahmed I. Yousif, Mebarek Lamara, Mohamed A. El-Sherbieny, Eman Ali Elwakeel, Ahmed M. Sallam

“…The animals were genotyped using the Illumina 65KSNP chip arrays v2, and their rumen bacteria and archaea were investigated using PCR-amplicon sequencing of the 16S rRNA gene.ResultsThe results showed that the ZA goats exhibited higher FE than the SH goats (p < 0.05) and a greater relative abundance (p < 0.05) of rumen bacterial groups that are involved in the degradation of cellulose and hemicelluloses, such as Bacteroidota and Fibrobacterota, along with genera such as Prevotella, Lachnospiraceae AC2044 group, Lachnospiraceae NK3A20 group, and Succiniclasticum, which are linked to carbohydrate and nitrogen metabolism pathways. In addition, breed differences were found to affect the proportions of milk fatty acids. …”
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The systematic analysis of genes related to butyrate metabolism suggests that CDKN3 could serve as a promising therapeutic target for lung adenocarcinoma treatment by Yanchao Luan, Chao Liang, Qingsong Han, Xueqin Zhou, Na Yang, li Zhao

“…Abstract Background Metabolic pathways are known to significantly impact the development and advancement of lung cancer. …”
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Uncovering novel functions of the enigmatic, abundant, and active Anaerolineae in a salt marsh ecosystem by Paige E. Payne, Loren N. Knobbe, Patricia Chanton, Julian Zaugg, Behzad Mortazavi, Olivia U. Mason

“…Yet, little is known about the metabolic pathways encoded and expressed in this abundant salt marsh clade. …”
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Glucometabolic-Related Genes as Diagnostic Biomarkers and Therapeutic Targets for Alzheimer’s Disease and Type 2 Diabetes Mellitus: A Bioinformatics Analysis by Shuo Liu, He Chen, Xiao-Dong He, Xiao-Ou Yang

“…These genes play crucial roles in metabolic pathways including glycolysis, pentose phosphate pathway, and amino sugar metabolism. …”
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Prominence of Microbiota to Predict Fibrous Stenosis in Crohn’s Disease by Yang X, Pan Y, Gao CP, Li H, Zhang YH, Huang CL, Cao L, Xiao SY, Zhou Z

“…Functional analysis revealed differential enrichment in five metabolic pathways at the KEGG pathway level in CD patients with fibrous stenosis, including sphingolipid metabolism, lipoic acid metabolism, and biosynthesis of neomycin, kanamycin and gentamicin. …”
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The Interactive Effects of Fruit Intake Frequency and Serum miR-484 Levels as Biomarkers for Incident Type 2 Diabetes in a Prospective Cohort of the Spanish Adult Population: The D... by Ana Lago-Sampedro, Wasima Oualla-Bachiri, Cristina Maldonado-Araque, Sergio Valdés, Inmaculada González-Molero, Viyey Doulatram-Gamgaram, Elias Delgado, Felipe J. Chaves, Luis Castaño, Alfonso Calle-Pascual, Josep Franch-Nadal, Gemma Rojo-Martínez, Sara García-Serrano, Eva García-Escobar

“…<b>Background/Objectives</b>: Although evidence suggests that miR-484 and several fruit components are involved in glucose metabolism and insulin resistance metabolic pathways, the relationship between serum miR-484 levels and fruit consumption in relation to the risk of Type 2 diabetes (T2DM) remains elusive. …”
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Reductive acetogenesis is a dominant process in the ruminant hindgut by Qiushuang Li, Jiabin Huo, Gaofeng Ni, Fan Zhang, Shizhe Zhang, Xiumin Zhang, Rong Wang, Jinzhen Jiao, Zhongtang Yu, Xuanxuan Pu, Yipeng Yue, Emilio M. Ungerfeld, Xiaoli Zhang, Jian Wu, Zhiliang Tan, Chris Greening, Min Wang

“…Further supporting these findings, two in vitro experiments demonstrated a marked difference in hydrogen metabolism pathways between the cecum and the rumen, with increased acetate production and reduced methanogenesis in the cecum. …”
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Transcriptome and Metabolome Analysis Unveil Anthocyanin Metabolism in Pink and Red Testa of Peanut (Arachis hypogaea L.) by Qiqin Xue, Xiurong Zhang, Hui Yang, Huadong Li, Yuying Lv, Kun Zhang, Yongguang Liu, Fengzhen Liu, Yongshan Wan

“…These differentially expressed genes were significantly enriched in the flavonoid biosynthesis, biosynthesis of secondary metabolites, and metabolic pathways. Integrated analysis of transcriptome and metabolome indicated CHS gene (arahy.CM90T6), F3′H genes (arahy. 8F7PE4 and arahy. …”
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Transcriptomic responses of sponge holobionts to in situ, seasonal anoxia and hypoxia by Strehlow, Brian W., Schuster, Astrid, Francis, Warren R., Eckford-Soper, Lisa, Kraft, Beate, McAllen, Rob, Nielsen, Ronni, Mandrup, Susanne, Canfield, Donald E.

“…Thaumarchaeota symbionts also upregulated stress response genes in hypoxia, while maintaining expression of oxygen-dependent metabolic pathways under hypoxia and anoxia. Gammaproteobacteria symbionts showed relatively few noteworthy changes in gene expression in response to anoxia but decreased metabolic gene expression in hypoxia. …”
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Mechanistic study on the mitigation of cadmium accumulation in Ligusticum sinense cv. Chuanxiong through plant growth-promoting rhizobacteria Arthrobacter sp. CX-2 by Shu-qi Niu, Ting Li, Lin Liu, Xiu-wen Bao, Xing-mao Yang, Hao-ran Song, Yang Li, Jing Bai, Li-ying He, Qing-he Wang, Si-jing Liu, Jin-lin Guo

“…In addition, regulation of Carbohydrate metabolism, Energy metabolism, and Xenobiotics biodegradation and metabolism pathways by CX-2 in rhizosphere microorganisms might ultimately lead to a change in Cd accumulation of L. …”
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Should we consider microbiota-based interventions as a novel therapeutic strategy for schizophrenia? A systematic review and meta-analysis by Lucas Hassib, Alexandre Kanashiro, João Francisco Cordeiro Pedrazzi, Bárbara Ferreira Vercesi, Sayuri Higa, Íris Arruda, Yago Soares, Adriana de Jesus de Souza, Alceu Afonso Jordão, Francisco Silveira Guimarães, Frederico Rogério Ferreira

“…This review also discusses clinical and preclinical studies to elucidate the neural, immune, and metabolic pathways by which microbiota manipulation, particularly with Lactobacillus and Bifidobacterium genera, may exert beneficial effects on schizophrenia symptoms via the gut-brain axis. …”
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ApWD40a, a Member of the WD40-Repeat Protein Family, Is Crucial for Fungal Development, Toxin Synthesis, and Pathogenicity in the Ginseng Alternaria Leaf Blight Fungus <i>Alternari... by Jinling Lan, Shengjie Mei, Yingxue Du, Meili Chi, Jiayi Yang, Shuliu Guo, Mingliang Chu, Ronglin He, Jie Gao

“…A comparative transcriptome analysis revealed that <i>ApWD40a</i> was involved in many metabolic and biosynthetic processes, including amino acid metabolism, carbon metabolism, sulfate metabolic pathways, and secondary metabolite pathways. In particular, a significantly upregulated gene that encoded a sulfate permease 2 protein in Δ<i>Apwd40a</i>, named <i>ApSulP2</i>, was deleted in the wild-type strain of <i>A. panax</i>. …”
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