Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. by Amanda L Kauffman, Jasmine M Ashraf, M Ryan Corces-Zimmerman, Jessica N Landis, Coleen T Murphy

“…Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improves memory performance early in adulthood and maintains learning ability better with age but, surprisingly, demonstrates no extension in long-term memory with age. By contrast, eat-2 mutants, a model of Dietary Restriction (DR), exhibit impaired long-term memory in young adulthood but maintain this level of memory longer with age. …”
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ERP and Behavioral Effects of Physical and Cognitive Training on Working Memory in Aging: A Randomized Controlled Study by Patrick D. Gajewski, Michael Falkenstein

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A semantic strength and neural correlates in developmental dyslexia by Sladjana Lukic, Sladjana Lukic, Sladjana Lukic, Fei Jiang, Maria Luisa Mandelli, Maria Luisa Mandelli, Ting Qi, Sarah M. Inkelis, Sarah M. Inkelis, Emily Rosenthal, Emily Rosenthal, Zachary Miller, Zachary Miller, Emma Wellman, Emma Wellman, Silvia A. Bunge, Silvia A. Bunge, Silvia A. Bunge, Maria Luisa Gorno-Tempini, Maria Luisa Gorno-Tempini, Christa Watson Pereira, Christa Watson Pereira

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Age-Related Decrease in the Schaffer Collateral-Evoked EPSP in Awake, Freely, Behaving Rats by C. A. Barnes, G. Rao, G. Orr

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Exploring cognitive and neuroimaging profiles of dementia subtypes of individuals with dementia in the Democratic Republic of Congo by Jean Ikanga, Jean Ikanga, Saranya Sundaram Patel, Saranya Sundaram Patel, Megan Schwinne, Caterina Obenauf, Caterina Obenauf, Emmanuel Epenge, Guy Gikelekele, Nathan Tshengele, Immaculee Kavugho, Samuel Mampunza, Lelo Mananga, Charlotte E. Teunissen, Julio C. Rojas, Brandon Chan, Argentina Lario Lago, Joel H. Kramer, Adam L. Boxer, Andreas Jeromin, Emile Omba, Alvaro Alonso, Alden L. Gross

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Nonfluent/Agrammatic PPA with In-Vivo Cortical Amyloidosis and Pick’s Disease Pathology by Francesca Caso, Benno Gesierich, Maya Henry, Manu Sidhu, Amanda LaMarre, Miranda Babiak, Bruce L. Miller, Gil D. Rabinovici, Eric J. Huang, Giuseppe Magnani, Massimo Filippi, Giancarlo Comi, William W. Seeley, Maria Luisa Gorno-Tempini

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DNA methylation, histone acetylation in the regulation of memory and its modulation during aging by Padmanabh Singh, Vijay Paramanik

“…Dysregulation of synaptic plasticity gene expression affects memory during aging and neurodegenerative diseases. Covalent modifications such as methylation on DNA and acetylation on histones regulate the transcription of synaptic plasticity genes. …”
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Amyloid Imaging in Aging and Dementia: Testing the Amyloid Hypothesis In Vivo by G. D. Rabinovici, W. J. Jagust

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A 15-Item modification of the PSP rating scale to improve clinical meaningfulness and statistical performance by Tien Dam, Lili Yang, Colin Gillis, Yumeng Li, John O’Gorman, Barbara Kolb, Adam L. Boxer, Lawrence Golbe, Samantha Budd Haeberlein, On behalf of the AL-108-231, PROSPERA, and 4RTNI investigators

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Treatment for Apraxia of Speech in Nonfluent Variant Primary Progressive Aphasia by M. L. Henry, M. V. Meese, S. Truong, M. C. Babiak, B. L. Miller, M. L. Gorno-Tempini

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Aspects of Growth Hormone and Insulin-Like Growth Factor-I Related to Neuroprotection, Regeneration, and Functional Plasticity in the Adult Brain by N. David Åberg, Katarina Gustafson Brywe, Jörgen Isgaard

“…The functional role of GH and IGF-I in the adult brain will be reviewed with reference to neurotransmitters, glucose metabolism, cerebral blood flow, gap junctional communication, dendritic arborization, exercise, enriched environment, depression, learning, memory, and aging.Briefly, these findings suggest that IGF-I functions as a putative regenerative agent in the adult CNS. …”
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Feasibility and psychometric quality of smartphone administered cognitive ecological momentary assessments in women with metastatic breast cancer by Ashley M Henneghan, Emily W Paolillo, Kathleen M Van Dyk, Oscar Y Franco-Rocha, Soyeong Bang, Rebecca Tasker, Tara Kaufmann, Darren Haywood, Nicolas H Hart, Raeanne C Moore

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Insulin in Central Nervous System: More than Just a Peripheral Hormone by Ana I. Duarte, Paula I. Moreira, Catarina R. Oliveira

“…Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may constitute a promising therapy against diabetes- and age-related neurodegenerative disorders. …”
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Sex in aging matters: exercise and chronic stress differentially impact females and males across the lifespan by D. Gregory Sullens, Kayla Gilley, Kayla Gilley, Luke E. Moraglia, Luke E. Moraglia, Sarah Dison, Jessica T. Hoffman, Madison B. Wiffler, Madison B. Wiffler, Robert C. Barnes, Robert C. Barnes, Annie T. Ginty, Melanie J. Sekeres, Melanie J. Sekeres

“…Running increased survival of BrdU-labelled hippocampal cells in both young and aged mice, and enhanced spatial memory in aged mice. These findings highlight the importance of considering sex when determining how aging is differently impacted by modifiable lifestyle factors across the lifespan.…”
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Comparison of age-related decline in C57BL/6J and CB6F1J male mice. by Gerald Yu Liao, Christina Pettan-Brewer, Warren Ladiges

“…In behavioral assays, C57BL/6J mice displayed superior performance in rotarod tasks but higher anxiety while CB6F1J mice exhibited a decline in short-term memory with age. Grip strength, long-term memory, and voluntary wheel running declined similarly with age in both strains. …”
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