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  1. 43161

    Genome-wide CRISPR-based screen identifies E2F transcription factor 1 as a regulator and therapeutic target of aristolochic acid-induced nephrotoxicity by Ziqi Liu, Huan Gao, Guoliang Li, Yongjiang Yu, Mengxing Cui, Honghao Peng, Xinchao Guan, Xue Zhang, Zhihan Zhang, Xiaoyu Shen, Shen Chen, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Lili Liu, Qing Wang

    Published 2025-01-01
    “…Aristolochic Acid I (AAI) is widely present in traditional Chinese medicines derived from the Aristolochia genus and is known to cause significant damage to renal tubular epithelial cells. …”
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    Pre-Hospital Point-of-Care Troponin: Is It Possible to Anticipate the Diagnosis? A Preliminary Report by Cristian Lazzari, Sara Montemerani, Cosimo Fabrizi, Cecilia Sacchi, Antoine Belperio, Marilena Fantacci, Giovanni Sbrana, Agostino Ognibene, Maurizio Zanobetti, Simone Nocentini

    Published 2025-01-01
    “…<b>Background</b>: Thanks to the evolution of laboratory medicine, point-of-care testing (POCT) for troponin levels in the blood (hs-cTn) has been greatly improved in order to quickly diagnose acute myocardial infarction (AMI) with an accuracy similar to standard laboratory tests. …”
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    Direct anterior approach (DAA) vs. conventional approaches in total hip arthroplasty: A RCT meta-analysis with an overview of related meta-analyses. by Philip Lazaru, Simon Bueschges, Nikolai Ramadanov

    Published 2021-01-01
    “…We conducted risk of bias and level of evidence assessment in accordance with the Cochrane's Risk of Bias 2 tool and with the guidelines of the Centre for Evidence-Based Medicine. We estimated mean differences (MD) with 95% confidence intervals (CI) through fixed and random effects models, using the DerSimonian and Laird method. …”
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    Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease by Liu X, Zhang Y, Wang Y, Xu Y, Xia W, Liu R, Xu S

    Published 2025-02-01
    “…Xing Liu,1,&ast; Yuanyuan Zhang,1,&ast; Yan Wang,2,3,&ast; Yanfeng Xu,2,4,5 Wenhao Xia,2,5– 7 Ruiming Liu,4,5 Shiyue Xu2,5,6 1Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 3Health Management Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 4Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 5National - Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 6NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 7Department of Cardiovascular Medicine, Guangxi Hospital Division of The First Affiliated Hospital of Sun Yat-sen University, Nanning, Guangxi, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Shiyue Xu, Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China, Email xushy25@mail.sysu.edu.cn Ruiming Liu, Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China, Email liuruim@mail2.sysu.edu.cnPurpose: Inflammatory activation of immune cells plays a pivotal role in the development of coronary artery diseases (CAD). …”
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  14. 43174

    Sex-specific analysis of individual and ski geometry-related risk factors for ACL injuries in recreational alpine skiing: A case-control study by Gerhard Ruedl, Martin Faulhaber, Markus Posch

    Published 2025-01-01
    “…British Journal of Sports Medicine, 56, 1104-1109. https://doi.org/10.1136/bjsports-2021-105221   …”
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