LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice by Annica Hedberg, Premasany Kanapathippillai, Ole Petter Rekvig, Kristin Andreassen Fenton

“…In this study we investigated the effect of LMW heparin on renal cytokine and chemokine expression and on nucleosome-mediated activation of nucleosome-specific splenocytes. …”
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The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development by Soeun Hwang, Junhee Park, Seo-Young Koo, Si-Yeon Lee, Yunju Jo, Dongryeol Ryu, Heounjeong Go, Chang-Woo Lee

“…Abstract Receptor-mediated signaling could be modulated by ubiquitination of pathway intermediates, but the role of such modification in the pathogenesis of inflammation and inflammation-related cancer is lesser known. …”
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Physical literacy among chinese elementary school students: the mediating role of physical knowledge and physical competency by Li Mengyu, Wang Yuxing, Zan Ziqing, Liu Lizhu, You Lili

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Inhibition of Src signaling induces autophagic killing of Toxoplasma gondii via PTEN-mediated deactivation of Akt. by Alyssa Hubal, Anusha Vendhoti, Charles N Shaffer, Sarah Vos, Yalitza Lopez Corcino, Carlos S Subauste

“…Epidermal Growth Factor Receptor (EGFR) is a mediator of this survival strategy. However, EGFR expression is limited in the brain and retina, organs affected in toxoplasmosis. …”
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The Influence of Depression, Anxiety, and Stress on Ageism Among Undergraduates: Mediating Roles of Life Satisfaction, Gratitude, and Prosociality by Chen S, Wan Z

“…Structural Equation Modeling (SEM) explored the pathways linking DAS to ageism via mediators.Results: A moderate level of ageism was observed, with significant variations across socio-demographic factors like academic year, physical health, and contact with older adults. …”
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Flow Mediated Dilation and Its Correlation with Coronary and Systemic Atherosclerosis in Patients Scheduled for Surgical Myocardial Revascularization by Boieriu AM, Luca CD, Tint D

Subjects: “…flow mediated dilation…”
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NLRP7 maintains the genomic stability during early human embryogenesis via mediating alternative splicing by Zhongliang Chen, Liangxia Jiang, Min Su, Qibing Zeng, Peng Luo, Liangzhao Chu

“…These results indicate that NLRP7-mediated Alternative splicing is potentially required for the maintenance of genome integrity during early human embryogenesis. …”
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Ionic Liquid-Mediated, Rapid N-Alkylation of Heterocyclic Compounds with Trialkyl Phosphites in the Presence of Dialkyl Acetylenedicarboxylates by Alireza Hassanabadi, Mohammad H. Mosslemin, Mohammad Anary-Abbasinejad, Azadeh Kalantarinejad, Mozhdeh Jerjisi Shirazi

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Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation by Ayla Valinezhad Orang, Reza Safaralizadeh, Mina Kazemzadeh-Bavili

“…This paper provides an overview of the current understandings of the miRNA characteristics including their genes and biogenesis, as well as their mediated downregulation. We also review up-to-date knowledge of miRNA-mediated gene upregulation through highlighting some notable examples and discuss the emerging concepts of their associations with other posttranscriptional gene regulation processes.…”
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The impact of ESG and the institutional environment on investment efficiency in China through the mediators of agency costs and financial constraints by Zhao Donghui, Wan Sallha Yusoff, Mohd Fairuz Md Salleh, Ngan Sue Lin, Ainul Huda Jamil, Mohd Juraij Abd Rani, Mohd Shahidan Shaari

“…Using data from 3380 non-financial Chinese firms (2010–2021) and a fixed-effects panel regression model, we explore how ESG influences investment efficiency through the mediating roles of agency costs and financial constraints. …”
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HnRNPR-mediated UPF3B mRNA splicing drives hepatocellular carcinoma metastasis by Hong Wang, Dong Qian, Jiabei Wang, Yao Liu, Wenguang Luo, Hongyan Zhang, Jingjing Cheng, Heng Li, Yang Wu, Wuhan Li, Jing Wang, Xia Yang, Tianzhi Zhang, Dong Han, Qinyao Wang, Chris Zhiyi Zhang, Lianxin Liu

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AMPK Activation Mediated by Hinokitiol Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells through Autophagy Flux by Ju-Hee Lee, Jae-Kyo Jeong, Sang-Youel Park

“…The inhibition of AMPK phosphorylation also suppressed hinokitiol-mediated inhibition of autophagy and antiadipogenic effects. …”
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Ambient air pollution and birth outcomes: a scoping review to investigate the mediating and moderating variables—protocol by Amy Mizen, Richard Fry, Lucy Perry, Kate Ellis-Davies, Amy Isham

“…This scoping review aims to understand the extent and type of evidence concerning the mediating and moderating factors between air pollution and birth outcomes. …”
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CDC20‐Mediated Selective Autophagy Degradation of PBRM1 Affects Immunotherapy for Renal Cell Carcinoma by Yizeng Fan, Weichao Dan, Taotao Que, Yi Wei, Bo Liu, Zixi Wang, Yulin Zhang, Yuzhao Wang, Tianjie Liu, Yanxin Zhuang, Mengxing Li, Chendong Guo, Jin Zeng, Bohan Ma, Lei Li

“…Meanwhile, CDC20 catalyzes K27 ubiquitination of PBRM1 and promotes its degradation via p62‐mediated selective autophagy. A bicyclic peptide (PB1‐p62) is designed and constructed to target PBRM1 and p62, thereby promoting the degradation of PBRM1. …”
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Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter Nanoparticles by Govindarajan Srimathveeravalli PhD, Dalya Abdel-Atti BS, Carlos Pérez-Medina PhD, Haruyuki Takaki MD, PhD, Stephen B. Solomon MD, Willem J. M. Mulder PhD, Thomas Reiner PhD

“…We investigated a radiolabeled liposomal nanoparticle ( 89 Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. …”
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Mediating role of fatigue driving in the influence of job demand and insecurity on safety incidents among bus drivers by Mustapha Amoadu, Isaac Tetteh Commey, Edward Wilson Ansah

“…Driving fatigue produced a partial mediation effect of job demands and job security on safety incidents of the drivers. …”
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The impact of physical exercise on adolescents’ mobile phone dependency: the serial mediating role of self-esteem and depression by Jingtao Wu, Yanhong Shao, Wanli Zang

“…Depression was negatively correlated with self-esteem (r = −0.396, p < 0.001). Mediation analysis revealed that self-esteem and depression significantly mediated the relationship between physical exercise and mobile phone dependency, with a total indirect effect of −0.116 (95% CI = [−0.239, −0.140]), accounting for 100% of the total effect. …”
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Complement-Mediated Hemolytic Uremic Syndrome Due to MCP/CD46 Mutation: A Case Report by Abdul Muhsen Abdeen MD, Jowan Al-Nusair MD, Malik Samardali MD, Mohamed Alshal MD, Amro Al-Astal MD, Zeid Khitan MD

“…Thrombotic microangiopathy (TMA) is a severe condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ damage, often involving the kidneys. Complement-mediated hemolytic uremic syndrome (cHUS), a rare form of TMA, arises from dysregulated alternative complement pathway activation, frequently due to genetic mutations. …”
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The Pathway Relationship Between Physical Activity Levels and Depressive Symptoms in University Students Mediated by Cognitive Flexibility by Fen Yu, Shuqi Jia, Qin Liu, Zhaohui Guo, Sen Li, Xing Wang, Pan Li

“…ABSTRACT Objective To explore the mediating pathway of cognitive flexibility in the relationship between physical activity and depressive symptoms among university students. …”
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How do social entrepreneurship factors influence sustainable business development? The mediating role of social network by Titik Kusmantini, Heru Tri Sutiono, Anis Siti Hartati, Anidah Robani, Aris Kusumo Diantoro, Ashila Metta Rahmadati

“…Firstly, it measured only two factors and one mediator of social entrepreneurship in addressing sustainable business development. …”
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