Utilizing physiologies, transcriptomics, and metabolomics to unravel key genes and metabolites of Salvia miltiorrhiza Bge. seedlings in response to drought stress by Yu Zhang, Hong Zhang, Yuru Zhang, Di Wang, Xue Meng, Juan Chen

“…In conclusion, our results suggest that drought stress inhibits S. miltiorrhiza seedling growth by enhancing membrane lipid peroxidation, attenuating the antioxidant system, photosynthesis, and regulating proline and glycine betaine metabolism, transcription factors and plant hormones, and tanshinones and phenolic acid metabolism pathways. This study provides new insights into the complex mechanisms by which S. miltiorrhiza responds to drought stress.…”
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Discovery and Validation of Potential Serum Biomarkers for Heart Failure by Untargeted Metabolomics by Guisheng Zhou, Junzhi Zhang, Hongli Guo, Xiaochao Hu, Yingzhuo Wang, Kunqun Shi, Tongtong Liu, Shengyan Yin, Huanhuan Liu, Chunling Liu, Shijia Liu

“…By identifying serum biomarkers and analyzing metabolic pathways, our study provided opportunities to enhance the understanding of the pathogenesis and early diagnosis of HF.…”
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A Metabolic Study on Colon Cancer Using 1H Nuclear Magnetic Resonance Spectroscopy by Zahra Zamani, Mohammad Arjmand, Farideh Vahabi, Seyed Mahmood Eshaq Hosseini, Sadegh Mohammad Fazeli, Ayda Iravani, Parastoo Bayat, Akbar Oghalayee, Mahshid Mehrabanfar, Reza Haj Hosseini, Mohammad Tashakorpour, Mohsen Tafazzoli, Sedigheh Sadeghi

“…We obtained a distinguishing pattern of metabolites and metabolic pathways between colon cancer patient and normal. …”
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Mechanistic insights into the role of traditional Chinese medicine in treating gastric cancer by Ziqiang Chen, Ting Yu, Yunhe Wang, Jiaxin Li, Bo Zhang, Liya Zhou

“…Specifically, we detail how TCM inhibits aerobic glycolysis by downregulating key glycolytic enzymes and metabolic pathways, thereby reducing the energy supply essential for cancer cell proliferation. …”
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Comparative transcriptomic and metabolomics analysis of ovary in Nilaparvata lugens after trehalase inhibition by Yongkang Liu, Fan Yang, Sijing Wan, Xianzhong Wang, Liwen Guan, Yan Li, Caidi Xu, Binghua Xie, Shigui Wang, Xiao-Ling Tan, Bin Tang

“…These results suggest that the inhibition of TRE expression may lead to alterations in ovarian nutrient and energy metabolism by modulating glucose transport and affecting amino acid metabolic pathways. These alterations may influence the reproduction of N. lugens by modulating reproductive regulatory signals. …”
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Biochemical and antioxidant responses of common carp (Cyprinus carpio) exposed to sublethal concentrations of the antiepileptic and analgesic drug gabapentin by J Blahova, P Mikula, P Marsalek, Z Svobodova

“…Our research shows that subchronic exposure to gabapentin may pose a significant risk to non-target aquatic organisms, such as disruption of metabolic pathways or induction of oxidative stress, even at environmentally relevant concentrations.…”
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Sustained Release of Prostaglandin E2 in Fibroblasts Expressing Ectopically Cyclooxygenase 2 Impairs P2Y-Dependent Ca2+-Mobilization by María Pimentel-Santillana, Paqui G. Través, Raquel Pérez-Sen, Esmerilda G. Delicado, Paloma Martín-Sanz, María Teresa Miras-Portugal, Lisardo Boscá

“…This Ca2+-mobilization was important for the activation of different metabolic pathways in fibroblasts. Moreover, inhibition of COX-2 with selective coxibs prevented UTP-dependent P2Y activation in these cells. …”
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Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque by Tingfu Du, Shuaiyao Lu, Qinfang Jiang, Yun Li, Kaili Ma

“…Expression change in tryptophan metabolism pathway was also found in this study which may be associations with diabetes. …”
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A Bioinformatics Analysis Reveals a Group of MocR Bacterial Transcriptional Regulators Linked to a Family of Genes Coding for Membrane Proteins by Teresa Milano, Sebastiana Angelaccio, Angela Tramonti, Martino Luigi Di Salvo, Roberto Contestabile, Stefano Pascarella

“…These regulators are involved in the expression of genes taking part in several metabolic pathways directly or indirectly connected to PLP chemistry, many of which are still uncharacterized. …”
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Elimination Kinetics of Ethanol in a 5-Week-Old Infant and a Literature Review of Infant Ethanol Pharmacokinetics by Jonathan B. Ford, Mac T. Wayment, Timothy E. Albertson, Kelly P. Owen, Joshua B. Radke, Mark E. Sutter

“…Primary ethanol metabolism occurs through alcohol dehydrogenase, but minor metabolic pathways such as the P450 enzymes CYP2E1 and CYP1A2 and the enzyme catalase exist. …”
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Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management by Eleonora Spinozzi, Marta Ferrati, Cecilia Baldassarri, Paolo Rossi, Guido Favia, Giorgio Cameli, Giovanni Benelli, Angelo Canale, Livia De Fazi, Roman Pavela, Luana Quassinti, Cristiano Giordani, Fabrizio Araniti, Loredana Cappellacci, Riccardo Petrelli, Filippo Maggi

“…A GC–MS-driven untargeted metabolomic analysis revealed 32 affected metabolic pathways in treated larvae. The EO non-target toxicity on Daphnia magna Straus (LC50 = 4.51 μL/L) and its cytotoxicity on a human kidney cell line (HEK293) (IC50 of 14.38 μg/mL) were also assessed. …”
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Fecal metabolomics reveals the positive effect of ethanol extract of propolis on T2DM mice by Chunmei Wang, Huiting Zhao, Kai Xu, Yali Du, Jinjia Liu, Jinfei Wang, Yusuo Jiang

“…EEP effectively regulated the dysfunction in the metabolic pathways of glycerophospholipids, sphingolipids, riboflavins, and sterol lipids caused by T2DM. …”
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smu_1558c-mediated regulation of growth and biofilm formation in Streptococcus mutans by Jing Zhou, Jing Zhou, Qizhao Ma, Qizhao Ma, Jingou Liang, Jingou Liang, Yangyang Pan, Yangyang Pan, Yang Chen, Yang Chen, Shuxing Yu, Shuxing Yu, Yaqi Liu, Yaqi Liu, Qiong Zhang, Qiong Zhang, Yuqing Li, Jing Zou, Jing Zou

“…These findings highlight that acetyltransferase smu_1558c plays a crucial role in the growth, biofilm formation, and EPS synthesis of S. mutans through its regulation of carbohydrate transport and metabolism pathways, as well as stress response mechanisms. …”
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Bacteriophage Treatment Induces Phenotype Switching and Alters Antibiotic Resistance of ESBL <i>Escherichia coli</i> by Árpád Rózsa, László Orosz, Nikoletta Szemerédi, Gabriella Spengler, Gábor Kecskeméti, Otília Vágó, Károly Péter Sárvári, Diana Szabó, Zoltán Szabó, Katalin Burián, Dezső Péter Virok

“…The downregulated proteins were involved in various metabolic pathways, including nucleic acid, protein and lipid metabolism, and iron acquisition. …”
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Ameliorative effect of Lacticaseibacillus rhamnosus Fmb14 from Chinese yogurt on hyperuricemia by Hongyuan Zhao, Xiaoyu Chen, Fanqiang Meng, Libang Zhou, Xinyi Pang, Zhaoxin Lu, Yingjian Lu

“…LC-MS analysis revealed that high concentrations of inosine could activate compensatory metabolic pathways of L. rhamnosus Fmb14 to catalyse inosine as an energy source and produce intracellular folic acid and riboflavin. …”
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N-Oxalylglycine-Conjugated Hyaluronic Acid as a Macromolecular Prodrug for Therapeutic Angiogenesis by Andrew H. DeMaria, Jeoung Soo Lee, Ken Webb

“…These studies demonstrate that HA-NOG releases NOG in response to cellular enzymatic activity, activating the HIF signaling pathway and culminating in the secretion of soluble factors that activate endothelial cells without adversely affecting other cellular metabolic pathways.…”
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GENES DETERMINING THE SYNTHESIS OF LAVONOID AND MELANIN PIGMENTS IN BARLEY by O. Yu. Shoeva, K. V. Strygina, E. K. Khlestkina

“…However, due to the comparative analysis of transcriptomes in the colored and uncolored lemma and grain pericarp of barley near-isogenic lines, it was possible to identify the metabolic pathways underlying the formation of the melanin pigmentation. …”
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Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios by Hu Liu, Peiqi Li, Tan Zhou, Ziqi Yu, Weigao Zhang, Yunfeng Zhu, Jiayi Xu, Xiaoxiao Wu, Jing Li, Chi Zhang, Lei Chen, Dan Weng

“…Transcriptome sequencing of liver tissues highlighted significant alterations in the expression of genes involved in metabolic pathways, further corroborated by real-time qPCR validation. …”
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Whole Genome Identification and Integrated Analysis of Long Non-Coding RNAs Responding ABA-Mediated Drought Stress in <i>Panax ginseng</i> C.A. Meyer by Peng Chen, Cheng Chang, Lingyao Kong

“…The DEGs and DELs target genes main enrichment is focused on the “biosynthesis of secondary metabolites”, “starch and sucrose metabolism”, and “carbon metabolism” pathways under drought + ABA vs. drought conditions according to KEGG pathway enrichment analysis, suggesting that these secondary metabolites biosynthesis pathways might be crucial for ABA-mediated drought stress response in ginseng. …”
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Development of a microbiome for phenolic metabolism based on a domestication approach from lab to industrial application by Wei Zhao, Liuyang Shi, Yifan Han, Xingbiao Wang, Jingjing Wang, Song Xu, Xiaoxia Zhang, Zhiyong Huang

“…This leads to an augmented biodiversity and the development of more intricate phenol and formaldehyde metabolic pathways. The incorporation of increased stochastic processes and random network characteristics further suggested the stability of the microbial community during the application phase. …”
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