S-Equol, a Major Isoflavone from Soybean, Inhibits Nitric Oxide Production in Lipopolysaccharide-Stimulated Rat Astrocytes Partially via the GPR30-Mediated Pathway by Mitsuaki Moriyama, Ayano Hashimoto, Hideyo Satoh, Kenji Kawabe, Mizue Ogawa, Katsura Takano, Yoichi Nakamura

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Resetting the Hsc70-mediated lysosomal degradation of PD-L1 via a supramolecular meso peptide for the restoration of acquired anti-tumor T cell immunity by Yujia Zhao, Dan Liu, Wenguang Yang, Wangxiao He, Jin Yan, Leiqing Yao

“…To overcome this issue, a meso chimeric peptide PEPPDL1 was designed to specifically bind the PD-1 binding domain of PD-L1 instead of the Hsc70/CMTM6 binding domain, while also binding to Hsc70 to facilitate the dragging of PD-L1 into Hsc70-mediated chaperone-mediated autophagy (CMA), thereby achieving lysosomal degradation. …”
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Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress by Saakshi Saini, Viney Kumar, Swati Haldar, Samrat Chauhan, Pratibha Demiwal, Souvik Ghosh, Sumeet Gupta, Debabrata Sircar, Bidhan Mahajon, Partha Roy

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A Pilot Survey of Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae Mediated by K pneumoniae Serine Carbapenemases in a Regional Referral Hospital in British Columbia by Aubrey Shannon, Ken Wagner, Naowarat Cheeptham, Gwen Stephens

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The Mediating Roles of Resilience and Flow in Linking Basic Psychological Needs to Tertiary EFL Learners’ Engagement in the Informal Digital Learning of English: A Mixed-Methods Study by Yang Gao, Xiaochen Wang, Barry Lee Reynolds

“…Conversely, flow partially mediates this relationship, though perceived competence does not significantly predict flow in this context. …”
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Assessing the Impact of Technology Use, Social Engagement, Emotional Regulation, and Sleep Quality Among Undergraduate Students in Jordan: Examining the Mediating Effect of Perceived and Academic Stress by Amjed Abojedi, Ahmad Sa'ad Alsheikh Ali, Judy Basmaji

“…This study assesses the impact of technology use, social engagement, emotional regulation, and sleep quality among undergraduate students in Jordan, while examining the mediating effect of perceived and academic stress. …”
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Mechanisms Mediating the Effects of γ-Tocotrienol When Used in Combination with PPARγ Agonists or Antagonists on MCF-7 and MDA-MB-231 Breast Cancer Cells by Abhita Malaviya, Paul W. Sylvester

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EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury by Shuangfei Ni, Bo Yang, Lei Xia, Huafeng Zhang

“…Mediators of Inflammation…”
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Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles by Zhang Hongyu, Guo Jingwen, Wang Zhi, Wang Na, Feng Nianping, Zhang Yongtai

“…This helps to comprehend the approach by which NLC-mediated oral bioavailability of trans-ferulic acid is better than that mediated by SLNs, as shown in our previous report.…”
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METTL3-Mediated m6A Modification Regulates the Osteogenic Differentiation through LncRNA CUTALP in Periodontal Mesenchymal Stem Cells of Periodontitis Patients by Xin Chen, Yuan Qin, Xian Wang, Hao Lei, Xiaochen Zhang, Houzhuo Luo, Changgang Guo, Weifu Sun, Shishu Fang, Wen Qin, Zuolin Jin

“…Our objective was to investigate the mechanism by which METTL3-mediated N6-methyladenosine modification regulates the osteogenic differentiation through lncRNA in periodontal mesenchymal stem cells in patients with periodontitis (pPDLSCs). …”
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PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling by Qinghui Zhang, Shihao Xiang, Qingqian Liu, Tao Gu, Yongliang Yao, Xiaojie Lu

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SPC25 upregulates CCND1 to promote the progression of esophageal squamous cell carcinoma by inhibiting MDM2-mediated E2F1 ubiquitination by Haoyao Jiang, Xiangfeng Jin, Haiyong Gu, Bin Li, Zhigang Li, Yifeng Sun

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p300/Sp1-Mediated High Expression of p16 Promotes Endothelial Progenitor Cell Senescence Leading to the Occurrence of Chronic Obstructive Pulmonary Disease by Zhihui He, Huaihuai Peng, Min Gao, Guibin Liang, Menghao Zeng, Xuefeng Zhang

“…Mediators of Inflammation…”
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Optimization of a Loop-Mediated Isothermal Amplification Assay as a Point-of-Care Tool for the Detection of Wuchereria bancrofti in Human Blood in Tana River Delta, Kenya by Kinyatta Nancy, Wambua Lillian, Mutahi Wilkinson, Mugasa Claire, Kamau Luna, Wachira Dorcas, Githae Rosemary, Lusweti Japheth, Ichugu Christine, Waigi Emily, Kagai Jim

“…In this study, we evaluated loop-mediated isothermal amplification (LAMP) tests to amplify Wuchereria bancrofti DNA in patients’ blood. …”
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Parents’ Role in Supporting, Brokering or Impeding Their Children’s Connected Learning and Media Literacy by Livingstone Sonia, Blum-Ross Alicia

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Exploring the associations between health confidence, self-efficacy, health activation and healthy behaviours in primary school children by Lixia Ge, Joseph Antonio De Castro Molina, Hui Ting Foo, Rochelle Chua, Chin Fung Ong

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Read. This. Slowly: mimicking spoken pauses in text messages by Rachel C. Poirier, Andrew M. Cook, Celia M. Klin

Subjects: “…computer-mediated communication…”
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Comprehensive Analysis Identifies <i>THEMIS2</i> as a Potential Prognostic and Immunological Biomarker in Glioblastoma by Jianan Chen, Qiong Wu, Anders E. Berglund, Robert J. Macaulay, Arnold B. Etame

Subjects: “…macrophage-mediated immunosuppression…”
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Unleashing the green potential: exploring the dynamic influence of the urban digital economy on carbon emissions by Xin Sun, Xueyu Rui, Zhikun Cui, Farhad Taghizadeh-Hesary, Xin Zhao

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Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation by Meritxell Boada-Pérez, Meritxell Boada-Pérez, Meritxell Boada-Pérez, Cristina Berastegui, Cristina Berastegui, Cristina Berastegui, Marta Erro, Marta Erro, Piedad Ussetti, Elena Crespo, Elena Crespo, Laura Donadeu, Laura Donadeu, Oriol Bestard, Oriol Bestard, Oriol Bestard, Gabriel Anguera, Amparo Solé, Ricardo Ponz Mir, Brian Molloy, Eva Revilla-López, Eva Revilla-López, Víctor Monforte, Víctor Monforte, Víctor Monforte, Susana Gómez-Ollés, Susana Gómez-Ollés, Susana Gómez-Ollés

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