Novel insights into insect mediated polystyrene biodegradation through bacterial genome analyses by Felice Zarra, Rebecca Funari, Claudio Cucini, Francesco Nardi, Antonio Carapelli, Laura Marri, Francesco Frati

“…The present study investigates the genetic profile of the newly isolated S. indicatrix strain DAI2m/c through genome sequencing, to identify enzyme-encoding genes involved in the intracellular metabolic pathways responsible for the biodegradation of the styrene monomer. …”
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The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and me... by Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu

“…Assessment of the changes in gene expression and metabolites revealed the significantly different expression of several genes encoding key enzymes and metabolites in choline metabolism pathway. The collective findings confirmed that choline metabolism plays an important role in the protective effects of TLMPS against acute alcoholic liver injury.…”
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Machine Learning and Multi-Omics Integration to Reveal Biomarkers and Microbial Community Assembly Differences in Abnormal Stacking Fermentation of Sauce-Flavor <i>Baijiu</i> by Shuai Li, Yueran Han, Ming Yan, Shuyi Qiu, Jun Lu

“…Differential gene analysis and KEGG pathway enrichment identify metabolic pathways for flavor markers. This study provides a theoretical basis for regulating stacking fermentation and ensuring <i>Baijiu</i> quality.…”
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Coactivators in PPAR-Regulated Gene Expression by Navin Viswakarma, Yuzhi Jia, Liang Bai, Aurore Vluggens, Jayme Borensztajn, Jianming Xu, Janardan K. Reddy

“…Peroxisome proliferator-activated receptor (PPAR)α, β (also known as δ), and γ function as sensors for fatty acids and fatty acid derivatives and control important metabolic pathways involved in the maintenance of energy balance. …”
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<i>Pneumocystis</i> Pneumonia Severity Is Associated with Taxonomic Shifts in the Respiratory Microbiota by Valentina Del Prete, Antonia Piazzesi, Matteo Scanu, Francesca Toto, Stefania Pane, Federica Berrilli, Giovangiacinto Paterno, Lorenza Putignani, David di Cave

“…Functionally, severe PCP was associated with a decrease in metabolic pathways of molecules with anti-inflammatory and antimicrobial properties. …”
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Effects of light regimes on circadian gene co‐expression networks in Arabidopsis thaliana by Quentin Rivière, Virginie Raskin, Romário deMelo, Stéphanie Boutet, Massimiliano Corso, Matthieu Defrance, Alex A. R. Webb, Nathalie Verbruggen, Armand D. Anoman

“…However, we found transcripts encoding components of the flavonoid metabolism pathway that were rhythmic in LL but not in LD. …”
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Microplastic-enhanced chromium toxicity in Scenedesmus obliquus: Synergistic effects on algal growth and biochemical responses by Luoxin Li, Jiani Yu, Yonghua Ma, Hui Tan, Fengxia Tan, Yi Chai, Hui Zhang

“…Transcriptomic analysis illuminated the complex regulatory mechanisms, indicating that toxicity primarily modulates metabolic pathways essential for photosynthesis, oxidative phosphorylation, the TCA cycle, and ribosome function in Scenedesmus obliquus. …”
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Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration by Jialiu Zeng, Jialiu Zeng, Lenny Yi Tong Cheong, Chih Hung Lo, Chih Hung Lo

“…Understanding the underlying disease mechanisms is crucial for developing therapeutic strategies to address defects in these inflammatory and metabolic pathways. In this review, we summarize and provide insights into different therapeutic strategies, including methods to alter gut dysbiosis, lifestyle changes, dietary supplementation, as well as pharmacological agents derived from natural sources, that target obesity-induced neuroinflammation and neurodegeneration.…”
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Dynamic Metabolic Footprinting Reveals the Key Components of Metabolic Network in Yeast Saccharomyces cerevisiae by Pramote Chumnanpuen, Michael Adsetts Edberg Hansen, Jørn Smedsgaard, Jens Nielsen

“…From the list of significant metabolite pairs, we reconstructed an interaction map that provides information of how different metabolic pathways have correlated patterns during growth on the different carbon sources.…”
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Lipopolysaccharide affects metabolic processes and energy homeostasis in the corpus luteum by Karol Mierzejewski, Robert Stryiński, Iwona Bogacka, Monika Golubska, Mónica Carrera, Aleksandra Kurzynska

“…Moreover, we demonstrated that LPS decreases glucose levels and increases progesterone levels in the CL.ConclusionThese findings suggest that LPS modulates key metabolic pathways in the CL, potentially impacting its functional activity.…”
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Dysbiosis and extraintestinal cancers by Ruishan He, Pingqian Qi, Linzhen Shu, Yidan Ding, Peng Zeng, Guosheng Wen, Ying Xiong, Huan Deng

“…Pathogenic microbiota, along with their metabolites, can undermine the integrity of the gut barrier through inflammatory or metabolic pathways, leading to increased permeability and the translocation of pathogens. …”
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In Vitro Cytotoxicity of Fluorinated Quaternary Ammonium Salts in Colorectal Cancer Cells and In Silico Pharmacology by Adriana Milena Olarte Aponte, Victoria Ospina, Sergio A. Pulido, Luz Amalia Ríos-Vásquez, Luz Adriana Betancur Jaramillo, Carlos Mario Muñetón Peña, Rogelio Ocampo-Cardona, Sara M. Robledo

“…Colorectal cancer (CRC) is a multifactorial disease driven by genetic and epigenetic alterations that modulate specific metabolic pathways. Despite the availability of effective treatments like 5-fluorouracil (5-FU), pharmacological therapy for CRC still faces significant challenges, including drug resistance, toxicity, and limited specificity. …”
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Metagenomic investigation of viruses in green sea turtles (Chelonia mydas) by Hongwei Li, Yuan Chen, Zhongrong Xia, Daohua Zhuang, Feng Cong, Yue-Xiao Lian

“…Furthermore, KEGG enrichment analysis showed that the viral genes were mainly involved in phage-associated and metabolic pathways. Phylogenetic tree reconstruction of Caudovirales terminase large-subunit (TerL) protein showed that most of the sequences were phylogenetically distant. …”
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Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms by Hannu Kankaanranta, Paula Kauppi, Leena E. Tuomisto, Pinja Ilmarinen

“…These emerging comorbidities often occur in the same multimorbid adult patient and may have in common metabolic pathways and inflammatory or other alterations such as early life exposures, systemic inflammation, inflammasome, adipokines, hyperglycemia, hyperinsulinemia, lung mechanics, mitochondrial dysfunction, disturbed nitric oxide metabolism, and leukotrienes.…”
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The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics by Arwa M. Amin, Lim Sheau Chin, Dzul Azri Mohamed Noor, Muhamad Ali SK Abdul Kader, Yuen Kah Hay, Baharudin Ibrahim

“…The advantage of pharmacometabolomics is that it does not only predict the response but also provide extensive information on the metabolic pathways implicated with the response. Integrating pharmacogenetics with pharmacometabolomics can give insight on unknown genetic and nongenetic factors associated with the response. …”
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Influence of nano-polystyrene on cyfluthrin toxicity in honeybee Apis cerana cerana Fabricius by Yunfei Xue, Xueyang Gong, Linfu Yang, Dandan Zhi, Qingxin Meng, Yulong Guo, Kun Dong, Yakai Tian

“…The changes in metabolites and metabolic pathways in honeybees after ingesting nanoPS were also studied. …”
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Comprehensive Analysis of the Proteome of <i>S. cerevisiae</i> Wild-Type and <i>pdr</i>5Δ Cells in Response to Bisphenol A (BPA) Exposure by Valentina Rossio, Joao A. Paulo

“…Proteomic analysis revealed that BPA induces widespread dose-dependent changes in protein abundance, including the upregulation of metabolic pathways such as arginine biosynthesis and the downregulation of mitochondrial proteins. …”
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Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery by Chananya Karunasumetta, Chotika Chatgasem, Suriya Punchai, Kittisak Sawanyawisuth

“…Key differential metabolites between the groups included histidine and alanine, which notably impacted the histidine metabolism pathway. Conclusion: The findings demonstrate that distinct cardioplegia solutions result in differential postoperative metabolomic alterations, with Custodiol exhibiting the most pronounced shifts, whereas St. …”
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New Insights into Aspirin’s Anticancer Activity: The Predominant Role of Its Iron-Chelating Antioxidant Metabolites by George J. Kontoghiorghes

“…The mechanisms of cancer risk reduction in LTLDA users is likely due to the ACM’s targeting of iron involved in free radical damage, iron-containing toxins, iron proteins, and associated metabolic pathways such as ferroptosis. The ACMs from non-absorbed aspirin (about 30%) may also mitigate the toxicity of heme and nitroso-heme and other iron toxins from food, which are responsible for the cause of colorectal cancer. …”
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Exploring the causal impact of body mass index on metabolic biomarkers and cholelithiasis risk: a Mendelian randomization analysis by Feng Zhao, Yanjiang Yang, Wenwen Yang

“…Future research should explore the specific metabolic pathways involved to identify potential therapeutic targets.…”
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