Identification of the Transcriptional Networks and the Involvement in Angiotensin II-Induced Injury after CRISPR/Cas9-Mediated Knockdown of Cyr61 in HEK293T Cells by Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yan Jiang, Rentong Hu, Yanwu You

“…Mediators of Inflammation…”
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METTL14-mediated m6A modification of DDIT4 promotes its mRNA stability in aging-related idiopathic pulmonary fibrosis by Dan Li, Li Qian, Yufeng Du, Lifang Liu, Ziyue Sun, Yongkang Han, Xiangrui Guo, Chao Shen, Zheng Zhang, Xuejun Liu

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miR-26a-5p/ADAM17-Mediated Proteolysis of TREM2 Regulates Neuroinflammation in Hypertensive Mice Following Lead Exposure by Yuran Wang, Zeming Wang, Han Hao, Yuwei Zhao, Jian Wang, Weixuan Wang

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The Ratio of CD226 and TIGIT Expression in Tfh and PD-1+ICOS+Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation by Ji-wen Fan, Yu Fan, Zheng-li Wan, Lin Yan, Ya-mei Li, Yang-juan Bai, Lan-lan Wang, Jie Chen, Yi Li

“…Kidney transplantation is the ideal treatment for end-stage renal disease (ESRD). Chronic antibody-mediated rejection (CAMR) is the main cause of graft failure. …”
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Influence of social support on technophobia in older adults in urban communities: the mediating role of self-efficacy and e-health literacy, a cross-sectional study by Jin Li, Chen Wang, Dan Luo, Yan Shi, Hua Qing Guo, Zhi Guang Duan

“…In addition, self-efficacy (β=−0.080) and e-health literacy (β=−0.098) significantly mediated the relationship between social support and technophobia.Conclusion Social support was found to affect technophobia in older adults via the independent or chained mediating effects of self-efficacy and e-health literacy.…”
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The tryptophan-aspartate (WD) repeat domain of bovine Coronin-1A promotes mycobacterial survival by inhibiting calcium signaling-mediated phagosome-lysosome fusion by Jing Yang, Zhunan Li, Aicong Li, Yayi Liu, Xinyan Zhang, Yong Zhang, Yuanpeng Gao

“…The WD repeat domain mediated a decrease in intracellular calcium levels, which reduced levels of calmodulin-dependent kinase II (CaMKII) and its activated forms, thereby inhibiting lysosomal delivery. …”
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Tangeretin offers neuroprotection against colchicine-induced memory impairment in Wistar rats by modulating the antioxidant milieu, inflammatory mediators and oxidative stress in the brain tissue by Olalekan Bukunmi Ogunro, Mojisola Esther Karigidi, Gideon Ampoma Gyebi, Areej Turkistani, Ahmad H. Almehmadi

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Dietary index for gut microbiota and its protective role against kidney stones: evidence of diabetes as a mediator from NHANES cross-sectional data by Lei Wang, Junjun Wu, Ziwen Jiang, Chao Wang, Fuxiang Lin, Yuxiang Zhong, Pengpeng Zhao, Wei Wei, Jianhua Huang, Zhanping Xu

“…The role of DI-GM and its mediation by diabetes in KS pathogenesis remains unclear.ObjectiveTo investigate the association between DI-GM and KS prevalence, assess the mediation effect of diabetes, and explore subgroup-specific effects and underlying mechanisms.MethodsA cross-sectional analysis of NHANES (2007–2018) data was conducted using a stratified, multistage probability sampling design. …”
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The nexus between social media advertising and customers’ purchase intention with the mediating role of customers’ brand consciousness: evidence from three South Asian countries by Md Sajjad Hosain, Abdullah Mohammad Ahshanul Mamun

“…Furthermore, the authors incorporated a single mediator: customers' brand consciousness (CBC) to test the mediating effects on the direct relationships. …”
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High-Intensity Interval Training Improves Physical Function, Prevents Muscle Loss, and Modulates Macrophage-Mediated Inflammation in Skeletal Muscle of Cerebral Ischemic Mice by Lu Luo, Meixi Liu, Hongyu Xie, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Junfa Wu, Congyu Jiang, Yi Wu

“…Mediators of Inflammation…”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…However, the mechanism how VSIG4+ TAMs mediate immune evasion in aggressive cancers have not been fully elucidated. …”
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Rapid and Specific Detection of Escherichia coli O157:H7 in Ground Beef Using Immunomagnetic Separation Combined with Loop-Mediated Isothermal Amplification by Qin Yu, Puthiyakunnon Santhosh, Zhang Yiduo, Wu Xianbo, Boddu Swapna, Luo Binde, Fan Hongying

“…The objective of this study was to develop a rapid and sensitive method for detection of EHEC O157:H7 from ground beef using a method that combined immunomagnetic separation (IMS) with loop-mediated isothermal amplification (LAMP). The EHEC O157:H7 cells were separated with Dynabeads coated with anti- EHEC O157:H7 after a short enrichment for 4 h. …”
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Coupling cobalt single-atom catalyst with recyclable LiBr redox mediator enables stable LiOH-based Li-O2 batteries by Kang Huang, Zhixiu Lu, Shilong Dai, Chunyu Cui, Nam Dong Kim, Huilong Fei

“…Herein, we for the first time introduce LiBr redox mediator (RM) into the Co-SACs-catalyzed LOB system to facilitate the decomposition of LiOH. …”
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Natural Killer Cell-Secreted IFN-γ and TNF-α Mediated Differentiation in Lung Stem-like Tumors, Leading to the Susceptibility of the Tumors to Chemotherapeutic Drugs by Kawaljit Kaur, Angie Perez Celis, Anahid Jewett

“…Treatment with anti-MHC-class I decreased NK cell-mediated cytotoxicity in hA549 tumors, whereas it increased NK cell-mediated cytotoxicity when differentiated tumors were treated with antibodies against MHC-class I.…”
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Regulation of ER stress-induced apoptotic and inflammatory responses via YAP/TAZ-mediated control of the TRAIL-R2/DR5 signaling pathway by Y. El Yousfi, F. J. Fernández-Farrán, F. J. Oliver, A. López-Rivas, R. Yerbes

“…Mechanistically, YAP/TAZ regulates apoptosis induced by ER stress in tumor cells by controlling the activation of the TRAIL-R2/DR5-mediated extrinsic apoptotic pathway through a dual mechanism. …”
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Correction: Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis by Jiaxin Ou, Kangxin Li, Hui Yuan, Shaohua Du, Tingting Wang, Qiannan Deng, Huimei Wu, Weiyan Zeng, Kui Cheng, Kutty Selva Nandakumar

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Genome-wide transcriptomics revealed carbon source-mediated gamma-aminobutyric acid (GABA) production in a probiotic, Lactiplantibacillus pentosus 9D3 by Nachon Raethong, Pitakthai Chamtim, Roypim Thananusak, Kanyawee Whanmek, Chalat Santivarangkna

“…., glucose, sucrose, and lactose, notably sugar phosphotransferase systems (PTS) (11 genes), indicating carbon source-mediated transcriptional change patterns in L. pentosus 9D3. …”
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Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering by Marshall S. Padilla, Kaitlin Mrksich, Yiming Wang, Rebecca M. Haley, Jacqueline J. Li, Emily L. Han, Rakan El-Mayta, Emily H. Kim, Sofia Dias, Ningqiang Gong, Sridatta V. Teerdhala, Xuexiang Han, Vivek Chowdhary, Lulu Xue, Zain Siddiqui, Hannah M. Yamagata, Dongyoon Kim, Il-Chul Yoon, James M. Wilson, Ravi Radhakrishnan, Michael J. Mitchell

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Low Self-Confidence and Diabetes Mismanagement in Youth with Type 1 Diabetes Mediate the Relationship between Behavioral Problems and Elevated HbA1c by Minke M. A. Eilander, Maartje de Wit, Joost Rotteveel, Frank J. Snoek

“…HbA1c was derived from hospital charts. Bootstrap mediation analysis for multiple mediation was utilized. …”
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Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype. by Florence E McLean, Brian R Omondi, Nouhoum Diallo, Stanley Otoboh, Carolyne Kifude, Abdirahman I Abdi, Rivka Lim, Thomas D Otto, Ashfaq Ghumra, J Alexandra Rowe

“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a diverse family of variant surface antigens, encoded by var genes, that mediates binding of infected erythrocytes to human cells and plays a key role in parasite immune evasion and malaria pathology. …”
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