Immunotherapy of Brain Cancers: The Past, the Present, and Future Directions by Lisheng Ge, Neil Hoa, Daniela A. Bota, Josephine Natividad, Andrew Howat, Martin R. Jadus

“…Treatment of brain cancers, especially high grade gliomas (WHO stage III and IV) is slowly making progress, but not as fast as medical researchers and the patients would like. Immunotherapy offers the opportunity to allow the patient's own immune system a chance to help eliminate the cancer. …”
Get full text

Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…“Exploitation and the Enterprise of Medical Research,” in Exploitation and Developing Countries, ed. …”
Get full text

Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst by Tiina Kelkka, Juha Petteri Laurila, Outi Sareila, Peter Olofsson, Mikko Olavi Laukkanen, Rikard Holmdahl

Get full text

Chemical Application of Topological Indices in Infertility Treatment Drugs and QSPR Analysis by Sobia Sultana

“…The main challenges faced by medical researchers while producing novel drugs are time commitment, amplified costs, creating a safety profile for the medications, reduced solubility, and a lack of experimental data. …”
Get full text

Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome by Mohamed Asrih, François Mach, Alessio Nencioni, Franco Dallegri, Alessandra Quercioli, Fabrizio Montecucco

Get full text

Insulin Resistance: A Proinflammatory State Mediated by Lipid-Induced Signaling Dysfunction and Involved in Atherosclerotic Plaque Instability by Fabrizio Montecucco, Sabine Steffens, François Mach

Get full text

The Immune Response Is Involved in Atherosclerotic Plaque Calcification: Could the RANKL/RANK/OPG System Be a Marker of Plaque Instability? by Fabrizio Montecucco, Sabine Steffens, François Mach

Get full text

Recent progress on anti-cancer activity of thiadiazoles: A review by C.R. Santhosh, Sampath Chinnam, Nagaraju Kottam, S Amreen, Guddekoppa S. Ananthnag, G.M. Madhu, Samata Gadde, Viola Tressa Fernandes, Haritha Arnipalli

“…Despite the fact that several decades of medication research and discovery have produced a number of helpful chemotherapeutic drugs, the hunt for novel chemical entities with enhanced efficacy and safety is still ongoing. …”
Get full text

Why Are There So Many Ways to Measure Pain? Epistemological and Professional Challenges in Medical Standardization by Hanna Grol-Prokopczyk

“…How, then, do pain researchers—specifically, quantitative medical researchers whose work is predicated on transforming pain into numbers—measure pain in their studies? …”
Get full text

Review of statistical methods for survival analysis using genomic data by Seungyeoun Lee, Heeju Lim

“…Presently, since most clinicians and medical researchers can easily assess statistical programs for analyzing survival data, a review article is helpful for understanding statistical methods used in survival analysis. …”
Get full text

Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis by Aldo Bonaventura, François Mach, Aline Roth, Sébastien Lenglet, Fabienne Burger, Karim J. Brandt, Aldo Pende, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Franco Dallegri, Michele Cea, Nicolas Vuilleumier, Fabrizio Montecucco, Federico Carbone

Get full text

The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis: Evidence from Basic Research and Clinical Studies by Fabrizio Montecucco, Aldo Pende, François Mach

Get full text

Advanced Glycation End Products Play Adverse Proinflammatory Activities in Osteoporosis by Roberta Sanguineti, Alessandra Puddu, François Mach, Fabrizio Montecucco, Giorgio Luciano Viviani

Get full text

A RESEARCH ON SOCIAL MEDIA ADDICTION AND DOPAMINE DRIVEN FEEDBACK by Gamze Macit, Hüseyin Bilal Macit, Orhan Güngör

“…However, statistical and medical researches have made in recent years that this attractive media is addictive. …”
Get full text

An Emerging Role of Glucagon-Like Peptide-1 in Preventing Advanced-Glycation-End-Product-Mediated Damages in Diabetes by Alessandra Puddu, François Mach, Alessio Nencioni, Giorgio Luciano Viviani, Fabrizio Montecucco

Get full text

A comprehensive review on the plant sources, pharmacological activities and pharmacokinetic characteristics of Syringaresinol by Lei Zhang, Yuqing Tian, Lingling Zhang, Huanyu Zhang, Jinghua Yang, Yi Wang, Na Lu, Wei Guo, Liang Wang

“…Syringaresinol, a phytochemical constituent belonging to lignan, is formed from two sinapyl alcohol units linked via a β-β linkage, which can be found in a wide variety of cereals and medicinal plants. Medical researches revealed that Syringaresinol possesses a broad spectrum of biological activities, including anti-inflammatory, anti-oxidation, anticancer, antibacterial, antiviral, neuroprotection, and vasodilation effects. …”
Get full text

Update on the Role of Cannabinoid Receptors after Ischemic Stroke by Luciano S. A. Capettini, Silvia Q. Savergnini, Rafaela F. da Silva, Nikos Stergiopulos, Robson A. S. Santos, François Mach, Fabrizio Montecucco

Get full text

Adipose-Derived Mesenchymal Stem Cell Exosomes Suppress Hepatocellular Carcinoma Growth in a Rat Model: Apparent Diffusion Coefficient, Natural Killer T-Cell Responses, and Histopa... by Sheung-Fat Ko, Hon-Kan Yip, Yen-Yi Zhen, Chen-Chang Lee, Chia-Chang Lee, Chung-Cheng Huang, Shu-Hang Ng, Jui-Wei Lin

Get full text

Using machine learning to predict patients with polycystic ovary disease in Chinese women by Chen-Yu Wang, Dee Pei, Chun-Kai Wang, Jyun-Cheng Ke, Siou-Ting Lee, Ta-Wei Chu, Yao-Jen Liang

“…Nowadays, machine learning (Mach-L) emerges as a new method and can be used in medical researches. In the present study, there were two goals: 1. …”
Get full text

Intestinal Radiation-Induced Stricture Favours Small Bowel Obstruction by Phytobezoar: Report of a Case by Alessandra Quercioli, Franco Dallegri, Luciano Ottonello, Fabrizio Montecucco, Giacomo Borgonovo

Get full text