«Så sitter du der og plutselig leser for alle» – en nærstudie av barnehageansatte som litteraturformidlere by Malgorzata Wild, Christina Berg Tveitan

“…ENGLISH ABSTRACT “All of the Sudden You Are Sitting There Reading for Everyone” – A Close Study of Pedagogical Staff as Literature Mediators Recent studies of pedagogical staff investigate practices that inform read-alouds in kindergartens (Alatalo & Westlund, 2021; Damber, 2015; Dybvik et al., 2022; Tjäru, 2023). …”
Get full text

The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells by Lijun Wang, Luqun Tang, Chengyun Yao, Chunyan Liu, Yongqian Shu

“…The results from Annexin V/PI staining and flow cytometry analysis suggested that celastrol enhanced tamoxifen-mediated apoptosis. In addition, exposure to a combination of celastrol and tamoxifen inhibited cell proliferation by causing G1 phase cell cycle arrest. …”
Get full text

Genetic evidence for the liver-brain axis: lipid metabolism and neurodegenerative disease risk by Zeyu Wang, Zixiao Yin, Guangyong Sun, Dong Zhang, Jianguo Zhang

“…The analysis included primary MR, sensitivity analyses, and multivariable MR, which considered potential mediators. Results MR via the inverse-variance weighted method revealed causal effects of cholesterol (CHOL, OR = 1.10, 95% CI: 1.03–1.18, P = 4.23 × 10⁻3) and low-density lipoprotein cholesterol (LDLC, OR = 1.10, 95% CI: 1.03–1.17, P = 3.28 × 10⁻3) on the risk of ALS, which were validated across multiple methods. …”
Get full text

Antibiotics Resistance Pattern of Food-Borne Bacteria Isolated from Ice Cream in Bangladesh: A Multidisciplinary Study by Md Sohel, Moushumi Akter, Md. Fahmid Hasan, Shahin Mahmud, Mohammod Johirul Islam, Ashekul Islam, Khairul Islam, Abdullah Al Mamun

“…The demographic characteristics showed that the degree of symptoms regarding microorganisms mediated disorders and rate of antibiotics intake in ice cream consumers were significantly higher than the nonconsumers. …”
Get full text

Scaling up computational thinking skills in computer-assisted language learning (CTsCALL) and its fitness with language learners’ intentions to use virtual exchange: A bi-symmetric... by Amir Reza Rahimi, Ana Sevilla-Pavón

“…It also revealed that language learners, who focused on the key information rather than the details while solving language tasks, as well as recognizing the pattern of task solving and applying them to other tasks, found VE, and CTsCALL to be aligned with their current capabilities, learning environment, and problem-solving skills that mediated their intention to learn and exchange information in this context in the future. …”
Get full text

Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling by Jennifer S. Ward, Karl J. Schreiber, John Tam, Ji-Young Youn, Roman A. Melnyk

“…Further characterizing the intoxication mechanisms of these proteins is important for the development of vaccines and treatments for toxin-mediated disease. Proximity-dependent biotinylation approaches offer an orthogonal approach to complement genetic screens. …”
Get full text

Preterm nutrition and brain development by Chiara Nava, Gianluca Lista, Enrica Lupo

“…In particular, HM components such as long-chain polyunsaturated fatty acids (LCPUFA) and Human Milk Oligosaccharides (HMOs) appear to play a key role in mediating this influence. As HM nutritional content is insufficient to meet the nutritional needs of most preterm infants, the use of multicomponent fortifiers derived from cow's milk has entered common practice in Neonatal Intensive Care Unit. …”
Get full text

Circulating miR-574–5p shows diagnostic and prognostic significance and regulates oxygen-glucose deprivation (OGD)-induced inflammatory activation of microglia by targeting ATP2B2... by Xia Yin, Chunlei Zhang

“…Conclusion: miR-574–5p acted as a biomarker for ischemic stroke and mediated neuroinflammation via targeting ATP2B2.…”
Get full text

Problematic Online Video Watching, Boredom Proneness and Loneliness Among First-Year Chinese Undergraduates: A Two-Wave Longitudinal Study by Yan Z, Yang Z, Xu X, Zhou C, Sang Q

“…To test the research hypotheses, cross-lagged panel models were performed using AMOS 24.0.Results: Our results revealed the that (1) Boredom proneness and problematic online video watching were mutually influenced. (2) Loneliness at T1 positively predicted the level of problematic online video watching at T2 but not vice versa. (3) Boredom proneness mediated the link between loneliness and problematic online video watching. (4) Chinese first-year undergraduates’ levels of problematic online video watching and boredom proneness significantly increased during their educational transition period from high school to university.Conclusion: The present study enhances our understanding of the dynamic relationships between problematic online video watching, boredom proneness and loneliness, highlighting the targeted prevention and interventions for first-year undergraduates.Keywords: problematic online video watching, boredom proneness, loneliness, cross-lagged panel model…”
Get full text

Study of Association of Vitamin D Receptor Gene Polymorphisms with Diabetic Nephropathy by Bhuiya Esha, Saravanan Yogaprabhu, Janaki Sneha, Karthick Vijayalakshmi, Viswanathan Mohan, Venkatesan Radha, Dhanasekaran Bodhini

“…The functions of vitamin D are mediated through vitamin D receptor (VDR). Three single nucleotide polymorphisms (SNPs) in VDR gene, namely, TaqI (rs731236), ApaI (rs7975232), and BsmI (rs1544410), have been widely studied in association with diabetes and nephropathy. …”
Get full text

Breast Implant Illness May Be Rooted in Mast Cell Activation: A Case-Controlled Retrospective Analysis by Èva S. Nagy, BMedSci(Hons), MBBS, PhD, FRACS, Grad Cert (Breast Surgery), Mark Westaway, MBBS, DCH, Grad Dip Allergy, Suzanne Danieletto, BSc, MBBS (Hons), FRCPA, MIAC, Lawrence B. Afrin, MD

“…Given that neoantigenic/xenobiotic exposures commonly trigger dysfunctional MCs in MCAS to heighten aberrant mediator expression driving inflammatory and other issues, further investigation of whether BII represents an implant-driven escalation of preexisting MCAS and whether an MCAS diagnosis flags risk for BII seems warranted.…”
Get full text

Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway by Zishuo Cheng, Shun Huang, Qiya Tang, Danlan Zhang, Lan Huang

“…Experimental data confirmed vitamin A’s effects on mitochondrial dynamics and metabolic reprogramming through the STAT3 pathway.ConclusionThe study demonstrates that vitamin A’s therapeutic effect on periodontitis is mediated through JAK-STAT pathway-guided mitochondrial metabolic reprogramming in macrophages. …”
Get full text

A comprehensive review and meta-analysis of the relationships between interleukin-7 levels and COVID-19 severity by Michal MATUSZEWSKI, Michal PRUC, Lukasz SZARPAK, Alla NAVOLOKINA, Katarzyna KIEZUN, Francesco CHIRICO, Gabriella NUCERA, Yuriy STEPANOVSKYY, Murat YILDIRIM, Anna HILFANOVA, Anastasia BONDARENKO

“…Introduction: As the major mechanism for coronavirus disease 2019, cytokine storm-mediated organ harm continues to dominate current understanding. …”
Get full text

Respiratory drive: a journey from health to disease by Dimitrios Georgopoulos, Maria Bolaki, Vaia Stamatopoulou, Evangelia Akoumianaki

“…During the involuntary act of breathing, chemical feedback, primarily mediated through CO2, is the main determinant of respiratory drive. …”
Get full text

Why should we strive to let them thrive? Exploring the links between homecare professionals thriving at work, employee ambidexterity, and innovative behavior by Terje Slåtten, Barbara Rebecca Mutonyi, Gudbrand Lien

“…Results The main results from the empirical study can be summarized as follows: (i) TAW was found to be positively linked to both EA (b = 0.46) and IIB (b = 0.22); (ii) TAW and EA explained about 30% (R2 = 0.29) the variance in IIB; (iii) The relationship between TAW and IIB was found to be mediated by the EA; (iv) TAW was positively linked to each of the two dimensions that constitute EA. …”
Get full text

Antibiofilm and Anti-Quorum Sensing Potential of Safely-Synthesized Hydrated Zirconium Oxide-Coated Alginate Beads against Some Pathogenic Bacteria by Alfred Ngenge Tamfu, Yasemin Ispirli Dogaç, Ozgur Ceylan, Andreea Botezatu Dediu, Selahattin Bozkurt, Rodica Mihaela Dinica

“…At MIC and sub-MIC concentrations, the synthesized beads inhibited the production of violacein in C. violaceum CV12472 and C. violaceum CV026, indicating that they can reduce QS-mediated virulence factors in bacteria. Antimicrobial activity was evaluated against Staphylococcus aureus, Enterococcus faecalis, Listeria monocytogenes, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Candida albicans, and Candida tropicalis, and MIC values ranged from 1.25 mg/mL to 10 mg/mL. …”
Get full text

Myocardin-Related Transcription Factor A (MRTF-A) Regulates the Balance between Adipogenesis and Osteogenesis of Human Adipose Stem Cells by Laura Hyväri, Sari Vanhatupa, Heidi T. Halonen, Minna Kääriäinen, Susanna Miettinen

“…Our results strongly indicate that MRTF-A is an important regulator of the balance between osteogenesis and adipogenesis of hASCs through its role in mediating the cytoskeletal dynamics. These results provide MRTF-A as a new interesting target for guiding the stem cell differentiation in tissue engineering applications for regenerative medicine.…”
Get full text

Parenting after a history of childhood maltreatment: A scoping review and map of evidence in the perinatal period. by Catherine Chamberlain, Graham Gee, Stephen Harfield, Sandra Campbell, Sue Brennan, Yvonne Clark, Fiona Mensah, Kerry Arabena, Helen Herrman, Stephanie Brown, ‘Healing the Past by Nurturing the Future’ group

“…Observational studies illustrate sociodemographic and mental health protective and risk factors that mediate/moderate intergenerational pathways to parental and child wellbeing. …”
Get full text

Combination of Fractional Exhaled Nitric Oxide (FeNO) Level and Asthma Control Test (ACT) in Detecting GINA-Defined Asthma Control in Treated Asthmatic Patients in Vietnam by Vinh Nguyen Nhu, Pham Le An, Niels H. Chavannes

“…FeNO has been used as a marker for Th2-mediated airway inflammation in asthma. There is evidence which recommends the use of this biomarker in asthma management. …”
Get full text

Impact of loneliness on suicidal ideation during the COVID-19 pandemic: findings from a cross-sectional online survey in Japan by Takahiro Tabuchi, Ryo Okubo, Hirokazu Tachikawa, Midori Matsushima, Haruhiko Midorikawa, Miyuki Aiba

“…Additionally, the results showed that those who were lonely, and continued to feel lonely during the pandemic, had the highest PRs of suicidal ideation.Conclusion Loneliness had both direct and indirect effects on suicidal ideation mediated through depression. Those who felt lonelier during the pandemic had the highest risk of suicidal ideation. …”
Get full text