Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective by Stefano Sanduzzi Zamparelli, Alessandro Sanduzzi Zamparelli, Marialuisa Bocchino

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Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial) by Marie C. Hyslop, Diana E. Papaioannou, Robert Bolt, Matthew J. Wilson, Michael Bradburn, Janet Clarkson, Esther Herbert, Nicholas Ireland, Jennifer Kettle, Amanda Loban, Amy C. Norrington, Christopher Vernazza, Christopher Deery

“…Background: Poor recruitment is one key reason for premature closure of randomised controlled trials. The Melatonin for Anxiety prior to General Anaesthesia In Children (MAGIC) trial was a multicentre randomised controlled trial of melatonin vs midazolam in the premedication of anxious children, before surgery. …”
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The expression of apoptosis-regulating proteins Bcl-2 and Bad in liver cells of C57Bl/6 mice under light-induced functional pinealectomy and after correction with melatonin by S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, A. Yu. Letyagin, M. A. Korolev, E. L. Zavjalov

Subjects: “…melatonin…”
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Bright night sleeping environment induces diabetes and impaired glucose tolerance in non-human primates by Shuxing Wang, Zhenyi Chen, Zihao Liang, Qiang Xu, Jiankai Zhang

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Delirium is one of the many faces of COVID-19. Literature review by A. Bagdonaitė, D. Tumas, E. Griškevičiūtė, A. Svirskytė

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Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparous women: the MyTIME study protocol by Miranda Davies-Tuck, Emily Callander, Mary Sharp, Scott W White, Dorota A Doherty, Jane Warland, Zoe Bradfield, Lesley Kuliukas, Monique Rose, Amber Pettitt, Kylie Ekin, JA Keelan

“…We will randomise 530 women to receive either 3 mg oral melatonin or placebo daily from 39+0 weeks’ gestation until they give birth. …”
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Insufficient Sleep Syndrome in Childhood by Teruhisa Miike

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Clinical and morphological features of gastroduodenal pathology at alcohol-induced liver disease by I. V. Kozlova, M. A. Suschenko

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The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? by Balahan Makay, Ozer Makay, Cigdem Yenisey, Gokhan Icoz, Gokhan Ozgen, Erbil Unsal, Mahir Akyildiz, Enis Yetkin

“…An inhibition of triiodothyronine and thyroxine was detected, as a result of melatonin administration. MDA, GSH, and NO•x levels were also affected by melatonin. …”
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The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy by Eduardo Spinedi, Daniel P. Cardinali

“…Melatonin therapy may protect against several metabolic syndrome comorbidities in polycystic ovary syndrome and could be applied from the initial phases of patients’ treatment.…”
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Effects of different monochromatic light on growth performance and liver circadian rhythm of Yangzhou geese by Yingqing Xu, Yi Tang, Yiyi Cheng, Wen Yang, Jie Liu, Binbin Guo, Gang Luo, Huanxi Zhu

“…The objective of this study is to examine the impact of monochromatic light on the circadian rhythms of blood melatonin and insulin-like growth factor 1 (IGF-1) levels, liver clock genes, and melatonin receptors. …”
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Sufentanil enhances the cortical neurogenesis of rats with traumatic brain injury via PI3K/AKT signal pathway by Wei Gu, Mimi Wu, Ruocui Zhang, Peiyu Liu, Yang Jiao, Hui Rong

“…The oxidative stress, inflammation, nerve cell damage, melatonin, brain-derived neurotrophic factor (BDNF), neuron regeneration and p-AKT protein level in the cortex were detected with ELISA, TUNEL, qRT-PCR, immunofluorescence and Western blot. …”
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Effects of multiples hormones on intraocular pressure: A narrative review by Ameenah A. Alkhaldi, Hanan G. Jamjoom, Sarah Alessa, Roaya Ayed Alsulami

“…The literature indicated that GH, IGF-1, progesterone, melatonin, testosterone, oxytocin, and estrogen were associated with reduced IOP. …”
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Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway by Ji-Ji Dao, Ji-Ji Dao, Wei Zhang, Wei Zhang, Chong Liu, Chong Liu, Qian Li, Qian Li, Chen-Meng Qiao, Chen-Meng Qiao, Chun Cui, Chun Cui, Yan-Qin Shen, Yan-Qin Shen, Shuang-Xi Chen, Shuang-Xi Chen, Wei-Jiang Zhao, Wei-Jiang Zhao

“…Both E4A and melatonin mitigated D-gal-induced aging in hippocampal neurons of mice. …”
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PAC-Mediated AKI Protection Is Critically Mediated but Does Not Exclusively Depend on Cell-Derived Microvesicles by H. Dihazi, K. Schwarze, S. Patschan, G. A. Müller, O. Ritter, M. Zeisberg, D. Patschan

“…Syngeneic murine PACs were stimulated with either melatonin, angiopoietin-1 or -2, or with bone morphogenetic protein-5 (BMP-5) for one hour, respectively. …”
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Synthesis and Anti-microbial Activities Investigation of New Mixed Ligand Complexes by Elaf A. Mousa, Basim I. Al-Abdaly

“…All chemicals were used strictly as provided, with no additional purification; CuCl2.2H2O and Ni(CH3CO2)2 salts were used to react with melatonin (L1), and one of the amino acids (L-cysteine) (L2) in a mole ratio of 1:1:1 (M: L1:L2) to produce mixed ligand metal complexes. …”
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The effect of nursing care provided to coronary intensive care patients according to their circadian rhythms on sleep quality, pain, anxiety, and delirium: a randomised controlled... by Meryem Pelin, Havva Sert

“…The post-test delirium score was higher in the control group compared to the intervention group (post-test ICDSC scores: intervention group 0.32 ± 0.48 vs. control group 1.18 ± 0.50, p < 0.001). Melatonin increased and cortisol decreased in both groups without statistically significant differences between them (melatonin and cortisol levels: p > 0.05). …”
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Analysis of the ASMT Gene Family in Pepper (Capsicum annuum L.): Identification, Phylogeny, and Expression Profiles by Luzhao Pan, Jiaqiu Zheng, Jia Liu, Jun Guo, Fawan Liu, Lecheng Liu, Hongjian Wan

“…Acetylserotonin methyltransferase (ASMT) in plant species, one of the most important enzymes in melatonin biosynthesis, plays a rate-limiting role in the melatonin production. …”
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Relationship of Morning Cortisol to Circadian Phase and Rising Time in Young Adults with Delayed Sleep Times by Mark S. Rea, Mariana G. Figueiro, Katherine M. Sharkey, Mary A. Carskadon

“…The results presented here are a secondary analysis of experimental data obtained from a study of advanced sleep-wake schedules and light exposures on circadian phase advances measured by dim-light melatonin onset (DLMO). The present results demonstrate that morning CAR is strongly related to rising time and more weakly related to DLMO phase.…”
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Calcium/Calmodulin-Dependent Kinases in the Hypothalamus, Pituitary, and Pineal Gland: An Overview by Vincenzo Cimini, Susan Van Noorden, Cristina Terlizzi, Giovanna Giuseppina Altobelli

“…We review the literature on the little-known roles of specific CaMKs in regulating endocrine functions of the pineal gland, the pituitary gland, and the hypothalamus. Melatonin activates hippocampal CaMKII, which then influences dendritogenesis. …”
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