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    Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies by Liu S, Li H, Xi S, Zhang Y, Sun T

    Published 2025-02-01
    “…Shuhan Liu,1– 3 Haisong Li,4 Shiwen Xi,1,2 Yuning Zhang,1,2,* Tianmeng Sun1,2,5,6,* 1Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 2National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, People’s Republic of China; 3Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 4Department of Neurosurgery, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 5International Center of Future Science, Jilin University, Changchun, People’s Republic of China; 6State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tianmeng Sun; Yuning Zhang, The First Hospital of Jilin University, 71 Xinmin St, Changchun, Jilin, People’s Republic of China, Email tsun41@jlu.edu.cn; zhangyuning@jlu.edu.cnAbstract: Given the complexity of the central nervous system (CNS) and the diversity of neurological conditions, the increasing prevalence of neurological disorders poses a significant challenge to modern medicine. These disorders, ranging from neurodegenerative diseases to psychiatric conditions, not only impact individuals but also place a substantial burden on healthcare systems and society. …”
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    Impact of Preoperative Daytime Sleepiness and Insomnia on Therapy Adherence and Neurostimulation Amplitude in Unilateral Hypoglossal Nerve Stimulation by Pordzik J, Ludwig K, Ruckes C, Gouveris H

    Published 2025-02-01
    “…Johannes Pordzik,1,* Katharina Ludwig,1,* Christian Ruckes,2 Haralampos Gouveris1 1Department of Otolaryngology/Head and Neck Surgery & Sleep Medicine Center, University Medical Center Mainz, Mainz, 55131, Germany; 2Interdisciplinary Center for Clinical Trials, University Medical Center Mainz, Mainz, 55131, Germany*These authors contributed equally to this workCorrespondence: Haralampos Gouveris, Email haralampos.gouveris@unimedizin-mainz.deIntroduction: Average adherence to hypoglossal nerve stimulation (HGNS) therapy is more than 5 h/night. …”
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