Effect of 5-Aminolevulinic Acid on the Quality and Volatile Metabolites of Korla Fragrant Pear Fruit by SUN Tianyu, WEN Bo, WANG Chunfeng, TIAN Jia, HAO Zhichao, LIN Yan, WEN Yue, ZHANG Feng

“…Among them, α-farnesene, 4-[((1E)-1,5-dimethyl-1,4-hexanedi-1-yl]-1-methyl-cyclohexene, δ-cadinene, (E)-1-methyl-4-(6-methylhept-5-en-2-ylidene) cyclohex-1-ene and germacrene B were annotated as key compounds to this pathway, which together endowed Korla fragrant pears with special citrus-like, lavender, lemony, astringent, thyme-like, spicy, earthy, non-medicinal and orange flower-like flavors. In conclusion, it is demonstrated that the exogenous application of 5-ALA significantly improved the quality of Korla fragrant pear fruit, the effect being most pronounced at 5-ALA concentration of 150 mg/L.…”
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New methods of treatment for severe and moderate postoperative pain syndrome in patients with cancer by D.V. Dmytriiev, M.M. Barsa

“…Objective: to evaluate the clinical efficacy and safety of a medicinal product with active ingredient dinalbuphine sebacate (150 mg/2 ml) in patients with moderate to severe pain syndrome following reconstructive mammoplasty due to breast cancer surgery. …”
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Anti-breast cancer activity of some novel quinoline derivatives by Ghorab Mostafa M., Alsaid Mansour S.

“…To discover new bioactive lead compounds for medicinal purposes, 2-cyano-3-(4-substituted)-N-(quinolin-3-yl) acrylamide derivatives 2–24, chromenes 25, 26 and benzochromenes 27, 28 were synthesized. …”
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Mechanism of melanoma suppression by Prosopis juliflora derived alkaloids: Apoptosis induction and signaling pathway inhibition by Jasoda Choudhari, Snehal K. Nimal, Shridhar Chougule, Trupti Shinde, N.R. Dhatrak, Gopal C. Kundu, Rajesh N. Gacche

“…Background: Traditional medicines remain integral to healthcare worldwide especially in developing countries. …”
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PHARMACEUTICAL CARE OF ACNE PATIENTS USING SYSTEMIC RETINOIDS by Yuliya Nastyukha, Andriy Zimenkovsky, Diana Klapko

“…The objects of the study: relevant information sources; current standards of pharmacotherapy, instructions for medical use of isotretinoin of the State Register of Medicines of Ukraine (n=4), 14th edition of the State Drug Formulary; questionnaires of acne patients who use systemic retinoids (n=53); pharmacy quotes for isotretinoin drugs and laboratory quotes for liver biopsy and lipid testing. …”
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Severe subcutaneous infection with Clostridium septicum in a herd of native Icelandic horses by Charlotta Oddsdóttir, Ólöf G. Sigurðardóttir, Vala Friðriksdóttir, Vilhjálmur Svansson, Birkir Þór Bragason, Sigríður Björnsdóttir

“…Clostridial infections of equine muscle or subcutis following injection with medicinal products have been described in other countries but have never been reported in Iceland. …”
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Multicentre adaptive randomised trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin versus calcineurin inhibitor-based or sirolimu... by Simon Gates, Matthew Collin, Victoria Potter, Rebecca Bishop, Ronjon Chakraverty, Kavita Raj, Adrian Bloor, Andrea Hodgkinson, Jeff Davies, Emma Kempshall, Fiona Dignan, Ram Malladi, Siobhan Smith, Charlotte Gaskell, Gabrielle Smith

“…Secondary outcomes include cumulative incidence of acute grade II-IV GvHD at 1 year, cumulative incidence of moderate and severe chronic GvHD at 1 year, overall survival at 1 year and cumulative incidence of non-relapse mortality at 1 year.Ethics and dissemination The protocol was approved by the West Midlands, Edgbaston Research Ethics Committee (20/WM/0195); initial approval was received on 11 September 2020, current protocol version (V.4.0) approval on 25 July 2023. The Medicines and Healthcare products Regulatory Authority also approved all protocol versions. …”
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Crystal structure of 5-(adamantan-1-yl)-3-[(4-trifluoromethylanilino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione, C20H22F3N3OS by Al-Wahaibi Lamya H., Ghabbour Hazem A., Al-Omary Fatmah A. M., Tiekink Edward R. T., El-Emam Ali A.

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Simple Meets Single: The Application of CRISPR/Cas9 in Haploid Embryonic Stem Cells by Zixi Yin, Lingyi Chen

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Crystal structure of 3,5-bis((E)-4-methoxy-2-(trifluoromethyl)benzylidene)-1-methylpiperidin-4-one, C24H21F6NO3 by Zhou Xia, Sun Zhong-Hao, Shan Guang-Zhi, Meng Qing-Guo

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Stability and Bioaccessibility of β-Arbutin in Simulated Digestion Conditions by Łukasz Sęczyk, Danuta Sugier, Piotr Sugier

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Development and Validation of a Derivative Spectrophotometric Method for Simultaneous Determination of Simvastatin and Ezetimibe by Effat Souri, Masoud Amanlou

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Lipid‐coated bismuth nanoflower as the thermos‐radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation by Shushu Xue, Junrong Jiao, Si Miao, Lijun Wang, Yang Liu, Qingjie Zhang, Qiyue Wang, Yu Xi, Yuanyuan Zhang

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Development of Spray-Dried Micelles, Liposomes, and Solid Lipid Nanoparticles for Enhanced Stability by Shradha Dattani, Xiaoling Li, Charina Lampa, Amanda Barriscale, Behzad Damadzadeh, David Lechuga-Ballesteros, Bhaskara R. Jasti

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Preparation of Iron Oxide and Titania-Based Composite, Core-Shell Populated, Nanoparticulates Material by Two-Step LASER Ablation in Aqueous Media as Antimicrobial and Anticancer A... by Hasan H. Bahjat, Raid A. Ismail, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Mohsen Al-Omar, Salman A. A. Mohammed, Riaz A. Khan

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Effect of Alkali Lignin on Laccase Activity and Mycelial Biomass of Flammulina velutipes by Mei-Ling Han, Yi-Lin Zhao, Tian-Yu Liu, Lu-Sen Bian, Zi-Han Li, Ming-Xue Li, Jia Li, Xiao-Qi Yang, Qi An

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Isoforsythiaside confers neuroprotection against Alzheimer’s disease by attenuating ferroptosis and neuroinflammation in vivo and in vitro by Chunyue Wang, Hongbo Jiang, Honghan Liu, Shanshan Chen, Hangyu Guo, Shuoshuo Ma, Weiwei Han, Yu Li, Di Wang

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Protocol to generate dual-target compounds using a transformer chemical language model by Sanjana Srinivasan, Jürgen Bajorath

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Rhizospheric Microflora Escalating Aroma Constituents and Yield Attributes in Ocimum tenuiflorum (L.) cv. CIM-Ayu by Shilpi Khare Saikia, Rakesh Pandey

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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

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