Minimal sourced and lightweight federated transfer learning models for skin cancer detection by Vikas Khullar, Prabhjot Kaur, Shubham Gargrish, Anand Muni Mishra, Prabhishek Singh, Manoj Diwakar, Anchit Bijalwan, Indrajeet Gupta

“…Abstract One of the most fatal diseases that affect people is skin cancer. Because nevus and melanoma lesions are so similar and there is a high likelihood of false negative diagnoses challenges in hospitals. …”
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Effect of Adalimumab on Refractory Arthritis in Juvenile Idiopathic Inflammatory Myopathy with Anti-MDA5 Autoantibody by Takako Miyamae, Takuma Hara, Aki Hanaya, Yumi Tani, Takayuki Kishi, Hisashi Yamanaka

“…Chest CT was normal; the anti-melanoma differentiation-associated protein-5 (anti-MDA5) autoantibody was positive. …”
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Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts by Ersilia Alexa, Corina Danciu, Isidora Radulov, Diana Obistioiu, Renata Maria Sumalan, Adriana Morar, Cristina Adriana Dehelean

“…In terms of biological activity against MDA-MB-231 breast carcinoma cell line, and A375 human melanoma cell line, at the highest employed concentration, 150 μg·mL–1, the tested extracts present a weak antiproliferative effect.…”
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An Analysis of Biopsies for Suspected Skin Cancer at a Tertiary Care Dermatology Clinic in the Western Cape Province of South Africa by Johann de Wet, Minette Steyn, Henry F. Jordaan, Rhodine Smith, Saskya Claasens, Willem I. Visser

“…The most commonly occurring malignancies were basal cell carcinoma (BCC) (54.8%), squamous cell carcinoma (SCC) (18.9%), squamous cell carcinoma in-situ (SCCI) (8.0%), Kaposi’s sarcoma (KS) (6.7%), malignant melanoma (MM) (6.1%), and keratoacanthoma (KA) (4.6%). …”
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Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer by Begüm Çalım GÜRBÜZ, Tuçe Söylemez AKKURT, Handan EREN, Hazal İzol ÖZMEN, Ebru ŞEN, Burçin PEHLİVANOĞLU

“…Objective: Angiotropism/perivascular invasion (PVI) is an emerging topic in various types of cancer, with studies primarily focusing on melanoma. However, limited data are available on the significance of PVI in breast cancer. …”
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Bioadhesive Chitosan Films Loading Curcumin for Safe and Effective Skin Cancer Topical Treatment by Seila Tolentino, Mylene M. Monteiro, Felipe Saldanha-Araújo, Marcilio Cunha-Filho, Tais Gratieri, Eliete N. Silva Guerra, Guilherme M. Gelfuso

“…A cytotoxicity test on metastatic melanoma cells showed that curcumin at topical doses exerted activity similar to that delivered via the skin. …”
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NOL-7 serves as a potential prognostic-related biomarker for hepatocellular carcinoma by Qiucheng Lei, Yingchun Huang, Feiwen Deng, Huazhen Zheng, Xitao Hong, Peng Wang, Jin Lv, Huanwei Chen, Zhenling Ji

“…While the involvement of NOL7 in influencing the unfavorable prognosis of metastatic melanoma has been reported, its significance in predicting the prognosis of patients with Hepatocellular Carcinoma (HCC) remains unclear. …”
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Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies by Sahar Balkhi, Giorgia Bilato, Andrea De Lerma Barbaro, Paola Orecchia, Alessandro Poggi, Lorenzo Mortara

“…Interleukin-2 (IL-2)-based therapies have shown efficacy in cancers such as metastatic melanoma and renal cell carcinoma but are limited by severe side effects. …”
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Characterization of the Merkel Cell Carcinoma miRNome by Matthew S. Ning, Annette S. Kim, Nripesh Prasad, Shawn E. Levy, Huiqiu Zhang, Thomas Andl

“…MicroRNAs have been implicated in various skin cancers, including melanoma, squamous cell carcinoma, and basal cell carcinoma; however, the expression of microRNAs and their role in Merkel cell carcinoma (MCC) have yet to be explored in depth. …”
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A Micro-RNA Connection in BRafV600E-Mediated Premature Senescence of Human Melanocytes by Gang Ren, Jingwei Feng, Ila Datar, Aaron H. Yeung, Srinivas Vinod Saladi, Yongqing Feng, Ivana de la Serna, Kam C. Yeung

“…Gain-of-function mutations like those identified in melanoma frequently lead to enhanced cell-survival and unrestrained growth. …”
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Tumor mutation burden for predicting immune checkpoint blockade response: the more, the better by Ming Zheng

“…Only in cancer types with higher TMB (category I), such as melanoma, colorectal cancer, bladder cancer, and non-small cell lung cancer, the associations between TMB-H and ICB treatment outcomes were less affected by TMB cut-off selection. …”
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Pediatric and adolescent cancer disparities in the Middle East and North Africa (MENA) region: incidence, mortality, and survival across socioeconomic strata by Ankita Shukla, Rouba Karen Zeidan, Basema Saddik

“…Materials and methods Data on cancer incidence and mortality were drawn from the Global Burden of Disease Study (GBD) 2019 for all malignant neoplasms (including non-melanoma skin cancers). The analysis was restricted to children and adolescents aged less than 20 years. …”
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The COVID‐19 pandemic and associated declines in cancer incidence by race/ethnicity and census‐tract level SES, rurality, and persistent poverty status by Benmei Liu, Mandi Yu, Jeffrey Byrne, Katheen A. Cronin, Eric J. Feuer

“…Significantly larger PCs were observed for the lowest versus highest SES groups (prostate cancer), PP versus non‐PP groups (prostate and female breast cancer), and all urban versus rural areas (prostate, female breast, female and male lung, colon, cervix, melanoma, liver, bladder, and kidney cancer). Conclusions The COVID‐19 pandemic coincided with reduction in incidence rates in the U.S. in 2020 and was associated with worsening disparities among groups, including race/ethnicity, SES, rurality, and PP groups, across most cancer sites. …”
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Enhanced antitumor efficacy of STING agonist MSA-2 by lipid nanoparticles delivering circular IL-23 mRNA and platinum-modified MSA-2 combination by Tian He, Yating Li, Weiqi Li, Muqing Zhang, Guishuan Wang, Peng Zhou, Guoqi Song, Wenqing Li

“…Finally, the combination of LNP36@cIL-23 mRNA and MSA-2-Pt significantly decreased the melanoma B16F10 tumor and prolonged the survival, demonstrating significant anti-tumor effects. …”
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EUS-FNA Diagnosis with Core Biopsy of Pancreatic Metastases from Primary Breast Cancer by Samuel Galante Romanini, Juan Pablo Román Serrano, Juliana Silveira Lima de Castro, Isabela Trindade Torres, Alex Ingold, André Lucchiari Borini, Luiz Augusto Sanches Zulske, Maria Bruna Feitosa Matias, Jéssica Said de Marchi, José Andrés Sanchez Pulla, José Celso Ardengh

“…The most commonly reported primary sites for pancreatic metastases are the kidneys, lungs, breast, bowel, and skin (melanoma). Case Summary. The authors report a case of pancreatic metastasis derived from a primary breast cancer that underwent endoscopic ultrasound fine-needle aspiration (EUS-FNA) core biopsy to obtain tissue, which made it possible to perform an immunohistochemical study. …”
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Carbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging by Zhang Y, Liu F, Shao C, Huang J, Yan G

“…The cellular uptake, cytotoxicity, and fluorescence imaging ability were evaluated.Results: Experiment results indicated that SD-PHEA-NI has low cytotoxic to Henrietta Lacks (HeLa) cells. Moreover, B16F10 melanoma cells can take up SD-PHEA-NI and show good green fluorescent images. …”
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A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines by Linghong Huang, Xinyuan Sun, Qinhua Zuo, Ting Song, Ning Liu, Zonghua Liu, Wei Xue

“…Bromodomain-containing protein 4 (BRD4) is a key protein that drives the development of malignant melanoma and is closely associated with the ferroptosis signaling pathway. …”
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Optimizing ibrutinib bioavailability: Formulation and assessment of hydroxypropyl-β-cyclodextrin-based nanosponge delivery systems by Sunitha Sampathi, Nitiraj Kulkarni, D.V.R.N. Bhikshapathi, Jagadish V. Tawade, Nainaru Tarakaramu, Rzgar Farooq Rashid, Aziz Kubaev

“…Conclusion: IBR-loaded HPβCD NSPs offer a promising strategy for improved drug release and bioavailability, which could significantly benefit melanoma treatment.…”
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Concurrent Viewing of H&E and Multiplex Immunohistochemistry in Clinical Specimens by Larry E. Morrison, Tania M. Larrinaga, Brian D. Kelly, Mark R. Lefever, Rachel C. Beck, Daniel R. Bauer

“…<b>Results:</b> Application is made to several clinically relevant specimens, including breast cancer (HER2, ER, and PR), prostate cancer (PSMA, P504S, basal cell, and CD8), Hodgkin’s lymphoma (CD15 and CD30), and melanoma (LAG3). Additionally, invisible chromogenic IHC was combined with conventional DAB IHC to present a multiplex IHC assay with unobscured DAB staining, suitable for visual interrogation. …”
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Single-Stage Orbital Socket Reconstruction Using the Oversized Dermis Fat Graft and the 22 mm Silicone Orbital Implant after an Extended Enucleation by Biljana Kuzmanović Elabjer, Mladen Bušić, Daliborka Miletić, Mirjana Bjeloš, Borna Šarić, Damir Bosnar

“…We would like to present a surgical technique of orbital socket reconstruction using oversized dermis fat graft and 22 mm silicone orbital implant in a single-stage after extended enucleation in two patients with massive local recurrence of anteriorly located choroidal melanoma previously treated with endoresection. Orbital tissues en bloc were removed leaving conjunctival lining only at the fornices. …”
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