LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress by Ying Yi, Min-Yu Wu, Kai-Tian Chen, An-Hai Chen, Lin-Qiu Li, Qin Xiong, Xian-Ren Wang, Wen-Bin Lei, Guan-Xia Xiong, Shu-Bin Fang

“…Abstract According to the World Health Organization, more than 12% of the world’s population suffers from noise-induced hearing loss (NIHL). Oxidative stress-mediated damage to the stria vascularis (SV) is one of the pathogenic mechanisms of NIHL. …”
Get full text

The mediating effect of self-efficacy and physical activity with the moderating effect of social support on the relationship between negative body image and depression among Chinese college students: a cross-sectional study by Ye Yuan, Yanling Tu, Yuqi Su, Lei Jin, Yu Tian, Xuesong Chang, Ke Yang, Haiyun Xu, Junyi Zheng, Daili Wu

“…Self-efficacy is an important mediator, and social support moderates adherence to physical exercise. …”
Get full text

Triptolide suppresses IL-1β-induced expression of interleukin-8 by inhibiting ROS-Mediated ERK, AP-1, and NF-κB molecules in human gastric cancer AGS cells by Shinan Li, Shinan Li, Dhiraj Kumar Sah, Archana Arjunan, Mohamed Yazeer Ameer, Bora Lee, Young-Do Jung

“…In this study, we showed that Triptolid inhibits ROS/ERK-mediated AP-1 and ROS-mediated NF-κB axes potentially leading to an improved treatment outcome for gastric cancer and its associated tumor microenvironment.…”
Get full text

Biogenic synthesis of silver nanoparticles/reduced graphene oxide (AgNPs/rGO) mediated Nephelium lappaceum leaf extract as an effective solid acid catalyst for liquid-phase benzene nitration by Dewi Yuanita Lestari, Akhmad Syoufian, Poedji Loekitowati Hariani, Amalia Kurnia Amin, Won-Chun Oh, Aldino Javier Saviola, Karna Wijaya

Get full text

Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition by Zhi-Hui Zhang, Hai-Xin Yan, Ming-Dong Liu, Feng-Wen Niu, Kai Yao, Shi-Yao Feng, Xi Li, Yuan-Hua Chen, Dong-Dong Xie

“…Akt is expected to be a potential therapeutic target for chronic arsenic exposure-mediated prostate cancer metastasis.…”
Get full text

Association between Healthy Eating Index-2020, alternative Mediterranean Diet scores, and gastrointestinal cancer risk in NHANES 2005–2018 by Weijie Wang, Yu Chang, Geng Chen

Subjects: Get full text

Antibodies to watch in 2024 by Silvia Crescioli, Hélène Kaplon, Alicia Chenoweth, Lin Wang, Jyothsna Visweswaraiah, Janice M. Reichert

Subjects: Get full text

Targeting TCMR-associated cytokine genes for drug screening identifies PPARγ agonists as novel immunomodulatory agents in transplantation by Lu Hu, Lu Hu, Xiaohan Zhang, Xiaohan Zhang, Weiqi Zhang, Weiqi Zhang, Shuai Jin, Shuai Jin, Jie Zhao, Jianming Zheng, Wenli Song, Zhongyang Shen, Zhongyang Shen, Zhongyang Shen

Subjects: “…T-cell-mediated rejection…”
Get full text

A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings by Steven P. Treon, Camille N. Kotton, David J. Park, Giorgia Moranzoni, Camilla K. Lemvigh, Joseph C. Gathe, Tilly A. Varughese, Christopher F. Barnett, Johnny M. Belenchia, Nina M. Clark, Charles M. Farber, Muhammad Bilal Abid, Gulrayz Ahmed, Christopher J. Patterson, Maria L. Guerrera, Jacob D. Soumerai, Vipheaviny A. Chea, Isabel P. Carulli, Jackson Southard, Shuqiang Li, Catherine J. Wu, Kenneth J. Livak, Eric Holmgren, Pil Kim, Carrie Shi, Holly Lin, Vanitha Ramakrishnan, Ying Ou, Scott Olszewski, Lars Rønn Olsen, Derin B. Keskin, Derin B. Keskin, Zachary R. Hunter, Christopher Tankersley, Todd Zimmerman, Binod Dhakal

Subjects: Get full text

Drawing on social approval as a linguistic strategy: A discourse semantic analysis of judgement evaluation in suspected online romance scammer dating profiles by Lee Kam-Fong, Chan Mei Yuit, Ali Afida Mohamad

Subjects: Get full text

Novel Cellulosic Fiber Composites with Integrated Multi-Band Electromagnetic Interference Shielding and Energy Storage Functionalities by Xuewen Han, Cheng Hao, Yukang Peng, Han Yu, Tao Zhang, Haonan Zhang, Kaiwen Chen, Heyu Chen, Zhenxing Wang, Ning Yan, Junwen Pu

Subjects: Get full text

How does the concentration of spatial allocation of urban construction land across cities affect carbon emission intensity in China? by Hui Yang, Cheng Chen, Jingye Li, Min Li, Stefan Sieber, Kaisheng Long

Subjects: Get full text

Research on the relationship between social support and academic self-efficacy among college students: a multivariate empirical analysis by Chunmei Chen, Yujie Zhu, Fanghao Xiao

Subjects: Get full text

Analyzing the Effect of Structural Differentiation and Inter-Organizational Relations on Organizational Ambidexterity with an Emphasis on the Mediating Role of the Organizational Platform to Increase Organizational Performance (Case Study: General Directorate of Sports and Youth of Ilam Province) by Peyman Akbari, Ali Karimi, Ibrahim Aeini

“…Purpose: This research aims to analyze the effect of structural differentiation and inter-organizational relations on organizational ambidexterity, emphasizing organizational content's mediating role in increasing organizational performance.Methodology: The current research is applied in terms of purpose and descriptive survey in nature and method. …”
Get full text

Prolyl 4‐hydroxylase α‐subunit family regulation of type I collagen deposition and IL17RB/c‐Jun activation synergistically mediate choline dehydrogenase promotion of colorectal cancer metastasis by Xiaowen Yang, Yifei Li, Xinzhuang Shen, Shuying Wang, Zhuqing Zhang, Wenfei Du, Chenglong Yang, Xinyu Jiang, Xiaoyuan Zhang, Yongming Huang, Wenzhi Shen

“…P4HA and c‐Jun inhibitors abolished CHDH‐mediated CRC cell metastasis in vitro and in vivo. …”
Get full text

Hypoxia Enhances HIF1α Transcription Activity by Upregulating KDM4A and Mediating H3K9me3, Thus Inducing Ferroptosis Resistance in Cervical Cancer Cells by Jing Xiong, Meifang Nie, Chun Fu, Xiaoshan Chai, Yongjing Zhang, Ling He, Shujuan Sun

Get full text

KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition by Deniz Gökbuget, Liana Goehring, Ryan M. Boileau, Kayla Lenshoek, Tony T. Huang, Robert Blelloch

Get full text

Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…BackgroundsNatural killer (NK) cell mediated cytotoxicity is a crucial form of anti-cancer immune response. …”
Get full text

ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in Bladder Cancer via Targeting miR-3666 by Hu Ke, Jiabin Zhang, Fei Wang, Yunhe Xiong

“…The results from CCK-8, EDU, Transwell migration, and NK cell-mediated cytotoxicity detection assays suggested that circRHOT1 knockdown could markedly suppress BC cell proliferation and migration level and could aggravate the sensitivity of BC cells to NK cells. …”
Get full text

Iron triggers TvPI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP2 signaling crucial for multiple pathogenic activities of the parasitic protozoan Trichomonas vaginalis by Kuan-Yi Wu, Yen-Ju Chen, Shu-Fan Lin, Hong-Ming Hsu

“…These findings highlight that TvArf220-mediated PIP2-calcium signaling cascade regulates actin cytoskeleton and cytopathogenicity of T. vaginalis. …”
Get full text