Effects of Fungi-Mediated Solid-State Fermentation on Phenolic Contents and Antioxidant Activity of Brown and White Teff (Eragrostis tef (Zucc.)... by Yoseph Asmelash Gebru, Desta Berhe Sbhatu

“…This study aimed at investigating changes in phenolic profiles and antioxidant activities of white and brown teff grains during mushroom-mediated solid-state fermentation. Fermentation with mushroom considerably increased total phenol contents of the soluble phenol fraction with Ganoderma lucidum showing relatively higher increase than Pleurotus ostreatus. …”
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The influence of light and heavy training weeks on the cortisol and testosterone awakening responses of elite male judokas: is skeletal muscle damage a mediating factor? by Blair T. Crewther, Benjamin G. Serpell, Christian J. Cook, Zbigniew Obmiński

“…The post-awakening decline in plasma testosterone (TAR Δb30 , TAR AUCb30 , TAR AUCb60 ) was found to be significantly less pronounced, whilst CK level was elevated, after heavy than light training with effect-size differences of 0.95–1.04 and 4.70, respectively. Causal mediation analysis confirmed that CK mediated, in part, the training effect on the CAR, but not TAR, measures. …”
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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

“…The immune escape of pathogens may be through suppressing the inflammatory response mediated by regulatory T cells (Tregs). The aim of this study was to explore whether A. fumigatus influences Gasdermin-D-dependent pyroptosis of the lung by regulating Toll-like receptor 2-mediated regulatory T cell differentiation. …”
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RamA upregulates the ATP-binding cassette transporter mlaFEDCB to mediate resistance to tetracycline-class antibiotics and the stability of membranes in Klebsiella pneumoniae by Xiaoyu Zhao, Yixin Zhang, Mohan Ju, Yang Yang, Haoqi Liu, Xiaohua Qin, Qingqing Xu, Min Hao

“…The mlaEFDCB operon could mildly mediate resistance to the tetracycline family of antibiotics under RamA regulation. …”
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Exosome-Like Vesicles as New Mediators and Therapeutic Targets for Treating Insulin Resistance and β-Cell Mass Failure in Type 2 Diabetes Mellitus by Qian Ge, Xin Xin Xie, Xiaoqiu Xiao, Xi Li

“…A growing body of evidence supports a novel role for ELVs as important mediators and therapeutic targets due to their effects on regulation of both insulin signaling and β-cell mass. …”
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UBE2T/CDC42/CD276 signaling axis mediates brain metastasis of triple-negative breast cancer via lysosomal autophagy by Lin Li, Rong Fu, Yan Chen, Jin Yao, Xiaobing Jiang, Tao Liang, Jun jun Li, Qian zhi Chen, Liang Liang Shi, Ming Xing Xie, Xin Wei Qiao, Qi Hong Cheng, Min Jie Wang

“…Mechanistically, UBE2T directly interacts with CDC42, promoting its K48-linked polyubiquitination and proteasomal degradation, thereby inhibiting CDC42 from degrading CD276 via the autophagy-lysosomal pathway, indirectly upregulating CD276 and thereby impairing the CD8+ T cells function, ultimately mediating tumor immune escape and BrM. Finally, animal experimental results also showed that inhibition of UBE2T elevated the TNBC sensitivity to immune checkpoint CD276 blockade and inhibited BrM of TNBC.Conclusions In conclusion, our results indicate a new mechanism whereby UBE2T-mediated ubiquitination positively controls the UBE2T/CDC42/CD276 axis to upregulate tumor cell expression of CD276 and thereby impair CD8+ T cells function, ultimately leading to tumor cell immune escape and BrM.…”
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Sulforaphane attenuates dextran sodium sulphate induced intestinal inflammation via IL-10/STAT3 signaling mediated macrophage phenotype switching by Yuyang Sun, Jiqing Tang, Cui Li, Jun Liu, Haijie Liu

“…However, the role of macrophages in sulforaphane mediated intestinal inflammation and the underlying molecular mechanisms have not been studied yet. …”
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Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread. by Alexander Tishchenko, Nicolás Romero, Cliff Van Waesberghe, Jonas L Delva, Oliver Vickman, Gregory A Smith, Thomas C Mettenleiter, Walter Fuchs, Barbara G Klupp, Herman W Favoreel

“…Here, we describe how the alphaherpesvirus pseudorabies virus (PRV) triggers ERK1/2-mediated phosphorylation of the main gap junction component connexin 43 (Cx43) and closure of GJIC, which depends on the viral protein pUL46. …”
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Effects of Hydrogen Bonding Solvation by Diverse Fluorinated Bulky Alcohols on the Reaction Rate and Selectivity in Crown Ether Mediated Nucleophilic Fluorination in an Aprotic Solvent by Eloah P. Ávila, Mauro V. de Almeida, Marcelo S. Valle, Josefredo R. Pliego

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The influence of childhood trauma on social media-induced secondary traumatic stress among college students: the chain mediating effect of self-compassion and resilience by Xiqin Liu, Ye Yao, Siyu Zhu, Qiyong Gong

“…Further, a chained mediating effect was observed with self-compassion and resilience consecutively mediated the relationship between childhood trauma and social media-induced STS (indirect effect = 0.02[0.01, 0.03]). …”
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Enhanced membrane protein production in HEK293T cells via ATF4 gene knockout: A CRISPR-Cas9 mediated approach by Byung-Jo Choi, Ba Reum Kim, Ho Joong Choi, Ok-Hee Kim, Say-June Kim

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Aloe Vera Extract-Mediated CuO NPs as Catalysts for the Synthesis of 4-Hydroxy-3-Methoxybenzaldehyde-Connected Piperidine Derivatives and Their Antibacterial Activity by Ponnusamy Packialakshmi, Perumal Gobinath, Anis Ahamed, Hissah Abdulrahman Alodaini, Ashraf Atef Hatamleh, Mohamed Taha Yassin, Akbar Idhayadhulla, Radhakrishnan Surendrakumar

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Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway by Li Wang, Chaofan Zhang, Muhammad Azhar Memon, Qianting Shi, Le Lu, Xishuai Tong, Yonggang Ma, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan

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Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs by Jinshuang Bo, Shiya Xie, Yi Guo, Chunli Zhang, Yanming Guan, Chunmei Li, Jianxin Lu, Qing H. Meng

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Lipoxin A4 levels correlate with severity in a Spanish COVID-19 cohort: potential use of endogenous pro-resolving mediators as biomarkers by Sergio Sánchez-García, Rafael I. Jaén, Roberto Lozano-Rodríguez, José Avendaño-Ortiz, Alejandro Pascual‐Iglesias, Laura Hurtado-Navarro, Eduardo López-Collazo, Eduardo López-Collazo, Lisardo Boscá, Lisardo Boscá, Patricia Prieto, Patricia Prieto, Patricia Prieto

“…Specialized pro-resolving lipid mediators (SPMs) as lipoxins are endogenous mediators synthesized from arachidonic acid in the resolution stage of any inflammatory process. …”
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COVID-19 on patients with immune-mediated rheumatic disease: a comparative study of disease activity, fatigue, and psychological distress over six months by Claudia Marques, Marcelo M. Pinheiro, Jennifer Lopes, Sandra Lúcia Euzébio Ribeiro, Mary Vânia Marinho de Castro, Lilian David de Azevedo Valadares, Aline Ranzolin, Nicole Pamplona Bueno de Andrade, Rafaela Cavalheiro do Espírito Santo, Nafice Costa Araújo, Cintya Martins Vieira, Valéria Valim, Flavia Patricia Sena Teixeira Santos, Laurindo Ferreira da Rocha, Adriana Maria Kakehasi, Ana Paula Monteiro Gomides Reis, Edgard Torres dos Reis-Neto, Gecilmara Salviato Pileggi, Gilda Aparecida Ferreira, Licia Maria Henrique da Mota, Odirlei Monticielo, Ricardo Machado Xavier

“…Abstract Objectives To compare the impact of COVID-19 on the clinical status and psychological distress of patients with immune-mediated rheumatic disease (IMRD) caused by SARS-CoV-2 infection with that of noninfected IMRD controls during a 6-month follow-up period. …”
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A Framework to Assess the Impact of Employee Perceived Equality on Contextual Performance and Mediating Role of Affective Commitment to Enhance and Sustain Positive Work Behavior by Ritika Dongrey, Varsha Rokade

“…Moreover, affective commitment mediated the positive relationship between perceived equality and contextual performance. …”
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MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy by Gaofeng Ni, Yuwei Sun, Hongling Jia, Zhikai Xiahou, Yumeng Li, Fu Zhao, Hongyan Zang

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Factors influencing the natural history of non-IgE-mediated gastrointestinal food allergies in paediatric age: a prospective multicentre cohort study by Giorgio Bedogni, Roberto Berni Canani, Laura Carucci, Rita Nocerino, Serena Coppola, Pasqualina Capasso, Veronica Giglio

“…Background We aimed at identifying the factors influencing the natural history of non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFA), a group of common paediatric conditions including food protein–induced: enteropathy (FPE), allergic proctocolitis (FPIAP), enterocolitis syndrome (FPIES), and motility disorders (FPIMD).Methods Prospective multicentre cohort study involving paediatric patients (both sexes, aged ≤14 y) with non-IgE-GIFA diagnosed and followed for 24 months at a Tertiary Centre for Paediatric Allergy, Gastroenterology and Nutrition. …”
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The contribution of subjective wellbeing to the improvement of the academic performance of university students through time management as a mediator factor: A structural equation modeling by Hicham KHABBACHE, Abdelhalim CHERQUI, Khalid OUAZIZI, Driss AIT ALI, Zakaria ABIDLI, Abdelaziz ALLIOUI, Joumana ELTURK, Mahmood BAHRAMIZADEH, Murat YILDIRIM, Nicola Luigi BRAGAZZI, Gabriella NUCERA, Lukasz SZARPAK, Amelia RIZZO, Francesco CHIRICO

“…This study aims to investigate how positive feelings (PF) and negative feelings (NF) predict academic performance (AP) through time management (TM) as a mediator in this process. Methods: This cross-sectional study was conducted among Moroccan students from the University of Sidi Mohamed ben Abdullah in Fez. …”
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