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261
Genetic Markers of Cardiovascular Disease in Rheumatoid Arthritis
Published 2012-01-01“…In this regard, besides a strong association between the HLA-DRB1*04 shared epitope alleles and both endothelial dysfunction, an early step in the atherosclerotic process, and clinically evident CV disease, other polymorphisms belonging to genes implicated in inflammatory and metabolic pathways, located inside and outside the HLA region, such as the 308 variant (G>A, rs1800629) of the TNFA locus, the rs1801131 polymorphism (A>C; position + 1298) of the MTHFR locus, or a deletion of 32 base pairs on the CCR5 gene, seem to be associated with the risk of CV disease in patients with RA. …”
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262
Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey
Published 2025-01-01“…The combination of active compounds from Chios mastiha rather than a single molecule may have a superior ability to control the intertwined MASLD metabolic pathways.…”
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263
GLP-1 Receptor Agonists’ Impact on Fertility - A Review
Published 2025-02-01“…They have proven their ability to impact a variety of hormonal as well as metabolic pathways. They manage glucose metabolism, appetite, as well as insulin secretion. …”
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264
Energy status regulated umami compound metabolism in harvested shiitake mushrooms (Lentinus edodes) with spores triggered to release
Published 2023-01-01“…Fifteen related gene expression levels in the energy metabolism pathway were downregulated. LecpdP1 and LeAK were significantly expressed in the conversion of ATP into AMP and played key roles in connecting the energy state and umami level. …”
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265
Implications of intratumoral microbiota in tumor metastasis: a special perspective of microorganisms in tumorigenesis and clinical therapeutics
Published 2025-02-01“…Intratumoral microbiota can modulate tumor progression through multiple mechanisms, including regulating immune responses, inducing genomic instability and gene mutations, altering metabolic pathways, controlling epigenetic pathways, and disrupting cancer-related signaling pathways. …”
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266
Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?
Published 2015-01-01“…These transcription factors regulate cellular adaptation to hypoxia and protect cells by responding acutely and inducing production of endogenous metabolites and proteins to promptly regulate metabolic pathways. Here, we review the role of the HIF pathway as a metabolic adaptation pathway and how this pathway plays a role in cell survival. …”
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267
A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseases
Published 2025-02-01“…WTFS equals the antioxidant activity of N-acetyl-cysteine and interferes with multiple inflammation and cellular transformation-sustaining metabolic pathways. In interventional studies, WTFS inhibits prostate experimental tumors and improves benign prostate hypertrophy-associated symptoms with no associated side-effects. …”
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268
Effect of genomic regions harboring putative lethal haplotypes on reproductive performance in closed experimental selection lines of Nellore cattle
Published 2025-02-01“…The gene networks were involved in metabolic pathways including ovarian steroidogenesis, oocyte meiosis, and insulin secretion. …”
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269
Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets
Published 2025-01-01“…An increasing amount of study is being done on the particular glutamine metabolic pathways in cancer cells. Further investigation into the function of glutamine in immune cells is warranted given the critical role these cells play in the fight against cancer. …”
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270
A NMR-Based Metabolomic Approach to Investigate the Antitumor Effects of the Novel [Pt(η1-C2H4OMe)(DMSO)(phen)]+ (phen = 1,10-Phenanthroline) Compound on Neuroblastoma Cancer Cells...
Published 2022-01-01“…NMR-based metabolomics demonstrated a peculiar alteration of the glutathione metabolism pathway and the diacylglycerol expression.…”
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271
Resensitizing β‐Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment
Published 2025-02-01“…Multi‐omics analysis revealed that the acquired high drug resistance is associated with altered flux in the purine metabolism pathway, attributable to mutations in the hypoxanthine phosphoribosyltransferase (hpt) gene. …”
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272
Pharmacologic Targets and Prototype Therapeutics in the Kallikrein-Kinin System: Bradykinin Receptor Agonists or Antagonists
Published 2006-01-01“…In addition, products of this system have multiple interactions with other important metabolic pathways, such as the renin-angiotensin system.…”
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273
Chemical Fingerprint and Metabolic Profile Analysis of Tianshu Tablets by Ultra-High Performance Liquid Chromatography/Quadrupole-Time of Flight Mass Spectrometry
Published 2019-01-01“…Hydroxylation and glucuronidation were finally confirmed as the main metabolic pathways. This is the first research on the chemical fingerprint and metabolites of TST, which lays a foundation for further investigation of TST.…”
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274
Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats
Published 2016-01-01“…Time-dependent changes in differential enzymes along the kynurenine metabolism pathway, particularly those involved in the production of quinolinic acid, were found within the amygdala, hypothalamus, and medial prefrontal cortex, with no changes seen in the hippocampus. …”
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275
Lead toxicity in Nicotiana tabacum L.: Damage antioxidant system and disturb plant metabolism
Published 2025-02-01“…Metabolomics results showed that Pb stress enhanced tryptophan metabolism, glutathione metabolism, alanine, aspartate, and glutamate metabolism, as well as cysteine and methionine metabolism pathways. These results indicate that increasing the content of photosynthetic pigments and hormones, clearing reactive oxygen species by enhancing antioxidant enzyme activity, and improving amino acid metabolism may play an important role in reducing the toxicity of Pb to tobacco.…”
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276
Integrated transcriptomic and metabolomic analyses reveal critical gene regulatory network in response to drought stress in Dendrobium nobile Lindl
Published 2025-02-01“…Conclusions The results showed that arginine and proline metabolism, glucosinolate biosynthesis and tyrosine metabolism pathways participated in regulating drought stress in D. nobile Lindl. …”
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277
Transcriptomic analysis of the root system of Platycodon grandiflorum in response to the fallen leaves of Acer truncatum
Published 2024-12-01“…[Results] A total of 15 727 SSR loci were detected. 753 differentially expressed genes (DEGs) were annotated into three major categories of the GO classification, and 314 DEGs were classified into 105 metabolic pathways in the KEGG classification. Compared with the control group, there were 17, 7, and 26 DEGs involved in the biosynthesis of terpenes, flavonoids, and phenylpropanoids, respectively. …”
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278
Twist-Induced Epithelial-to-Mesenchymal Transition Confers Specific Metabolic and Mitochondrial Alterations
Published 2025-01-01“…Here, we analyze Twist-induced EMT in non-transformed HMLE cells as well as a breast cancer cell line with (MDA-MB-231) and without (MCF7) EMT features to compare differences in metabolic pathways and mitochondrial morphology. Analysis of oxidative and glycolytic metabolism reveals a general EMT-associated glycolytic metabolic phenotype accompanied by increased ATP production. …”
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279
Proteomics of the Dark-Ventral-Patch Sexual Signal in Male Red Deer
Published 2025-01-01“…Characterization of the origin and functionality of the proteins found in the hair of the dark ventral patch of male red deer, and their relationship to distinct metabolic pathways, provides an initial understanding of the potential role of these compounds in chemical communication in red deer intrasexual competition for mates.…”
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280
Host plants selection of Centranthera grandiflora Benth. and nontargeted metabolomics analysis of its parasitic and non-parasitic samples.
Published 2025-01-01“…Analysis of the 37 pathways in combination with the differential metabolites showed that in addition to being involved in the synthesis pathway of iridoid terpenes, the up-regulated metabolites of parasitized plants were involved in the synthesis pathways of several functional components, while that of non-parasitic plants were involved in the subsequent catabolism of monoterpenoid compounds, as well as the metabolic pathways of nutrients synthesis and catabolism, energy generation, and phytohormone production required for plant growth.…”
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