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281
Navigating the Role and Approach of Gut Microbiota in Addressing Alzheimer's Disease Pathogenesis
Published 2024-11-01“…Graphical abstract: The bidirectional interaction between the brain and the gut through neuroendocrine, immune, and metabolic pathways. Created with BioRender.com …”
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282
Urine metabolomic profiles of autism and autistic traits-A twin study.
Published 2024-01-01“…Based on the nominally significant metabolites for autism diagnosis, the arginine and proline metabolism pathway (p = 0.024) was enriched. We also investigated the association between quantitative autistic traits, as measured by the Social Responsiveness Scale 2nd Edition, and metabolite differences, identifying a greater number of nominally significant metabolites and pathways. …”
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283
Using moss as a bio-indicator to evaluate soil quality in litchi orchard.
Published 2022-01-01“…Furthermore, the metabolic pathways of soil bacteria and fungi were also degraded in the moss-growth area. …”
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284
The Importance of Magnesium in Clinical Healthcare
Published 2017-01-01“…Magnesium is an essential element required as a cofactor for over 300 enzymatic reactions and is thus necessary for the biochemical functioning of numerous metabolic pathways. Inadequate magnesium status may impair biochemical processes dependent on sufficiency of this element. …”
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285
Impact of Ultraviolet Radiation on Skin and Blood Melanin Traits in Xichou Black-Boned Chicken: A Transcriptomic and Metabolomic Study
Published 2025-01-01“…Omics studies revealed that the mTOR pathway and tryptophan metabolism pathway are potentially involved in the biological processes by which UVA radiation affects the blackness traits of Xichou Black-boned Chickens, with the <i>FZD3</i> gene being a candidate gene for these effects. …”
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286
Oligodendrocyte Injury in Multiple Sclerosis.
Published 2025-01-01“…Emerging therapeutic strategies, such as targeting metabolic pathways, reducing oxidative stress, and enhancing autophagy, have demonstrated potential in preclinical studies. …”
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287
Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry for Identification of In Vitro and In Vivo Metabolites of Bornyl Gallate in Rats
Published 2013-01-01“…The proposed method confirmed to be a reliable and sensitive alternative for characterizing metabolic pathways of BG.…”
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288
The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and me...
Published 2021-07-01“…Assessment of the changes in gene expression and metabolites revealed the significantly different expression of several genes encoding key enzymes and metabolites in choline metabolism pathway. The collective findings confirmed that choline metabolism plays an important role in the protective effects of TLMPS against acute alcoholic liver injury.…”
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289
Machine Learning and Multi-Omics Integration to Reveal Biomarkers and Microbial Community Assembly Differences in Abnormal Stacking Fermentation of Sauce-Flavor <i>Baijiu</i>
Published 2025-01-01“…Differential gene analysis and KEGG pathway enrichment identify metabolic pathways for flavor markers. This study provides a theoretical basis for regulating stacking fermentation and ensuring <i>Baijiu</i> quality.…”
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290
Coactivators in PPAR-Regulated Gene Expression
Published 2010-01-01“…Peroxisome proliferator-activated receptor (PPAR)α, β (also known as δ), and γ function as sensors for fatty acids and fatty acid derivatives and control important metabolic pathways involved in the maintenance of energy balance. …”
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291
<i>Pneumocystis</i> Pneumonia Severity Is Associated with Taxonomic Shifts in the Respiratory Microbiota
Published 2025-01-01“…Functionally, severe PCP was associated with a decrease in metabolic pathways of molecules with anti-inflammatory and antimicrobial properties. …”
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292
Effects of light regimes on circadian gene co‐expression networks in Arabidopsis thaliana
Published 2024-08-01“…However, we found transcripts encoding components of the flavonoid metabolism pathway that were rhythmic in LL but not in LD. …”
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293
Microplastic-enhanced chromium toxicity in Scenedesmus obliquus: Synergistic effects on algal growth and biochemical responses
Published 2025-02-01“…Transcriptomic analysis illuminated the complex regulatory mechanisms, indicating that toxicity primarily modulates metabolic pathways essential for photosynthesis, oxidative phosphorylation, the TCA cycle, and ribosome function in Scenedesmus obliquus. …”
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294
Dynamic Metabolic Footprinting Reveals the Key Components of Metabolic Network in Yeast Saccharomyces cerevisiae
Published 2014-01-01“…From the list of significant metabolite pairs, we reconstructed an interaction map that provides information of how different metabolic pathways have correlated patterns during growth on the different carbon sources.…”
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295
Dysbiosis and extraintestinal cancers
Published 2025-02-01“…Pathogenic microbiota, along with their metabolites, can undermine the integrity of the gut barrier through inflammatory or metabolic pathways, leading to increased permeability and the translocation of pathogens. …”
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296
In Vitro Cytotoxicity of Fluorinated Quaternary Ammonium Salts in Colorectal Cancer Cells and In Silico Pharmacology
Published 2024-01-01“…Colorectal cancer (CRC) is a multifactorial disease driven by genetic and epigenetic alterations that modulate specific metabolic pathways. Despite the availability of effective treatments like 5-fluorouracil (5-FU), pharmacological therapy for CRC still faces significant challenges, including drug resistance, toxicity, and limited specificity. …”
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297
Metagenomic investigation of viruses in green sea turtles (Chelonia mydas)
Published 2025-01-01“…Furthermore, KEGG enrichment analysis showed that the viral genes were mainly involved in phage-associated and metabolic pathways. Phylogenetic tree reconstruction of Caudovirales terminase large-subunit (TerL) protein showed that most of the sequences were phylogenetically distant. …”
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298
Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms
Published 2016-01-01“…These emerging comorbidities often occur in the same multimorbid adult patient and may have in common metabolic pathways and inflammatory or other alterations such as early life exposures, systemic inflammation, inflammasome, adipokines, hyperglycemia, hyperinsulinemia, lung mechanics, mitochondrial dysfunction, disturbed nitric oxide metabolism, and leukotrienes.…”
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299
The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics
Published 2017-01-01“…The advantage of pharmacometabolomics is that it does not only predict the response but also provide extensive information on the metabolic pathways implicated with the response. Integrating pharmacogenetics with pharmacometabolomics can give insight on unknown genetic and nongenetic factors associated with the response. …”
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300
Influence of nano-polystyrene on cyfluthrin toxicity in honeybee Apis cerana cerana Fabricius
Published 2025-01-01“…The changes in metabolites and metabolic pathways in honeybees after ingesting nanoPS were also studied. …”
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