Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis by Sandra M Herrmann, Riley Fadden, Ryan J Sullivan, Kerry L Reynolds, Harish Seethapathy, Meghan E Sise, Shruti Gupta, Alexandra-Chloe Villani, Qiyu Wang, Daiana Moreno, Destiny Harden, R Neal Smith, Ivy A Rosales, Robert B Colvin, Sarah Chute, Lynn D Cornell, Nancy J Yang, Sara Barmettler, Sophia Wells, Jocelyn Farmer

“…By peripheral blood flow cytometry analysis, lower absolute CD8+T cells, CD45RA+CD8+ T cells, memory CD27+B cells, and expansion of plasmablasts were prominent features of ICI-nephritis compared with ICI-treated controls. …”
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Medical Jousting: Going for the kill! by Dr.Fuad Ahmed Khan Niazi

“…A comment which might have touched a sensitive wire somewhere in your emotional memory, is an actual recollection of what I myself overheard once. …”
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Chemotherapy-induced cellular senescence promotes stemness of aggressive B-cell non-Hodgkin’s lymphoma via CCR7/ARHGAP18/IKBα signaling activation by Yangyang Wang, Fan Wu, Yang Wan, Huiping Wang, Linhui Hu, Qianshan Tao, Zhimin Zhai, Jiyu Wang, Keke Huang, Anwen Ren, Jinlan Li, Liuying Yi, Yanjie Ruan, Zhixiang Wanyan, Chaohong Liu

“…Finally, inhibitors GS143 and Y27632 were used to examine the effect of IKBα and ARHGAP/RhoA inhibition on B-NHL-TIS.Results Here we identified a distinct group of TIS, composed of memory B-cell population characterized by strong positive expression of CCR7, which was significantly elevated in TIS population compared with normal proliferating and autonomously senescent lymphoma cell populations. …”
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Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway by Ji-Ji Dao, Ji-Ji Dao, Wei Zhang, Wei Zhang, Chong Liu, Chong Liu, Qian Li, Qian Li, Chen-Meng Qiao, Chen-Meng Qiao, Chun Cui, Chun Cui, Yan-Qin Shen, Yan-Qin Shen, Shuang-Xi Chen, Shuang-Xi Chen, Wei-Jiang Zhao, Wei-Jiang Zhao

“…Behavioral assessments were conducted to evaluate therapeutic efficacy in memory and cognitive functions. Immunofluorescence staining, western blot, and biochemical assays were primarily employed to assess changes in both senescence- and ferroptosis-related molecules in mouse hippocampal tissues in response to each treatment. …”
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Structural damage-driven brain compensation among near-centenarians and centenarians without dementia by Hui Tang, Haichao Zhao, Hao Liu, Jiyang Jiang, Nicole Kochan, Jing Jing, Henry Brodaty, Wei Wen, Perminder S. Sachdev, Tao Liu

“…The strongest effects were found between attention and somatomotor network (SMN) (r=0.397, p<0.001), memory and SMN (r=0.333 p<0.001), fluency and visual network (VIS) - control network (CN) (r=0.406, p<0.001), language and VIS (r=0.309, p<0.001), visuospatial ability and VIS-default mode network (DMN) (r=0.464, p<0.001), as well as global cognition and VIS-DMN (r=0.335, p<0.001). …”
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The expression of CCL17 and potential prognostic value on tumor immunity in thyroid carcinoma based on bioinformatics analysis by Xue Gu, Bingfeng Chen, Shengcan Zhang, Xinyu Zhai, Ying Hu, Hui Ye

“…Our findings showed that B cells naïve, T cells CD4 memory resting, T cells CD8, T cells regulatory (Tregs), and dendritic cells resting were the main immune components of THCA tumor microenvironment (TME). …”
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Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflamma... by Chaokai Yang, Enlong Zhao, Hu Zhang, Liqi Duan, Xinyue Han, Hongli Ding, Yan Cheng, Dengkun Wang, Dengkun Wang, Dengkun Wang, Xiaojing Lei, Xiaojing Lei, Xiaojing Lei, Yongchang Diwu, Yongchang Diwu, Yongchang Diwu

“…In vivo studies demonstrated that XXD improved spatial learning and memory abilities in SAMP8 mice, reduced the amount of Evans blue extravasation in brain tissues, modulated the BBB-associated P-gp/ECS axis, RAGE/LRP1 receptor system, as well as MRP2 and Mfsd2a proteins, and decreased the accumulation of Aβ in the brains of SAMP8 mice. …”
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Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial by Simon Valayer, Marie Alexandre, Mélanie Prague, Abdoul Habib Beavogui, Seydou Doumbia, Mark Kieh, Brian Greenwood, Bailah Leigh, Marie Poupelin, Christine Schwimmer, Samba O. Sow, Irina Maljkovic Berry, Jens H. Kuhn, Daniela Fusco, Natasha Dubois Cauwelaert, Deborah Watson-Jones, Rodolphe Thiébaut, Yves Lévy, Yazdan Yazdanpanah, Laura Richert, Edouard Lhomme

“…In combination with knowledge on memory response, characterization of the major determinants of immune response durability of both vaccinations may guide future EVD control protocols.Trial registration: ClinicalTrials.gov identifier: NCT02876328.…”
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Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…During CAR-T cell production culture, hMN-14 CAR-T cells exhibit a larger proportion of memory-like T cells, while M5A CAR-T cells showed a more differentiated phenotype, suggesting a greater tonic signal of M5A scFv. …”
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Real-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention by Shuyan Liu, Matthias Haucke, Rika Groß, Kay Schneider, Jaekyung Shin, Fabian Arntz, Patrick Bach, Tobias Banaschewski, Christian Beste, Lorenz Deserno, Ulrich Ebner-Priemer, Tanja Endrass, Marvin Ganz, Ali Ghadami, Marco Giurgiu, Andreas Heinz, Falk Kiefer, Reinhold Kliegl, Bernd Lenz, Marta Anna Marciniak, Andreas Meyer-Lindenberg, Andreas B. Neubauer, Michael Rapp, Michael N. Smolka, Jens Strehle, Rainer Spanagel, Gianna Spitta, Heike Tost, Henrik Walter, Hilmar Zech, Dominic Reichert, Markus Reichert

“…Using a Within-Person-Encouragement-Design and Just-In-Time-Adaptive-Interventions, we will manipulate the contexts of loneliness and alcohol craving with cognitive reappraisal and physical activity interventions against a control condition (working memory task). Results Recruitment started in June 2024, with data collection and processing expected by June 2027. …”
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Hypoxia-driven mobilization of altruistic cancer stem cells in platinum-treated head and neck cancer by Lekhika Pathak, Lekhika Pathak, Lekhika Pathak, Bidisha Pal, Bidisha Pal, Joyeeta Talukdar, Partha Jyoti Saikia, Sorra Sandhya, Wale Tasabehji, Wale Tasabehji, Hong Li, Jyotirmoy Phukan, Jyotirmoy Phukan, Anjan Bhuyan, Sanjukta Patra, Bikul Das, Bikul Das, Bikul Das, Bikul Das, Bikul Das

“…Previously, we identified a novel population of CSCs exhibiting an “altruistic” phenotype, sacrificing self-renewal to promote niche defense (tumor stemness defense, TSD), potentially protecting a dormant subpopulation of CSCs, the reawakening CSC (R-CSC) retaining stress memory. This TSD phenotype involves the activation of the MYC-HIF2α pathway and, importantly, is linked to a hypoxic tumor microenvironment. …”
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Image Segmentation Method of Chinese Yam Leaves in Complex Background Based on Improved ENet by LU Bibo, LIANG Di, YANG Jie, SONG Aiqing, HUANGFU Shangwei

“…PConv applied conventional convolution to only a portion of the input channels and left the rest of the channels unchanged, which reduced memory accesses and redundant computations for more efficient spatial feature extraction. …”
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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way by Wei Huang, Ji Zhou, Jia Li, Yakun Wan, Chao Hu, Meng Liu, Pan Xu, Feng Tang, Jianhua Sun, Xiaolu Yu, Yiru Long, Binfan Chen, Yongliang Tong, Mengwen Shan, Xiaomin Jia, Henglei Lu, Runqiu Chen, Jin Ren, Guangyi Jin, Likun Gong

“…After coupling to form dual-targeting NDCs, TLR7 agonists and PD-L1 nanobodies exerted synergistic antitumor effects and safety in either ‘hot’ or ‘cold’ tumor and early or advanced tumor models, reshaped the tumor immune microenvironment and induced antitumor immune memory. CD8+ T cells and natural killer cells were the main effector cells for NDCs to function. …”
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Multi-dimensional outcomes following extracorporeal cardiopulmonary resuscitation by Tharusan Thevathasan, Vanessa Wahl, Joshua Boettel, Megan Kenny, Julia Paul, Sophie Selzer, Abdulla Al Harbi, Eva-Maria Dorsch, Heinrich Audebert, Matthias Rose, Christoph Paul Klapproth, Sonia Lech, Katharina Schmitt, Steffen Desch, Ulf Landmesser, Ralf Westenfeld, Fabian Voss, Carsten Skurk

“…Despite normal neurological scores, 46% had memory issues, 39% struggled with daily organization, 52% had depression and 12% had suicidal thoughts. …”
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Corrigendum: Lack of Helios during neural development induces adult schizophrenia-like behaviors associated with aberrant levels of the TRIF-recruiter protein WDFY1 by Anna Sancho-Balsells, Anna Sancho-Balsells, Anna Sancho-Balsells, Anna Sancho-Balsells, Veronica Brito, Veronica Brito, Veronica Brito, Veronica Brito, Belissa Fernández, Belissa Fernández, Belissa Fernández, Belissa Fernández, Mónica Pardo, Mónica Pardo, Mónica Pardo, Mónica Pardo, Marco Straccia, Marco Straccia, Marco Straccia, Marco Straccia, Marco Straccia, Silvia Ginés, Silvia Ginés, Silvia Ginés, Silvia Ginés, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Isabel Hernández, Belén Arranz, Josep M. Canals, Josep M. Canals, Josep M. Canals, Josep M. Canals, Josep M. Canals, Albert Giralt, Albert Giralt, Albert Giralt, Albert Giralt, Albert Giralt

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MRD-driven phase 2 study of daratumumab, carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma by Manisha Bhutani, Myra Robinson, David Foureau, Shebli Atrash, Barry Paul, Fei Guo, Jason M. Grayson, Anna Ivanina-Foureau, Mauricio Pineda-Roman, Cindy Varga, Reed Friend, Christopher J. Ferreri, Xhevahire Begic, Sarah Norek, Tiffany Drennan, Michelle B. Anderson, James T. Symanowski, Peter M. Voorhees, Saad Z. Usmani

“…We observed that Dara-KRd strongly activated memory T cells, which was associated with an MRD-negative state post induction. …”
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A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…HK013-G1 enhanced antitumour immunity and induced durable antigen-specific immune memory to prevent rechallenged tumour growth, even at a dose as low as 1 mg/kg. …”
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Solar Energetic Particle Events Detected in the Housekeeping Data of the European Space Agency's Spacecraft Flotilla in the Solar System by Beatriz Sánchez‐Cano, Olivier Witasse, Elise W. Knutsen, Dikshita Meggi, Shayla Viet, Mark Lester, Robert F. Wimmer‐Schweingruber, Marco Pinto, Richard Moissl, Johannes Benkhoff, Hermann Opgenoorth, Uli Auster, Jos deBrujine, Peter Collins, Guido DeMarchi, David Fischer, Yoshifumi Futaana, James Godfrey, Daniel Heyner, Mats Holmstrom, Andrew Johnstone, Simon Joyce, Daniel Lakey, Santa Martinez, David Milligan, Elsa Montagnon, Daniel Müller, Stefano A. Livi, Timo Prusti, Jim Raines, Ingo Richter, Daniel Schmid, Peter Schmitz, Håkan Svedhem, Matt G. G. T. Taylor, Elena Tremolizzo, Dimitri Titov, Colin Wilson, Simon Wood, Joe Zender

“…In particular, energetic particles that impact detectors and subsystems on a spacecraft can be identified by certain housekeeping sensors, such as the Error Detection and Correction (EDAC) memory counters, and their effects can be assessed. …”
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Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation by Meritxell Boada-Pérez, Meritxell Boada-Pérez, Meritxell Boada-Pérez, Cristina Berastegui, Cristina Berastegui, Cristina Berastegui, Marta Erro, Marta Erro, Piedad Ussetti, Elena Crespo, Elena Crespo, Laura Donadeu, Laura Donadeu, Oriol Bestard, Oriol Bestard, Oriol Bestard, Gabriel Anguera, Amparo Solé, Ricardo Ponz Mir, Brian Molloy, Eva Revilla-López, Eva Revilla-López, Víctor Monforte, Víctor Monforte, Víctor Monforte, Susana Gómez-Ollés, Susana Gómez-Ollés, Susana Gómez-Ollés

“…All seronegative patients did not respond to either antigen.ConclusionsTherefore, over 20% of CMV seropositive LT candidates showed weak CMV-specific cellular immune responses despite detectable serological memory against CMV. This may be important in assessing the risk of developing a CMV infection after transplantation.…”
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Investigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective coho... by Stefanie Aeschbacher, David Conen, Diederick E Grobbee, Raphael Twerenbold, Thomas Lung, Theo Rispens, Jakob Kjellberg, Lorenz Risch, Martin Risch, Marianna Mitratza, Harald Renz, Spiros Denaxas, Billy Franks, Diederick Grobbee, Martina Rothenbühler, Janneke Wijgert, Santiago Montes, Richard Dobson, Hans Reitsma, Christian Simon, Titia Leurink, Charisma Hehakaya, Patricia Bruijning, Kirsten Grossmann, Ornella C Weideli, Marc Kovac, Fiona Pereira, Nadia Wohlwend, Corina Risch, Dorothea Hillmann, Daniel Leibovitz, Vladimir Kovacevic, Andjela Markovic, Paul Klaver, Timo B Brakenhoff, George S Downward, Ariel Dowling, Maureen Cronin, Brianna M Goodale, Brianna Goodale, Ornella Weideli, Regien Stokman, Hans Van Dijk, Eric Houtman, Jon Bouwman, Kay Hage, Lotte Smets, Marcel van Willigen, Maui Chodura, Niki de Vink, Tessa Heikamp, Timo Brakenhoff, Wendy van Scherpenzeel, Wout Aarts, Alison Kuchta, Antonella Chiucchiuini, Steve Emby, Annemarijn Douwes, George Downward, Nathalie Vigot, Pieter Stolk, Duco Veen, Daniel Oberski, Amos Folarin, Pablo Fernandez Medina, Eskild Fredslund

“…The developed long short-term memory (LSTM) based recurrent neural network (RNN) algorithm had a recall (sensitivity) of 0.73 in the training set and 0.68 in the testing set when detecting COVID-19 up to 2 days prior to SO.Conclusion Wearable sensor technology can enable COVID-19 detection during the presymptomatic period. …”
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