Asymptomatic Hyperuricemia Is Associated with Achilles Tendon Rupture through Disrupting the Normal Functions of Tendon Stem/Progenitor Cells by Jingjing Liang, Biao Chen, Yanmei Li, Daibang Nie, Changbin Lei, Qing Yang, Yiqin Zhou, Shenglong Li, Shuaizhi Chen, Bin Li, Lin Shu, Liaobin Chen, Wang Wang

“…Hyperuricemia is a metabolic disorder that is essential to the development of inflammatory gout, with increasing prevalence over recent years. …”
Get full text

Type 2 Diabetes, Atrial Fibrillation, and Direct Oral Anticoagulation by Dana Prídavková, Matej Samoš, Tomáš Bolek, Ingrid Škorňová, Jana Žolková, Peter Kubisz, Ján Staško, Marián Mokáň

“…Type 2 diabetes (T2D) is an independent risk factor of stroke and systemic embolism in patients with atrial fibrillation (AF), and T2D patients with AF-associated stroke seem to have worse clinical outcome and higher risk of unfavorable clinical course compared to individuals without this metabolic disorder. Long-term anticoagulation is indicated in majority of T2D patients with AF to prevent adverse AF-associated embolic events. …”
Get full text

Clinical Features in Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency: A Systematic Review by Susanna Rizzi, Carlotta Spagnoli, Daniele Frattini, Francesco Pisani, Carlo Fusco

“…Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare congenital autosomal recessive metabolic disorder caused by pathogenic homozygous or compound heterozygous variants in the dopa decarboxylase (DDC) gene. …”
Get full text

Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis by Zheng Gao, Hekai Shi, Wei Xu, Zhengzhao Guan, Xiuxiu Su, Nuojin Guo, Huijie Ma

“…Keywords used in literature search were hyperuricemia, atrial fibrillation, metabolic disorder, endocrine disorder, or uric acid. Three studies were provided by the authors. …”
Get full text

A Study of Serum Adiponectin Levels in Patients with Polycystic Ovarian Syndrome and its Correlation with Various Cardiometabolic Risk Markers by G. Surendra Prasad, Uma Kaimal Saikia, Ashok Krishna Bhuyan, Abhamoni Baro

“…Background: Polycystic ovarian syndrome (PCOS) is the most common metabolic disorder in the reproductive age group, the pathogenesis of which is constantly evolving with the discovery of novel molecules and the lookout for potential therapeutic targets. …”
Get full text

The Comparison of Food and Nutrient Intake among Iranian Diabetic and Non-Diabetic Adults by Najmeh Maayeshi, Hassan Mozaffari-Khosravi, Sayyed Saeid Khayyatzadeh, Hossein Fallahzadeh

“…Background: Diabetes is known as a rising global health metabolic disorder. Eating choices are considered as a main factor in type 2 diabetes (T2D) prevention and treatment. …”
Get full text

Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function by Atenea A. Perez-Serna, Daniel Guzman-Llorens, Reinaldo S. Dos Santos, Laura Marroqui

“…Diabetes is a chronic metabolic disorder whose prevalence increases every year, affecting more than 530 million adults worldwide. …”
Get full text

A Rare Case of Concomitant Maxilla and Mandible Brown Tumours, Papillary Thyroid Carcinoma, Parathyroid Adenoma, and Osteitis Fibrosa Cystica by Thaís Borguezan Nunes, Sheyla Batista Bologna, Andréa Lusvarghi Witzel, Marcello Menta Simonsen Nico, Silvia Vanessa Lourenço

“…The brown tumour of hyperparathyroidism is a result of a metabolic disorder caused by primary hyperparathyroidism. …”
Get full text

The Effect of P-Cymene on Glucose, Insulin, Antioxidant Power, and the Level of AKT Gene mRNA in Streptozotocin-Induced Diabetes Model in Male Wistar Rats by Maryam Arabloei Sani, Zahra Hajebrahimi, Parichehreh Yaghmaei, Nasim Hayati Roodbari

“…Background and Aim: Diabetes is a main metabolic disorder in middle-aged and older people. Oxidative stress can interfere with insulin signaling and are directly relevant to the incidence of diabetes. …”
Get full text

Extreme Maternal Metabolic Acidosis Leading to Fetal Distress and Emergency Caesarean Section by Nicolas Cecere, Corinne Hubinont, Arnauld Kabulu Kadingi, Marie-Françoise Vincent, Peter Van den Bergh, Anna Onnela, Philippe Hantson

“…Starvation ketoacidosis is a rare metabolic disorder that may occur mainly in the third trimester of pregnancy. …”
Get full text

The Impact of Modifiable Risk Factors on the Endothelial Cell Methylome and Cardiovascular Disease Development by Hashum Sum, Alison C. Brewer

“…This review will evaluate the extensive evidence that environmental risk factors, known to be associated with atherosclerosis, such as diabetes, metabolic disorder, smoking, hypertension and hypercholesterolaemia etc. can affect the methylome of the endothelium and consequently act to alter gene transcription and function. …”
Get full text

Mitigation of Diabetes Mellitus Using Euphorbia helioscopia Leaf Ethanolic Extract by Modulating GCK, GLUT4, IGF, and G6P Expressions in Streptozotocin-Induced Diabetic Rats by Ahmed Raza, Muhammad Naveed Mushtaq, Sadia Hassan, Ali Sharif, Bushra Akhtar, Muhammad Furqan Akhtar

“…Diabetes mellitus is a metabolic disorder. Synthetic antidiabetics are the commonly used treatment options associated with complications. …”
Get full text

Identification of mitophagy-related biomarkers and immune infiltration in polycystic ovarian syndrome by bioinformatic study by Hongjuan Ye, Xicheng Wang, Zhiying He

“…Background: Polycystic ovarian syndrome (PCOS) is a common endocrine and metabolic disorder in women of reproductive age. In this study, we aimed to investigate the potential prognostic value of mitophagy-related genes in PCOS patients and to analyze their role in immune infiltration during PCOS pathogenesis and progression. …”
Get full text

Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice by Wenbin Zheng, Jing Zhou, Shasha Song, Wen Kong, Wenfang Xia, Lulu Chen, Tianshu Zeng

“…Body weight gain, lipid metabolic disorder, and hepatic steatosis as well as systemic and hepatic insulin sensitivity in ob/ob mice were significantly attenuated after sitagliptin treatment. …”
Get full text

A comprehensive analysis of trends in the burden of gout in China and globally from 1990 to 2021 by Shiwei Xie, Heng Xiao, Lei Xu, Gengwu Li, Fan Zhang, Mingwei Luo

“…Abstract Gout is a prevalent metabolic disorder characterized by urate crystal accumulation in joints, leading to acute arthritis and tophi formation. …”
Get full text

Cangfudaotan Decoction Alleviates Insulin Resistance and Improves Follicular Development in Rats with Polycystic Ovary Syndrome via IGF-1-PI3K/Akt-Bax/Bcl-2 Pathway by Chenye Wang, Caifei Ding, Zhoujia Hua, Chunyue Chen, Jia Yu

“…Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder prevalent in females of reproductive age; insulin resistance (IR) is the major pathogenic driver. …”
Get full text

Trimethylamine-N-Oxide Promotes High-Glucose-Induced Dysfunction and NLRP3 Inflammasome Activation in Retinal Microvascular Endothelial Cells by Lidan Xue, Lili Huang, Yajing Tian, Xin Cao, Yu Song

“…Along with blood glucose levels, diabetic retinopathy (DR) development also involves endogenous risk factors, such as trimethylamine-N-oxide (TMAO), a product of intestinal flora metabolic disorder, which exacerbates diabetic microvascular complications. …”
Get full text

A retrospective study of 5S behaviours of Physical Activity (PA) among suburban Mumbai population with Type 2 Diabetes Mellitus (T2DM) by Kosha Parikh, Shikha Thosani, Ameya Joshi, Apoorva Hajirnis, Chandani Seth

“…Background: T2DM is a chronic metabolic disorder to manage the same lifestyle modification is cornerstone. …”
Get full text

Two faces of the same coin non alcoholic fatty liver disease; with and without diabetes: Comparative clinico pathological analysis: A cross sectional observational study by Syed Mushfiq, Ghulam Nabi Yatoo, Bilal Ahmad Mir, Zubaida Rasool

“…Background and Aim: Non-alcohol fatty liver disease (NAFLD) is a metabolic disorder that represents the hepatic manifestation of systemic process, and is a strong risk factor for diabetes Meletus, whereas the presence of DM increases the severity of NAFLD/NASH and its progression. …”
Get full text

Impact of High Glucose on Bone Collagenous Matrix Composition, Structure, and Organization: An Integrative Analysis Using an Ex Vivo Model by Rita Araújo, Ricardo N. M. J. Páscoa, Raquel Bernardino, Pedro S. Gomes

“…Diabetes mellitus is a widespread metabolic disorder linked to numerous systemic complications, including adverse effects on skeletal health, such as increased bone fragility and fracture risk. …”
Get full text