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SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
Published 2025-01-01Get full text
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Quality of life and its influencing factors in patients with gynecologic tumor (妇科肿瘤患者生存质量现状及影响因素调查研究)
Published 2021-04-01Get full text
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Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis
Published 2025-01-01“…Dong Zheng,1,* Tong Chen,2,* Kaiyuan Yang,1 Guangrong Yin,1 Yang Chen,3 Jianchao Gui,4 Chao Xu,1 Songwei Lv5 1Department of Orthopedics, The Affiliated Changzhou No.2 People’s Hospital with Nanjing Medical University, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, People’s Republic of China; 2Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 3Changzhou Productivity Development Center, Changzhou, People’s Republic of China; 4Department of Sports Medicine and Joint Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 5School of Pharmacy, Changzhou University, Changzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chao Xu; Songwei Lv, Email xuchao_06@163.com; lvsw@cczu.edu.cnIntroduction: Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degeneration. …”
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Ultrasonic/compound enzyme extraction, comparative characterisation and biological activity of Lonicera macranthoides polysaccharides
Published 2025-03-01“…Our findings demonstrate that the extraction method significantly influences the structural and functional properties of LMP, suggesting that UAE may be a more effective approach for extracting bioactive polysaccharides with potential applications in medicine and nutrition.…”
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A multiplex method for rapidly identifying viral protease inhibitors
Published 2025-01-01“…Among >100,000 compound-target interactions explored within our initial screen, a series of broad-acting inhibitors against coronavirus proteases were uncovered and validated through orthogonal assays. A medicinal chemistry campaign was performed to improve one of the inhibitor’s potency while maintaining its broad activity. …”
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Glucagon-Like Peptide-2 Analogue ZP1849 Augments Colonic Anastomotic Wound Healing
Published 2020-01-01Get full text
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Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives
Published 2025-02-01“…Abstract Background Because of their many bioactivities, which include psychoanalytic, antifungal, antihypertensive, anti-inflammatory, and antiviral properties, pyrazoles and their derivatives are attracting interest in pharmacology and medicine, the pressing need for novel fungicides is increased for lessened by the growing microbiological resistance of illnesses to recognized antibiotics. …”
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