American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Score: a study protocol for the translation and validation of the Dutch language version by Cornelis H Van der Vlies, Esther M M van Lieshout, Michael H J Verhofstad, Duncan E Meuffels, A Siebe de Boer, Wim E Tuinebreijer, P Ted Den Hoed

“…Descriptive statistics (including floor and ceiling effects), internal consistency, construct validity, reproducibility (ie, test–retest reliability, agreement and smallest detectable change) and responsiveness will be assessed for the AOFAS DLV.Ethics and dissemination This study has been exempted by the Medical Research Ethics Committee (MREC) Erasmus MC (Rotterdam, the Netherlands). …”
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Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges by George Awuku Asare, Perpetua Dagadu, Samuel Adjei, Bernice Asiedu, Samkeliso Takaidza, Vivash Naidoo, Brodrick Amoah, Ifeoma Celestina Orabueze, Kwasi Bugyei

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The effect of preoperative deep breathing exercise with incentive spirometer initiated in the preoperative period on respiratory parameters and complications in patients underwent... by Hatice Öner Cengiz, Zeynep Uluşan Özkan, Eylem Gani

“…Data were collected with the Sociodemographic and Medical Data Form and Patient Follow-up Form (respiratory rate, oxygen saturation (SpO2) level, arterial blood gas parameters and posteroanterior chest X-ray were monitored with this form prepared by the investigators). The Medical Research Council Scale was used to determine the severity of dyspnea in the patients included in the study. …”
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Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes by Chee Wai Wong, Boon Wee Teo, Ecosse Lamoureux, Mohammad Kamran Ikram, Jie Jin Wang, E. Shyong Tai, Sunil Sethi, Tien Yin Wong, Charumathi Sabanayagam

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IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex by Tae Sik Goh, Yuna Jo, Byunghyuk Lee, Geona Kim, Hyunju Hwang, Eunhee Ko, Seung Wan Kang, Sae-Ock Oh, Sun-Yong Baek, Sik Yoon, Jung Sub Lee, Changwan Hong

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Translation, cross-cultural adaptation, and psychometric properties of the Finnish version of the Malocclusion Impact Questionnaire (MIQ) by Lucas Arrais Campos, Terhi Kaikkonen, Kaisa Ylitervo, Leena Ylikontiola, Anna- Sofia Silvola

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Comprehensive bioinformatics analysis identifies metabolic and immune-related diagnostic biomarkers shared between diabetes and COPD using multi-omics and machine learning by Qianqian Liang, Yide Wang, Zheng Li, Zheng Li, Zheng Li, Zheng Li

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Daily iron supplementation does not impact on prevalence of exclusive breastfeeding or growth in young breastfed Gambian infants by Sophie Moore, Carla Cerami, Isabella Stelle, Mamadou Bah, Hans Verhoef

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Prognostic Features and Potential for Immune Therapy in Metastatic Mismatch Repair‐Deficient Colorectal Cancer: A Retrospective Analysis of a Large Consecutive Population‐Based Pat... by Erkki‐Ville Wirta, Hanna Elomaa, Jukka‐Pekka Mecklin, Toni T. Seppälä, Marja Hyöty, Jan Böhm, Maarit Ahtiainen, Juha P. Väyrynen

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HBV DNA integration and somatic mutations in HCC patients with HBV-HCV dual infection reveals profiles intermediate between HBV- and HCV-related HCC by Chiao-Ling Li, Chia-Lang Hsu, You-Yu Lin, Ming-Chih Ho, Rey-Heng Hu, Sheng-Tai Tzeng, Ya-Chun Wang, Yasuhito Tanaka, Pei-Jer Chen, Shiou-Hwei Yeh

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Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE) by Jennifer Clough, Peter Irving, A Toby Prevost, Graham M Lord, Joana Vasconcelos, James B Canavan, Beverley Rodger, D Macallan

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Cloning, expression, and purification of fusion antigens MPT83 and ESAT6 from the local strain of Mycobacterium tuberculosis in Escherichia coli as a seed vaccine candidate against... by Rusdina Bte Ladju, Ahyar Ahmad, Abdul Karim, Rugaiyah Arfah, Rosana Agus, Najdah Hidayah, Muhammad Nasrum Massi, Astutiati Nurhasanah, Harningsih Karim, Irda Handayani

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The Predictive Factors of Acne Scarring and Post-Inflammatory Hyperpigmentation: A Retrospective Cohort Study by Alamri A, Alzahrani D, Alharbi G, Jan R, Alsubaie LA, Alghamdi A, Abualola AH, Jfri A

“…Awadh Alamri,1– 3 Dhaii Alzahrani,1,2 Ghadi Alharbi,1,2 Rami Jan,1,2 Lulu Abdullah Alsubaie,1,2 Amjad Alghamdi,1,2 Amal H Abualola,1,2 Abdulhadi Jfri1– 3 1College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; 2King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; 3Department of Dermatology, King Abdulaziz Medical City, Jeddah, Saudi ArabiaCorrespondence: Rami Jan, College of Medicine – Jeddah, King Saud bin Abdulaziz University for Health Sciences, P.O.Box.9515, Jeddah, 21423, Saudi Arabia, Email ramiqj@gmail.comIntroduction: Acne vulgaris, a prevalent dermatological condition, often results in long-term complications such as scarring and hyperpigmentation. …”
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Effects of the Proactive Interdisciplinary Self-Management (PRISMA) Program on Online Care Platform Usage in Patients with Type 2 Diabetes in Primary Care: A Randomized Controlled... by Esther du Pon, Nanne Kleefstra, Frits Cleveringa, Ad van Dooren, Eibert R. Heerdink, Sandra van Dulmen

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Comparison Between Topographic-Based and Manifest-Based Astigmatism Corrections in the Second (Visumax 800)-Generation Keratorefractive Lenticule Extraction Surgery: A Real-World S... by Chia-Yi Lee, Hung-Chi Chen, Shun-Fa Yang, Yi-Jen Hsueh, Chin-Te Huang, Jing-Yang Huang, Ie-Bin Lian, Chao-Kai Chang

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Effects of a cardiopulmonary rehabilitation programme on submaximal exercise in Tunisian patients with long-COVID19: A randomized clinical trial by Rania Kaddoussi, Hadhemi Rejeb, Amine Kalai, Eya Zaara, Naceur Rouetbi, Zohra Ben Salah Frih, Piotr Zmijewski, Helmi Ben Saad

“…Conducted as a single-blinded RCT, the study included Tunisian LC19Ps with persistent dyspnoea (i.e. modified medical research council (mMRC) level ≥2) at least three months postdiagnosis. …”
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Clinical Big Data and Deep Learning: Applications, Challenges, and Future Outlooks by Ying Yu, Min Li, Liangliang Liu, Yaohang Li, Jianxin Wang

“…The explosion of digital healthcare data has led to a surge of data-driven medical research based on machine learning. In recent years, as a powerful technique for big data, deep learning has gained a central position in machine learning circles for its great advantages in feature representation and pattern recognition. …”
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Safety and effectiveness of appropriately and inappropriately dosed rivaroxaban or apixaban versus warfarin in patients with atrial fibrillation: a cohort study with nested case–co... by Luis Alberto García Rodríguez, Pareen Vora, Luke Roberts, Gunnar Brobert, Samuel Fatoba, María Eugenia Sáez, Antonio González-Pérez

“…Objectives To investigate effects of appropriately and inappropriately dosed apixaban/rivaroxaban versus warfarin on effectiveness and safety outcomes in patients with non-valvular atrial fibrillation (NVAF).Design Cohort study with nested case–control analyses using primary care electronic health records (IQVIA Medical Research Data UK database).Setting UK primary care.Participants Patients aged ≥18 years with NVAF newly prescribed apixaban (N=14 701), rivaroxaban (N=14 288) or warfarin (N=16 175) between 1 January 2012 and 30 June 2018, and followed up to 31 December 2018.Primary and secondary outcome measures Incident cases of ischaemic stroke/systemic embolism (IS/SE) and intracranial bleeding (ICB). …”
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Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol by Andre Pascal Kengne, Eugene Sobngwi, Jean Jacques N Noubiap, Jobert Richie N Nansseu, Joël Fokom-Domgue, Eric V Balti

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Optimal treatment approach for intracranial germinoma: a systematic review and meta-analysis by Zhirui Zhou, Jiabing Liu, Qi Yue, Lingxiao Chen, Xiwei Zhang, Xin Lin, Lin Zheng, Enmin Wang, Yang Wang, Ying Mao

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