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    TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer by Cui Chen, Zehong Chen, Jinze Zhao, Xinyun Wen, Hanming Yao, Zijin Weng, Huiping Xiong, Zongheng Zheng, Juekun Wu

    Published 2025-02-01
    “…Collectively, our findings suggest that TMEM45A may be a therapeutic target for overcoming palbociclib resistance, and exosomal siRNA delivery could be a viable strategy for precision medicine in HR+ breast cancer.…”
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  13. 41793

    Mapping decision-making pathways: Determination of intervention entry points for diagnostic tests in suspected serious infection [version 2; peer review: 2 approved] by Raasti Naseem, Sara Pretorius, Nicola Howe, Clare Lendrem, Cameron Williams, Enitan D Carrol, Philip Pallmann

    Published 2025-01-01
    “…Results Two use cases of rapid diagnostic tests for serious infection were identified; (1) in acute emergency medicine to decide on antimicrobial initiation and/or escalation of care, and (2) in hospitalised patients to monitor treatment response. …”
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    Optimizing Clinical Postgraduate Training: Perspectives of Postgraduate Alumni Regarding Their Residency Training at Mbarara University of Science and Technology, Uganda by Tibaijuka L, Atimango L, Kajjimu J, Owaraganise A, Kamukama N, Kato PK, Mugyenyi GR, Kayondo M, Boatin AA, Ngonzi J

    Published 2025-01-01
    “…Leevan Tibaijuka,1,2 Lorna Atimango,1 Jonathan Kajjimu,1 Asiphas Owaraganise,3 Nixon Kamukama,4 Paul Kalyebara Kato,1 Godfrey Rwambuka Mugyenyi,1 Musa Kayondo,1 Adeline Adwoa Boatin,5 Joseph Ngonzi1 1Department of Obstetrics and Gynecology, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda; 2Department of Obstetrics and Gynecology, Mbarara Regional Referral Hospital, Mbarara, Uganda; 3Clinical Division, Infectious Diseases Research Collaboration, Kampala, Uganda; 4Office of the Deputy Vice Chancellor Academic Affairs, Mbarara University of Science and Technology, Mbarara, Uganda; 5Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USACorrespondence: Leevan Tibaijuka, Department of Obstetrics and Gynecology, Mbarara University of Science and Technology, P.O. …”
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    Prediction and verification of the influence of the rs367781716 SN P on the interaction of ТАТА -binding protein with the promoter of the human АВСА9 gene by O. V. Arkova, I. A. Drachkova, T. V. Arshinova, D. A. Rasskazov, V. V. Suslov, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, L. K. Savinkova

    Published 2016-01-01
    “…The high-throughput sequencing project “1 000 Genomes” made it possible to catalog and utilize genetic loci and single nucleotide polymorphisms (SNPs) in medicine. Analysis of SNP markers (significantly frequent differences of individual genomes of patients from the reference human genome) allows physicians to optimize treatment. …”
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