Clinical Utility of an Alzheimer’s Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study by Mark Monane, Demetrius M. Maraganore, Robert M. Carlile, Kim G. Johnson, David A. Merrill, Darren R. Gitelman, Kenneth S. Sharlin, Lawren A. VandeVrede, Kristi K. George, Jimin Wang, Tim West, Leslie Jacobs, Philip B. Verghese, Joel B. Braunstein

“…The composite primary endpoint, defined as a change in AD diagnostic certainty, drug therapy, or additional brain amyloid evaluation pre- and post-BBM testing, was 75% (<i>p</i> < 0.0001 versus the pre-specified threshold of 20% clinically meaningful change). Anti-AD medication orders decreased among negative APS2 patients and increased among positive APS2 patients (<i>p</i> < 0.0001). …”
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Effect of an Electronic Pill Bottle on Hydroxychloroquine Adherence in Pediatric Lupus: Results of a Novel Direct‐to‐Family Pilot Trial by Rachel L. Randell, Laura E. Schanberg, Claire Beard, Thomas Phillips, Christoph P. Hornik, Michael Cohen‐Wolkowiez, Stephen J. Balevic, with the CARRA Registry investigators

“…Secondary outcomes included plasma HCQ concentrations and Medication Adherence Self‐Report Inventory (MASRI) scores, collected during four home visits. …”
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Characterization of Clinical Isolates of Enterococci with Special Reference to Glycopeptide Susceptibility at a Tertiary Care Center of Eastern Nepal by Aasish Karna, Ratna Baral, Basudha Khanal

“…Enterococci, once considered as a harmless commensal of intestine, have now emerged as medically important pathogens and are associated with both community-acquired and nosocomial infections. …”
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Phytomedicine nanoformulations for Parkinson's disease by Chinthu V. Saji, K P Mohanakumar, Rajesh A Shenoi

“…Background: Current medications for Parkinson's disease (PD) primarily offer symptomatic relief, and often lead to adverse effects on long-term use. …”
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Assessing HIV/AIDS patients’ access to antiretroviral drugs using the healthcare accessibility framework: a cross-sectional study from Shandong, China by Zhixin Fan, Songlin Zheng, Weiming Cui, Chao Zheng, Qiang Sun, Jia Yin

“…For the ability to perceive, only 16.6% of respondents self-reported low knowledge of HIV progression and medication. For the ability to seek, 24.3% self-reported having experienced social discrimination, and 21.9% reported 'choosing not to seek health insurance reimbursement due to fear of privacy disclosure. …”
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Cost-savings and health impact of strategies for prevention of Respiratory Syncytial Virus with nirsevimab in Chile based on the integrated analysis of 2019–2023 national databases... by Denis Sauré, Miguel O’Ryan, Juan Pablo Torres, Natalia Trigo, Gonzalo Diaz, Marcel Goic, Charles Thraves, Jorge Pacheco, Patricio Aguilera, Andrea Caro, Leonardo J. Basso

“…We first characterize RSV burden among Chilean infants between 2019 and 2023, focusing on medically attended lower respiratory tract infections (MA LRTI), hospital admissions (HA LRTI), and severe cases requiring ICU admission (ICU LRTI). …”
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Cohort profile: Health in Central Denmark (HICD) cohort - a register-based questionnaire survey on diabetes and related complications in the Central Denmark Region by Annelli Sandbæk, Else-Marie Dalsgaard, Kasper Norman, Lasse Bjerg, Anders Aasted Isaksen

“…In addition to questionnaire data, the cohort is linked to nationwide registries that provide extensive data on hospital diagnoses and procedures, medication use and socioeconomic status decades before enrolment while laboratory registries has provided repeated measures of biochemical markers, for example, lipids, albuminuria and glycated haemoglobin up to 10 years before enrolment.Future plans The HICD will serve as an extensive resource for studies on patient-related information and inequality in type 1 diabetes and type 2 diabetes. …”
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Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysis by Bernd Bokemeyer, Leonarda Serdani-Neuhaus, Juliane Sünwoldt, Christina Dünweber, Svitlana Schnaidt, Detlef Schuppan

“…HCRU (hospitalisations, outpatient visits, medication use, sick leaves) and healthcare costs (outpatient services, inpatient services, outpatient pharmaceuticals, sick leaves and aids and remedies) were compared between CeD patients and controls. …”
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Methods to address functional unblinding of raters in CNS trials by Steven D. Targum, William P. Horan, Vicki G. Davis, Alan Breier, Stephen K. Brannan

“…Abstract Treatment-emergent adverse events (TEAEs) associated with the unique properties of a pharmaceutical product may functionally unblind clinician ratings, obscure true medication effects, and affect confidence about clinical trial results. …”
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Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression by Aditya Singh, Mandakh Bekhbat, David R. Goldsmith, Ngoc-Anh Le, Evanthia C. Wommack, Zhihao Li, Ebrahim Haroon, Jennifer C. Felger

“…To extend our previous findings on relationships between plasma lipids and antidepressant response to anti-cytokine therapy, we explored in secondary analyses whether lipid-related biomarkers similarly predicted change in anhedonia or functional connectivity (FC) in dopamine-rich corticostriatal reward circuitry in medically-stable, depressed patients with a range of inflammation levels (indexed by plasma C-reactive protein [CRP]) who were administered inflammation-targeted therapies. …”
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Thyrotoxicosis due to Gestational Trophoblastic Disease: Unmet Needs in the Management of Gestational Thyrotoxicosis by Kalyan Mansukhbhai Shekhda, Vladislav Zlatkin, Bernard Khoo, Eleni Armeni

“…The Burch–Wartofsky Point Scale scores were 20 and 15 points, respectively, suggesting that they were less likely to be in thyroid storm at presentation. Antithyroid medications were administered, followed by evacuation of the products of conception. …”
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Evaluation of the antidiabetic and antinephritic effects of Pueraria tuberosa and Pterocarpus santalinus extracts co-encapsulated in nanostructured lipid carriers in streptozotocin... by Gyamcho Tshering Bhutia, Asit Kumar De, Manas Bhowmik, Pavia Bera, Tanmoy Bera

“…New strategies and medications are needed to manage DN more effectively. …”
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Association between polypharmacy and falls in older adults: a longitudinal study from England by Nafeesa N Dhalwani, Melanie J Davies, Kamlesh Khunti, Harini Sathanapally, Radia Fahami, Sam Seidu

“…Further exploration of the effects of these complex drug combinations in the real world with a detailed standardised assessment of polypharmacy is greatly required along with pragmatic studies in primary care, which will help inform whether the threshold for a detailed medication review should be lowered.…”
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The Rate of Clinical Outcomes in Atrial Fibrillation according to Antithrombotic Strategy: The COOL-AF Registry by Rungroj Krittayaphong, Arjbordin Winijkul, Komsing Methavigul, Poom Sairat, C. O. O. L.-A. F. investigators

“…Clinical, laboratory, and medication data were collected at baseline and during follow-up. …”
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Use of amantadine in traumatic brain injury: an updated meta-analysis of randomized controlled trials by João Félix, Luísa Araújo, Antônio Henriques, Ana Pereira, Saul Carneiro

“…No other statistically significant results were found related to the use of this medication.Systematic review registration: https://www.crd.york.ac.uk/prospero/display_ record.php?…”
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Digital measurement of ocular microtremor in Parkinson's disease: Protocol for a pilot study to assess reliability and clinical validation. by Lisa Graham, Rodrigo Vitorio, Richard Walker, Alan Godfrey, Rosie Morris, Samuel Stuart

“…People with PD will be assessed both off, and on, their anti-parkinsonian medication following a 12 hour washout period. We will recruit 30 People with PD, 30 people with suspected PD and 30 age-matched healthy control participants for assessment of OMT. 20 People with PD will complete a test-retest reliability assessment at the same approximate time, exactly one week after their initial visit under the same conditions to explore consistency. …”
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HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related c... by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

“…The study will recruit 90 participants who will undergo serial clinical assessment over 12 months with advanced cardiovascular imaging (CMR scans with automated analysis at baseline, 6 and 12 months), cardiac biomarker measurement (six time points over 12 months), plus complete heart failure QoL and medication disutility questionnaires. This is the first multicentre study to address this significant clinical issue.Ethics and dissemination This study was approved by the research ethics committee (London—London Bridge, 23/LO/0152). …”
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Biomaterial-based strategies: a new era in spinal cord injury treatment by Shihong Zhu, Sijun Diao, Xiaoyin Liu, Zhujun Zhang, Fujun Liu, Wei Chen, Xiyue Lu, Huiyang Luo, Xu Cheng, Qiang Liao, Zhongyu Li, Jing Chen

“…Traditional approaches for spinal cord injury repair include surgery, oral or intravenous medications, and administration of neurotrophic factors; however, the efficacy of these approaches remains inconclusive, and serious adverse reactions continue to be a concern. …”
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Cyclophotocoagulation in Neovascular Glaucoma with Near-Total Synechial Angle Closure by Jessie Wang, Lindsay Y. Chun, Mary Qiu

“…Five patients did not require subsequent aqueous shunts through a mean follow-up of 15 months; most recent visual acuities ranged from 20/40 to LP, and IOPs ranged from 5 to 11 mmHg on 0 to 3 IOP-lowering medications. Three patients who required subsequent tubes had complete regression of active anterior segment NV at the time of surgery. …”
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Omega-3 supplements in the prevention and treatment of youth depression and anxiety symptoms: A scoping review. by Natalie M Reily, Samantha Tang, Ashlee Negrone, Daniel Z Q Gan, Veronica Sheanoda, Helen Christensen

“…<h4>Introduction</h4>Omega-3 supplements may be efficacious in reducing symptoms of depression and anxiety in adults, particularly as an adjunct to antidepressant medication. However, research in young people is limited. …”
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