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341
Human papillomavirus, vaginal microbiota and metagenomics: the interplay between development and progression of cervical cancer
Published 2025-01-01“…Alterations in microbial composition, function, and metabolic pathways may contribute to this process. Despite the potential of metagenomics to explore these interactions, studies on the vaginal microbiota’s role in cervical cancer are limited. …”
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342
Fucose as a nutrient ligand for Dikarya and a building block of early diverging lineages
Published 2023-09-01“…Massive gene loss has shaped the evolutionary history of these metabolic pathways, leading to a repeated reduction of these pathways in most yeast-forming lineages. …”
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343
The influence of depth on the global deep-sea plasmidome
Published 2025-01-01“…Plasmids of Alphaproteobacteria and Gammaproteobacteria were predominant across the oceans, particularly in this depth range, which also showed the highest species diversity and abundance of metabolic pathways, including aromatic compound degradation. …”
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344
A Review on The Impact of Thermal Stress on Fish Biochemistry
Published 2024-03-01“…Enzymes involved in metabolic pathways have optimal temperature and pH ranges altered by thermal stress. …”
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345
The role of the pAbp gene encoding the cytoplasmic poly(A)-binding protein in spermatogenesis of Drosophila melanogaster
Published 2017-11-01“…Cytoplasmic PABPs participate in the metabolic pathways of the mRNA: translation initiation and termination, cytoplasmic polyadenylation/deadenylation, mRNA stability, mRNA degradation. …”
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346
Using DIMet for Differential Analysis of Labeled Metabolomics Data: A Step-by-step Guide Showcasing the Glioblastoma Metabolism
Published 2025-01-01“…By incorporating isotopes, such as 13C, into substrates, researchers can trace reaction rates across specific metabolic pathways. Integrating metabolomics data with gene expression profiles further enriches the analysis, as we demonstrated in our prior study on glioblastoma metabolic symbiosis. …”
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347
Pathological and Molecular Characterization of Grass Carp Co-Infected with Two <i>Aeromonas</i> Species
Published 2025-01-01“…Gene ontology and KEGG pathway analyses revealed significant enrichment of immune-related genes primarily associated with Toll-like receptor signaling and TNF signaling cascades. Notably, metabolic pathways showed substantial suppression while immune responses were significantly activated after infected. …”
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348
Metabolomics reveal the mechanism for anti-renal fibrosis effects of an n-butanol extract from Amygdalus mongolica
Published 2022-09-01“…Sixteen possible biomarkers were identified by metabolomic analysis and six key metabolic pathways, including the TCA cycle and tyrosine metabolism, were analyzed. …”
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349
Noncoding RNA profiling in omentum adipose tissue from obese patients and the identification of novel metabolic biomarkers
Published 2025-02-01“…Gene network analysis highlighted the most significant features associated with metabolic pathways, specifically ENST00000605862, ENST00000558885, and ENST00000686149. …”
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350
Proteomic Characterization of Liver Cancer Cells Treated with Clinical Targeted Drugs for Hepatocellular Carcinoma
Published 2025-01-01“…<b>Results</b>: Utilizing KEGG pathway enrichment analysis, biological process enrichment analysis, and protein interaction network analysis, we elucidated the common and specific metabolic pathways, biological processes, and protein interaction regulatory networks influenced by three liver cancer therapeutics. …”
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351
Impact of Enzymatic Degradation Treatment on Physicochemical Properties, Antioxidant Capacity, and Prebiotic Activity of Lilium Polysaccharides
Published 2025-01-01“…Metabolomic analysis revealed that LPSs with varying molecular weights exerted comparable promoting effects on multiple amino acid and carbohydrate metabolic pathways. Importantly, with the reduction in molecular weight, G-LPS(16) also particularly stimulated sphingolipid metabolism, nucleotide metabolism, as well as ascorbic acid and uronic acid metabolism, leading to the significant increase in specific metabolites such as sphingosine. …”
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352
Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone?
Published 2025-01-01“…Overnutrition disturbs key metabolic pathways, including insulin/insulin-like growth factor signaling (IIS), the mammalian target of rapamycin (mTOR), and AMP-activated protein kinase. …”
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353
Polyethylene microplastic exposure adversely affects oocyte quality in human and mouse
Published 2025-01-01“…Elevated PE levels altered metabolites primarily involved in metabolic pathways, ferroptosis, and ovarian steroidogenesis. …”
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354
A multi-dimensional validation strategy of pharmacological effects of Radix Isatidis Mixtures against the co-infection of Mycoplasma gallisepticum and Escherichia coli in poultry
Published 2025-01-01“…To further demonstrate the various mechanisms underlying the pharmacological effects of RIM, we conducted a validation study focusing on gene expression, protein interactions, metabolic pathways, and molecular docking. Through a multi-omics joint analysis network, we identified key targets and metabolites associated with co-infection and conducted targeted verification experiments with RIM aqueous extracts. …”
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355
Divergence in the Morphology and Energy Metabolism of Adult Polyphenism in the Cowpea Beetle <i>Callosobruchus maculatus</i>
Published 2024-12-01“…Moreover, there are differences in the energy metabolism pathways between the two forms, including carbohydrate metabolism and oxidative phosphorylation. …”
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356
Effects of <i>Lutjanus erythropterus</i> Protein on Depression-like Behavior and Gut Microbiota in Stressed Juvenile Mice
Published 2025-01-01“…Lep upregulated gut <i>Muribaculaceae</i> and downregulated SCFA-producing bacteria by replenishing deficient amino acid (AA) (tryptophan, alanine, aspartate, glutamate) and decreased (<i>p</i> < 0.01) the gene abundance of the AA metabolism pathway of SCFA-producing bacteria, thereby preventing gut SCFA enrichment and alleviating associated depression-like behavior. …”
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357
Study of Zuojin Pill in Treating Chronic Atrophic Gastritis by UPLC-Q-TOF/MS Based on Serum and Urine Metabolomics Combined with Network Pharmacology
Published 2021-01-01“…This study was the first to use a combination of metabolomics and network pharmacology to clarify the therapeutic effects of ZJP on CAG and the regulation of multiple metabolic pathways.…”
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358
Fabrication of taxifolin loaded zein-caseinate nanoparticles and its bioavailability in rat
Published 2023-11-01“…Glucuronidation was the dominating metabolism pathway of taxifolin in vivo.…”
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359
Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi <i>Penicillium</i> spp.: Chemical Diversity and Biological Activity
Published 2024-12-01“…Mangrove plants, soil, or sediment-derived fungi, especially the <i>Penicillium</i> species, possess unique metabolic pathways to produce secondary metabolites with novel structures and potent biological activities. …”
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360
Study on factors influencing the transport and transformation of polycyclic aromatic hydrocarbons in soil–groundwater systems
Published 2025-06-01“…Soil organic matter fixes PAHs through adsorption sites and active functional groups (including carbonyl and carboxyl groups), while microbial communities mineralize PAHs into H2O, CO2 (aerobic), and CH4 (anaerobic) through metabolic pathways, such as oxygenase, dehydrogenase, and lignin decomposer. …”
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