Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein by Marie-Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde

“…The most well-studied approach to enhance brain influx of protein therapeutics, is receptor-mediated transcytosis (RMT) by targeting nutrient receptors to shuttle protein therapeutics over the blood–brain barrier (BBB) along with their endogenous cargos. …”
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Canopy structure modulates the sensitivity of subalpine forest stands to interannual snowpack and precipitation variability by M. Berkelhammer, G. F. M. Page, G. F. M. Page, F. Zurek, C. Still, C. Still, M. S. Carbone, M. S. Carbone, W. Talavera, L. Hildebrand, J. Byron, K. Inthabandith, A. Kucinski, M. Carlson, K. Foss, W. Brown, R. W. H. Carroll, A. Simonpietri, M. Worsham, I. Breckheimer, I. Breckheimer, A. Ryken, R. Maxwell, R. Maxwell, D. Gochis, M. S. Raleigh, E. Small, K. H. Williams, K. H. Williams

“…Using the sap velocity data along with supporting measurements of soil moisture and snow depth, we propose three mechanisms that lead to stand density modulating the tree-level response to changing seasonality of precipitation: </p><ol><li> <p id="d2e396"><span id="page702"/>Topographically mediated convergence zones have consistent access to recharge from snowmelt which supports denser stands with high water demands that are more reliant and sensitive to changing snow.…”
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A socio-ecological model of the management of leprosy reactions in Indonesia and India using the experiences of affected individuals, family members and healthcare providers by Annisa Ika Putri, Ruth M. H. Peters, Kevin De Sabbata, Brittney S. Mengistu, Regitta I. Agusni, Medhi Denisa Alinda, Joydeepa Darlong, M. Yulianto Listiawan, Cita R. S. Prakoeswa, Stephen L. Walker, Marjolein B. M. Zweekhorst

“…Abstract Background Leprosy reactions (LR) are immune-mediated complications of leprosy that may be associated with severe and irreversible nerve damage. …”
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Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section by Mathieu Di Miceli, Moïra Rossitto, Maud Martinat, Flore Marchaland, Sarah Kharbouche, Marion Graland, Farah Younes, Alexandra Séré, Agnès Aubert, Lydia Rabbaa Khabbaz, Charlotte Madore, Jean-Christophe Delpech, Rebeca Martín, Sophie Layé

“…We then measured the expression of genes associated to neuroimmune interactions (microglia phenotype), inflammatory mediators and lipids in several brain structures of VD and CSD mice at PND21 and PND55. …”
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Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study by Fiona Reid, Sophie Papa, John Maher, Jean-Pierre Jeannon, James Spicer, Victoria Gibson, Selvam Thavaraj, Michael Metoudi, Christopher Fisher, Nicholas Beckley-Hoelscher, Andrew Hope, Maria Elstad, Antonella Adami, Richard Beatson, Molly Sarah George, Daniela Achkova, Evangelia Williams, Sefina Arif, Abdel Douri, Marc Delord, Mike Lyne, Dharshene Shivapatham, Sakina Gooljar, Arindam Mitra, Linda Gomm, Cienne Morton, Rhonda Henley-Smith, Alice Santambrogio, Cynthia Andoniadou, Sarah Allen, Gary J R Cook, Ana C Parente-Pereira, David M Davies, Farzin Farzaneh, Anna Schurich, Teresa Guerrero-Urbano

“…Patient-derived T-cells are engineered by retroviral transduction to coexpress a panErbB-specific CAR called T1E28ζ and an IL-4-responsive chimeric cytokine receptor, 4αβ, which allows IL-4-mediated enrichment of transduced cells during manufacture. …”
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Systemic and mammary inflammation and mammary gland development of Holstein dairy cows around dry-off and calving by J. Gao, T.N. Marins, J.O.S. Calix, Z. Qi, C.G. Savegnago, A.M. Roper, M.W. Woldemeskel, J.K. Bernard, S. Tao

“…Our data also suggested that the increased mammary growth during the late gestation and early dry periods was mediated by different mechanisms. The concurrent increases in immune cell infiltration and mammary cell proliferation in the mammary gland following dry-off suggest an association between mammary immune responses and growth during the early dry period.…”
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Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

“…Notably, HIV-negative KS samples showed alterations in NK cell-mediated immunity and cytotoxic response pathways, whereas HIV-positive samples exhibited changes in growth regulation and protein kinase activity pathways at the time of initial diagnosis. …”
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Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…To further improve efficacy, we explored AAV-mediated delivery of the soluble PD-L1 (sPD-L1) to CIA mice.ResultAfter intra-articular injection of AAV6 vectors expressing the optimal isoform of sPD-L1 (shPD-L1), more potency was observed when compared to wild type PD-L1, with a lower dose of AAV6/shPD-L1 needed for arthritis improvement. …”
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Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adults by Jung Hyuk Lee, Yuna Shin, Kwang-Soo Shin, Ju Yeon Park, Mi Sun Kim, Young-Shin Park, Wuhyun Kim, Joon Young Song, Ji Yun Noh, Hee Jin Cheong, Chang-Yuil Kang, Sang Hwan Seo, Jae-Ouk Kim, Deok Ryun Kim, Nathaniel S. Hwang, Jae Seung Yang, Jerome H. Kim, Byoung-Shik Shim, Manki Song

“…In addition to neutralizing antibodies, non-neutralizing antibodies that mediate Fc-dependent effector functions play a key role in protection against various infectious diseases, including coronavirus disease 2019. …”
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OXA β-lactamases from Acinetobacter spp. are membrane bound and secreted into outer membrane vesicles by Lucia Capodimonte, Fernando Teixeira Pinto Meireles, Guillermo Bahr, Robert A. Bonomo, Matteo Dal Peraro, Carolina López, Alejandro J. Vila

“…The ubiquity of this phenomenon suggests that it may have influenced the dissemination of resistance mediated by Acinetobacter spp., particularly in polymicrobial infections, being a potent evolutionary advantage.…”
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Correlation between social support, self-efficacy and quality of life in primary trigeminal neuralgia patients (原发性三叉神经痛患者社会支持、自我效能感与生活质量的相关性研究)... by SUN Xiuxiu (孙秀秀), JIA Jianhua (贾建华), LI Yeyuan (李业园)

“…Structural equation modeling showed that social support and self-efficacy were negatively correlated with quality of life, and self-efficacy had a significant mediating effect between social support and quality of life. …”
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Inflammatory and Redox Blood Gene Expression Fingerprint of Severe Obstructive Sleep Apnoea in Patients With Mild Alzheimer&rsquo;s Disease by Romero-ElKhayat L, Dakterzada F, Huerto R, Carnes-Vendrell A, Mínguez O, Pujol Sabaté M, Targa A, Barbé F, Milanesi E, Dobre M, Manda G, Cuadrado A, Piñol-Ripoll G

“…A pathway enrichment analysis showed a strong enrichment of the serotonergic synapse pathway in severe OSA AD patients.Discussion: Our results show an upregulation of nine genes involved in NF-κB-mediated inflammation and redox metabolism in the blood of patients with mild AD with severe OSA. …”
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Reproducibility of indirect persistent inward current indicators with neuromuscular electrical stimulation by Timothée Popesco, Davide D'Amato Brunetta, Stefano Pata, Nicolas Place

“…Notably, PICs play an important role in motor unit behavior (Heckman & Enoka, 2012) and are thought to be involved in the centrally mediated responses to NMES. This study aimed to examine the reproducibility of indirect PIC indicators, such as extra force production during wide-pulse high-frequency (WPHF) NMES, sustained electromyographic (EMG) activity following WPHF NMES and force production in response to Achille’s tendon vibration combined with NMES. …”
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Characterization of the colostrum proteome of primiparous Holstein cows and its association with colostrum immunoglobulin G concentrations by Ezequias Castillo-Lopez, Patrick Biber, Arife Sener-Aydemir, Karin Hummel, Ebrahim Razzazi-Fazeli, Nicole Reisinger, Qendrim Zebeli, Susanne Kreuzer-Redmer, Thomas Hartinger

“…This resulted in enrichment of the biological processes predominantly for complement activation alternative pathway, complement activation, complement activation classical pathway, humoral immune response, leukocyte mediated immunity, and negative regulation of endopeptidase activity in excellent-quality colostrum. …”
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The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman  Pinschers of efficacy and outcomes by Sabine Werner, Gerd Wallukat, Niels‐Peter Becker, Katrin Wenzel, Johannes Müller, Ingolf Schimke, Gerhard Wess

“…Abstract Aims Aptamer BC 007, a 15‐mer single‐strand DNA oligonucleotide (5'‐GGTTGGTGTGGTTGG‐3'), was developed to neutralize functional autoantibodies that bind to the extracellular domains of G protein‐coupled receptors (GPCR‐AAB), leading to the modulation of receptor‐mediated signalling cascades that induce pathophysiological states. …”
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KiKli Fit: Investigating the Implementation of a Physical Activity Program in Pediatric Cancer by Lars Rehbein, Ann Christin Schneider, Christina Hillebrech, Christina Schindera, Amika Singh, Katharina Eva, Valentin Benzing

“…., & Schmidt, M. (2022). The mediational role of executive functions for the relationship between motor ability and academic performance in pediatric cancer survivors. …”
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KiKli Fit: Insights into the Development and Practice of a Physical Activity Program in Pediatric Cancer by Lisa Hillebrech, Lars Rehbein, Ann Christin Schneider, Sara Müller, Christina Schindera, Katharina Eva, Valentin Benzing

“…., & Schmidt, M. (2022). The mediational role of executive functions for the relationship between motor ability and academic performance in pediatric cancer survivors. …”
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Synthesis, Characterization, and Cytotoxic Activity of New Lanthanum(III) Complexes of Bis-Coumarins

“…The findings suggest that the observed cytotoxicity of the lanthanum complex of <mml:math alttext="$chem{H_{2}}$"> <mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> </mml:math>L1 on BV-173 is at least partly mediated through induction of programmed cell death.…”
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Physical health in young males and risk of chronic musculoskeletal, cardiovascular, and respiratory diseases by middle age: A population-based cohort study. by Aleksandra Turkiewicz, Karin Magnusson, Simon Timpka, Ali Kiadaliri, Andrea Dell'Isola, Martin Englund

“…We speculate that these associations are mediated by chronic overload or acute trauma.…”
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Genomic insights into genetic diversity and seed coat color change in common bean composite populations by Eva Plestenjak, Eva Plestenjak, Mohamed Neji, Lovro Sinkovič, Vladimir Meglič, Barbara Pipan

“…Key GO terms included phosphatidylinositol-biphosphate binding, exocytosis, and vesicle-mediated transport, suggesting a link between cellular transport and pigment deposition in the seed coat.DiscussionThe study demonstrates significant genetic diversity within and among common bean composite populations, with KIS_Amand and SRGB_00366 exhibiting the highest phenotypic and genetic variability. …”
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