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    Ultrasonic/compound enzyme extraction, comparative characterisation and biological activity of Lonicera macranthoides polysaccharides by Mengdie Ren, Yiru Hou, Danli Peng, Hui Li, Xuxiang Zhang, Lei Qiao, XiaoShuang Wang, Yongmei Jiang, FaMing Wu, Gang Wang

    Published 2025-03-01
    “…Our findings demonstrate that the extraction method significantly influences the structural and functional properties of LMP, suggesting that UAE may be a more effective approach for extracting bioactive polysaccharides with potential applications in medicine and nutrition.…”
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    A multiplex method for rapidly identifying viral protease inhibitors by Seo Jung Hong, Samuel J Resnick, Sho Iketani, Ji Won Cha, Benjamin Alexander Albert, Christopher T Fazekas, Ching-Wen Chang, Hengrui Liu, Shlomi Dagan, Michael R Abagyan, Pavla Fajtová, Bruce Culbertson, Brooklyn Brace, Eswar R Reddem, Farhad Forouhar, J Fraser Glickman, James M Balkovec, Brent R Stockwell, Lawrence Shapiro, Anthony J O’Donoghue, Yosef Sabo, Joel S Freundlich, David D Ho, Alejandro Chavez

    Published 2025-01-01
    “…Among >100,000 compound-target interactions explored within our initial screen, a series of broad-acting inhibitors against coronavirus proteases were uncovered and validated through orthogonal assays. A medicinal chemistry campaign was performed to improve one of the inhibitor’s potency while maintaining its broad activity. …”
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    Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives by Basma T. Abd-Elhalim, Ghada G. El-Bana, Ahmed F. El-Sayed, Ghada E. Abdel-Ghani

    Published 2025-02-01
    “…Abstract Background Because of their many bioactivities, which include psychoanalytic, antifungal, antihypertensive, anti-inflammatory, and antiviral properties, pyrazoles and their derivatives are attracting interest in pharmacology and medicine, the pressing need for novel fungicides is increased for lessened by the growing microbiological resistance of illnesses to recognized antibiotics. …”
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    Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China by Liu A, Li X, Zhang X, Chen K, Zou Z, Sun Y, Zhou J, Li Z, Wu X, Lv X, Li H, Guo Z, Li Y

    Published 2025-02-01
    “…Ao Liu,1 Xin Li,2 Xueyi Zhang,1 Keke Chen,3 Zhi Zou,4 Yongbing Sun,1 Jing Zhou,5 Zhonglin Li,4 Xiaoling Wu,6 Xue Lv,5 Hao Li,7 Zhiping Guo,8 Yongli Li5 1Department of Medical Imaging, People’s Hospital of Zhengzhou University, Zhengzhou, 450003, People’s Republic of China; 2Department of Medical Imaging, People’s Hospital of Henan University, Zhengzhou, 450003, People’s Republic of China; 3Department of Medical Imaging, Henan Provincial People’s Hospital, Xinxiang Medical College, Zhengzhou, 450003, People’s Republic of China; 4Department of Medical Imaging, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China; 5Department of Health Management, Henan Provincial Key Laboratory of Chronic Disease Health Management, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China; 6Department of Nuclear Medicine, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China; 7Department of Health Management, Fuwai Central China Cardiovascular Hospital, Zhengzhou, 451464, People’s Republic of China; 8Henan Provincial Key Laboratory of Chronic Disease Health Management, Fuwai Huazhong Cardiovascular Hospital, Zhengzhou, 450003, People’s Republic of ChinaCorrespondence: Yongli Li, Department of Health Management, Henan Provincial Key Laboratory of Chronic Disease Health Management, Henan Provincial People’s Hospital, Zhengzhou, 450003, People’s Republic of China, Email shyliyongli@126.comPurpose: The impact of hepatic lipid accumulation on hyperuricemia presents an intriguing research avenue, particularly in light of existing studies linking obesity with hyperuricemia. …”
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