The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs) by Camila Sabatini, Huey-Jiun Lin, Galib Ovik, Richard Hall, Techung Lee

“…This in vitro study demonstrates a novel odontogenic mechanism mediated by ectopic expression of the transcription factor Atoh1 in human DPSCs. …”
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Effect of Propolis on PPP2R1A and Apoptosis in Cancer Cells by Burak Durmaz, Latife Merve Oktay Çelebi, Ayşe Çekin, Ayshan Ahadova, Nur Selvi Günel, Hatice Kalkan Yıldırım, Ali Mert Özgönül, Eser Yıldırım Sözmen

“…Recently, it has been shown that protein phosphatase 2A (PP2A) dysfunction was common in many cancer types and was mediated by various inactivation mechanisms. Although many research studies observed antitumor effect of propolis extracts in various types of cancer, the mechanism of effect are still obscure. …”
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Changes in Aqueous Humor Cytokine Profile Following Intravitreal Brolucizumab Injection by Ruamviboonsuk V, Kongwattananon W, Chuaypen N

“…The results suggested that type IV cell-mediated hypersensitivity could play a role in IOI following intravitreal brolucizumab injection.Keywords: anti-VEGF, intravitreal injection, inflammation, hypersensitivity, intravitreal injection…”
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HLA-DMB correlates with antitumor immunity and an improved prognosis in endometrial carcinoma tumors by Xiaoyu Xi, Xiaona Zhang, Jianxin Tang, Xiumei Fan, Jiexian Du

“…Mechanistically, HLA-DMB primarily participates in CD22-mediated regulation of B cell receptors (BCR), leading to BCR antigen activation and the production of second messengers. …”
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Environmental microbial communications in gram-positive and gram-negative bacteria by P. Srikanth, D. Sivakumar, J. Nouri

“…The scope of quorum sensing extends to inter-nation communication, mediate through numerous newly diagnosed extra-cell signal molecules known as autoinducers. …”
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The relationship between vision status and its influencing factors among primary and secondary school students: The masking effect of physical activity level and the moderating eff... by Jiyan Xu, Yanjun Li, Siyuan Ma, Shimeng Dai, Weiwei Xu, Mengjiao Sang, Kaijie Feng

“…The physical activity level played a significant masking effect between lifestyle behaviors and vision status (a*b = 0.002, c’=-0.044), and academic stress played a moderating role in the process of lifestyle behaviors affecting physical activity level and vision status. A moderated mediator model was constructed and fitted well (RMSEA = 0.028, CFI = 0.953, NFI = 0.934). …”
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Role of Vigilin and RACK1 in dengue virus-Aedes aegypti-Wolbachia interactions by Guijie Wang, Mazhar Hussain, Zhi Qi, Sassan Asgari

“…Vigilin is, therefore, a multifunctional protein reported to be associated with RNA transport and metabolism, sterol metabolism, chromosome segregation, carcinogenesis, and heterochromatin-mediated gene silencing. The receptor for activated C kinase 1 (RACK1) is another highly conserved protein involved in many cellular pathways. …”
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Rutas literarias: (inter)espacio didáctico para leer, caminar y hablar el libro / Reading itinerary: (inter)didactic space to read, walk and talk the book by Miguel Sánchez García, Juana Rosa Suárez-Robaina

“…The relationship already established between reader and text is now joined by the experience with whom the work mediates on the route: an expert voice that encourages interaction in the recognized and vivified space of the story. …”
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Murine DX5+NKT Cells Display Their Cytotoxic and Proapoptotic Potentials against Colitis-Inducing CD4+CD62Lhigh T Cells through Fas Ligand by Jens M. Werner, Michael Damian, Stefan A. Farkas, Hans J. Schlitt, Edward K. Geissler, Matthias Hornung

“…Furthermore, DX5+NKT cells likely mediate their cytotoxic and proapoptotic potentials via FasL, confirming recent reports about iNKT cells. …”
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Association of ultra-processed food-related metabolites with selected biochemical markers in the UK Biobank by Anthony Kityo, Byeonggeun Choi, Jung-Eun Lee, Chulho Kim, Sang-Ah Lee

“…This metabolomic profile should be explored as a potential mediators of UPF-disease associations, and as an objective marker of UPF intake.…”
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The small GTPases FoRab5, FoRab7, and FoRab8 regulate vesicle transport to modulate vegetative development and pathogenicity in Fusarium oxysporum f. sp. conglutinans by Xiangyu Tan, Lin Chen, Ying Chen, Yuxin Li, Lihan Lu, Erfeng Li

“…In addition, we also employed a PEG-mediated homologous recombination approach to create deletion mutants and complementary strains for the FoRab5, FoRab7, and FoRab8 genes, thereby facilitating a comprehensive investigation into the functional roles of these genes. …”
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Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK/PGC1- α/Irisin pathway by Haijuan Liu, Guohua Wang, Conglu Sui, Yanan Guo, Xiangyu He

“…These effects may be mediated through the activation of AMPK/PGC1-α pathway in muscle to promote the secretion of irisin.…”
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Virulence factor discovery identifies associations between the Fic gene family and Fap2+ fusobacteria in colorectal cancer microbiomes by Geicho Nakatsu, Duhyun Ko, Monia Michaud, Eric A. Franzosa, Xochitl C. Morgan, Curtis Huttenhower, Wendy S. Garrett

“…Fap2 is a fusobacteria-specific outer membrane galactose-binding lectin that mediates Fusobacterium adherence to and invasion of CRC tumors. …”
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Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain by Chen Y, Tang G, Lu J, Tang S, Xiong X, Chen C, Pei L, Shi J

“…This study aims to clarify the mechanism of C/EBP-β regulating TGF-β 1 mediated spinal astrocyte A1/A2 polarization in the neuropathic pain caused by vincristine.Methods: Neuropathic pain model was established in rats by intraperitoneal injection of Vincristine (VCR). …”
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Exosomal miR-122 derived from M2 macrophages induces osteogenic differentiation of bone marrow mesenchymal stem cells in the treatment of alcoholic osteonecrosis of the femoral hea... by Guoping Le, Riyou Wen, Huaixi Fang, Zhifa Huang, Yong Wang, Hanwen Luo

“…This study will confirm whether M2 macrophage exosome (M2-Exo) miR-122 mediates alcohol-induced BMSCs osteogenic differentiation, ultimately leading to the inhibition of femoral head necrosis. …”
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Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia by Fei Xie, Ting-juan Zhang, Xin-long Zhang, Zi-jun Xu, Liang Qiao, Yun Wang, Yang-jing Zhao, Jun Qian, Jing-dong Zhou

“…However, very few studies determined the DNA methylation-mediated epigenetic regulation of the HOXA cluster genes in AML. …”
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The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats by Steve Mabry, Jessica L. Bradshaw, Jennifer J. Gardner, E. Nicole Wilson, Janak Sunuwar, Hannah Yeung, Sharad Shrestha, J. Thomas Cunningham, Rebecca L. Cunningham

“…However, the mechanisms mediating OSA-induced cognitive impairments are unclear. …”
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Clonal Spread and Genetic Mechanisms Underpinning Ciprofloxacin Resistance in <i>Salmonella enteritidis</i> by Zengfeng Zhang, Hang Zhao, Chunlei Shi

“…Pulsed-field gel electrophoresis (PFGE) results suggested that clonal spread might have persisted among these 34 isolates in the local area for several years. Multiple plasmid-mediated quinolone resistance (PMQR) genes, GyrA mutations in the quinolone resistance-determining region (QRDR), and overexpression of RND efflux pumps were identified as potential contributors to ciprofloxacin resistance. …”
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Itinerarios para la formación de la ciudadanía de acuerdo con la Agenda 2030. Literatura infantil y ODS / Itineraries for citizenship education in accordance with the 2030 Agenda.... by Lourdes Hernández Delgado, Amando López Valero

“…Furthermore, the presence of the key themes of the 2030 Agenda is noted in both classic and more contemporary texts, with the mission of the mediator being to bring the two together in order to achieve the intended goals. …”
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Sacral neuromodulation outcomes in the management of lower urinary tract symptoms in multiple sclerosis patients by Tyler Trump, Po-Ming Chow, Vivian Hua, Omer Anis, Mazen Mansour, Howard B. Goldman

“…INTRODUCTION/OBJECTIVE:: Multiple sclerosis (MS) is a common immune mediated disease of the central nervous system. The majority of patients will experience bothersome lower urinary tract symptoms (LUTS) over the course of their lifetime. …”
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