Alternative Cell Death Pathways and Cell Metabolism by Simone Fulda

“…This network of regulatory mechanisms includes metabolic pathways, especially those linked to mitochondrial signaling events. …”
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Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders by Shihan Zhang, Shasha Tang, Yalei Liu, Binghua Xue, Qinyuan Xie, Lingyun Zhao, Huijuan Yuan

“…This review explores the interactions among heart, kidney, and metabolic pathways in the context of uremic toxins and underscores the significant role of uremic toxins as potential therapeutic targets in the pathophysiology of these diseases. …”
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Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets by Jean-Ehrland Ricci

“…This review highlights the regulation of antitumor immune responses through metabolic reprogramming in cancer and immune cells and explores therapeutic strategies that target these metabolic pathways in cancer immunotherapy, including using chimeric antigen receptor (CAR)-T cells. …”
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MATRIX: a platform for cultivation profiling and bioactive discovery in natural product research by Zeinab G. Khalil, Thulasi Sritharan, Angela A. Salim, Robert J. Capon

“…By employing a variety of media compositions and cultivations, MATRIX enhances the understanding of microbial metabolic pathways and interactions. This protocol provides a robust platform for natural product discovery, microbial ecology studies, and drug development, showcasing its potential to uncover new natural products and other valuable bioactives. …”
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Distinct Urinary Metabolite Signatures Mirror In Vivo Oxidative Stress-Related Radiation Responses in Mice by Yaoxiang Li, Shivani Bansal, Baldev Singh, Meth M. Jayatilake, William Klotzbier, Marjan Boerma, Mi-Heon Lee, Jacob Hack, Keisuke S. Iwamoto, Dörthe Schaue, Amrita K. Cheema

“…Exposure to ionizing radiation disrupts metabolic pathways and causes oxidative stress, which can lead to organ damage. …”
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Interaction between diet composition and gut microbiota and its impact on gastrointestinal tract health by Muhammad Shahid Riaz Rajoka, Junling Shi, Hafiza Mahreen Mehwish, Jing Zhu, Qi Li, Dongyan Shao, Qingsheng Huang, Hui Yang

“…Alterations of gut microbiota have clear consequences on intestinal homeostasis, physiology, gut microbiome, immune system and host metabolic pathways. Diet composition plays an important role in the control of gut microbial populations and, thus, in the prevention, management and treatment of certain diseases such as cancer, diabetes. …”
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Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum by Tabish Qidwai, Farrukh Jamal, Mohd Y. Khan, Bechan Sharma

“…To overcome the problem of falciparum malaria, the metabolic pathways in parasite apicoplast have been used as antimalarial drug targets. …”
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Marine fungi as a goldmine for novel antibiotics: a 2024 perspective by Chengqian Pan, Syed Shams ul Hassan, Ishaq Muhammad, Huizi Jin

“…These factors contribute to significant distinctions in secondary metabolic pathways and enzymatic reaction mechanisms between marine and terrestrial microorganisms. …”
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Combined metabolomic and transcriptomic analysis to reveal the response of rice to Mn toxicity stress by Feng Li, Yushuang Yao, Jiapeng Ma, Zhengwei Wu, Dianfeng Zheng, Yingbin Xue, Ying Liu

“…The phenylalanine metabolism pathway was significantly enriched in both the roots and leaves. …”
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Physiological and multi-omics analysis revealed the mechanism of arbuscular mycorrhizal fungi to cadmium toxicity in green onion by Kunhao Xie, Yixuan Chen, Xiaoqin Wang, Xiaoya Zhou, Yizhe Cheng, Xianchang Yu, Jun Wang, Mintao Sun, Yansu Li, Chaoxing He

“…Transcriptomic and metabolomic correlation analyses revealed that differentially expressed genes and metabolites in AMF-inoculated green onion under Cd stress were predominantly enriched in the “phenylpropanoid biosynthesis” and “phenylalanine metabolism” pathways, upregulated the expression of the HCT, PRDX6, HPD, MIF, and HMA3 genes, and accumulation of the phenylalanine, L-tyrosine, and 1-O-sinapoyl-β-glucose metabolites. …”
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Identification of the Transcriptional Networks and the Involvement in Angiotensin II-Induced Injury after CRISPR/Cas9-Mediated Knockdown of Cyr61 in HEK293T Cells by Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yan Jiang, Rentong Hu, Yanwu You

“…Functional mechanisms of the differentially expressed lncRNAs and mRNAs as well as identification of metabolic pathways will provide new therapeutic targets for Cyr61-realated diseases.…”
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A novel interplay between bacteria and metabolites in different early-stage lung cancer: an integrated microbiome and metabolome analysis by Xiaoqian Zhai, Xiaoqian Zhai, Dongqi Lin, Dongqi Lin, Yi Shen, Yi Shen, Ni Zhai, Fan Yu, Fan Yu, Jiabi Zhang, Yiyun Lin, Yuqing Wang, Qinghua Zhou, Qinghua Zhou, Xi Zheng, Xi Zheng

“…The metabolites of both early adenocarcinomas (SN and GGN) are mainly involved in energy metabolic pathways, while early LUSC is mainly involved in glutathione metabolism. …”
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Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing by Yafeng Jiang, Zhaolan Hu, Roujie Huang, Kaying Ho, Pengfei Wang, Jin Kang, Jin Kang

“…Synovial macrophages exhibited increased heterogeneity and were enriched in distinct metabolic pathways, including complement cascades and glutathione metabolism. …”
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Different expression of circulating microRNA profile in tibetan OSAHS with metabolic syndrome patients by Xue-feng Shi, Xiang He, Ze-rui Sun, Jie Duo, Hao Yang

“…Enrichment analysis results suggest that differentially expressed miRNAs may involved in the development of OSAHS-related metabolic disorders by regulating metabolic pathways. We also revealed that IKBKB, PIK3R1, and MAP2K1 are mostly associated with metabolic disorder in OSAHS, and miR-503-5p and miR-497-5p may regulate the development of MetS associated with OSAHS by modulating IKBKB, PIK3R1, and MAP2K1.…”
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Effects and function of citric acid on fermentation quality and microbial community in sugarcane tops silage with high and low water-soluble carbohydrate content by Qichao Gu, Jie Zhang, Bo Lin, Hao Ding, Qi Yan, Caixiang Wei, Yipei Yao, Ruizhanghui Wang, Caixia Zou

“…The objectives of this study were to investigate the effects of CA on the chemical composition, fermentation quality, microbial communities, and metabolic pathways of STS with high and low WSC contents before or after aerobic exposure. …”
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Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets by Huahua Li, Lingling Zou, Zhaowei Long, Junkun Zhan, Junkun Zhan

“…Drug enrichment analysis highlighted potential therapeutic agents targeting these TFs and related pathways, including Suloctidil, Chlorpropamide, and other compounds modulating inflammatory and metabolic pathways.ConclusionThis study underscores significant immunometabolic dysfunction in T2DM, characterized by alterations in immune cell composition, metabolic pathways, and intercellular communication. …”
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Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia by Xin Ma, Xin-Meng Wang, Guo-Zhang Tang, Yi Wang, Xue‑Chun Liu, Shuai-Deng Wang, Peng Peng, Xiu-Hong Qi, Xin-Ya Qin, Yue‑Ju Wang, Chen-Wei Wang, Jiang-Ning Zhou

“…These fundings give novel perspectives of serum amino acids for predicting metabolic pathways in AD and VD pathogenesis.…”
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Research progress on energy metabolism regulation in stored platelets by GAO Chengyan, LOU Can, LEI Hang, CAI Xiaohong

“…The regulation and flexibility of these metabolic pathways play a critical role in the survival and function of platelets in different states.…”
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Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications by Yating Cong, Na Li, Zixin Zhang, Yan Shang, Hailong Zhao

“…In this review, we delve into the cellular metabolic pathways of copper, highlighting the role of copper in biomolecule synthesis, mitochondrial respiration, and antioxidant defense. …”
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Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (orCCL2) in the Regulation of Metabolism by Anna Rull, Jordi Camps, Carlos Alonso-Villaverde, Jorge Joven

“…This coordination requires a complex relationship between cells, hormones, and cytokines in which inflammatory and metabolic pathways are convergent at multiple levels. Recruitment of macrophages to metabolically compromised tissue is a primary event in which chemokines play a crucial role. …”
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