Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria D... by Saverio Massimo Lepore, Valeria Maria Morittu, Marilena Celano, Francesca Trimboli, Manuela Oliverio, Antonio Procopio, Carla Di Loreto, Giuseppe Damante, Domenico Britti, Stefania Bulotta, Diego Russo

“…The observed beneficial properties of Ole and Ac-Ole make these compounds and in particular Ac-Ole promising candidates for a potential pharmaceutic use in metabolic disorders.…”
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Lipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine Diseases by Tae-Woo Kim, Min-Hee Kang, Hee-Myung Park

“…These changes may originate from genetic predispositions or underlying metabolic disorders, including cholestasis and endocrine diseases. …”
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Beneficial effects of AOS-iron supplementation on intestinal structure and microbiota in IDA rats by Hong He, Hui Teng, Qun Huang, Dan He, Fengping An, Lei Chen, Hongbo Song

“…These findings indicated that AOS-iron effectively repaired the damaged intestinal tissue and ameliorated iron metabolic disorders by regulating gut microbiota desirably, which could provide references for the treatment of IDA.…”
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Comment on “Prevalence and Risk Factors for Diabetic Lower Limb Amputation: A Clinic-Based Case Control Study” by M. Bakhtiyari, M. A. Mansournia

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A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases by Seungjae Lee, Woojoo Lee

“…We describe widely used MR methods, using an example from obesity-related metabolic disorders. We describe situations in which instrumental variable assumptions are violated and explain how to evaluate these violations and employ robust methods for accommodating such violations.…”
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The beneficial effects of Tartary buckwheat (Fagopyrum tataricum Gaertn.) on diet-induced obesity in mice are related to the modulation of gut microbiota composition by Yiming Zhou, Haoyu Lu, Shen Zhao, Beibei Yan, Hong Wang, Xiaoli Zhou, Ying Xiao

“…A growing body of evidence suggests that a high-fat diet is closely associated with many metabolic disorders, including fatty liver and type 2 diabetes. …”
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Negative Effects of High Glucose Exposure in Human Gonadotropin-Releasing Hormone Neurons by Annamaria Morelli, Paolo Comeglio, Erica Sarchielli, Ilaria Cellai, Linda Vignozzi, Gabriella B. Vannelli, Mario Maggi

“…Metabolic disorders are often associated with male hypogonadotropic hypogonadism, suggesting that hypothalamic defects involving GnRH neurons may impair the reproductive function. …”
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Differences in metabolic characteristics between Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUO) in weight reduction therapy by Shiori Kawai, Hajime Yamakage, Kazuhiko Kotani, Mitsuhiko Noda, Noriko Satoh-Asahara, Koshi Hashimoto

“…Metabolically Healthy Obesity (MHO) is generally recognized as the absence of any metabolic disorders and cardiovascular diseases, including type 2 diabetes, dyslipidemia, and hypertension, in obese individuals; however, it is not clearly defined. …”
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Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin by Michał Biernacki, Elżbieta Skrzydlewska

“…This review is the first systemic and very detailed approach presenting both the causes and consequences of changes in phospholipid metabolism leading to the generation of eicosanoids, changes in the level of which result in specific metabolic disorders in skin cells leading to the development of various diseases. …”
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Parental perception of treatment options for mucopolysaccharidosis: a survey to bridge the gap for personalized medicine by Anna-Maria Wiesinger, Florian B. Lagler

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Identifying non-communicable disease multimorbidity patterns and associated factors: a latent class analysis approach by Sanghamitra Pati, Parul Puri, Shri Kant Singh

“…Additionally, socioeconomic, demographic, lifestyle and anthropometric factors are significantly associated with one or more identified disease patterns.Conclusions The identified classes ‘hypertension’, ‘metabolic disorders’ and ‘complex cardiometabolic disorders’ reflect three stages of cardiometabolic morbidity with hypertension as the first and ‘complex cardiometabolic disorders’ as the last stage of disease progression. …”
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Disparate Intent-to-Treat Outcomes for Pediatric Liver Transplantation Based on Indication by Anna Lang, Cameron Goff, Ashley Montgomery, Jake Lynn, Spoorthi Kamepalli, John Goss, Abbas Rana

“…The Kaplan–Meier method and log-rank test were used to assess differences in waitlist, post-transplant, and intent-to-treat mortality among the top 5 indications of biliary atresia, acute hepatic necrosis, metabolic disorders, hepatoblastoma, and autoimmune cirrhosis. …”
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Hyperhomocisteinemia, hypercysteinemia, glutamate excitotoxicity, taurine deficiency at hepatitis C by V. K. Pozdeev, N. V. Pozdeev, O. Ye. Nikitina

“…An estimation of metabolic disorders related to chronic course of hepatitis C.Material and methods. …”
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PPAR-α regulates metabolic remodelling and participates in myocardial fibrosis in patients with atrial fibrillation of rheumatic heart disease by Xiaoying Hu, Daisong Jiang, Zheng Zhang, Zhenmei An

“…Material and methods The left atrial appendage tissues were evaluated by Masson staining for fibrosis degree, and Western Blot was used to detect the expression of proteins related to glucose metabolism disorder, lipid metabolism abnormality, and mitochondrial dysfunction. …”
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Combined metabolomics and 16S rDNA sequence analyses of the gut microbiome reveal the action mechanism of Fructus Akebiae against hepatic fibrosis by Rong-Rong Wu, Duo-Rui Nie, Fang-Hui He, Zhi-Hang Li, Fei Xu, Fei Xu, Fei Xu

“…Additionally, metabolomic analysis showed that FAE treatment reversed the CCl4-induced metabolic disorders by regulating amino and nucleotide sugar metabolism. …”
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Tangduqing Granules Attenuate Insulin Resistance and Abnormal Lipid Metabolism through the Coordinated Regulation of PPARγ and DGAT2 in Type 2 Diabetic Rats by Qinghua Zhang, Yingying Huang, Xiaojin Li, Hongyi Liu, Baichuan He, Bin Wang, Yuntao Ma, Xiang Zhou, Yaqin Liu, Shentao Wu

“…TDQ are, therefore, a potential Chinese medicinal formula that relieves IR and lipid metabolism disorder might be through promotion of PPARγ and decrease of DGAT2 expression.…”
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From Rarity to Recognition: Infantile Botulism and the Broad Spectrum of Differential Diagnoses by Matthew C. Authement, Brandon M. Jones, Robert J. Kahoud, Elizabeth H. Ristagno

“…The differential for an ill-appearing infant should always include infectious etiologies and may include metabolic disorders, congenital anomalies, nonaccidental trauma, neurologic disorders, and endocrine disorders. …”
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The Effect of Aerobic Exercise on the Oxidative Capacity of Skeletal Muscle Mitochondria in Mice with Impaired Glucose Tolerance by Dan Wang, Dong-Mou Jiang, Rong-Rong Yu, Lin-Lin Zhang, Yan-Zhong Liu, Jia-Xin Chen, Hai-Chun Chen, Yi-Ping Liu

“…Results. (1) Mice with high-fat diet for 30 weeks showed impaired glucose tolerance, insulin resistance, and lipid metabolism disorders. The level of LDH, PDH, SDH, and CCO in the gastrocnemius homogenate of mice was reduced. …”
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Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease by Lindsey Van Haute, Petra Páleníková, Jia Xin Tang, Pavel A Nash, Mariella T Simon, Angela Pyle, Monika Oláhová, Christopher A Powell, Pedro Rebelo-Guiomar, Alexander Stover, Michael Champion, Charulata Deshpande, Emma L Baple, Karen L Stals, Sian Ellard, Olivia Anselem, Clémence Molac, Giulia Petrilli, Laurence Loeuillet, Sarah Grotto, Tania Attie-Bitach, Jose E Abdenur, Robert W Taylor, Michal Minczuk

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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…At diet-induced NAFLD the liver undergoes a complex of histological and metabolic disorders to the high extent close to clinical symptoms of this disease in humans.Conclusion. …”
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