Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension by Justin H. Berger, Yuji Shi, Timothy R. Matsuura, Kirill Batmanov, Xian Chen, Kelly Tam, Mackenzie Marshall, Richard Kue, Jiten Patel, Renee Taing, Russell Callaway, Joanna Griffin, Attila Kovacs, Dinesh Hirenallur-Shanthappa, Russell Miller, Bei B. Zhang, Rachel J. Roth Flach, Daniel P. Kelly

“…Transcriptomic and metabolomic profiling of HFD-Renin myocardium demonstrated upregulation of pro-fibrotic pathways and downregulation of metabolic pathways, in particular branched chain amino acid catabolism, similar to human HFpEF. …”
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Effects of <i>Lutjanus erythropterus</i> Protein on Depression-like Behavior and Gut Microbiota in Stressed Juvenile Mice by Jinjin Luo, Chen Wang, Weichang Ye, Ruiyang He, Ling Huang, Zhijia Fang, Qi Deng, Mei Qiu, Lijun Sun, Ravi Gooneratne

“…Lep upregulated gut <i>Muribaculaceae</i> and downregulated SCFA-producing bacteria by replenishing deficient amino acid (AA) (tryptophan, alanine, aspartate, glutamate) and decreased (<i>p</i> < 0.01) the gene abundance of the AA metabolism pathway of SCFA-producing bacteria, thereby preventing gut SCFA enrichment and alleviating associated depression-like behavior. …”
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Metabolomic profiling of saliva from cystic fibrosis patients by M. Caterino, M. Costanzo, A. Castaldo, P. Iacotucci, V. Carnovale, M. Ruoppolo, M. Gelzo, G. Castaldo

“…We applied a targeted metabolomic approach by LC-MS/MS on saliva samples from 70 adult CF patients and 63 age/sex-matched controls to investigate alterations in metabolic pathways related to pancreatic insufficiency (PI), Pseudomonas aeruginosa (PA) colonization, CF liver disease (CFLD), and CF related diabetes (CFRD). …”
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Study of Zuojin Pill in Treating Chronic Atrophic Gastritis by UPLC-Q-TOF/MS Based on Serum and Urine Metabolomics Combined with Network Pharmacology by Shihua Wu, Xing Chen, Honghong Liu, Ruilin Wang, Jianyu Li, Jianxia Wen, Tao Yang, Ying Wei, Sichen Ren, Shizhang Wei, Manyi Jing, Haotian Li, Min Wang, Houlin Xia, Yanling Zhao

“…This study was the first to use a combination of metabolomics and network pharmacology to clarify the therapeutic effects of ZJP on CAG and the regulation of multiple metabolic pathways.…”
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Targeted lipidomics analysis of possible molecular mechanisms of lipid changes in temporal lobe epilepsy models by Huaiyu Sun, Xuewei Li, Zhiqing Chen, Hongmei Meng

“…In-depth studies at multiple levels are urgently needed to elucidate lipid composition, distribution, and metabolic pathways in the brain after seizure.MethodsIn this research, a cutting-edge targeted quantitative lipidomics study was conducted on the hippocampal tissues of six rats with temporal lobe epilepsy and six normal rats. …”
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Fabrication of taxifolin loaded zein-caseinate nanoparticles and its bioavailability in rat by Ying Li, Hang Su, Wenjun Wang, Zhongping Yin, Jing’en Li, En Yuan, Qingfeng Zhang

“…Glucuronidation was the dominating metabolism pathway of taxifolin in vivo.…”
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Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi <i>Penicillium</i> spp.: Chemical Diversity and Biological Activity by Guojun Zhou, Jin Cai, Bin Wang, Wenjiao Diao, Yu Zhong, Shaodan Pan, Weijia Xiong, Guolei Huang, Caijuan Zheng

“…Mangrove plants, soil, or sediment-derived fungi, especially the <i>Penicillium</i> species, possess unique metabolic pathways to produce secondary metabolites with novel structures and potent biological activities. …”
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Study on factors influencing the transport and transformation of polycyclic aromatic hydrocarbons in soil–groundwater systems by Wenxiang Hu, Jie Zhang, Dan Li, Ying Yuan, Ying Tang, Kunlong Hui, Yu Jiang, Wenbing Tan

“…Soil organic matter fixes PAHs through adsorption sites and active functional groups (including carbonyl and carboxyl groups), while microbial communities mineralize PAHs into H2O, CO2 (aerobic), and CH4 (anaerobic) through metabolic pathways, such as oxygenase, dehydrogenase, and lignin decomposer. …”
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Adaptation of Archaeal Communities to Summer Hypoxia in the Sediment of Bohai Sea by Xiaoxiao Guo, Yanying Li, Guisheng Song, Liang Zhao, Jing Wang

“…Furthermore, adaptions to hypoxia of archaea were also displayed by variation in relative abundance of the predicted ecological functions and the metabolic pathways. The enrichment of specific nitrogen transformation enzymes showed the potential for nitrogen fixation and removal, which might contribute to the balance of N budget and thus facilitate the ecological restoration under eutrophication in Bohai Sea. …”
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Transcriptomic and metabolomic analyses reveal the spatial role of carnitine metabolism in the progression of hepatitis B virus cirrhosis to hepatocellular carcinoma by Pengxiang Gao, Qiuping Liu, Ziye Luo, Wenjun Pu, Wenjun Pu

“…Mass spectrometry imaging was used to evaluate the spatial distribution of key metabolites.Results and discussionThe results revealed significant changes in gene expression and metabolic pathways along with disease progression. The upregulated genes were associated with extracellular matrix remodeling and cancer pathways, including LAMC1-3, COL9A2, COL1A1, MYL9, MYH11, and KAT2A. …”
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GABA promotes peroxisome proliferation in Triticum monococcum leaves by Yunus Şahin, Taras Nazarov, Ercan Selçuk Ünlü, Andrei Smertenko, Nusret Zencrici

“…Here, we used published RNA‐seq data to analyze the expression patterns of genes encoding 21 peroxisome metabolic pathways at successive developmental stages of Zea mays and Oryza sativa. …”
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Biodegradation potential of low-density polyethylene (LDPE) using Aspergillus niger and Phanerochaete chrysosporium by Pankaj R. Sutkar, Smriti S. Hadkar, Subodh A. Kamble, Vinayak P. Dhulap

“…However, with these findings adaptive metabolic pathways for LDPE biodegradation need to be linked and studied. …”
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Effects of maternal Escherichia coli lipopolysaccharide exposure on offspring: insights from lncRNA analysis in laying hens by Lei Liu, Wei Wang, Adeyinka Abiola Adetula, Zhixun Yan, Huagui Liu, Ying Yu, Qin Chu

“…LPS primarily affected the metabolic pathways of the offspring, possibly reducing the egg-laying rate of the F1 hens by inhibiting the ferroptosis signaling pathway and the expression of DEGs involved, such as NCOA4, SLC40A1, STEAP3, and TFRC. …”
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Single-cell transcriptomes of dissecting the intra-tumoral heterogeneity of breast cancer microenvironment by Peixian Chen, Kaifeng Liang, Xiaofan Mao, Qiuyuan Wu, Zhiyan Chen, Yabin Jin, Kairong Lin, Tiancheng He, Shuqing Yang, Huiqi Huang, Guolin Ye, Juntao Gao, Dan Zhou, Zhihao Zeng

“…The changes of lipid metabolism pathways in macrophages are closely related to the microenvironment of breast cancer. …”
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The Effects of Disinfection Byproduct 2,6-Dichloro-1,4-benzoquinone on the Cyanobacterium <i>Microcystis aeruginosa</i>: From the Perspectives of Biochemistry and Non-Targeted Meta... by Tianqi Zhang, Zhaoyang Wang, Liang Wu, Chaonan Liu, Liang Meng, Fuxiang Tian, Meifang Hou, Haizhuan Lin, Jing Ye

“…In addition, nontargeted metabolomics of <i>M. aeruginosa</i> cells exposed to 0.1 mg/L 2,6-DCBQ identified 208 differential metabolites belonging to 10 metabolic pathways and revealed the considerable interference caused by 2,6-DCBQ among ABC transporters, the two-component system, and folate biosynthesis. …”
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Blood transcriptome resources of chinstrap () and gentoo () penguins from the South Shetland Islands, Antarctica by Bo-Mi Kim, Jihye Jeong, Euna Jo, Do-Hwan Ahn, Jeong-Hoon Kim, Jae-Sung Rhee, Hyun Park

“…In the blood transcriptomes, KEGG analyses detected many essential genes involved in the major innate immunity pathways, which are key metabolic pathways for maintaining homeostasis against exogenous infections or toxins. …”
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Metabolomics insights into doxorubicin and 5-fluorouracil combination therapy in triple-negative breast cancer: a xenograft mouse model study by Mai M. Hassanein, Mai M. Hassanein, Yousra A. Hagyousif, Yousra A. Hagyousif, Ruba A. Zenati, Ruba A. Zenati, Hamza M. Al-Hroub, Farman Matloob Khan, Ahmad Y. Abuhelwa, Ahmad Y. Abuhelwa, Karem H. Alzoubi, Karem H. Alzoubi, Nelson C. Soares, Nelson C. Soares, Waseem El-Huneidi, Waseem El-Huneidi, Eman Abu-Gharbieh, Eman Abu-Gharbieh, Eman Abu-Gharbieh, Hany Omar, Hany Omar, Dana M. Zaher, Yasser Bustanji, Yasser Bustanji, Yasser Bustanji, Mohammad H. Semreen, Mohammad H. Semreen

“…Univariate and enrichment analyses identified alterations in metabolic pathways. The combination treatment of DOX + 5-FU induced the most extensive metabolic alterations disrupting key pathways including purine, pyrimidine, beta-alanine, and sphingolipid metabolism. …”
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The influence of depth on the global deep-sea plasmidome by Melany Calderón-Osorno, Dorian Rojas-Villalta, Franck Lejzerowicz, Jorge Cortés, Maria Arias-Andres, Keilor Rojas-Jimenez

“…Plasmids of Alphaproteobacteria and Gammaproteobacteria were predominant across the oceans, particularly in this depth range, which also showed the highest species diversity and abundance of metabolic pathways, including aromatic compound degradation. …”
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FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction by Zhukai Chen, Jiacheng Xu, Kang Fang, Hanyu Jiang, Zhuyun Leng, Hao Wu, Zehua Zhang, Zeyu Wang, Zhaoxing Li, Mingchuang Sun, Ziying Zhao, Anqi Feng, Shihan Zhang, Yuan Chu, Lechi Ye, Meidong Xu, Lingnan He, Tao Chen

“…Serine metabolism plasticity is one of the crucial metabolic pathways influencing 5-FU resistance in CRC. However, the mechanisms by which CRC modulates serine metabolic reprogramming under serine-deprived conditions remain unknown. …”
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A Review on The Impact of Thermal Stress on Fish Biochemistry by Manoj Kumar Pati, Mohammad Aftabuddin, Prasun Roychowdhury

“…Enzymes involved in metabolic pathways have optimal temperature and pH ranges altered by thermal stress. …”
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