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241
Detection and Characterization of the Metabolites of Ciwujianoside B in Rats Based on UPLC-Fusion Lumos Orbitrap Mass Spectrometry
Published 2024-01-01“…Finally, ciwujianoside B metabolism and hederasaponin B metabolism were compared, reaching the following conclusions: (i) more than 40 metabolites were identified in both, with the majority of metabolites identified in feces; (ii) the corresponding metabolic pathways in vivo were basically similar, including deglycosylation, acetylation, hydroxylation, glucuronidation, oxidation, and glycosylation; and (iii) deglycosylation was considered the main metabolic reaction, and its metabolites accounted for approximately 50% of all metabolites. …”
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242
Metabolomics-based study on the effect of low-voltage electrostatic field treatment on the storage quality of postharvest square bamboo shoots
Published 2025-01-01“…These changes were closely related to fatty acid metabolism, TCA cycle, and phenylalanine metabolism pathways. Overall, LP treatment can effectively improve the storage quality of square bamboo shoots.…”
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243
Application of lipidomics in the study of traditional Chinese medicine
Published 2025-02-01“…Lipidomics is an emerging discipline that systematically studies the various types, functions, and metabolic pathways of lipids within living organisms. This field compares changes in diseases or drug impact, identifying biomarkers and molecular mechanisms present in lipid metabolic networks across different physiological or pathological states. …”
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244
Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells
Published 2016-01-01“…We summarize on what is known about regenerative therapy in type 1 diabetes focusing on pancreatic islet transplantation and new avenues of cell substitution. Metabolic pathways and energy production of transplanted cells are required to be balanced and protection from inflammation in their intravascular bed is desired. …”
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245
Effects of microbial biocontrol agents on tea plantation microecology and tea plant metabolism: a review
Published 2025-01-01“…While biotic stress generally has detrimental effects on plants, it also activates defense metabolic pathways, leading to shifts in microbial communities. …”
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246
New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis
Published 2012-01-01“…The discovery of the angiotensin-converting enzyme homologue ACE2 revealed important metabolic pathways involved in the Ang-(1–7) synthesis. …”
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247
Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair
Published 2025-02-01“…Currently, a large number of studies have focused on changes in metabolic levels before and after the proliferation window of cardiomyocytes, so it is crucial to search for relevant factors in metabolic pathways to regulate the cell cycle in cardiomyocyte progression. …”
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248
Metagenomics approaches for studying the human microbiome
Published 2024-12-01“…Hence, metagenomics analysis is a powerful advanced technology for comprehensively studying human microbial composition and diversity, exploring novel and antibiotic resistance genes, microbial metabolic pathways, functional dysbiosis, and co-evolution of the microbiome with the host. …”
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249
Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice
Published 2022-01-01“…The urine of DENV-, JEV-, and ZIKV-infected mice had 68, 64, and 47 different differential metabolites, respectively, compared with the urine of control mice. Among the metabolic pathways designed by these metabolites, ABC transporters, arginine and proline metabolism, and regulation of lipolysis play an important role. …”
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250
Neuroprotection Caused by Hyperoxia Preconditioning in Animal Stroke Models
Published 2011-01-01“…The changes in the metabolic pathways are generally short lived and reversible, while the consequences of gene expression are a long-term process and may lead to the permanent alteration in the pattern of gene expression. …”
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251
Extracellular vesicles—a new player in the development of urinary bladder cancer
Published 2025-01-01“…EVs isolated from urinary bladder cancer cells affect other lower-grade cancer cells or normal cells by inducing different metabolic pathways (transforming growth factor β/Smads pathway; phosphoinositide 3-kinase/Akt pathway) that promote epithelial–mesenchymal transition. …”
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252
Pantoprazole – safety in drug-drug interaction
Published 2012-09-01“…To carry out comparative analysis of metabolic pathways of proton pump inhibitors (PPI), to determine the agent with lowest effect on activity of cytochrome CYP2C19 isoenzyme for improvement of safety of combined treatment by pharmaceuticals metabolized by this isoenzyme.Key points. …”
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253
Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure
Published 2019-01-01“…This paper introduced intestinal flora and its metabolites, summarized the changes of intestinal flora in patients with heart failure, clarified that intestinal barrier damage and bacterial translocation induced inflammation and immune response aggravated heart failure, and altered intestinal microflora affected various metabolic pathways including trimethylamine/TMAO, SCFA, and Bile acid pathway leads to heart failure. …”
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254
Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis
Published 2025-02-01“…We analyze the immunological networks, metabolic pathways, and microbial factors contributing to their development and progression. …”
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255
Representative Metagenomes of Mesophilic Biogas Reactor Across South Korea
Published 2025-02-01“…Over the past decade, this has driven global research on biogas-producing microbiomes, leading to significant advances in our understanding of microbial diversity and metabolic pathways within AD plants. However, substantial knowledge gaps persist, particularly in understanding the specific microbial communities involved in biogas production in countries such as South Korea. …”
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256
Study on Effect of Producing Region on the Metabolome Composition of Rice
Published 2025-01-01“…By principal component analysis (PCA) and partial least square discriminant analysis (OPLS-DA), the results showed that the numbers of differential metabolites between the comparison groups (GJYH290 vs MLYH290, MZYH290 vs GJYH290, MZYH290 vs MLYH290) were 130, 180, and 192, respectively, only 6 different metabolites were common to all three comparison groups, with the main metabolic pathways involving amino acid metabolism and flavonoid metabolism. …”
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257
Stevioside mitigates metabolic dysregulation in offspring induced by maternal high-fat diet: the role of gut microbiota-driven thermogenesis
Published 2025-12-01“…In summary, maternal STV supplementation could alleviate lipid metabolic disorders in offspring by enhancing L. apodemi levels and promoting thermogenic activity, potentially involving changes in bile acid metabolism pathways.…”
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258
Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor
Published 2018-01-01“…PPARγ coactivator-1α (PGC-1α), initially identified as a PPARγ-interacting protein, is an important regulator of diverse metabolic pathways, such as oxidative metabolism and energy homeostasis. …”
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259
Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications
Published 2021-01-01“…Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. …”
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260
Transcriptome Analysis of Cryptolestes ferrugineus under Low-temperature Stress
Published 2025-01-01“…KEGG analysis revealed that differentially expressed genes were primarily enriched in metabolic pathways, fatty acid biosynthesis, and secondary metabolite biosynthesis. …”
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