Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis by Lea-Jessica Albrecht, Simone C. Tauber, Julika Merres, Eugenia Kress, Matthias B. Stope, Sandra Jansen, Thomas Pufe, Lars-Ove Brandenburg

“…The most frequent pathogen that causes bacterial meningitis is the Gram-positive bacterium Streptococcus pneumoniae. …”
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Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37) by Z. Razzaque, D. Shaw, M. Bock, L. Maskell, J. Pickard, D. Sirinathsinghji, J. Longmore

“…We investigated whether the antagonists BIBN4096BS[2], Compound 1 (WO98/11128, [3]), and CGRP(8-37) are functionally selective for CGRP receptors in human middle meningeal arteries (HMMA).…”
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Improving vaccination uptake in pediatric Cochlear implant recipients by Lisa Jin, Paula Téllez, Ruth Chia, Daphne Lu, Neil K. Chadha, Julie Pauwels, Simon Dobson, Hazim Al Eid, Frederick K. Kozak

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Virulence and pathogenicity of group B Streptococcus: Virulence factors and their roles in perinatal infection by Christina J. Megli, Sophia M. Carlin, Elizabeth J. Giacobe, Gideon H. Hillebrand, Thomas A. Hooven

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Clinical study on the treatment of acute epidural hematoma by embolization of middle meningeal artery through radial artery access combined with minimally invasive burr hole drainage by Cui Zhang, Qingbo Wang, Chenglong Li, Zixuan Jing, Xinyu Zhao, Yang Chen, Zefu Li

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Clinical profile of dengue encephalopathy: A series of twelve cases and a profile of other complications by Biswajit Bhuyan, Bandita Panda, Rabinarayan Rout, Lalatendu Mohanty, Bangam Rajendra Prasad Rao

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“Unmasking the Uncommon”: A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates [version 2; peer review: 2 approved] by Anisha Maria Fernandes, Sinchana Bhat, Suchitra Shenoy M., Prajnha U.P.

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Clinical management of community-acquired meningitis in adults in the UK and Ireland in 2017: a retrospective cohort study on behalf of the National Infection Trainees Collaborative for Audit and Research (NITCAR) by Amy Robinson, Kamaljit Khalsa, Arjun Chandna, John Bowen, Viva Levee, Jan Coebergh, Tom Solomon, Clive Graham, David Turner, Robert Tilley, Tim Jones, Susan Hopkins, Matthew Stevens, Daniel White, Celestine Eshiwe, Anna Goodman, Ramandeep Singh, Robert S Heyderman, Nicholas Davies, Joseph Thompson, Ed Moran, Martin Williams, Rhea O’Regan, Simon Tiberi, Jonathan Lambourne, Naomi Bulteel, Susan Larkin, Ruth McEwen, Hassan Paraiso, Aarti Shah, Martin Wiselka, Sylviane Defres, Ernest Mutengesa, Maria Krutikov, Ruth Owen, David Griffith, David Harvey, Trupti Patel, Brendan Davies, Emma Mclean, Joanna Allen, Ali Khan, Alastair Miller, Ashutosh Deshpande, Christopher Green, Lewis Jones, Mark Melzer, Fiona McGill, Amanda Fife, Nimal Wickramasinghe, Stephanie Harris, Ewan Hunter, Jayne Ellis, Benedict Rogers, Imogen Fordham, Elen Vink, Victoria Ward, Anna Smith, Andrew Rosser, Alison Muir, Ken Woodhouse, John Shone, Iain Crossingham, Ryan Jayesinghe, Eavan Muldoon, Avneet Shahi, Terry John Evans, Jeremy Wong, Eloisa MacLachlan, Amy Chue, Karishma Gokani, Katherine Ajdukiewicz, Lucinda Barrett, Frances Edwards, Adam Usher, Mairi McLeod, Su su Htwe, Grace Duane, Nicholas Wong, Jennifer Poyner, Jenni Crane, Ollie Lloyd, Emma Chisholm, Ildiko Kustos, Sam Sutton, M. Estee Torok, Isobel Ramsay, Monica Ivan, Joshua York, Jennifer Ansett, Maithili Varadarajan, Priya Sekhon, James Cruise, Shivani Kanabar, Mirella Ling, Charlotte Milne, Jayanta Sarma, Aline Wilson, Lynn Urquhart, Sahar Eldirdiri, Leila White, Jody Aberdein, Phillip Simpson, Hnin Hay Mar, Keying Tan, Eint Shwe Zin thein, Mahmoud Aziz, Anthony Cadwgan, Natasha Weston, Salman Zeb, Angela Houston, Louise Wootton, Iona Willingham, Aimee Johnson, Ashley Horsley, Eamonn Trainor, Olivier Gaillemin, Nicholas J Norton, Katie Cheung, Megan Duxbury, Emilie Bellhouse, Helena Brezovjakova, Kanitkar Tanmay, Alexsander Dawidziuk, Razan Saman, Hugh Adler, Elshadai Ejere, Yiwen Soo, Wendy Beadles, Heather Sturgeon, Brodie Cameron, David Chadwick Ben Tomlinson, Claire McGoldrick, Katie McDowell, Mpho Molosiwa, Katherine FlackAdrian Kennedy, Phoebe Cross, Fay Perry, Vithusha Inpadhas, Sarathy Selvam, Vhairi Bateman, Henry Wu, Monika Pasztor, Ajanthiha Karunakaran, Basma Soliman, Andrew Blanshard, Harish Reddy, Helen Chesterfield, Ben Schroeder, Tee Keat Teoh, Sathyavani Subbarao, Caryn RosmarinLucy Bell, Emma McGuire, Robert Serafino, Ishaan Bhide, Karanjeet Sagoo, Indran Balakrishnan, Kajal Patel, Barzo Faris, Graeme Calver, Ricky Singh, Hazel Sanghvi, Mohamed Eltayeb, Rathur Haris

“…Objectives To assess practice in the care of adults with suspected community-acquired bacterial meningitis in the UK and Ireland.Design Retrospective cohort study.Setting 64 UK and Irish hospitals.Participants 1471 adults with community-acquired meningitis of any aetiology in 2017.Results None of the audit standards, from the 2016 UK Joint Specialists Societies guideline on diagnosis and management of meningitis, were met in all cases. …”
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Letter to the editor regarding the response to “Multidisciplinary consensus-based statement on the current role of Middle Meningeal Artery embolization (MMAE) in chronic SubDural Hematoma (cSDH)” by M. Foppen, W.P. Vandertop, D. Verbaan

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Evaluation of low cryptococcal antigen titer as determined by the lateral flow assay in serum and cerebrospinal fluid among HIV-negative patients: a retrospective diagnostic accura... by Xuan Wang, Jia-Hui Cheng, Ling-Hong Zhou, Jun-Hao Zhu, Rui-Ying Wang, Hua-Zhen Zhao, Ying-Kui Jiang, Li-Ping Huang, Ching-Wan Yip, Chun-Xing Que, Min Zhu, Li-Ping Zhu

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Clinical performance of real-time nanopore metagenomic sequencing for rapid identification of bacterial pathogens in cerebrospinal fluid: a pilot study by Yoon Hyun Sung, Yong Kuk Ju, Hak Jun Lee, Seung Min Park, Jin Woong Suh, Jeong Yeon Kim, Jang Wook Sohn, Young Kyung Yoon

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Anaesthetic management of infant with occipital encephalocele associated with Arnold Chiari III malformation - A Case Report by Vandana Patilbuwa Pakhare, K. Naga Sri Sowmya, Mohammed Mohsin Ali, Reshma Sultana, Doli Suresh Chander

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Pradofloxacin Minimum Inhibitory Concentration Profiling of <i>Streptococcus suis</i> Isolates: Insights into Antimicrobial Susceptibility in Swine by Jessica Risser, Ronald Tessman, Don Bade, Orhan Sahin, Maria J. Clavijo, Saumya Dhup, Patrick Hoffmann

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Review of the aetiologies of central nervous system infections in Vietnam by Hannah E. Brindle, Hannah E. Brindle, Marc Choisy, Marc Choisy, Robert Christley, Neil French, Michael Griffiths, Pham Quang Thai, H. Rogier van Doorn, H. Rogier van Doorn, Behzad Nadjm, Behzad Nadjm

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Combination of metagenomic next-generation sequencing and morphology for identifying Coccidioides immitis: a case report by Hong Liu, Kaixin Zhou, Chaoran Zhong, Ming Guan

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Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tuberculous meningitis [version 1; peer review: 2 approved, 1 approved with reservations] by Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

Subjects: “…tuberculous meningitis…”
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Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tuberculous meningitis [version 2; peer review: 2 approved, 1 approved with reservations] by Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

Subjects: “…tuberculous meningitis…”
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A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons by Joon Pio Hong, Wei F. Chen, Dung H. Nguyen, Qingping Xie

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Neuroinvasive Infection from O117:K52:H-Escherichia coli following Acute Pyelonephritis by H. Cromlin, H. Rodriguez-Villalobos, A. Deplano, T. Duprez, P. Hantson

“…Spontaneous or nosocomial Escherichia coli meningitis remains rare in healthy adults but is still carrying a high mortality rate despite adapted antimicrobial treatment for susceptible strains. …”
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Cryptococcal cerebrospinal fluid shunt infection treated with fluconazole by Daniel Eymard, François Lebel

“…A 37-year-old woman with a cadaveric renal allotransplantation required intra-cranial shunting devices after a presumptive episode of tuberculous meningitis. Six months later, she developed a culture-proven cryptococcal meningitis. …”
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