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381
Transforming monosaccharides: Recent advances in rare sugar production and future exploration
Published 2025-01-01“…After the birth of life, the “chemical origin” saccharides thus survived were transformed into a variety of “bricolage products”, which include galactose and other recognition saccharides like fucose and sialic acid through the invention of diverse metabolic pathways (biological evolution era). The remaining monosaccharides that have deviated from this scenario are considered rare sugars. …”
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382
Restriction of mitochondrial oxidation of glutamine or fatty acids enhances intracellular growth of Mycobacterium abscessus in macrophages
Published 2025-12-01“…Furthermore, targeting metabolic pathways related to glutamine and fatty acid oxidation exacerbated Mab growth within macrophages, suggesting these pathways play a protective role against infection. …”
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383
Integrated omics revealed the altered colonic microenvironment after inhibition of peripheral serotonin synthesis by LP533401
Published 2024-12-01“…Additionally, altered metabolic pathways (e.g., nucleotide metabolism, signal transduction, metabolism of cofactors and vitamins) suggested an impact on the colonic function. …”
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384
Decoding the trajectory of antibiotic resistance genes in saline and alkaline soils: Insights from different fertilization regimes
Published 2025-01-01“…Meta-genomic and Meta-transcriptomic analysis consistently demonstrated bacterial antibiotic resistance was primarily associated with pyruvate, energy and lipid metabolic pathways. The functional gene related to salinity and alkalinity, like cysH, cysK, plsB and plsC showed negative correlations with MDR. …”
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385
The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome
Published 2025-01-01“…The disrupted correlations between these biomolecules suggest alterations in their metabolic pathways and potential utility as biomarkers. …”
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386
Tetrastigma hemsleyanum as a feed additive: modulating gut microbiota for enhancing nutritional transport and growth performance in Jinhua yellow chickens
Published 2025-01-01“…Additionally, TH supplementation notably increased gut microbiota richness, then selectively increased the colonization of potential probiotics and the microbial abundance associated to amino acid synthesis and metabolic pathways in duodenum. Furthermore, qPCR analysis results preliminarily verified that dietary TH not only enhanced intestinal amino acids (rBAT and EAAT3) and peptides (PepT1 and APN) transport but also alleviated the inflammation (IL-1β, IL-6 and IFN-γ), thus thereby improved intestinal development and growth performance in Jinhua yellow chickens. …”
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387
Effects of supplemental feeding of feeds with different protein levels on the metabolism of the gut microbiota of bighead carp (Hypophthalmichthys nobilis)
Published 2025-03-01“…KEGG enrichment analyses showed that differential metabolites between the different groups were mainly enriched in the gastric acid secretion, vitamin B6 metabolism, arginine and proline metabolism, and tryptophan metabolism pathways. Overall, the addition of an artificial feed with a protein level of 40 % to traditional culture method promotes the amino acid metabolism in the gut microbiota of bighead carp and improves growth performance. …”
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388
Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance
Published 2025-01-01“…Future studies examining specific metabolic pathways and targeting approaches to reduce the heterogeneity in the TME will likely lead to better outcomes with immunotherapies, drug delivery, etc., for cancer treatments. …”
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389
Glutathione reductase plays a role in the metabolism of methylmercury degradation in Rhodotorula mucilaginosa
Published 2025-02-01“…Understanding the metabolic pathways involved, particularly the role of glutathione reductase, enhances our knowledge of how Rhodotorula mucilaginosa responds to methylmercury and opens up new possibilities for future research in bioremediation strategies.…”
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390
Chemical Diversity of UK-Grown Tea Explored Using Metabolomics and Machine Learning
Published 2025-01-01“…It provides insightful data on the metabolic pathways influencing tea cultivation and production and underscores the importance of these variables in determining the final chemical profile and organoleptic characteristics of tea products.…”
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391
Investigating Metabolic Phenotypes for Sarcoidosis Diagnosis and Exploring Immunometabolic Profiles to Unravel Disease Mechanisms
Published 2024-12-01“…<b>Conclusions:</b> we explored immunometabolic phenotypes by comparing patients with sarcoidosis with patients with COVID-19 and healthy controls, revealing potential metabolic pathways associated with acute and chronic inflammation across the stages of sarcoidosis.…”
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392
Assessment of the effect of agro-industrial by-products rich in polyphenols on in vitro fermentation and methane reduction in sheep
Published 2025-01-01“…The concentration of polyphenols in the selected agro-industrial by-products could modify fermentation parameters and metabolic pathways, leading to reduced methane production.…”
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393
Uncovering the molecular mechanisms of Acer fabri in adjusting to low-temperature stress through integrated physiological and transcriptomic analysis
Published 2025-01-01“…Differentially expressed genes (DEGs) were significantly enriched in metabolic pathways, phytohormone signaling, and plant mitogen-activated protein kinase (MAPK) signaling pathways. …”
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394
The role of Beringia in human adaptation to Arctic conditions based on results of genomic studies of modern and ancient populations
Published 2023-07-01“…The adaptation of Amerindian ancestors to high latitudes and cold climates is supported by genomic data showing that adaptive genetic variants in Native Americans are associated with various metabolic pathways: melanin production processes in the skin, hair and eyes, the functioning of the cardiovascular system, energy metabolism and immune response characteristics. …”
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395
Metagenomic next-generation sequencing for lung cancer low respiratory tract infections diagnosis and characterizing microbiome features
Published 2025-01-01“…GSVA revealed significant correlations between these genera and tumor metabolic pathways as well as various signaling pathways including PI3K, Hippo, and p53.ConclusionmNGS showed a higher pathogen detection rate than culture-based CMTs in lung cancer patients with LRTIs, and also characterizing LRT microbiome composition and revealing potential microbial functions linked to lung carcinogenesis.…”
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396
Uncovering proteome variations and concomitant quality changes of different drying methods Cordyceps sinensis by 4D-DIA structural proteomics
Published 2025-02-01“…The process of drying Cordyceps sinensis resulted in a significant upregulation of the expression of proteins linked to various metabolic pathways. This observation suggests that the drying treatment might activate or enhance certain biochemical processes within the organism, potentially influencing its overall metabolic activity. …”
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397
A Chromosome-Scale Genome of <i>Trametes versicolor</i> and Transcriptome-Based Screening for Light-Induced Genes That Promote Triterpene Biosynthesis
Published 2025-01-01“…Transcriptomic analysis under dark and light conditions revealed significant changes in the expression of genes related to secondary metabolism, suggesting that light signals regulate metabolic pathways. A total of 2577 transporter proteins and 2582 membrane proteins were identified and mapped in the <i>T. versicolor</i> genome, and 33 secondary metabolite gene clusters were identified, including two light-sensitive triterpene biosynthesis clusters. …”
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398
The Invasion and Metastasis of Colon Adenocarcinoma (COAD) Induced by SALL4
Published 2022-01-01“…GSEA analysis suggested that the SALL4 upregulated the GO and pathway of growth and cancer development and downregulated metabolization pathway. The relationship between lymph node metastasis, histological grading, clinical staging, and the expression of SALL4 in carcinoma tissues was analyzed. …”
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399
Inulin Reduces Kidney Damage in Type 2 Diabetic Mice by Decreasing Inflammation and Serum Metabolomics
Published 2024-01-01“…This beneficial effect is attributed to its impact on various metabolic pathways, including glycerophospholipid metabolism, taurine and hypotaurine metabolism, arginine biosynthesis, and tryptophan metabolism. …”
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400
DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis
Published 2021-01-01“…It is considered that the transformation of normal cells to cancerous ones involves “recoding” of certain metabolic pathways. Diacylglycerol O-acyltransferase 1 (DGAT1) can synthesize triglycerides by transferring acyl-CoA to diacylglycerol, which plays a key role in lipid synthesis. …”
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