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    Time Perception Test in IntelliCage System for Preclinical Study: Linking Depression and Serotonergic Modulation by Olga Sysoeva, Rauf Akhmirov, Maria Zaichenko, Ivan Lazarenko, Anastasiya Rebik, Nadezhda Broshevitskaja, Inna Midzyanovskaya, Kirill Smirnov

    Published 2025-01-01
    “…<b>Background/Objectives::</b> The link between serotonergic modulation and depression is under debate; however, serotonin reuptake inhibitors (SRIs) are still the first-choice medicine in this condition. Disturbances in time perception are also reported in depression with one of the behavioral schedules used to study interval timing, differential-reinforcement-learning-of-low-rate, having been shown to have high predictive validity for an antidepressant effect. …”
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  11. 52431

    Medication Belief and Adherence among Patients with Epilepsy by Yirga Legesse Niriayo, Abraham Mamo, Kidu Gidey, Gebre Teklemariam Demoz

    Published 2019-01-01
    “…The most common cause of nonadherence was forgetfulness (48.7%) followed by inability to get medicine (28.8) and safety concern (23.5%). The majority (78.4%) of the patients had high medication necessity belief while 44.1% had high concern belief about the potential adverse effect of their medications. …”
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    Theophylline Revisited. Mechanisms, Challenges, and New Horizons by Jakub Szarłowicz, Michał Mazur, Dorota Waz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła

    Published 2025-01-01
    “…Materials and Methods A detailed analysis of 23 peer-reviewed studies from scientific databases, including PubMed, focused on theophylline’s pharmacokinetics, pharmacodynamics, clinical safety, and novel applications in areas such as immunomodulation, metabolic disorders, and regenerative medicine. Results Theophylline shows anti-inflammatory effects, mitochondrial support, and modulation of key pathways (e.g., PI3K/Akt, NF-κB). …”
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    Erbin Regulates Tissue Factors Through Ras/Raf Pathway in Coagulation Disorders in Sepsis by Yang C, Lei C, Jing G, Xia Y, Zhou H, Wu D, Zuo J, Gong H, Wang X, Dong Y, Aidebaike D, Wu X, Song X

    Published 2025-02-01
    “…Cheng Yang,1,&ast; Chuntian Lei,1,&ast; Guoqing Jing,1 Yun Xia,1 Huimin Zhou,1 Die Wu,1 Jing Zuo,1 Hailong Gong,1 Xing Wang,1 Yingyue Dong,1 Delida Aidebaike,1 Xiaojing Wu,2 Xuemin Song1 1Research Centre of Anesthesiology and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, 430062, People’s Republic of China; 2Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaojing Wu; Xuemin Song, Email RM000851@whu.edu.cn; xueminsong@whu.edu.cnBackground: Sepsis, as a clinically critical disease, usually induces coagulation disorders. …”
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  18. 52438

    Angesinenolide B, A Phthalide Dimeric Peroxide, Exerts Anti-Inflammatory Properties by Suppressing MAPK/STATs Signaling Pathways and ROS Production by Zhang L, Liu Y, Wang H, Guo S, Lv J

    Published 2025-02-01
    “…Laibin Zhang, Yuan Liu, Huanhuan Wang, Shuangyan Guo, Jieli Lv School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, People’s Republic of ChinaCorrespondence: Laibin Zhang; Jieli Lv, School of Pharmacy, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, Henan, 453003, People’s Republic of China, Email zhanglb@xxmu.edu.cn; jielilv2009@xxmu.edu.cnPurpose: Angesinenolide B (ASB), a phthalide dimer with a peroxy bridge, is uniquely isolated from Chinese medicine Angelica sinensis radix and demonstrates significant anti-inflammatory properties. …”
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